Cancer Biology & Medicine

Article	Citations
Breast cancer incidence and mortality in women in China: temporal trends and projections to 2030	116
Effects of cancer on patients with COVID-19: a systematic review and meta-analysis of 63,019 participants	91
Current cancer burden in China: epidemiology, etiology, and prevention	91
Stimuli-responsive nanocarriers for therapeutic applications in cancer	44
Predictive value of MGMT promoter methylation on the survival of TMZ treated <i>IDH</i>-mutant glioblastoma	39
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies	35
Recent progress of nanotechnology-based theranostic systems in cancer treatments	30
Tumorigenic bacteria in colorectal cancer: mechanisms and treatments	29
Advances in lung cancer screening and early detection	28
Competing endogenous RNAs in lung cancer	27
The advanced development of molecular targeted therapy for hepatocellular carcinoma	27
Breast cancer screening and early diagnosis in Chinese women	27
Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China (2011–2017): a multicenter retrospective study from CGGA	26
Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer	25
Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas	25
Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation	25
Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines in 2022: stratification and classification	25
Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data	24
Strategies to enhance monoclonal antibody uptake and distribution in solid tumors	23
Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance	23
Major roles of the circadian clock in cancer	23
The role and its mechanism of intermittent fasting in tumors: friend or foe?	23
Methods for monitoring cancer cell pyroptosis	23
Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development	23
Anlotinib has good efficacy and low toxicity: a phase II study of anlotinib in pre-treated HER-2 negative metastatic breast cancer	22

Circular RNAs: new biomarkers of chemoresistance in cancer	22
Personalized immunotherapy in cancer precision medicine	21
Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity	21
The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization	21
Gold-based nanomaterials for the treatment of brain cancer	21
Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies	20
Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases	20
Morphine-3-glucuronide upregulates PD-L1 expression <i>via</i> TLR4 and promotes the immune escape of non-small cell lung cancer	19
Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells	19
VEGFR2 inhibition hampers breast cancer cell proliferation <i>via</i> enhanced mitochondrial biogenesis	19
BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas	18
Bacterial outer membrane vesicle-based cancer nanovaccines	18
Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas	18
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy	18
Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion	18
NEDD9 promotes cancer stemness by recruiting myeloidderived suppressor cells <i>via</i> CXCL8 in esophageal squamous cell carcinoma	17
Biological roles and potential clinical values of circular RNAs in gastrointestinal malignancies	16
Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives	16
Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events	16
Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial	16
The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study	16
Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies	15
Targeting myeloid-derived suppressor cells for cancer therapy	15
VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer <i>in vivo</i>	14
Reduced anoctamin 7 (ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer	14
Targeting PP2A for cancer therapeutic modulation	14
Living biobank-based cancer organoids: prospects and challenges in cancer research	13
Immunology and immunotherapy in breast cancer	13
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer	13
LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA	13
Epigenetics of cutaneous T-cell lymphoma: biomarkers and therapeutic potentials	13
Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids	13
N6-methyladenosine (m6A) RNA modification in tumor immunity	13
L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma	13
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ	12
Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds: A large-scale, retrospective study	12
Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling	12
Anti-tumor pharmacology of natural products targeting mitosis	11
PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells	11
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma	11
A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cance	11
Prospective study of the effect of ERAS on postoperative recovery and complications in patients with gastric cancer	11
The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma	11
The commensal consortium of the gut microbiome is associated with favorable responses to anti-programmed death protein 1 (PD-1) therapy in thoracic neoplasms	10
The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma	10
CD13 inhibition augments DR4-induced tumor cell death in a p-ERK1/2-independent manner	10
Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment	10
Updating targets for natural killer/T-cell lymphoma immunotherapy	10
SHP-1 acts as a tumor suppressor by interacting with EGFR and predicts the prognosis of human breast cancer	9
Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation	9

