Cancer Biology & Medicine

Article	Citations
Effects of cancer on patients with COVID-19: a systematic review and meta-analysis of 63,019 participants	81
Breast cancer incidence and mortality in women in China: temporal trends and projections to 2030	79
Current cancer burden in China: epidemiology, etiology, and prevention	53
Stimuli-responsive nanocarriers for therapeutic applications in cancer	40
Predictive value of MGMT promoter methylation on the survival of TMZ treated <i>IDH</i>-mutant glioblastoma	28
Tumorigenic bacteria in colorectal cancer: mechanisms and treatments	25
Competing endogenous RNAs in lung cancer	24
Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation	24
Circular RNAs: new biomarkers of chemoresistance in cancer	21
Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance	21
Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer	21
Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data	20
Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development	20
The role and its mechanism of intermittent fasting in tumors: friend or foe?	19
Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas	19
Breast cancer screening and early diagnosis in Chinese women	18
The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization	18
Gold-based nanomaterials for the treatment of brain cancer	18
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	17
BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas	16
Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity	16
Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies	16
Anlotinib has good efficacy and low toxicity: a phase II study of anlotinib in pre-treated HER-2 negative metastatic breast cancer	16
Strategies to enhance monoclonal antibody uptake and distribution in solid tumors	16
The advanced development of molecular targeted therapy for hepatocellular carcinoma	16

Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases	16
Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial	15
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	15
Morphine-3-glucuronide upregulates PD-L1 expression <i>via</i> TLR4 and promotes the immune escape of non-small cell lung cancer	15
Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells	15
VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer <i>in vivo</i>	14
Bacterial outer membrane vesicle-based cancer nanovaccines	14
Recent progress of nanotechnology-based theranostic systems in cancer treatments	14
Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas	14
Reduced anoctamin 7 (ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer	13
Advances in lung cancer screening and early detection	13
Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion	13
The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study	13
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	13
Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events	13
NEDD9 promotes cancer stemness by recruiting myeloidderived suppressor cells <i>via</i> CXCL8 in esophageal squamous cell carcinoma	12
VEGFR2 inhibition hampers breast cancer cell proliferation <i>via</i> enhanced mitochondrial biogenesis	12
Methods for monitoring cancer cell pyroptosis	11
Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids	11
Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies	11
Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds: A large-scale, retrospective study	11
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	11
Major roles of the circadian clock in cancer	11
Targeting myeloid-derived suppressor cells for cancer therapy	11
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma	10
Updating targets for natural killer/T-cell lymphoma immunotherapy	10
Personalized immunotherapy in cancer precision medicine	10
Epigenetics of cutaneous T-cell lymphoma: biomarkers and therapeutic potentials	10
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	10
LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA	10
The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma	9
The advance of adjuvant treatment for triple-negative breast cancer	9
The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma	9
Modulating microRNAs in cancer: Next-generation therapies	9
Immunology and immunotherapy in breast cancer	9
L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma	9
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ	9
Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives	9
The commensal consortium of the gut microbiome is associated with favorable responses to anti-programmed death protein 1 (PD-1) therapy in thoracic neoplasms	8
PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells	8
Living biobank-based cancer organoids: prospects and challenges in cancer research	8
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cance	8
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	8
CD13 inhibition augments DR4-induced tumor cell death in a p-ERK1/2-independent manner	8
Cancer immunology and immunotherapy	8
The cancer-testis gene, <i>MEIOB</i>, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency	7
The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma	7
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy	7
Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling	7
Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies	7

Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	7
LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients	7
Akt isoforms differentially provide for chemoresistance in prostate cancer	7
The biogenesis, function and clinical significance of circular RNAs in breast cancer	7
Targeting PP2A for cancer therapeutic modulation	7
SNORA23 inhibits HCC tumorigenesis by impairing the 2'-O-ribose methylation level of 28S rRNA	7
A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma	6
Circular RNAs: implications of signaling pathways and bioinformatics in human cancer	6
N6-methyladenosine (m6A) RNA modification in tumor immunity	6
Is adjuvant chemotherapy necessary for early gastric cancer?	6
SHP-1 acts as a tumor suppressor by interacting with EGFR and predicts the prognosis of human breast cancer	6
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	6
Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma	6
Analysis of the <i>HNF4A</i> isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis	6
Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP	6
Single-cell trajectories of melanoma cell resistance to targeted treatment	6
sLe<sup>x</sup> expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator	6
The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma	6
Epstein-Barr virus DNA loads in the peripheral blood cells predict the survival of locoregionally-advanced nasopharyngeal carcinoma patients	5
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation	5
The power of a healthy lifestyle for cancer prevention: the example of colorectal cancer	5
The efficacies and biomarker investigations of anti-programmed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma	5
Current research on circular RNAs and their potential clinical implications in breast cancer	5
Phase II study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA	5
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	5
Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma	5
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	5
Updates in endocrine therapy for metastatic breast cancer	5
Smart drug delivery systems to overcome drug resistance in cancer immunotherapy	5
Cancer metabolism and dietary interventions	5
Anti-tumor pharmacology of natural products targeting mitosis	5
Development and validation of a risk model for noninvasive detection of cancer in oral potentially malignant disorders using DNA image cytometry	5
CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells	5
Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway	4
Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma	4
Targeting the COP9 signalosome for cancer therapy	4
Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network	4
EZH2 identifies the precursors of human natural killer cells with trained immunity	4
Research progress in hepatitis B virus covalently closed circular DNA	4
Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study	4
Cyclophosphamide abrogates the expansion of CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells and enhances the efficacy of bleomycin in the treatment of mouse B16-F10 melanom	4
FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma	4
Heterogeneity of neutrophils in cancer: one size does not fit all	4
Tumor organoids for cancer research and personalized medicine	4
The role of DLL1 in long-term vascular normalization and cancer immunotherapy	4
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	4
Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma	4
Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment	4
Microwave ablation vs. surgical resection for treatment naïve hepatocellular carcinoma within the Milan criteria: a follow-up of at least 5 years	4
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	4
Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies	4
A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer	4
The choice of a neoadjuvant chemotherapy cycle for breast cancer has significance in clinical practice: results from a population-based, real world study	4
Comparative profiling of immune genes improves the prognoses of lower grade gliomas	4
Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer	4
Synergistic effects of AAGL and anti-PD-1 on hepatocellular carcinoma through lymphocyte recruitment to the liver	3
MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2	3
Biological insights in non-small cell lung cancer	3
Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study	3
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells	3
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer	3
Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma: a long-term follow-up study	3
Multiplex imaging reveals the architecture of the tumor immune microenvironment	3
Genomic medicine and cancer clinical trial in Thailand	3
Comparison of outcomes between immediate implant-based and autologous reconstruction: 15-year, single-center experience in a propensity score-matched Chinese cohort	3
Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages	3
Repurposing glucocorticoids as adjuvant reagents for immune checkpoint inhibitors in solid cancers	3
Radiotherapy delays malignant transformation and prolongs survival in patients with IDH-mutant gliomas	3
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	3
Cellular immunotherapy for hematological malignancy: recent progress and future perspectives	3
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	3
Peripheral blood indices to predict PFS/OS with anlotinib as a subsequent treatment in advanced small-cell lung cancer	3
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	3
ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines	3
Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations	3
Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma	3
Decoding the complexity of metastasis	3
The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?	3
Molecular testing for acute myeloid leukemia	3
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	2

Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study	2
Aberrantly expressed GFRα-1/RET in patients with lacrimal adenoid cystic carcinoma is associated with high recurrence risk: a retrospective study of 51 LACC cases	2
Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma	2
EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression	2
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	2
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma	2
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	2
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	2
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	2
Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome	2
Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma	2
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	2
Epigenetic reprogramming in small cell lung cancer	2
A truncated protein product of the germline variant of the <i>DUOX2</i> gene leads to adenomatous polyposis	2
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	2
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	2
<i>BRCA</i> mutation rate and characteristics of prostate tumor in breast and ovarian cancer families: analysis of 6,591 Italian pedigrees	2
A novel recurrence-associated metabolic prognostic model for risk stratification and therapeutic response prediction in patients with stage I lung adenocarcinoma	2
Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy	2
Ferritin as a diagnostic, differential diagnostic, and prognostic marker for immune-related adverse events	2
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	2
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	2
Intercellular transmission of cGAS-STING signaling in cancer	2
Early detection of gastric cancer in China: progress and opportunities	2
Biomaterial-based platforms for cancer stem cell enrichment and study	2
Epigenetic modulation of the tumor immune microenvironment by nanoinducers to potentiate cancer immunotherapy	2
Development of glioblastoma organoids and their applications in personalized therapy	2
Imaging in translational cancer research	2
Decoding the intercellular communication network during tumorigenesis	2
Optimization of regional nodal irradiation in the era of sentinel lymph node biopsy	2
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	2
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma	2
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	2
Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy: a comprehensive review	2