Aging and Disease

Article	Citations
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	236
Is the β Common Receptor the Key Molecule for the Protective Effect of Erythropoietin?	107
Vascular Contributions to Healthy Aging and Dementia	101
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	77
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	71
Protein Synthesis Errors and Longevity: A Lesson from a Single Amino Acid Mutation Study	70
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	64
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	60
EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease	58
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	56
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	54
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	53
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	52
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	48
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	43
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	43
Lysine Malonylation and Its Links to Metabolism and Diseases	43
Vascular Aging and Atherosclerosis: A Perspective on Aging	43
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	42
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	41
Perspectives on Movement and Eating Behaviours in Brazilian Elderly: An Analysis of Clusters Associated with Disease Outcomes	41
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	41
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	40
Citicoline for Supporting Memory in Aging Humans	40
Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression	39

Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	38
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	37
Current Animal Model Systems for Ovarian Aging Research	37
Telomeres: Dysfunction, Maintenance, Aging and Cancer	36
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	35
Autophagy in Disease Onset and Progression	33
Aging and “Age-Related” Diseases - What Is the Relation?	32
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	30
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	30
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	30
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	29
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	29
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	29
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	28
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	28
Emerging Roles of Ceramide in Cardiovascular Diseases	28
Elderly Dementia Needs Better Care in Post-COVID-19 Era	27
Different Aspects of Aging in Migraine	27
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	27
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration	26
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	26
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	26
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	25
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	25
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	25
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	25
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	25
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	25
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	24
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	24
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	23
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	23
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	23
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	22
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	22
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	22
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	22
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	22
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	22
Stem Cell-derived Exosomal MicroRNA as Therapy for Vascular Age-related Diseases	22
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	22
DNA Methylation Modulates Aging Process in Adipocytes	21
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	21
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	20
Senescent T Cells in Age-Related Diseases	20
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	20
Intrinsic Capacity in Older Adults: Recent Advances	19
Acute Sarcopenia after Elective and Emergency Surgery	19
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	19
Animal Models of Epilepsy: A Phenotype-oriented Review	19

Cerebral Glucose Metabolism and Potential Effects on Endoplasmic Reticulum Stress in Stroke	19
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	18
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	18
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	18
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	18
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	18
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	18
Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life	17
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases	17
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	17
The Metabolic Landscape in Osteoarthritis	17
Conceptual Overview of Biological Age Estimation	17
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	17
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	17
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease	17
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	16
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	16
	16
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	16
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	16
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	16
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	16
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	16
Association Between Dementia and Optical Coherence Tomography Scan Quality	16
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	15
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	15
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	15
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	15
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	15
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	15
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	14
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	14
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	14
Mitochondria: A Potential Rejuvenation Tool against Aging	14
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	14
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	14
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	14
COVID-19 Pandemic and Osteoporosis in Elderly Patients	14
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	13
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	13
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	13
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	13
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	13
Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics	13
Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment	13
Are Older People Really More Susceptible to SARS-CoV-2?	13
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	13
Aging Gut Microbiome in Healthy and Unhealthy Aging	13
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	13
Neuronal Senescence in the Aged Brain	13
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	13
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	13
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	13
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	13
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	13
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	12
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation	12
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	12
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	12
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque	12
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	12
Irreversibility of Pulmonary Fibrosis	12
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	11
Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China	11
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	11
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	11
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	11
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	11
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	11
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	11
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	11
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	11
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	11
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	10
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	10
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	10
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	10
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	10
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	10
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	10

Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	10
Sarcopenic Obesity: An Emerging Public Health Problem, But an Answer Appears to Be Available	10
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	10
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	10
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	9
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	9
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	9
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	9
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	9
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	9
Predictive Value of Plasma Neurofilament Light Chain for Neurological Outcomes in Patients with Intracerebral Hemorrhage	9
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	9
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	9
Toward the Identification of Neurophysiological Biomarkers for Alzheimer’s Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis	9
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	8
A Framework for an Effective Healthy Longevity Clinic	8
Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways	8
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications	8
Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy	8
Will New Variants Emerge after Delta and Omicron?	8
CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis	8
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy	8
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression	8
COVID-19 and Cardiovascular Diseases: From Cellular Mechanisms to Clinical Manifestations	8
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	8
SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence	8
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	8
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	8
Endothelial Senescence in Neurological Diseases	8
HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes	8