Biomedical Optics Express

Article	Citations
Robotic microscopy for everyone: the OpenFlexure microscope	95
Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review [Invited]	80
Label-free plasmonic immunosensor for cortisol detection in a D-shaped optical fiber	77
Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy	59
Deep learning improves contrast in low-fluence photoacoustic imaging	55
Application of the generalized contrast-to-noise ratio to assess photoacoustic image quality	53
Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system	52
HER2 biosensing through SPR-envelope tracking in plasmonic optical fiber gratings	49
High-speed adaptive optics line-scan OCT for cellular-resolution optoretinography	47
Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids	45
High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source	44
Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry	43
Convolutional neural network for resolution enhancement and noise reduction in acoustic resolution photoacoustic microscopy	43
ML-SIM: universal reconstruction of structured illumination microscopy images using transfer learning	43
Machine learning-based LIBS spectrum analysis of human blood plasma allows ovarian cancer diagnosis	42
Reconstruction of high-resolution 6×6-mm OCT angiograms using deep learning	42
Quasi-distributed fiber optic sensor-based control system for interstitial laser ablation of tissue: theoretical and experimental investigations	42
End-to-end Res-Unet based reconstruction algorithm for photoacoustic imaging	41
In vivo imaging of the human cornea with high-speed and high-resolution Fourier-domain full-field optical coherence tomography	41
Multi-scale GCN-assisted two-stage network for joint segmentation of retinal layers and discs in peripapillary OCT images	41
Gold nanoparticle enhanced detection of EGFR with a terahertz metamaterial biosensor	39
Terahertz dielectric spectroscopy of human brain gliomas and intact tissues ex vivo: double-Debye and double-overdamped-oscillator models of dielectric response	39
Comparative study of the influence of imaging resolution on linear retardance parameters derived from the Mueller matrix	39
Smartphone-based optical spectroscopic platforms for biomedical applications: a review [Invited]	38
Compact off-axis holographic slide microscope: design guidelines	38

AV-Net: deep learning for fully automated artery-vein classification in optical coherence tomography angiography	38
Choosing a model for laser speckle contrast imaging	38
Pitch-rotational manipulation of single cells and particles using single-beam thermo-optical tweezers	37
Photoacoustic computed tomography for functional human brain imaging [Invited]	37
Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network	36
Multicolor structured illumination microscopy and quantitative control of polychromatic light with a digital micromirror device	36
Photoacoustic-guided surgery from head to toe [Invited]	36
High-throughput 3D imaging of single cells with light-sheet fluorescence microscopy on chip	35
Impact of skin tone on photoacoustic oximetry and tools to minimize bias	35
Multi-resolution open-top light-sheet microscopy to enable efficient 3D pathology workflows	33
Respiratory and heart rate monitoring using an FBG 3D-printed wearable system	33
Imaging intracellular motion with dynamic micro-optical coherence tomography	32
Two-photon image-scanning microscopy with SPAD array and blind image reconstruction	32
Real-time, wide-field and high-quality single snapshot imaging of optical properties with profile correction using deep learning	32
Planar Airy beam light-sheet for two-photon microscopy	32
Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina	31
Imaging of vitreous cortex hyalocyte dynamics using non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy in human subjects	31
Fluorescence imaging and Raman spectroscopy applied for the accurate diagnosis of breast cancer with deep learning algorithms	31
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy	31
Hybrid mesh and voxel based Monte Carlo algorithm for accurate and efficient photon transport modeling in complex bio-tissues	30
Dual-view oblique plane microscopy (dOPM)	29
Photoacoustic imaging of hemodynamic changes in forearm skeletal muscle during cuff occlusion	29
Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation	29
Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages	29
Real-time noise reduction based on ground truth free deep learning for optical coherence tomography	28
High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging	28
Towards in-vivo label-free detection of brain tumor margins with epi-illumination tomographic quantitative phase imaging	28
Hyperspectral imaging and robust statistics in non-melanoma skin cancer analysis	28
