Aging and Disease

Article	Citations
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives	71
DeepMAge: A Methylation Aging Clock Developed with Deep Learning	69
Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke	68
Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration	61
Cellular Senescence in Cardiovascular Diseases: A Systematic Review	53
The Impact of Frailty on Spine Surgery: Systematic Review on 10 years Clinical Studies	45
Acute Stroke Management: Overview and Recent Updates	45
Regulatory T cells in COVID-19	43
Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease	43
Radiomics in Stroke Neuroimaging: Techniques, Applications, and Challenges	43
MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis	42
The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review	42
Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia	42
Mechanism of Ferroptosis: A Potential Target for Cardiovascular Diseases Treatment	40
New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases	40
Metabolomics Signatures of Aging: Recent Advances	39
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease	38
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke	37
Neuromodulation in Drug Resistant Epilepsy	35
Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease	34
Sleep Disorders in Stroke: An Update on Management	34
Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19	32
Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration	31
The Molecular Regulation in the Pathophysiology in Ovarian Aging	29
NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice	29

Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases	29
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease	28
Aging and Renal Disease: Old Questions for New Challenges	28
Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease	28
Sarcopenic Obesity: An Emerging Public Health Problem	28
Metformin: A Potential Candidate for Targeting Aging Mechanisms	28
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection	28
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases	27
Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal	26
Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a	26
Intrinsic Capacity in Older Adults: Recent Advances	25
Transcranial Focused Ultrasound Stimulation Improves Neurorehabilitation after Middle Cerebral Artery Occlusion in Mice	25
An Update on Medical and Surgical Treatments of Parkinson’s Disease	24
Autophagy and Renal Fibrosis	24
Coagulation Disorders and Thrombosis in COVID-19 Patients and a Possible Mechanism Involving Endothelial Cells: A Review	23
Clinical Characteristics, Transmissibility, Pathogenicity, Susceptible Populations, and Re-infectivity of Prominent COVID-19 Variants	23
Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China	23
Intestinal Inflammation and Parkinson’s Disease	23
A Comprehensive Summary of the Knowledge on COVID-19 Treatment	23
Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine	23
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice	23
The Role of SGLT2 Inhibitors in Vascular Aging	22
Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective	22
SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases	22
The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies	22
NIHSS Consciousness Score Combined with ASPECTS is a Favorable Predictor of Functional Outcome post Endovascular Recanalization in Stroke Patients	22
The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress	21
Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions	21
Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation	21
Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease	21
Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction	21
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy	21
Irreversibility of Pulmonary Fibrosis	21
Pediatric Stroke: Overview and Recent Updates	20
Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis	20
Aquaporin-4 and Cognitive Disorders	20
Amyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and Challenges	20
CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway	20
Tumor Immune Microenvironment and Immunotherapy in Non-Small Cell Lung Cancer: Update and New Challenges	20
Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging	20
Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19	20
Emerging Roles of Ceramide in Cardiovascular Diseases	20
Depression and Dementia in Older Adults: A Neuropsychological Review	19
SARS-CoV-2: the “Uncensored” Truth about Its Origin and Adipose-Derived Mesenchymal Stem Cells as New Potential Immune-Modulatory Weapon	19
Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench	19
Endogenous Repair and Regeneration of Injured Articular Cartilage: A Challenging but Promising Therapeutic Strategy	19
A Next-Generation Vaccine Candidate Using Alternative Epitopes to Protect against Wuhan and All Significant Mutant Variants of SARS-CoV-2: An Immunoinformatics Approach	19
HIF-1α promotes the migration and invasion of cancer-associated fibroblasts by miR-210	19
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease	19
Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk	18

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease	18
VEGF, a Key Factor for Blood Brain Barrier Injury After Cerebral Ischemic Stroke	18
ACE2 and COVID-19 Susceptibility and Severity	18
Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia	18
Outcomes in Endovascular Therapy for Basilar Artery Occlusion: Intracranial Atherosclerotic Disease vs. Embolism	18
Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management	17
Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults	17
The Pathogenesis and Treatment of Cardiovascular Autonomic Dysfunction in Parkinson’s Disease: What We Know and Where to Go	17
A Systematic Review of Parkinson’s Disease Cluster Analysis Research	17
Systematic Review of Studies on Telomere Length in Patients with Multiple Sclerosis	17
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents	16
Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke	16
Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians	16
Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?	16
Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction	16
Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death	16
Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd	16
Animal Models of Epilepsy: A Phenotype-oriented Review	16
SARS-CoV-2 Emergency and Long-Term Cognitive Impairment in Older People	16
Extracellular Vesicles in Health and Disease	15
Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjo¨gren’s Syndrome	15
Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena	15
Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review	15
Skeletal Muscle Metabolic Alternation Develops Sarcopenia	14
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice	14
Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity	14
DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice	14
Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review	14
Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis	14
Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions	13
Pathogenesis and Management in Cerebrovenous Outflow Disorders	13
Reflex Epilepsy	13
Lysine Malonylation and Its Links to Metabolism and Diseases	13
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction	13
Ferroptosis in Intracerebral Hemorrhage: A Panoramic Perspective of the Metabolism, Mechanism and Theranostics	13
Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium	13
Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke	13
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors	13
CD36 Signaling in Diabetic Cardiomyopathy	13
The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy	13
The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies	13
Metabolic Abnormalities in Patients with Chronic Disorders of Consciousness	13
Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments	13
SIRT6 in Vascular Diseases, from Bench to Bedside	12
Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy	12
Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis	12
Oligodendrocyte Precursor Cells Transplantation Improves Stroke Recovery via Oligodendrogenesis, Neurite Growth and Synaptogenesis	12
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression	12
Current Animal Model Systems for Ovarian Aging Research	12
tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases	12
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update	12
The Metabolic Landscape in Osteoarthritis	12
Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging	12
The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review	12
Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles	12
Contrasting Metabolic Insufficiency in Aging and Dementia	12
Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport	12
Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19	12
Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy	12
Promising Intervention Approaches to Potentially Resolve Neuroinflammation And Steroid Hormones Alterations in Alzheimer’s Disease and Its Neuropsychiatric Symptoms	11
cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders	11
Cell Heterogeneity Uncovered by Single-Cell RNA Sequencing Offers Potential Therapeutic Targets for Ischemic Stroke	11
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging	11
Comprehensive Perspectives on Experimental Models for Parkinson’s Disease	11
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity	11
Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination	11
Roles of the MYST Family in the Pathogenesis of Alzheimer’s Disease via Histone or Non-histone Acetylation	11
Coronavirus Disease (COVID-19): A Perspective from Immunosenescence	11
Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era	11
Bioenergetic Impairment in the Neuro-Glia-Vascular Unit: An Emerging Physiopathology during Aging	11
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions	11
Ischemic Stroke: An Underestimated Complication of COVID-19	11
Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment	10
Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson’s Disease: Current Understanding and Knowledge Gaps	10
G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model	10
Pharmacological Mechanisms and Clinical Applications of Curcumin: Update	10
Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins	10
Dehydroepiandrosterone, Cancer, and Aging	10
Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19	10
Obstructive Sleep Apnea-hypopnea Syndrome as a Novel Potential Risk for Aging	10

Risk Factors, Pathophysiologic Mechanisms, and Potential Treatment Strategies of Futile Recanalization after Endovascular Therapy in Acute Ischemic Stroke	10
Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?	10
COVID-19 Pandemic and Osteoporosis in Elderly Patients	10
Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson’s Disease	10
The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	10
Neurological and Neurodegenerative Disorders: Novel Concepts and Treatment	10
Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators	10
The Aged Intestine: Performance and Rejuvenation	10
Investigating the Clinical Utility of the Anti-Mullerian Hormone Testing for the Prediction of Age at Menopause and Assessment of Functional Ovarian Reserve: A Practical Approach and Recent Updates	10
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice	10
Interdisciplinary Research in Alzheimer’s Disease and the Roles International Societies Can Play	10
Effects of Pyruvate Administration on Mitochondrial Enzymes, Neurological Behaviors, and Neurodegeneration after Traumatic Brain Injury	9
A Paradigm Shift in the Combination Changes of SARS-CoV-2 Variants and Increased Spread of Delta Variant (B.1.617.2) across the World	9
Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders	9
Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells	9
Potential Crosstalk Between Parkinson's Disease and Energy Metabolism	9
Are Older People Really More Susceptible to SARS-CoV-2?	9
