Aging and Disease

Papers
(The H4-Index of Aging and Disease is 39. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty137
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations126
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology122
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity89
Vascular Contributions to Healthy Aging and Dementia89
Correlations between Aging, Telomeres, and Natural Compounds89
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review75
Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations74
KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging73
Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review67
Quantum Sensing for Precision Organ Aging Assessment66
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases65
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer’s Disease63
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen63
The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting59
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis59
Cross-Tissue Proteomic Mendelian Randomization Identifies Therapeutic Targets for Vascular Dementia59
Neuronal Intranuclear Inclusion Disease with NOTCH2NLC GGC Repeat Expansion: A Systematic Review and Challenges of Phenotypic Characterization58
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine58
A Biological Alignment Framework for Interpreting Anti-Inflammatory Cardiovascular Trials in Atherosclerosis58
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism56
IRG1/Itaconate Inhibits Microglial Senescence-Like Transition by Modulating Mitochondrial Dynamics through Rhoa Alkylation in Subarachnoid Hemorrhage54
Staging of Neuropil Morphological Alterations in Alzheimer’s Disease54
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung53
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies51
Functional Imaging in Osteoarthritis: Bridging Mechanistic Insight and Therapeutic Translation51
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies50
Vascular Aging and Atherosclerosis: A Perspective on Aging49
Lysine Malonylation and Its Links to Metabolism and Diseases49
A Systematic Review of Intervention Trials Utilizing Biomarkers Among Informal Caregivers of People with Alzheimer's Disease & Related Dementias48
Unmet Medication Needs and the Association with Mortality in Older Adults: Equality-Oriented Monitoring toward Universal Health Coverage47
Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy47
Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus46
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting43
Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy42
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease41
Overcoming Extracellular Matrix Barriers: Biomaterial-Assisted microRNA Delivery for Fibrous Musculoskeletal Regeneration41
Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions40
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies39
Autophagy in Disease Onset and Progression39
Beyond Amyloid: Rethinking the Foundations of Alzheimer’s Disease Pathogenesis and Therapy39
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer39
Immunosenescence: Shaping the Hematological Narrative in the Era of Aging39
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