Wearable and wireless time-domain near-infrared spectroscopy system for brain and muscle hemodynamic monitoring	28
Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities	28
Terahertz spectroscopic diagnosis of early blast-induced traumatic brain injury in rats	28
Hybrid deep learning network for vascular segmentation in photoacoustic imaging	28
Skull acoustic aberration correction in photoacoustic microscopy using a vector space similarity model: a proof-of-concept simulation study	27
Integrating adaptive optics-SLO and OCT for multimodal visualization of the human retinal pigment epithelial mosaic	27
Ballistocardiography monitoring system based on optical fiber interferometer aided with heartbeat segmentation algorithm	27
Optical ptychography for biomedical imaging: recent progress and future directions [Invited]	27
Fast TIRF-SIM imaging of dynamic, low-fluorescent biological samples	27
Differentiation of burn wounds in an in vivo porcine model using terahertz spectroscopy	27
Automatic classification of esophageal disease in gastroscopic images using an efficient channel attention deep dense convolutional neural network	27
Motion-compensated noninvasive periodontal health monitoring using handheld and motor-based photoacoustic-ultrasound imaging systems	27
Applications of augmented reality in ophthalmology [Invited]	27
Lightweight UV-C disinfection system	26
Acoustic impact of the human skull on transcranial photoacoustic imaging	26
Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration	26
Polarization and depolarization metrics as optical markers in support to histopathology of ex vivo colon tissue	26
Wearable device for remote monitoring of transcutaneous tissue oxygenation	25
Deep learning approach to improve tangential resolution in photoacoustic tomography	25
Accelerating multicolor spectroscopic single-molecule localization microscopy using deep learning	25
Monte Carlo analysis of optical heart rate sensors in commercial wearables: the effect of skin tone and obesity on the photoplethysmography (PPG) signal	25
Terahertz polarization sensing based on metasurface microsensor display anti-proliferation of tumor cells with aspirin	25

Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy	25
Optical monitoring of cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass	25
Vision-correcting holographic display: evaluation of aberration correcting hologram	24
Blood cancer diagnosis using ensemble learning based on a random subspace method in laser-induced breakdown spectroscopy	24
UNMIX-ME: spectral and lifetime fluorescence unmixing via deep learning	24
Polarimetric visualization of healthy brain fiber tracts under adverse conditions: ex vivo studies	24
Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and semantic segmentation classification	23
Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping	23
Probing variations of fibrous structures during the development of breast ductal carcinoma tissues via Mueller matrix imaging	23
Bayesian deep learning for reliable oral cancer image classification	23
High-resolution wide-field OCT angiography with a self-navigation method to correct microsaccades and blinks	23
Wavelength and pulse energy optimization for detecting hypoxia in photoacoustic imaging of the neonatal brain: a simulation study	23
Portable ultra-widefield fundus camera for multispectral imaging of the retina and choroid	23
Dictionary learning technique enhances signal in LED-based photoacoustic imaging	23
Computational tissue staining of non-linear multimodal imaging using supervised and unsupervised deep learning	23
Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy	23
Deep-learning-assisted microscopy with ultraviolet surface excitation for rapid slide-free histological imaging	22
Holo-UNet: hologram-to-hologram neural network restoration for high fidelity low light quantitative phase imaging of live cells	22
Dual GRIN lens two-photon endoscopy for high-speed volumetric and deep brain imaging	22
Quantitative analysis of homocysteine in liquid by terahertz spectroscopy	22
Photothermally tunable Fabry-Pérot fiber interferometer for photoacoustic mesoscopy	22
Transfontanelle photoacoustic imaging: ultrasound transducer selection analysis	22
Depth-selective data analysis for time-domain fNIRS: moments vs. time windows	22
Deep learning-based light scattering microfluidic cytometry for label-free acute lymphocytic leukemia classification	22
Towards label-free 3D segmentation of optical coherence tomography images of the optic nerve head using deep learning	22
Deep-learning based multi-modal retinal image registration for the longitudinal analysis of patients with age-related macular degeneration	22
Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography	22