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications	9
All Nations Must Prioritize the COVID-19 Vaccination Program for Elderly Adults Urgently	9
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective	9
Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers	9
The Alteration of Brain Interstitial Fluid Drainage with Myelination Development	9
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis	9
Information and Communication Technologies for Managing Frailty: A Systematic Literature Review	9
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis	9
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets	9
The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies	8
Body adaptation to Dance: A Gerontological Perspective	8
Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients	8
Exercise in Aging: Be Balanced	8
Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases	8
Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures	8
Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases	8
Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients	8
The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India	8
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration	8
Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity via AMPK/SOD2 Pathway	8
DNA Methylation Modulates Aging Process in Adipocytes	7
Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level	7
Impact of CircRNAs on Ischemic Stroke	7
Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells	7
The Added Value of Vessel Wall MRI in the Detection of Intraluminal Thrombus in Patients Suspected of Craniocervical Artery Dissection	7
The Proper Diet and Regular Physical Activity Slow Down the Development of Parkinson Disease	7
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application	7
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice	7
A Review of Insomnia Treatments for Patients with Mild Cognitive Impairment	7
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity	7
LncRNAs as the Regulators of Brain Function and Therapeutic Targets for Alzheimer’s Disease	7
A Challenge to Healthy Aging: Limited Social Participation in Old Age	7
Skeletal Muscle Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Underlying Mechanisms and Physical Therapy Perspectives	6
Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice	6
QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis	6
Intestinal Flora: A Potential New Regulator of Cardiovascular Disease	6
Synergistic Effects of Multiple Factors Involved in COVID-19-dependent Muscle Loss	6
Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s Disease	6
Melatonin as an Antioxidant Agent in Stroke: An Updated Review	6
Locomotor Hyperactivity in the Early-Stage Alzheimer’s Disease-like Pathology of APP/PS1 Mice: Associated with Impaired Polarization of Astrocyte Aquaporin 4	6
Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life	6
Chronic Limb Remote Ischemic Conditioning may have an Antihypertensive Effect in Patients with Hypertension	6
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression	6
Crosstalk between Lipid Rafts and Aging: New Frontiers for Delaying Aging	6
Elderly Patient Care: A New Reality of the SARS-CoV-2 Pandemic	6
Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion	6
Melatonin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-related Diseases	6
The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies	6
Prediction Models for Osteoporotic Fractures Risk: A Systematic Review and Critical Appraisal	6
HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes	6
Metabolic Strategies in Healthcare: A New Era	6
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H2S in Diabetes	6
Atrial Fibrillation Underlies Cardiomyocyte Senescence and Contributes to Deleterious Atrial Remodeling during Disease Progression	6
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease	5
Neurological Manifestations of COVID-19: Causality or Coincidence?	5
Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives	5
Cancer-Associated Fibroblasts Promote Lymphatic Metastasis in Cholangiocarcinoma via the PDGF-BB/PDGFR-β Mediated Paracrine Signaling Network	5
Folic acid Ameliorates the Declining Quality of Sodium Fluoride-Exposed Mouse Oocytes through the Sirt1/Sod2 Pathway	5
Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways	5
State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease	5
Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair	5
Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage	5
Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence	5
Effect Of Exercise on Muscle Mass, Fat Mass, Bone Mass, Muscular Strength and Physical Performance in Community Dwelling Older Adults: Systematic Review and Meta-Analysis	5
Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?	5
Mechanical Ventilation in COVID-19 Patients: Insights into the Role of Age and Frailty from a Multicentre Observational Study	5
Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke	5
The Therapeutic Potential of tRNA-derived Small RNAs in Neurodegenerative Disorders	5
Prevention and Management of COVID-19 in Patients with Dementia Living at Home: Experience from China	5
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review	5
Neuroglia Cells Transcriptomic in Brain Development, Aging and Neurodegenerative Diseases	5
Polyphenols Could Prevent SARS-CoV-2 Infection by Modulating the Expression of miRNAs in the Host Cells	5
Stem Cell-derived Exosomal MicroRNA as Therapy for Vascular Age-related Diseases	5
An Integrative Multi-Omics Analysis of The Molecular Links between Aging and Aggressiveness in Thyroid Cancers	5
Clinical Features and Outcomes of COVID-19 Patients with Acute Kidney Injury and Acute Kidney Injury on Chronic Kidney Disease	5
Aging Impairs the Cellular Interplay between Myeloid Cells and Mesenchymal Cells during Skin Healing in Mice	4
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging	4
Novel Concepts for the Role of Chloride Cotransporters in Refractory Seizures	4