Aging and Disease

Article	Citations
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives	146
Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration	86
DeepMAge: A Methylation Aging Clock Developed with Deep Learning	83
Cellular Senescence in Cardiovascular Diseases: A Systematic Review	79
Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke	79
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis	73
Acute Stroke Management: Overview and Recent Updates	57
Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease	56
Radiomics in Stroke Neuroimaging: Techniques, Applications, and Challenges	54
Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia	54
New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases	52
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease	50
The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review	49
The Impact of Frailty on Spine Surgery: Systematic Review on 10 years Clinical Studies	49
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke	49
Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment	49
Regulatory T cells in COVID-19	49
Sarcopenic Obesity: An Emerging Public Health Problem	47
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease	46
Sleep Disorders in Stroke: An Update on Management	46
Metabolomics Signatures of Aging: Recent Advances	45
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	41
Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective	40
Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration	40
Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease	40

Neuromodulation in Drug Resistant Epilepsy	38
Aging and Renal Disease: Old Questions for New Challenges	38
The Molecular Regulation in the Pathophysiology in Ovarian Aging	38
Intrinsic Capacity in Older Adults: Recent Advances	38
Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases	37
Intestinal Inflammation and Parkinson’s Disease	37
Autophagy and Renal Fibrosis	35
NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice	35
Irreversibility of Pulmonary Fibrosis	34
Metformin: A Potential Candidate for Targeting Aging Mechanisms	34
Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal	34
Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease	34
Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19	33
SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases	33
Depression and Dementia in Older Adults: A Neuropsychological Review	33
Tumor Immune Microenvironment and Immunotherapy in Non-Small Cell Lung Cancer: Update and New Challenges	32
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy	32
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection	31
CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway	31
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a	31
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice	30
Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China	29
NIHSS Consciousness Score Combined with ASPECTS is a Favorable Predictor of Functional Outcome post Endovascular Recanalization in Stroke Patients	29
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease	29
An Update on Medical and Surgical Treatments of Parkinson’s Disease	29
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	28
Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A Review	28
Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine	28
Amyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and Challenges	28
The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy	28
The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies	28
The Role of SGLT2 Inhibitors in Vascular Aging	28
The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress	27
Transcranial Focused Ultrasound Stimulation Improves Neurorehabilitation after Middle Cerebral Artery Occlusion in Mice	27
Endogenous Repair and Regeneration of Injured Articular Cartilage: A Challenging but Promising Therapeutic Strategy	27
VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke	27
Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis	26
Pediatric Stroke: Overview and Recent Updates	26
Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions	26
Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging	26
Emerging Roles of Ceramide in Cardiovascular Diseases	26
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction	25
Pharmacological Mechanisms and Clinical Applications of Curcumin: Update	25
HIF-1α promotes the migration and invasion of cancer-associated fibroblasts by miR-210	25
Animal Models of Epilepsy: A Phenotype-oriented Review	25
A Comprehensive Summary of the Knowledge on COVID-19 Treatment	24
Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease	24
Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction	24
Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench	24
Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction	24