Transcranial photobiomodulation-induced changes in human brain functional connectivity and network metrics mapped by whole-head functional near-infrared spectroscopy in vivo	21
Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography	21
Model of dynamic speckle evolution for evaluating laser speckle contrast measurements of tissue dynamics	21
Sustained fatigue assessment during isometric exercises with time-domain near infrared spectroscopy and surface electromyography signals	21
Signal quality index: an algorithm for quantitative assessment of functional near infrared spectroscopy signal quality	21
Optimizing deep bone ablation by means of a microsecond Er:YAG laser and a novel water microjet irrigation system	21
Non-contact terahertz spectroscopic measurement of the intraocular pressure through corneal hydration mapping	21
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy	21
Terahertz dielectric spectroscopy and solid immersion microscopy of ex vivo glioma model 101.8: brain tissue heterogeneity	21
Fast in vivo multiphoton light-sheet microscopy with optimal pulse frequency	20
Quantitative Jones matrix imaging using vectorial Fourier ptychography	20
High compression deep learning based single-pixel hyperspectral macroscopic fluorescence lifetime imaging in vivo	20
Characterization of natural frequencies from nanoscale tissue oscillations using dynamic optical coherence elastography	20
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast	20
Deep iterative vessel segmentation in OCT angiography	20
OCT-GAN: single step shadow and noise removal from optical coherence tomography images of the human optic nerve head	20
Deep learning architecture “LightOCT” for diagnostic decision support using optical coherence tomography images of biological samples	20
Strip-based digital image registration for distortion minimization and robust eye motion measurement from scanned ophthalmic imaging systems	20
Weakly supervised anomaly segmentation in retinal OCT images using an adversarial learning approach	19
Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy	19
Second harmonic generation characterization of collagen in whole bone	19
Non-invasive investigation of adipose tissue by time domain diffuse optical spectroscopy	19
Label-free redox imaging of patient-derived organoids using selective plane illumination microscopy	19
Deep-learning super-resolution light-sheet add-on microscopy (Deep-SLAM) for easy isotropic volumetric imaging of large biological specimens	19
Fast whole-brain imaging of seizures in zebrafish larvae by two-photon light-sheet microscopy	19
Automatic stent reconstruction in optical coherence tomography based on a deep convolutional model	19
IA-net: informative attention convolutional neural network for choroidal neovascularization segmentation in OCT images	19
Organelle-specific phase contrast microscopy enables gentle monitoring and analysis of mitochondrial network dynamics	19
Phasor-based image segmentation: machine learning clustering techniques	19
Frequency-doubled femtosecond Er-doped fiber laser for two-photon excited fluorescence imaging	19
In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device	18
Effects of high intensity non-ionizing terahertz radiation on human skin fibroblasts	18
Optical design and performance of a trifocal sinusoidal diffractive intraocular lens	18
Evaluation of transdermal drug delivery using terahertz pulsed imaging	18
Machine learning model with physical constraints for diffuse optical tomography	18
Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe	18
Deconvolution for multimode fiber imaging: modeling of spatially variant PSF	18
Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging	18
Complex wavelet filter improves FLIM phasors for photon starved imaging experiments	18
Robust non-contact peripheral oxygenation saturation measurement using smartphone-enabled imaging photoplethysmography	18
Understanding the relationship between visual-angle and eye-angle for reliable determination of the field-of-view in ultra-wide field fundus photography	18
Histopathology for Mohs micrographic surgery with photoacoustic remote sensing microscopy	17
Fast, multiplane line-scan confocal microscopy using axially distributed slits	17
Highly sensitive detection of cytochrome c in the NSCLC serum using a hydrophobic paper based–gold nanourchin substrate	17
Evolution of adaptive optics retinal imaging [Invited]	17
Diagnosis and staging of multiple myeloma using serum-based laser-induced breakdown spectroscopy combined with machine learning methods	17
Fluorescence intensity and lifetime redox ratios detect metabolic perturbations in T cells	17
Polarimetric data-based model for tissue recognition	17
Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease	17
Photoacoustic imaging of microenvironmental changes in facial cupping therapy	17
Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture	17
