OOIR: Observatory of International Research

Papers

(The TQCC of Current Medical Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy	178
Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial	153
Enhancing Orthopedic Knowledge Assessments: The Performance of Specialized Generative Language Model Optimization	67
Development of a Compact Photoacoustic Tomography Imaging System with Dual Single-Element Transducers for Image Enhancement	41
Surgical Treatment of Craniopharyngiomas in Adults: Comparison between Primary Surgery and Surgery for Recurrence	36
Age-dependent Changes in Skeletal Muscle Mass and Visceral Fat Area in a Chinese Population	36
Effect of An Atmospheric Plasma Jet on the Differentiation of Melanoblast Progenitor	35
Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases	33
Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia	29
Construction of Influenza Early Warning Model Based on Combinatorial Judgment Classifier: A Case Study of Seasonal Influenza in Hong Kong	24
Ticagrelor Protects against Sepsis-Induced Acute Kidney Injury through an Adenosine Receptor-Dependent Pathway	24
Effect of Dual Trigger In Vitro Fertilization and Intracytoplasmic Sperm Injection During the Gonadotropin-releasing Hormone-Antagonist Cycle on Final Oocyte Maturation and Cumulative Live Birth Rate	22
Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation	22
Correlation between Surface Area Ratio of Medial to Lateral Tibial Plateau and Knee Alignment in Adults	20
TSR: A User-Friendly R Shiny Application for Assessment of Optimal Blood Product Selection in ABO-Incompatible Hematopoietic Stem Cell Transplantation	19
Value of Contrast-enhanced Ultrasound in Evaluating Synovitis and Predicting Recurrent Joint Bleeding of Hemophilia	18
Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial	17
Incidence, Survival Outcome, and Prognostic Nomogram of Patients with Angioimmunoblastic T-cell Lymphoma: a Population-based Analysis	17
Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease	17
Outcomes of Three Different Minimal Invasive Approaches for Secundum Atrial Septal Defect Closure: A Single Institute Experience	17
Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia: A Prospective, Randomized, Open, Parallel Controlled and Multicenter Clinical Study	16
Scoring the Clinical Application of a Novel Scale in a Hybrid Operating Room for Neurosurgery	14
MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells	14
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway	14
Hope During the COVID-19 Epidemic Decreased Anxiety and Depression Symptoms Mediated by Perceived Stress: Coping Style Differences Among Patients with COVID-19	14

Statins Combined with AAV8-TBG-LOX-1 Reduce the Vascular Lipid-driven Inflammatory Response and Inhibit Atherosclerosis	14
Acid Water-ground Nano-realgar Is Superior to Crude Realgar in Promoting Apoptosis of MCF-7 Breast Cancer Cells	14
Curcumin Synergizes with Cisplatin to Inhibit Colon Cancer through Targeting the MicroRNA-137-Glutaminase Axis	13
Standard-definition White-light, High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas: A Multicenter Randomized Controlled Trial	13
Physiological Reconstruction for Moderate–Severe Pelvic Organ Prolapse: A Multicenter Retrospective Self-Controlled Study	13
A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath	13
Correlation between the Human Development Index and the Incidence and Mortality of Non-Hodgkin Lymphoma	12
Expert Consensus on the Diagnosis and Treatment of Anticancer Drug-Induced Interstitial Lung Disease	12
Imbalance of Circulating Follicular Regulatory and Follicular Helper T Cell Subpopulations Is Associated with Disease Progression and Serum CYFRA 21-1 Levels in Patients with Non-small Cell Lung Cance	12
Application and Prospects of Deep Learning Technology in Fracture Diagnosis	12
Erratum to: PHOSPHO1 Serves as a Key Metabolism-Related Biomarker in the Tumorigenesis of Diffuse Large B-cell Lymphoma	12
Acupuncture Treats Sepsis through Immune Modulation and Organ Protection	12
Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia	11
Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice	11
Development and Validation of a Nomogram for Predicting the 1-, 3-, and 5-year Survival in Patients with Acinar-predominant Lung Adenocarcinoma	11
Transforming Adolescent Smiles: Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners	10
A Nomogram Model for Prediction of Mortality Risk of Patients with Dangerous Upper Gastrointestinal Bleeding: A Two-center Retrospective Study	10
Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions	10
Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model	10
