Cancer Biology & Medicine

Article	Citations
Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study	138
The Warburg effect drives dedifferentiation through epigenetic reprogramming	71
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	46
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	44
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	43
Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II tria	40
SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation	34
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	33
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	32
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	32
Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis	31
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	27
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	25
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	21
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	21
Nodal peripheral T-cell lymphomas in the new classification systems	20
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	20
Immune checkpoint inhibitors: breakthroughs in cancer treatment	20
Advances in lung cancer screening and early detection	19
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	19
Facing challenges with hope: universal immune cells for hematologic malignancies	19
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	18
Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study	17
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies	17
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	16

Biological insights in non-small cell lung cancer	16
Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review	15
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	13
First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects	13
Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer	13
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity	12
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids	12
The efficacies and biomarker investigations of anti-programmed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma	12
PD-1 and LAG-3 dual blockade: emerging mechanisms and potential therapeutic prospects in cancer	12
Current and future trends in whole genome sequencing in cancer	11
Liquid-liquid phase separation in DNA double-strand break repair	11
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	11
Is adjuvant chemotherapy necessary for early gastric cancer?	11
Perspective on novel proteins encoded by circular RNAs in glioblastoma	11
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	10
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	9
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	9
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma	9
From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy	9
Major roles of the circadian clock in cancer	8
Treatment strategies for patients with HER2-positive gastric cancer	8
Research progress in tumor angiogenesis and drug resistance in breast cancer	8
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	8
Comparative profiling of immune genes improves the prognoses of lower grade gliomas	8
Anti-tumor pharmacology of natural products targeting mitosis	8
Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	7
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	7
Metabolic regulation of immune responses to cancer	7
Early detection of gastric cancer in China: progress and opportunities	7
Single-arm trials for domestic oncology drug approvals in China	7
JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ	7
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	7
The evidence and concerns about screening ultrasound for breast cancer	7
Drug clinical trials on high-grade gliomas: challenges and hopes	7
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	7
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation	7
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	7
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	7
Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma: a long-term follow-up study	6
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	6
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	6
Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	6
N6-methyladenosine (m6A) RNA modification in tumor immunity	6
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	6
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	6
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	6
A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer	6
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	6
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	6
Decoding the complexity of metastasis	6

Epigenetic regulators as the foundation for molecular classification of colorectal cancer	6
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	5
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	5
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	5
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells	5
Genomic medicine in clinical practice: national genomic medicine program in Japan	5
Development of glioblastoma organoids and their applications in personalized therapy	5
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine	5
Global, regional, and national burden of early-onset gastric cancer	5
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	5
Erratum to DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors	5
Targeting PP2A for cancer therapeutic modulation	5
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	5
Neoantigen cancer vaccines: a new star on the horizon	5
Evolving molecular subtyping of breast cancer advances precision treatment	4
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis	4
Immunotherapy for multiple myeloma: new chances and hope	4
Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP	4
EZH2 identifies the precursors of human natural killer cells with trained immunity	4
Recent advances in the systemic treatment of gastrointestinal stromal tumors	4
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	4
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma	4
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?	4
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	4
Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study	4
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	4
Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies	4
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan	4
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	4
Peptide drugs: a new direction in cancer immunotherapy	4
Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives	4
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	3
Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis	3
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	3
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	3
Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF	3
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies	3
Multifaceted efforts of governments, medical institutions, and financial organizations contribute to reducing the health inequality caused by economic differences	3
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	3
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	3
Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study	3
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study	3
Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors	3
The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?	3
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	3
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical tria	3
PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells	3
Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial	2
Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers	2
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	2
Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives	2
Antibody-drug conjugates in breast cancer: advances and prospects	2
Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells	2
Circulating cell-free mtDNA as a new biomarker for cancer detection and management	2
Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling	2
Hot issues in triple-negative breast cancer	2
Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment	2
Methods for monitoring cancer cell pyroptosis	2
SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens	2
Cervical cancer prevention in China: where are we now, and what’s next?	2
Esophageal cancer global burden profiles, trends, and contributors	2
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells	2
Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	2
Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma	2
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	2
Nanomedicine-based combination therapies for overcoming temozolomide resistance in glioblastomas	2
Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment	2
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity	2
Epigenetic reprogramming in small cell lung cancer	2
Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy	2
The role of DLL1 in long-term vascular normalization and cancer immunotherapy	2
Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis	2
Genomic medicine and cancer clinical trial in Thailand	2
Insight into the evolution of breast cancer driven by genetic alterations	2
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) Guidelines in 2024: International Contributions from China	2
Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events	2
EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression	2
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ	2
The interplay between RNA m<sup>6</sup>A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review	2
IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages	2

Natural killer cells in tumor immunotherapy	2
Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity	2
DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer	2
The interplay between H3K36 methylation and DNA methylation in cancer	2
Evolution-driven crosstalk between glioblastoma and the tumor microenvironment	2
Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting	2
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	2
Innate IgM antibodies to mannose in patients with gastric cancer	2
Inflammatory signaling in targeted therapy resistance: focus on EGFR-targeted treatment	2
Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma: a multicenter cohort study in China	2