Cancer Biology & Medicine

Article	Citations
Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity	168
The Warburg effect drives dedifferentiation through epigenetic reprogramming	91
Early-onset gastric cancer global burden profile, trends, and contributors	56
Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study	51
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	49
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	43
Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II tria	39
Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis	38
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	36
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	36
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	34
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	32
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	29
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	28
Immune checkpoint inhibitors: breakthroughs in cancer treatment	26
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	25
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	24
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	23
Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier	22
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	21
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	21
Advances in lung cancer screening and early detection	21
Nodal peripheral T-cell lymphomas in the new classification systems	21
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies	20
Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study	19

Facing challenges with hope: universal immune cells for hematologic malignancies	18
Biological insights in non-small cell lung cancer	18
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	17
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids	16
Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review	16
The efficacies and biomarker investigations of anti-programmed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma	16
First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects	16
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity	16
Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer	15
PD-1 and LAG-3 dual blockade: emerging mechanisms and potential therapeutic prospects in cancer	15
Perspective on novel proteins encoded by circular RNAs in glioblastoma	14
Current and future trends in whole genome sequencing in cancer	13
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	13
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	13
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	12
Liquid-liquid phase separation in DNA double-strand break repair	12
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma	12
From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy	11
Anti-tumor pharmacology of natural products targeting mitosis	11
CAR T-cell therapy for relapsed/refractory CD5-positive diffuse large B-cell lymphoma yields more favorable outcomes than standard therapy	11
Major roles of the circadian clock in cancer	10
Research progress in tumor angiogenesis and drug resistance in breast cancer	10
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	10
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	10
Treatment strategies for patients with HER2-positive gastric cancer	10
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	9
Early detection of gastric cancer in China: progress and opportunities	9
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	9
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation	9
The evidence and concerns about screening ultrasound for breast cancer	9
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	9
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	9
Single-arm trials for domestic oncology drug approvals in China	9
Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	9
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	8
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	8
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	8
Comparative profiling of immune genes improves the prognoses of lower grade gliomas	8
Metabolic regulation of immune responses to cancer	8
N6-methyladenosine (m6A) RNA modification in tumor immunity	8
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	8
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	8
Drug clinical trials on high-grade gliomas: challenges and hopes	8
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	8
JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ	8
Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	7
Decoding the complexity of metastasis	7
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	7
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	7
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells	7

Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	7
Erratum to DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors	7
Epigenetic regulators as the foundation for molecular classification of colorectal cancer	7
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	7
Neoantigen cancer vaccines: a new star on the horizon	7
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	7
A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer	7
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	7
Development of glioblastoma organoids and their applications in personalized therapy	7
Targeting PP2A for cancer therapeutic modulation	7
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine	7
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma	6
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	6
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities	6
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis	6
Global, regional, and national burden of early-onset gastric cancer	6
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan	6
Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP	6
Genomic medicine in clinical practice: national genomic medicine program in Japan	6
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	6
Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study	5
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	5
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	5
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	5
Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors	5
Evolving molecular subtyping of breast cancer advances precision treatment	5
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	5
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	5
EZH2 identifies the precursors of human natural killer cells with trained immunity	5
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?	5
Recent advances in the systemic treatment of gastrointestinal stromal tumors	5
Organoid models in oncology: advancing precision cancer therapy and vaccine development	5
National prevention programs and their effects on gastric cancer Incidence and mortality in East Asian countries	5
Multifaceted efforts of governments, medical institutions, and financial organizations contribute to reducing the health inequality caused by economic differences	5
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study	5
Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives	5
Peptide drugs: a new direction in cancer immunotherapy	5
Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies	5
Immunotherapy for multiple myeloma: new chances and hope	5
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	5
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	5
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies	5
Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis	5
Insight into the evolution of breast cancer driven by genetic alterations	4
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	4
XPO1 as a key regulator in small cell lung cancer: mechanisms, biomarkers, and therapeutic implications	4
The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?	4
Nanomedicine-based combination therapies for overcoming temozolomide resistance in glioblastomas	4
The interplay between RNA m<sup>6</sup>A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review	4
Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial	4
SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens	4
Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives	4
Global disparities in childhood neuroblastoma: trends, burden, and inequities from 1990 to 2021	4
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	4
Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF	4
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ	4
Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma	4
Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	4
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	4
IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages	4
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical tria	4
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	4
Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study	4
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	4
Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities	4
Natural killer cells in tumor immunotherapy	3
Increased and persistent absolute CD4&#x002B; T cell count in an HIV-associated Burkitt lymphoma patient with central nervous system involvement after axicabtagene ciloleucel therapy	3
Cervical cancer prevention in China: where are we now, and what’s next?	3
The role of DLL1 in long-term vascular normalization and cancer immunotherapy	3
Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells	3
Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers	3
Antibody-drug conjugates in breast cancer: advances and prospects	3
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	3
Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis	3
Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment	3
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) Guidelines in 2024: International Contributions from China	3
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells	3
Hot issues in triple-negative breast cancer	3
Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma: a multicenter cohort study in China	3
Evolution-driven crosstalk between glioblastoma and the tumor microenvironment	3

EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression	3
Multi-omics in colorectal cancer liver metastasis: applications and research advances	3
Genomic medicine and cancer clinical trial in Thailand	3
Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment	3
Methods for monitoring cancer cell pyroptosis	3
Epigenetic reprogramming in small cell lung cancer	3
Innate IgM antibodies to mannose in patients with gastric cancer	3
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity	3
Esophageal cancer global burden profiles, trends, and contributors	3
Inflammatory signaling in targeted therapy resistance: focus on EGFR-targeted treatment	3
Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms	2
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	2
Target identification of natural products in cancer with chemical proteomics and artificial intelligence approaches	2
Application and future prospects of bispecific antibodies in the treatment of non-small cell lung cancer	2
Advances in gut microbiota-related treatment strategies for managing colorectal cancer in humans	2
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	2
Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer	2
The interplay between H3K36 methylation and DNA methylation in cancer	2
Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity	2
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer	2
Comprehensive strategies for management of postoperative hyper-progression recurrence (HPR) of hepatocellular carcinoma: a 12-year large sample multi-center study	2
Prognostic value of peripheral eosinophil counts in patients with newly diagnosed multiple myeloma	2
Decreased LDHB expression in breast tumor cells causes NK cell activation and promotes tumor progression	2
The arginine metabolism battlefield: how metabolite exchange in the tumor microenvironment shapes an immunosuppressive ecosystem	2
The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families	2
Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine	2
Circulating cell-free mtDNA as a new biomarker for cancer detection and management	2
Breast surgeons at the forefront: preserving lymph nodes for enhanced immunotherapy efficacy	2
Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting	2
DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer	2
Research progress in hepatitis B virus covalently closed circular DNA	2
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors	2
Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine	2
A retrospective analysis of mature T- and NK-cell lymphomas	2
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration	2
Neutrophils in cancer: from immune defense to tumor promotion	2
Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling	2
The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity	2
Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances	2
The outpost against cancer: universal cancer only markers	2
Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling	2
Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants	2