Effects of Atmospheric Pressure Plasma in the Treatment of Experimental Periodontitis in Beagle Dogs	10
Roles of MT-ND1 in Cancer	9
Jianpi Huoxue Decoction Ameliorates Alcohol-associated Liver Disease by Improving Intestinal Barrier Function in Rats	9
The Role of Casr Inhibition-Mediated M2 Microglial Transformation in Ischemic Preconditioning Against Stroke	9
Targeting Glycolytic Enzymes with 3-Bromopyruvic Acid to Enhance the Efficacy of Interventional Embolization in Hepatocellular Carcinoma	9
NOX4 Suppresses Ferroptosis Through Regulation of the Pentose Phosphate Pathway in Colorectal Cancer	9
MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4	8
Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies	8
LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization	8
Comment on: Clinical Characteristics, Diagnosis, and Treatments for COVID-19	8
Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients	8
Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in Young Adult Rats	8
ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer	8
Retraction Note: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation	8
Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells	8
Causal Links Between Gut Microbiota and Vitamin Deficiencies: Evidence from Mendelian Randomization Analysis	7
Achieving Total Enteroscopy by Consecutive Bidirectional Double-balloon Enteroscopy Procedures	7
Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage	7
Associations Between Gut Microbiota, Short-Chain Fatty Acids, and High-Salt Diet-Induced Hypertension in Rats	7
Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections	7
Image Quality Optimization in 60 kVp Head-Neck CTA: A Comparative Study of FBP, ClearView, and ClearInfinity Reconstruction Algorithms	7
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats	7
P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice	7
Intrinsic Wave Velocity Propagation: A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on Cardiac Diastolic Function in Breast Cancer Patients	7
DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma	7
Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel by Regulating the Wnt/β-catenin Signaling Pathway	6
The History of Controlling and Treating Infectious Diseases in Ancient China	6
Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes	6
Interplay Between Vestibular Dysfunction and Sleep Disorders	6
Periplaneta Americana Extract Ameliorates LPS-induced Acute Lung Injury Via Reducing Inflammation and Oxidative Stress	6
ELMOD2 Overexpression Predicts Adverse Outcomes and Regulates Tumor Progression in Gliomas	6

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis	6
Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model	6
Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice	6
Liver Transplantation Outcomes of HBV-, HCV-, and Alcohol-induced Hepatocellular Carcinoma in the United States: Analysis of National Inpatient Samples	6
A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells	6
Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells	6
Small Extracellular Vesicles Secreted by Peri-urethral Tissues Regulate Fibroblast Function and Contribute to the Pathogenesis of Female Stress Urinary Incontinence	6
RETRACTED ARTICLE: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation	6
Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice	6
Efficacy of Sitagliptin on Nonalcoholic Fatty Liver Disease in High-fat-diet-fed Diabetic Mice	6
LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR	6
Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients	5
Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis	5
Chemotherapy-Induced Myelosuppression in Esophageal Cancer Patients: Risks and Suggestions for Its Management	5
Increased Prevalence of Thyroid Nodules Across Nearly 10 Years in Shanghai, China	5
Inhibitory Effect of PPARδ Agonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway	5
Effects of Custom-made Insoles on Plantar Biomechanics and Upper Extremity Muscle Performance	5
Neoadjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma: Expecting Its Application in Temporal Bone Squamous Cell Carcinoma	5
Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation	5
LncRNA H19 Activates the RAS-MAPK Signaling Pathway via miR-140-5p/SOS1 Axis in Malignant Liver Tumors	5
High Expression of Fibronectin 1 Predicts a Poor Prognosis in Glioblastoma	5
Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs	5
HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor	5
Expert Consensus on Cognitive Dysfunction in Diabetes	5
Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms	5
