Aging and Disease

Article	Citations
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	291
Is the β Common Receptor the Key Molecule for the Protective Effect of Erythropoietin?	124
Vascular Contributions to Healthy Aging and Dementia	117
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	98
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	93
Protein Synthesis Errors and Longevity: A Lesson from a Single Amino Acid Mutation Study	86
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations	80
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	70
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	68
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	66
EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease	64
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	63
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	62
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism	59
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	56
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases	52
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty	51
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	51
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	48
Vascular Aging and Atherosclerosis: A Perspective on Aging	47
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	46
Lysine Malonylation and Its Links to Metabolism and Diseases	46
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	45
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	45
Perspectives on Movement and Eating Behaviours in Brazilian Elderly: An Analysis of Clusters Associated with Disease Outcomes	44

Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	43
Citicoline for Supporting Memory in Aging Humans	43
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss	42
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting	40
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation	40
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	40
Emerging Roles of Ceramide in Cardiovascular Diseases	38
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	36
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	36
Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression	35
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	35
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program	35
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	34
Telomeres: Dysfunction, Maintenance, Aging and Cancer	34
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus	34
Autophagy in Disease Onset and Progression	33
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	33
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	33
Current Animal Model Systems for Ovarian Aging Research	32
Aging and “Age-Related” Diseases - What Is the Relation?	31
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	31
Elderly Dementia Needs Better Care in Post-COVID-19 Era	30
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	30
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	30
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	30
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	30
(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies	29
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	29
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	29
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	28
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	28
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	28
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	27
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	27
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	27
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions	27
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	27
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	27
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	26
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	26
Different Aspects of Aging in Migraine	26
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration	26
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	26
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	26
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	25
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	25
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	25
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	25
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	25
DNA Methylation Modulates Aging Process in Adipocytes	24

Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	24
Stem Cell-derived Exosomal MicroRNA as Therapy for Vascular Age-related Diseases	24
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	24
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	24
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy	24
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	24
Senescent T Cells in Age-Related Diseases	24
Animal Models of Epilepsy: A Phenotype-oriented Review	23
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	23
Acute Sarcopenia after Elective and Emergency Surgery	23
Intrinsic Capacity in Older Adults: Recent Advances	23
Cerebral Glucose Metabolism and Potential Effects on Endoplasmic Reticulum Stress in Stroke	23
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	23
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	23
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	22
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	22
Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life	22
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease	22
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	22
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	22
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice	21
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases	21
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	21
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development	21
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	21
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	21
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	21
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	20
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	20
The Metabolic Landscape in Osteoarthritis	20
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	20
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	20
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	19
Conceptual Overview of Biological Age Estimation	19
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	19
Neuronal Senescence in the Aged Brain	18
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	18
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	18
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	18
	18
Are Older People Really More Susceptible to SARS-CoV-2?	18
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	18
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	17
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	17
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	17
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	17
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	17
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	16
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	16
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	16
Association Between Dementia and Optical Coherence Tomography Scan Quality	16
Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment	16
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	16
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	16
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief	16
COVID-19 Pandemic and Osteoporosis in Elderly Patients	16
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	16
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	15
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	15
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	15
Mitochondria: A Potential Rejuvenation Tool against Aging	15
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	14
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	14
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation	14
Aging Gut Microbiome in Healthy and Unhealthy Aging	14
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	14
Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation	14
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	14
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	14
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	14
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI	14
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque	13
Irreversibility of Pulmonary Fibrosis	13
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	13
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults	13
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study	13
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	13
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	13
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease	13
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	13

Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	13
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	13
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	13
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	13
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	12
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	12
Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics	12
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	12
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	11
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	11
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	11
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	11
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	11
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	11
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	11
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	11
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	11
Sarcopenic Obesity: An Emerging Public Health Problem, But an Answer Appears to Be Available	11
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	11
nillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence	11
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	11
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	11
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	11
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	11
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	11
Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China	11
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	10
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	10
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	10
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	10
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	10
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	10
Predictive Value of Plasma Neurofilament Light Chain for Neurological Outcomes in Patients with Intracerebral Hemorrhage	10
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	10
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	10
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	10
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	10
Will New Variants Emerge after Delta and Omicron?	10
CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis	10
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer	10