Automatic geographic atrophy segmentation using optical attenuation in OCT scans with deep learning	17
Miniature structured illumination microscope for in vivo 3D imaging of brain structures with optical sectioning	17

Resolution enhancement and realistic speckle recovery with generative adversarial modeling of micro-optical coherence tomography	17
Rapid computational cell-rotation around arbitrary axes in 3D with multi-core fiber	17
Imaging human blood cells in vivo with oblique back-illumination capillaroscopy	17
Improving vascular imaging with co-planar mutually guided photoacoustic and diffuse optical tomography: a simulation study	17
Adaptive optics enables aberration-free single-objective remote focusing for two-photon fluorescence microscopy	17
Reflective mirror-based line-scan adaptive optics OCT for imaging retinal structure and function	17
Label-free imaging of fibroblast membrane interfaces and protein signatures with vibrational infrared photothermal and phase signals	17
Red and blue light in antitumor photodynamic therapy with chlorin-based photosensitizers: a comparative animal study assisted by optical imaging modalities	17
Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy	17
Measurement of tissue optical properties in a wide spectral range: a review [Invited]	17
Evaluation of the robustness of cerebral oximetry to variations in skin pigmentation using a tissue-simulating phantom	17
Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes	17
In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second	17
Laser-induced optical breakdown effects of micro-lens arrays and diffractive optical elements on ex vivo porcine skin after 1064 nm picosecond laser irradiation	17
Effects of excitation light polarization on fluorescence emission in two-photon light-sheet microscopy	16
Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography	16
Sensorless adaptive-optics optical coherence tomographic angiography	16
Quantification of scar collagen texture and prediction of scar development via second harmonic generation images and a generative adversarial network	16
Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery	16
Wavelet-based background and noise subtraction for fluorescence microscopy images	16
Full-field spectral-domain optical interferometry for snapshot three-dimensional microscopy	16
High-speed multicolor structured illumination microscopy using a hexagonal single mode fiber array	16
Probing layered structures by multi-color backscattering polarimetry and machine learning	16
Comparison between image texture and polarization features in histopathology	16
Identification and quantification of fibrotic areas in the human retina using polarization-sensitive OCT	16
Imaging deeper than the transport mean free path with multiphoton microscopy	16
Heterogeneity of circulating tumor cell dissemination and lung metastases in a subcutaneous Lewis lung carcinoma model	16
Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms	16
Nanosensitive optical coherence tomography to assess wound healing within the cornea	16
AOTF-based hyperspectral imaging phase microscopy	16
Photoacoustic dual-scan mammoscope: results from 38 patients	16
Stokes polarization imaging applied for monitoring dynamic tissue optical clearing	16
High-speed, multi-modal, label-free imaging of pathological slices with a Bessel beam	16
Automated phase unwrapping in digital holography with deep learning	16
Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics	16
A compact photonic resonator absorption microscope for point of care digital resolution nucleic acid molecular diagnostics	16
Machine learning for composition analysis of ssDNA using chemical enhancement in SERS	16
Measuring glucose concentration in a solution based on the indices of polarimetric purity	16
Quantitative multi-height phase retrieval via a coded image sensor	16
Spectroscopic detection of traumatic brain injury severity and biochemistry from the retina	16
Analysis of sensitivity in quantitative micro-elastography	16
Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited]	16
Phototoxicity induced in living HeLa cells by focused femtosecond laser pulses: a data-driven approach	15
Investigating the depolarization property of skin tissue by degree of polarization uniformity contrast using polarization-sensitive optical coherence tomography	15
Light-adapted flicker optoretinograms captured with a spatio-temporal optical coherence-tomography (STOC-T) system	15
Disrupted signal variability of spontaneous neural activity in children with attention-deficit/hyperactivity disorder	15
Deep learning-based single-shot autofocus method for digital microscopy	15
0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding	15
Recipes for diffuse correlation spectroscopy instrument design using commonly utilized hardware based on targets for signal-to-noise ratio and precision	15
