OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Biology & Medicine is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Eliminating cervical cancer: a global health imperative for women	229
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy	138
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer	70
Artificial intelligence in breast cancer: applications and advancements	66
Early-onset gastric cancer global burden profile, trends, and contributors	63
Drugging the ‘undruggable’ KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer	60
Click chemistry-driven tumor theranostics: recent advances, challenges, and future perspectives	56
Lactate drives immune resistance via a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma	51
Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity	39
The Warburg effect drives dedifferentiation through epigenetic reprogramming	38
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	36
Unraveling vascular mechanisms in melanoma: roles of angiogenesis and vasculogenic mimicry in tumor progression and therapeutic resistance	34
Lung cancer mortality trends in China from 2013 to 2021 and projections to 2030	33
<italic>Bifidobacterium animalis</italic> suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8<sup>+</sup> T cells	33
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	32
Tumor-resident bacteria in gastrointestinal cancers: from regulatory mechanisms to clinical implications	32
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	31
Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis	30
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	30
Biological mechanism and immune response of MHC-II expression in tumor cells	30
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	30
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	28
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	27
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	27
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	27

The role of radiomics in predicting the response to neoadjuvant chemotherapy for breast cancer	27
Immune checkpoint inhibitors: breakthroughs in cancer treatment	26
Chinese expert consensus on additional surgery following endoscopic resection for early colorectal cancer (2025 edition)	25
FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells	24
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	23
Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy	20
Pyroptosis in cancer: a dual regulator of tumor cell fate and immune activation	20
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	20
Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC	19
Human papillomavirus vaccination willingness under resource inequities: momentary intervention effects of an educational video	18
Nodal peripheral T-cell lymphomas in the new classification systems	18
Enhancing cancer immunotherapy through polymer-based antibody conjugation technologies	18
Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer	18
Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier	18
Glofitamab vs. real-world regimens in Chinese patients with third- or later-line relapsed/refractory diffuse large B-cell lymphoma: an external control study	17
Progress toward cervical cancer elimination: global disparities and China’s contributions	17
SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway	16
From overtreatment to precision: a new clinical standard for DCIS management	16
Expert consensus on the detection and clinical application of tumor mutational burden	16
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	15
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies	15
Evolution in single-cell proteomics drives new frontiers in cancer biology and precision medicine	15
Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review	15
Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blockage response in head and neck squamous cell carcinoma	15
Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study	15
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	15
Facing challenges with hope: universal immune cells for hematologic malignancies	14
Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer	14
Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis	14
Ferumoxytol triggers cancer ferroptosis via an NF-κB-driven IRONKILL mechanism	14
Biological insights in non-small cell lung cancer	14
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity	14
Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer	13
Advances in antibody-drug conjugates for urothelial carcinoma treatment	13
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	13
First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects	13
Current and future trends in whole genome sequencing in cancer	13
Gut microbiome: an emerging player and therapeutic target in cancer	13
Immunological and metabolic optimization of tumor neoantigen vaccines	12
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids	12
From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy	12
PD-1 and LAG-3 dual blockade: emerging mechanisms and potential therapeutic prospects in cancer	12
Metabolic regulation of tumor-associated macrophage function and immunotherapy in cancer	12
Chromatin relaxation dynamics and histone PTMs in the early DNA damage response	11
Treatment strategies for patients with HER2-positive gastric cancer	11
Liquid-liquid phase separation in DNA double-strand break repair	11
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	11
Major roles of the circadian clock in cancer	10
Lenvatinib triggers an EGR1-ZNF768-SLC7A11 adaptive response to limit ferroptosis-mediated therapeutic efficacy in hepatocellular carcinoma	10
The evidence and concerns about screening ultrasound for breast cancer	10

Research progress in tumor angiogenesis and drug resistance in breast cancer	10
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	10
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway	10
Drug clinical trials on high-grade gliomas: challenges and hopes	10
CAR T-cell therapy for relapsed/refractory CD5-positive diffuse large B-cell lymphoma yields more favorable outcomes than standard therapy	10
Current status of management of immune-related adverse events and practical needs for oncologist education	10
Induction immunochemotherapy followed by definitive radiotherapy in patients with limited-stage small cell lung cancer: a multicenter study	10
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	9
Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer	9
Gut microbiota and pancreatic cancer: tumorigenesis, progression, and clinical applications	9
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	9
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	9
Metabolic regulation of immune responses to cancer	9
Expansion of IL-2-independent tumor-infiltrating lymphocytes through a feeder-free process: a preclinical study for solid tumors	9
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	9
Early detection of gastric cancer in China: progress and opportunities	9
Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	9
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	9
Erratum to PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells	9
Single-arm trials for domestic oncology drug approvals in China	9
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	9
Effectiveness of postoperative adjuvant radiochemotherapy versus radiotherapy in thoracic esophageal squamous cell carcinoma with lymph node metastasis: a multicenter randomized study	9
Modeling cervical cancer elimination: a pathway to inform policy decisions	8
Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms	8
Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors	8
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	8
Epigenetic regulators as the foundation for molecular classification of colorectal cancer	8
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities	7
Genomic medicine in clinical practice: national genomic medicine program in Japan	7
Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma	7
Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	7
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	7
Development of glioblastoma organoids and their applications in personalized therapy	7
A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses	7
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis	7
Neoantigen cancer vaccines: a new star on the horizon	7
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	7
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	7
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine	7
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	7
Global, regional, and national burden of early-onset gastric cancer	7
Integrated pretreatment stratification system for pancreatic cancer: combining anatomical resectability and tumor biological parameters	7
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	7
Targeting PP2A for cancer therapeutic modulation	7
Apatinib enhances targeted immunotherapy <italic>via</italic> the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer	7
Virtual histology imaging of lymph nodes via dynamic full-field optical coherence tomography and deep learning to differentiate metastasis	7
Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis	7