Cancer Biology & Medicine

Article	Citations
Eliminating cervical cancer: a global health imperative for women	225
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy	129
The Warburg effect drives dedifferentiation through epigenetic reprogramming	69
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer	57
Artificial intelligence in breast cancer: applications and advancements	56
Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity	53
Early-onset gastric cancer global burden profile, trends, and contributors	52
Lactate drives immune resistance via a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma	47
Unraveling vascular mechanisms in melanoma: roles of angiogenesis and vasculogenic mimicry in tumor progression and therapeutic resistance	46
Drugging the ‘undruggable’ KRAS: breakthroughs, challenges, and opportunities in pancreatic cancer	45
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	42
Click chemistry-driven tumor theranostics: recent advances, challenges, and future perspectives	37
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer	37
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	36
Tumor-resident bacteria in gastrointestinal cancers: from regulatory mechanisms to clinical implications	33
The role of radiomics in predicting the response to neoadjuvant chemotherapy for breast cancer	33
<italic>Bifidobacterium animalis</italic> suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8<sup>&#x002B;</sup> T cells	33
Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer Research Center (DKFZ) and its partnerships with university medical cente	31
ACSL3 regulates breast cancer progression via lipid metabolism reprogramming and the YES1/YAP axis	30
Lung cancer mortality trends in China from 2013 to 2021 and projections to 2030	29
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	28
Immune checkpoint inhibitors: breakthroughs in cancer treatment	28
Cancer stem cells: a target for overcoming therapeutic resistance and relapse	27
Chinese Society of Clinical Oncology Non-small Cell Lung Cancer (CSCO NSCLC) guidelines in 2024: key update on the management of early and locally advanced NSCLC	27
Biological mechanism and immune response of MHC-II expression in tumor cells	27

Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis	25
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	25
Chinese expert consensus on additional surgery following endoscopic resection for early colorectal cancer (2025 edition)	25
Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy	24
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	24
Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier	24
Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a	23
Nodal peripheral T-cell lymphomas in the new classification systems	22
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	22
Enhancing cancer immunotherapy through polymer-based antibody conjugation technologies	21
Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer	21
Facing challenges with hope: universal immune cells for hematologic malignancies	21
Pyroptosis in cancer: a dual regulator of tumor cell fate and immune activation	21
Human papillomavirus vaccination willingness under resource inequities: momentary intervention effects of an educational video	20
Glofitamab vs. real-world regimens in Chinese patients with third- or later-line relapsed/refractory diffuse large B-cell lymphoma: an external control study	19
Progress toward cervical cancer elimination: global disparities and China’s contributions	18
Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies	17
SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway	17
Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review	16
From overtreatment to precision: a new clinical standard for DCIS management	16
Expert consensus on the detection and clinical application of tumor mutational burden	16
Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China: a retrospective multicenter study	15
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	15
Evolution in single-cell proteomics drives new frontiers in cancer biology and precision medicine	15
Biological insights in non-small cell lung cancer	15
Current and future trends in whole genome sequencing in cancer	14
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	14
First-line immunotherapy for advanced non-small cell lung cancer: current progress and future prospects	14
Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity	14
Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer	14
Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer	14
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids	13
Advances in antibody-drug conjugates for urothelial carcinoma treatment	13
Ferumoxytol triggers cancer ferroptosis via an NF-κB-driven IRONKILL mechanism	13
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	13
CAR T-cell therapy for relapsed/refractory CD5-positive diffuse large B-cell lymphoma yields more favorable outcomes than standard therapy	12
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	12
PD-1 and LAG-3 dual blockade: emerging mechanisms and potential therapeutic prospects in cancer	12
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	12
Liquid-liquid phase separation in DNA double-strand break repair	12
Immunological and metabolic optimization of tumor neoantigen vaccines	12
Chromatin relaxation dynamics and histone PTMs in the early DNA damage response	12
Treatment strategies for patients with HER2-positive gastric cancer	12
From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy	12
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	11
Research progress in tumor angiogenesis and drug resistance in breast cancer	11
Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer	11
Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window	11
Major roles of the circadian clock in cancer	11
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	11

Metabolic regulation of immune responses to cancer	11
Anti-tumor pharmacology of natural products targeting mitosis	11
Metabolic regulation of tumor-associated macrophage function and immunotherapy in cancer	11
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway	11
Effectiveness of postoperative adjuvant radiochemotherapy versus radiotherapy in thoracic esophageal squamous cell carcinoma with lymph node metastasis: a multicenter randomized study	10