Direct mapping from diffuse reflectance to chromophore concentrations in multi-fx spatial frequency domain imaging (SFDI) with a deep residual network (DRN)	15
Mapping metabolism of liver tissue using two-photon FLIM	15
Generating large field of view en-face projection images from intra-acquisition motion compensated volumetric optical coherence tomography data	15
Complete head cerebral sensitivity mapping for diffuse correlation spectroscopy using subject-specific magnetic resonance imaging models	15
Evaluation of bone perfusion during open orthopedic surgery using quantitative dynamic contrast-enhanced fluorescence imaging	15
Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography	15
Dynamic time domain near-infrared optical tomography based on a SPAD camera	15
Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy	15
Fast multi-directional DSLM for confocal detection without striping artifacts	15
Hyperspectral imaging and spectral unmixing for improving whole-body fluorescence cryo-imaging	15
Multi-speckle diffuse correlation spectroscopy to measure cerebral blood flow	15
Detection of single-base mutation of DNA oligonucleotides with different lengths by terahertz attenuated total reflection microfluidic cell	15
Imaging the dynamics of individual processes of microglia in the living retina in vivo	15
Label-free histological imaging of tissues using Brillouin light scattering contrast	15
Retinal layer segmentation in optical coherence tomography (OCT) using a 3D deep-convolutional regression network for patients with age-related macular degeneration	15
Synergistic performance of triggered drug release and photothermal therapy of MCF7 cells based on laser activated PEGylated GO + DOX	15
Moisture adsorption by decellularized bovine pericardium collagen matrices studied by terahertz pulsed spectroscopy and solid immersion microscopy	15
A wide field-of-view, modular, high-density diffuse optical tomography system for minimally constrained three-dimensional functional neuroimaging	15
Multimodal fusion of EEG-fNIRS: a mutual information-based hybrid classification framework	15
Real-time OCT image denoising using a self-fusion neural network	14
MF-AV-Net: an open-source deep learning network with multimodal fusion options for artery-vein segmentation in OCT angiography	14
Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptors	14
Tilt (in)variant lateral scan in oblique plane microscopy: a geometrical optics approach	14
Tomographic STED microscopy	14
Effects of photobiomodulation on the redox state of healthy and cancer cells	14
In vivo assessment of corneal biomechanics under a localized cross-linking treatment using confocal air-coupled optical coherence elastography	14
Real-time tool to layer distance estimation for robotic subretinal injection using intraoperative 4D OCT	14
Evaluation of resonant scanning as a high-speed imaging technique for two-photon imaging of cortical vasculature	14
Characterization of continuous wave ultrasound for acousto-optic modulated diffuse correlation spectroscopy (AOM-DCS)	14
Wavefront sensor-less adaptive optics using deep reinforcement learning	14
Stress management using fNIRS and binaural beats stimulation	14
Photonic Bragg waveguide platform for multichannel resonant sensing applications in the THz range	14
Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection	14
Laser-induced fluorescent visualization and photodynamic therapy in surgical treatment of glial brain tumors	14
Graph convolutional network based optic disc and cup segmentation on fundus images	14
Accuracy of diffuse correlation spectroscopy measurements of cerebral blood flow when using a three-layer analytical model	14
Machine learning-based rapid diagnosis of human borderline ovarian cancer on second-harmonic generation images	14
Probe-hosted large area silicon photomultiplier and high-throughput timing electronics for enhanced performance time-domain functional near-infrared spectroscopy	14
Slide-free clinical imaging of melanin with absolute quantities using label-free third-harmonic-generation enhancement-ratio microscopy	14
Empirical assessment of laser safety for photoacoustic-guided liver surgeries	14
Multi-camera infrared thermography for infant respiration monitoring	14
FLImBrush: dynamic visualization of intraoperative free-hand fiber-based fluorescence lifetime imaging	14
Adaptive optics for optical microscopy [Invited]	14
Volumetric Lissajous confocal microscopy with tunable spatiotemporal resolution	14
Polarization and Orbital Angular Momentum of Light in Biomedical Applications: feature issue introduction	14
Multi-layer optical fiber surface plasmon resonance biosensor based on a sandwich structure of polydopamine-MoSe2@Au nanoparticles-polydopamine	14