Aging and Disease

Article	Citations
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine	280
Is the β Common Receptor the Key Molecule for the Protective Effect of Erythropoietin?	119
Vascular Contributions to Healthy Aging and Dementia	113
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review	94
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen	87
Protein Synthesis Errors and Longevity: A Lesson from a Single Amino Acid Mutation Study	86
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations	74
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung	66
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations	66
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review	63
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis	62
Vascular Aging and Atherosclerosis: A Perspective on Aging	60
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism	55
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization	54
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies	53
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies	52
EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease	50
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging	49
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases	48
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty	47
Lysine Malonylation and Its Links to Metabolism and Diseases	46
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	45
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis	44
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias	43
Perspectives on Movement and Eating Behaviours in Brazilian Elderly: An Analysis of Clusters Associated with Disease Outcomes	42

Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies	42
Citicoline for Supporting Memory in Aging Humans	41
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss	40
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting	39
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation	39
Aging and “Age-Related” Diseases - What Is the Relation?	38
EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age	36
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage	35
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria	34
Age-, sex-, and ancestry-specific prevalence of hearing loss in UK Biobank and All of Us Research Program	34
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy	34
Telomeres: Dysfunction, Maintenance, Aging and Cancer	34
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis	33
Current Animal Model Systems for Ovarian Aging Research	33
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects	32
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer	32
Autophagy in Disease Onset and Progression	32
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	31
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy	30
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	30
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus	30
Age-related Loss of miR-124 Causes Cognitive Deficits via Derepressing RyR3 Expression	29
Elderly Dementia Needs Better Care in Post-COVID-19 Era	29
Emerging Roles of Ceramide in Cardiovascular Diseases	29
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency	29
New Clues to Cardiovascular Disease: Erythrocyte Lifespan	29
NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation	28
Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis	27
Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines	27
Clinical Potential of Immunotherapies in Subarachnoid Hemorrhage Treatment: Mechanistic Dissection of Innate and Adaptive Immune Responses	27
Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration	27
Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid	27
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions	27
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging	27
Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions	26
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice	26
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	26
Mortality Outcomes in a Large Population with and without Covert Cerebrovascular Disease	26
Role of Microglia, Decreased Neurogenesis and Oligodendrocyte Depletion in Long COVID-Mediated Brain Impairments	26
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease	25
Histone Methylation, Energy Metabolism, and Alzheimer's Disease	25
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration	25
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential	24
Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging	24
Emerging Roles of Adaptive Immune Response in Alzheimer's Disease	24
Different Aspects of Aging in Migraine	24
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk	24
Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia	24
(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies	24
Minocycline Administration Does Not Have an Effect on Retinal Ganglion Cell Survival in a Murine Model of Ocular Hypertension	24

Senescent T Cells in Age-Related Diseases	23
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside	23
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training	23
Stem Cell-derived Exosomal MicroRNA as Therapy for Vascular Age-related Diseases	23
Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice	23
Cerebral Glucose Metabolism and Potential Effects on Endoplasmic Reticulum Stress in Stroke	23
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy	23
Intrinsic Capacity in Older Adults: Recent Advances	22
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	22
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	22
Acute Sarcopenia after Elective and Emergency Surgery	22
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis	22
DNA Methylation Modulates Aging Process in Adipocytes	22
The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging	21
Astrocyte-Derived Extracellular Vesicles for Ischemic Stroke: Therapeutic Potential and Prospective	21
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke	21
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases	21
Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects	21
Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life	21
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43	21
Animal Models of Epilepsy: A Phenotype-oriented Review	21
Probiotic Limosilactobacillus Reuteri (Lactobacillus Reuteri) Extends the Lifespan of Drosophila Melanogaster through Insulin/IGF-1 Signaling	20
Conceptual Overview of Biological Age Estimation	20
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases	20
Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel Disease	20
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development	20
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice	20
Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury	20
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter	19
Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency	19
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	19
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	18
Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance	18
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways	18
Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway	18
The Metabolic Landscape in Osteoarthritis	18
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The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression	17
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice	17
CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration	17
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics	17
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	17
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	17
Shock Resuscitation - the Necessity and Priority of Renal Blood Perfusion Assessment	16
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke	16
Mitochondria: A Potential Rejuvenation Tool against Aging	16
Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms	16
Are Older People Really More Susceptible to SARS-CoV-2?	16
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications	16
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	16
CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes	16
Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis	16
Association Between Dementia and Optical Coherence Tomography Scan Quality	15
Redefinition of Synovial Fibroblasts in Rheumatoid Arthritis	15
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline	15
COVID-19 Pandemic and Osteoporosis in Elderly Patients	15
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	15
Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease	14
Neuronal Senescence in the Aged Brain	14
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass	14
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study	14
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease	14
Deep Learning Based on Computed Tomography Predicts Response to Chemoimmunotherapy in Lung Squamous Cell Carcinoma	14
Aging Gut Microbiome in Healthy and Unhealthy Aging	14
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments	14
Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques	14
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief	14
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer	14
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences	14
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study	13
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice	13
Irreversibility of Pulmonary Fibrosis	13
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI	13
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response	13
Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics	13
cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque	13
Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis	13
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease	13
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?	13
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	13

Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation	13
Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation	12
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	11
A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study	11
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence	11
Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?	11
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults	11
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians	11
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses	11
Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform	11
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	11
Age-Related Hormones Changes and Its Impact on Health Status and Lifespan	11
Sarcopenic Obesity: An Emerging Public Health Problem, But an Answer Appears to Be Available	11
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates	11
Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations	11
YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis	10
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping	10
Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China	10
Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies	10
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	10
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases	10
Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway	10
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis	10
nillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence	10
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice	10
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration	10
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling	10
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases	10
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions	10
Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease	10
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer	10
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	10
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	10
CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis	9
Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy	9
Chondroitin Sulfate Proteoglycans Revisited: Its Mechanism of Generation and Action for Spinal Cord Injury	9
Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies	9
HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes	9
Predictive Value of Plasma Neurofilament Light Chain for Neurological Outcomes in Patients with Intracerebral Hemorrhage	9
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review	9
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	9
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	9
SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence	9
Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain	9
Toward the Identification of Neurophysiological Biomarkers for Alzheimer’s Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis	9
NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke	9
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis	9
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis	9
Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways	9
A Framework for an Effective Healthy Longevity Clinic	9
Endothelial Senescence in Neurological Diseases	9
Will New Variants Emerge after Delta and Omicron?	9