Current status of management of immune-related adverse events and practical needs for oncologist education	10
Gut microbiota and pancreatic cancer: tumorigenesis, progression, and clinical applications	10
Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer	10
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	10
Induction immunochemotherapy followed by definitive radiotherapy in patients with limited-stage small cell lung cancer: a multicenter study	10
Single-arm trials for domestic oncology drug approvals in China	10
Lenvatinib triggers an EGR1-ZNF768-SLC7A11 adaptive response to limit ferroptosis-mediated therapeutic efficacy in hepatocellular carcinoma	10
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	9
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy	9
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB	9
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	9
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	9
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	9
Drug clinical trials on high-grade gliomas: challenges and hopes	9
The evidence and concerns about screening ultrasound for breast cancer	9
Expansion of IL-2-independent tumor-infiltrating lymphocytes through a feeder-free process: a preclinical study for solid tumors	9
Next-generation antibody–drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer	9
Early detection of gastric cancer in China: progress and opportunities	9
Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors	8
Epigenetic regulators as the foundation for molecular classification of colorectal cancer	8
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism	8
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer	8
Modeling cervical cancer elimination: a pathway to inform policy decisions	8
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer	8
Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms	8
Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma	8
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	8
Treatment strategies for advanced neuroendocrine neoplasms: current status and future prospects	8
Targeting PP2A for cancer therapeutic modulation	8
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer	7
Erratum to Treatment strategies for patients with HER2-positive gastric cancer	7
Development of glioblastoma organoids and their applications in personalized therapy	7
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan	7
Integrated pretreatment stratification system for pancreatic cancer: combining anatomical resectability and tumor biological parameters	7
Neoantigen cancer vaccines: a new star on the horizon	7
A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses	7
Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis	7
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis	7
Accelerating the elimination of global cervical cancer through intelligent training for colposcopy	7
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	7
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine	7
Virtual histology imaging of lymph nodes via dynamic full-field optical coherence tomography and deep learning to differentiate metastasis	7
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities	7
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma	7
Global, regional, and national burden of early-onset gastric cancer	7
Genomic medicine in clinical practice: national genomic medicine program in Japan	7
Organoid models in oncology: advancing precision cancer therapy and vaccine development	6
Toward the precision use of Chinese PARP inhibitors in ovarian cancer: clinical progress, resistance mechanisms, and future perspectives	6
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?	6
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	6
Peptide drugs: a new direction in cancer immunotherapy	6
Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left- and right-sided colorectal neoplasia	6
Immunotherapy for multiple myeloma: new chances and hope	6
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	6
Recent advances in the systemic treatment of gastrointestinal stromal tumors	6
Potential new applications of immunotherapy for neuroendocrine neoplasms: immune landscape, current status and future perspectives	6
Targeting tumor-infiltrating regulatory T cells based on immunometabolism	6
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	6
Harnessing the power of cancer-associated fibroblasts to revolutionize pancreatic cancer treatment	6
Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II study	6
Evolving molecular subtyping of breast cancer advances precision treatment	5
From bone marrow to the tumor microenvironment: how neutrophil maturation shapes cancer immunity	5
Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis	5
Psychological health mediates the association between diet and upper gastrointestinal cancer: a cross-sectional analysis from a large-scale population-based screening project	5
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study	5
National prevention programs and their effects on gastric cancer Incidence and mortality in East Asian countries	5
Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications	5
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies	5
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	5
Multifaceted efforts of governments, medical institutions, and financial organizations contribute to reducing the health inequality caused by economic differences	5
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	5
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	5
Inflammatory signaling in targeted therapy resistance: focus on EGFR-targeted treatment	4
Insight into the evolution of breast cancer driven by genetic alterations	4
SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens	4

Biomarkers for immune checkpoint inhibitors in colorectal cancer: recent advances and future perspectives	4
Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF	4
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	4
Global disparities in childhood neuroblastoma: trends, burden, and inequities from 1990 to 2021	4
Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial	4
HBx-mediated GPT2 suppression promotes liver cancer development by downregulating ADH1A	4
The interplay between RNA m<sup>6</sup>A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review	4
Multi-omics in colorectal cancer liver metastasis: applications and research advances	4