Editorial Commentary: Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis wit	5
Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics	5
Intraperitoneal and Extraperitoneal Pringle Hepatic Hilar Occlusion in Laparoscopic Liver Resection: A Prospective Randomized Controlled Study	5
Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5	5
Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer’s Disease	5
Transarterial Chemoembolization Combined with Apatinib for Treatment of Advanced Hepatocellular Carcinoma: Analysis of Survival and Prognostic Factors	5
From Diabetes to Diabetic Complications: Role of Autophagy	5
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway	5
Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage	4
Erratum to: TOPK Activation Exerts Protective Effects on Cisplatin-induced Acute Kidney Injury	4
Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma	4
CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children	4
Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology	4
Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES	4
Guben Tongluo Formula Protects LPS-induced Damage in Lamina Propria B Lymphocytes Through TLR4/MyD88/NF-κB Pathway	4
Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet	4
NEP1-40 Regulates the Development of Hippocampal Neural Stem Cells in Schizophrenic Mice	4
Impact of Helicobacter pylori Eradication on Clinical and Laboratory Parameters in Non-alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials	4
High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1	4
FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition	4
A Novel Low Air Pressure-Assisted Approach for the Construction of Cells-Decellularized Tendon Scaffold Complex	4
Associations of Gestational Diabetes Mellitus and Excessive Gestational Weight Gain with Offspring Obesity Risk	4
Machine Learning-Based Mortality Prediction for Acute Gastrointestinal Bleeding Patients Admitted to Intensive Care Unit	4
Impact of Azithromycin on Forsythiaside Pharmacokinetics in Rats: A Population Modeling Method	4
Prognostic Factors of Liver Transplantation for Hepatocellular Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis	4
Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17	4
Scientific Hepatectomy for Hepatocellular Carcinoma	4
Integration of Artificial Intelligence, Blockchain, and Wearable Technology for Chronic Disease Management: A New Paradigm in Smart Healthcare	4
Nutritional Assessment Tools for Patients with Cancer: A Narrative Review	4
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening	4
Avocado Oil: Recent Advances in Its Anti-diabetic Potential	4
Konjac Oligosaccharide Alleviates Constipation in Mice via 5-HT4R/cAMP/PKA/p-CREB Pathway Activation	4
The 2010–2020 National Natural Science Foundation of China: Radiation Therapy	4
Dual-Stream Attention-Based Classification Network for Tibial Plateau Fractures via Diffusion Model Augmentation and Segmentation Map Integration	4
Nucleus Pulposus Cells from Calcified Discs Promote the Degradation of the Extracellular Matrix through Upregulation of the GATA3 Expression	4
Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis	4
Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits	4
CD44v6 CAR-T Cells Target DNMT3A-Mutant AML: Synergistic Enhancement by Decitabine	4
Artificial Intelligence in Medical Metaverse: Applications, Challenges, and Future Prospects	4
Editorial Commentary: Copper Homeostasis in Neurodegenerative Diseases	4
Association Between the Uric Acid to High-Density Lipoprotein Ratio and Carotid Atherosclerosis in Patients with T2DM	4
Effects of Exosomes from Menstrual Blood-derived Stem Cells and Ginger on Endometriotic Stem Cells	4
A Comparative Study Between Tumor Blood Vessels and Dynamic Contrast-enhanced MRI for Identifying Isocitrate Dehydrogenase Gene 1 (IDH1) Mutation Status in Glioma	4
Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses	4
Modified Glucose-insulin-potassium Therapy for Hemorrhage-induced Traumatic Cardiac Arrest in Rabbits	4
Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study	4
Xiaoke Decoction Inhibits COX-2-Mediated LDLr Pathway Dysfunction and Protects Renal Function in Diabetic Nephropathy Rats	4
KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro	4
Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis	4
Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases	4
Efficacy of Children Neuropsychological and Behavioral Scale in Screening for Autism Spectrum Disorders through a Combination of Developmental Surveillance	4
ANP Increases Zn2⁺ Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts	4