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease	23
Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia	23
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19	23
Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk	23
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis	23
Aquaporin-4 and Cognitive Disorders	23
Extracellular Vesicles in Health and Disease	22
A Next-Generation Vaccine Candidate Using Alternative Epitopes to Protect against Wuhan and All Significant Mutant Variants of SARS-CoV-2: An Immunoinformatics Approach	22
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors	22
Tryptophan Metabolism in Central Nervous System Diseases: Pathophysiology and Potential Therapeutic Strategies	22
Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management	22
Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians	22
Skeletal Muscle Metabolic Alternation Develops Sarcopenia	22
ACE2 and COVID-19 Susceptibility and Severity	22
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	22
Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation	22
Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity	21
Risk Factors, Pathophysiologic Mechanisms, and Potential Treatment Strategies of Futile Recanalization after Endovascular Therapy in Acute Ischemic Stroke	21
A Systematic Review of Parkinson’s Disease Cluster Analysis Research	21
Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism	21
Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjo¨gren’s Syndrome	21
SARS-CoV-2: the “Uncensored” Truth about Its Origin and Adipose-Derived Mesenchymal Stem Cells as New Potential Immune-Modulatory Weapon	21
Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?	20
Systematic Review of Studies on Telomere Length in Patients with Multiple Sclerosis	20
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies	20
Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis	20
The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	20
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	20
Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death	20
Dehydroepiandrosterone, Cancer, and Aging	19
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity	19
CD36 Signaling in Diabetic Cardiomyopathy	19
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	19
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice	19
Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd	18
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression	18
Reflex Epilepsy	18
Oligodendrocyte Precursor Cells Transplantation Improves Stroke Recovery via Oligodendrogenesis, Neurite Growth and Synaptogenesis	18
Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19	18
Ferroptosis in Intracerebral Hemorrhage: A Panoramic Perspective of the Metabolism, Mechanism and Theranostics	18
Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke	18
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	18
Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults	18
Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination	18
DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice	18
Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis	17
Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review	17
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions	17
SARS-CoV-2 Emergency and Long-Term Cognitive Impairment in Older People	17
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena	17
The Pathogenesis and Treatment of Cardiovascular Autonomic Dysfunction in Parkinson’s Disease: What We Know and Where to Go	17
Lysine Malonylation and Its Links to Metabolism and Diseases	17
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	17
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	17
cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders	16
The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies	16
Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke	16
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	16
Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases	16
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	15
COVID-19 Pandemic and Osteoporosis in Elderly Patients	15
Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment	15
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications	15
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	15
Comprehensive Perspectives on Experimental Models for Parkinson’s Disease	15
Potential Crosstalk Between Parkinson's Disease and Energy Metabolism	15
Cell Heterogeneity Uncovered by Single-Cell RNA Sequencing Offers Potential Therapeutic Targets for Ischemic Stroke	15
Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson’s Disease: Current Understanding and Knowledge Gaps	15
Are Older People Really More Susceptible to SARS-CoV-2?	15
Pathogenesis and Management in Cerebrovenous Outflow Disorders	15
Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy	15
Metabolic Abnormalities in Patients with Chronic Disorders of Consciousness	15
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	14
SIRT6 in Vascular Diseases, from Bench to Bedside	14
Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins	14
The Metabolic Landscape in Osteoarthritis	14
Obstructive Sleep Apnea-hypopnea Syndrome as a Novel Potential Risk for Aging	14
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	14
Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders	14
The Aged Intestine: Performance and Rejuvenation	14

LncRNAs as the Regulators of Brain Function and Therapeutic Targets for Alzheimer’s Disease	14
Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions	14
Roles of the MYST Family in the Pathogenesis of Alzheimer’s Disease via Histone or Non-histone Acetylation	14
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	14
tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases	14
Contrasting Metabolic Insufficiency in Aging and Dementia	14
Locomotor Hyperactivity in the Early-Stage Alzheimer’s Disease-like Pathology of APP/PS1 Mice: Associated with Impaired Polarization of Astrocyte Aquaporin 4	14
Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging	14
Current Animal Model Systems for Ovarian Aging Research	14
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity	13
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	13
The Alteration of Brain Interstitial Fluid Drainage with Myelination Development	13
The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review	13
Investigating the Clinical Utility of the Anti-Mullerian Hormone Testing for the Prediction of Age at Menopause and Assessment of Functional Ovarian Reserve: A Practical Approach and Recent Updates	13
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice	13
Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19	13
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression	13
State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease	13
Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era	13
Skeletal Muscle Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Underlying Mechanisms and Physical Therapy Perspectives	13
DNA Methylation Modulates Aging Process in Adipocytes	13
Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles	13
G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model	13
Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers	12
Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer’s Disease and Its Neuropsychiatric Symptoms	12
Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications	12
Information and Communication Technologies for Managing Frailty: A Systematic Literature Review	12
Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells	12
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging	12
Bioenergetic Impairment in the Neuro-Glia-Vascular Unit: An Emerging Physiopathology during Aging	12
Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport	12
Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies	12
Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s Disease	12
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	12
Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?	12
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	12
A Challenge to Healthy Aging: Limited Social Participation in Old Age	12
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	12
Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment	12
Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy	12