Artificial intelligence empowering precision diagnosis and treatment of breast cancer: advancing global clinical practice with regional insights	4
Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis	4
IL-33/ST2 signalling promotes tumor growth by regulating polarization of alternatively activated macrophages	4
Nanomedicine-based combination therapies for overcoming temozolomide resistance in glioblastomas	4
XPO1 as a key regulator in small cell lung cancer: mechanisms, biomarkers, and therapeutic implications	4
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	4
Cervical cancer burden and trends in China, 2000&#x2013;2020: Asia-Pacific international comparisons and insights for elimination goals	4
Weight gain after 35 years of age is associated with increased breast cancer risk: findings from a large prospective cohort study	4
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	4
Beyond origin: multimodal AI synthesis to resolve cancers of unknown primary	4
Impact of pre-neoadjuvant radioactive iodine seed marking on pathologic complete response and survival in early-stage breast cancer patients	4
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	4
First-line immunotherapy for advanced HER2-negative gastric cancer: differences between Asian and non-Asian patients	4
Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma	4
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	4
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical tria	4
CAMK2D isoform 15 facilitates gefitinib resistance <italic>via</italic> AKT phosphorylation in lung adenocarcinoma	4
Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities	4
Esophageal cancer global burden profiles, trends, and contributors	4
SARS-CoV-2 infection in brain tumors and the association with alterations in the tumor immune microenvironment	4
Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment	3
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) Guidelines in 2024: International Contributions from China	3
Natural killer cells in tumor immunotherapy	3
Antibody-drug conjugates in breast cancer: advances and prospects	3
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells	3
Postbiotics: emerging bioactive agents in cancer therapy	3
Cervical cancer prevention in China: where are we now, and what’s next?	3
Mechanisms underlying prostate cancer sensitivity to reactive oxygen species: overcoming radiotherapy resistance and recent clinical advances	3
Genomic medicine and cancer clinical trial in Thailand	3
Evolution-driven crosstalk between glioblastoma and the tumor microenvironment	3
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity	3
Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma: a multicenter cohort study in China	3
Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-&#x03B2;RI and activating the TGF-&#x03B2;/SMAD3 signaling pathway in breast cancer	3
Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers	3
Comprehensive strategies for management of postoperative hyper-progression recurrence (HPR) of hepatocellular carcinoma: a 12-year large sample multi-center study	3
Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment	3
Innate IgM antibodies to mannose in patients with gastric cancer	3
Coordinated DNA methyltransferase 3A and methyltransferase-like 7A activity reprograms the tumor microenvironment through discoidin domain receptor 1 signaling	3
Increased and persistent absolute CD4&#x002B; T cell count in an HIV-associated Burkitt lymphoma patient with central nervous system involvement after axicabtagene ciloleucel therapy	3
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression	2
Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine	2
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	2
Breast surgeons at the forefront: preserving lymph nodes for enhanced immunotherapy efficacy	2
Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants	2
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration	2
Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells	2
The arginine metabolism battlefield: how metabolite exchange in the tumor microenvironment shapes an immunosuppressive ecosystem	2
Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting	2
Strengthening human papillomavirus vaccination programs through multi-country peer learning: lessons from the CHIC initiative	2
IL-17A blockade alleviates immune checkpoint inhibitor-associated psoriasiform rash: preclinical and clinical responses	2
Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling	2
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	2
A retrospective analysis of mature T- and NK-cell lymphomas	2
Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort	2
Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer	2
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors	2
Epigenetic reprogramming in small cell lung cancer	2
Application and future prospects of bispecific antibodies in the treatment of non-small cell lung cancer	2
Evaluation of an intelligent digital platform for population management in cervical cancer screening	2
The interplay between H3K36 methylation and DNA methylation in cancer	2
Poor prognosis outcome tumors, bacteria-infected tumors and nanodrugs: current evidence and hypotheses towards a paradigm change for treatment	2
The outpost against cancer: universal cancer only markers	2
Circulating cell-free mtDNA as a new biomarker for cancer detection and management	2
Microbial reprogramming of immunogenic cell death: a new paradigm in tumor immunotherapy	2
Impact of government-organized screening programs on the economic burden of cervical cancer across five disease courses: a multistage regression and mediation analysis	2
COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC	2
Targeting mitochondrial dysfunction to intervene in liver cancer	2
Unravelling the role of PANoptosis in diseases: from emerging molecular mechanisms-to-therapeutic implications	2
Gut microecology empowers cancer immunotherapy: commensal microbiota-mediated mechanisms and translational prospects of PD-1/PD-L1 therapy	2
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer	2
DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer	2
Hot issues in triple-negative breast cancer	2
Current status of traditional Chinese medicine in modulating mitochondrial metabolic abnormalities in tumors	2
Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity	2