A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer	9
Circular RNAs: implications of signaling pathways and bioinformatics in human cancer	9
The cancer-testis gene, <i>MEIOB</i>, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency	8
Radiotherapy delays malignant transformation and prolongs survival in patients with IDH-mutant gliomas	8
Cancer immunology and immunotherapy	8
The biogenesis, function and clinical significance of circular RNAs in breast cancer	8
LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients	8
Analysis of the <i>HNF4A</i> isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis	8
Prognostic value of BCL2 and TP53 genetic alterations for diffuse large B-cell lymphoma patients treated with R-CHOP	8
Modulating microRNAs in cancer: Next-generation therapies	8
The advance of adjuvant treatment for triple-negative breast cancer	8
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up	8
Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma	7
SNORA23 inhibits HCC tumorigenesis by impairing the 2'-O-ribose methylation level of 28S rRNA	7
BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibi	7
The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma	7
Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations	7
Early detection of gastric cancer in China: progress and opportunities	7
The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer	7
Research progress in hepatitis B virus covalently closed circular DNA	7
Akt isoforms differentially provide for chemoresistance in prostate cancer	7
Phase II study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA	7
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy	7
Tumor organoids for cancer research and personalized medicine	7
A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma	7
Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study	7
Is adjuvant chemotherapy necessary for early gastric cancer?	6
Single-cell trajectories of melanoma cell resistance to targeted treatment	6
sLe<sup>x</sup> expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator	6
Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer	6
Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma	6
Updates in endocrine therapy for metastatic breast cancer	6
Cancer metabolism and dietary interventions	6
Frequent low dose alcohol intake increases gastric cancer risk: the Health Examinees-Gem (HEXA-G) study	6
The power of a healthy lifestyle for cancer prevention: the example of colorectal cancer	6
Current progress in cancer treatment by targeting FGFR signaling	6
Targeting the COP9 signalosome for cancer therapy	6
The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma	6
EZH2 identifies the precursors of human natural killer cells with trained immunity	6
Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network	5
Epstein-Barr virus DNA loads in the peripheral blood cells predict the survival of locoregionally-advanced nasopharyngeal carcinoma patients	5
The role of DLL1 in long-term vascular normalization and cancer immunotherapy	5
Comparative profiling of immune genes improves the prognoses of lower grade gliomas	5
The efficacies and biomarker investigations of anti-programmed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma	5
Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma	5
Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma	5
CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells	5
Development of glioblastoma organoids and their applications in personalized therapy	5
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer	5
Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma	5
Intercellular transmission of cGAS-STING signaling in cancer	5
Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway	5
Microwave ablation vs. surgical resection for treatment naïve hepatocellular carcinoma within the Milan criteria: a follow-up of at least 5 years	5
Development and validation of a risk model for noninvasive detection of cancer in oral potentially malignant disorders using DNA image cytometry	5
Current research on circular RNAs and their potential clinical implications in breast cancer	5
Smart drug delivery systems to overcome drug resistance in cancer immunotherapy	5
Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma: a long-term follow-up study	5
Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer	5
Epigenetic reprogramming in small cell lung cancer	5
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets	5
Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting	5
Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study	5
Heterogeneity of neutrophils in cancer: one size does not fit all	5
Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer	4
Cyclophosphamide abrogates the expansion of CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells and enhances the efficacy of bleomycin in the treatment of mouse B16-F10 melanom	4
Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer	4
Combined chemo-endocrine therapy as a potential new option for HR+/HER2− advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine	4
Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy	4
The choice of a neoadjuvant chemotherapy cycle for breast cancer has significance in clinical practice: results from a population-based, real world study	4
Biomaterial-based platforms for cancer stem cell enrichment and study	4
Genomic medicine and cancer clinical trial in Thailand	4
Optimization of regional nodal irradiation in the era of sentinel lymph node biopsy	4
Repurposing glucocorticoids as adjuvant reagents for immune checkpoint inhibitors in solid cancers	4
The emerging role of long noncoding RNA RMRP in cancer development and targeted therapy	4
Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells	4
Cellular immunotherapy for hematological malignancy: recent progress and future perspectives	4
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation	4
Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages	4
FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma	4
Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells	4

Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies	4
Diagnosis of malnutrition in cancer patients	4
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis	4
Molecular testing for acute myeloid leukemia	4
Comparison of outcomes between immediate implant-based and autologous reconstruction: 15-year, single-center experience in a propensity score-matched Chinese cohort	4
ANTP-SMACN7 fusion peptide alone induced high linear energy transfer irradiation radiosensitization in non-small cell lung cancer cell lines	3
Conceptualizing the complexity of ferroptosis to treat triple-negative breast cancer: theory-to-practice	3
Decoding the complexity of metastasis	3
A novel recurrence-associated metabolic prognostic model for risk stratification and therapeutic response prediction in patients with stage I lung adenocarcinoma	3
Immune checkpoint inhibitors: breakthroughs in cancer treatment	3
Peripheral blood indices to predict PFS/OS with anlotinib as a subsequent treatment in advanced small-cell lung cancer	3
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma	3
Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome	3
MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2	3
Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy: a comprehensive review	3
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment	3
Synergistic effects of AAGL and anti-PD-1 on hepatocellular carcinoma through lymphocyte recruitment to the liver	3
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells	3
EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression	3
Multiplex imaging reveals the architecture of the tumor immune microenvironment	3
Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma	3
Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma	3
<i>BRCA</i> mutation rate and characteristics of prostate tumor in breast and ovarian cancer families: analysis of 6,591 Italian pedigrees	3
The active surveillance management approach for patients with low risk papillary thyroid microcarcinomas: is China ready?	3
PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas	3
Aberrantly expressed GFRα-1/RET in patients with lacrimal adenoid cystic carcinoma is associated with high recurrence risk: a retrospective study of 51 LACC cases	3
Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy	3
Epigenetic modulation of the tumor immune microenvironment by nanoinducers to potentiate cancer immunotherapy	2
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis	2
A machine learning model to predict efficacy of neoadjuvant therapy in breast cancer based on dynamic changes in systemic immunity	2
Repurposing drugs for solid tumor treatment: focus on immune checkpoint inhibitors	2
The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer	2
Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma	2
Therapeutic implications of cancer stem cells in prostate cancer	2
Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy	2
Chemotherapy-free radiotherapy combined with immune checkpoint inhibitors: a new regimen for locally advanced non-small cell lung cancer?	2
Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study	2
Ferritin as a diagnostic, differential diagnostic, and prognostic marker for immune-related adverse events	2
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma	2
Microbiome changes in esophageal cancer: implications for pathogenesis and prognosis	2
Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine	2
Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods	2
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity	2
Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma	2
SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation	2
Imaging in translational cancer research	2
Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity, and potential therapeutic strategies	2
Targeting endoplasmic reticulum stress signaling in ovarian cancer therapy	2
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer	2
Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data	2
Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population	2
A breakthrough in liver regeneration for treatment of liver cancer	2
Phase Ib study of anti-EGFR antibody (SCT200) in combination with anti-PD-1 antibody (SCT-I10A) for patients with RAS/BRAF wild-type metastatic colorectal cancer	2
Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women	2
Biological insights in non-small cell lung cancer	2
CSCO guidelines for metastatic colorectal cancer: personalized medicine in clinical practice	2
Decoding the intercellular communication network during tumorigenesis	2
PD-1 inhibitors provide new opportunities in conversion therapy for stage IV gastric cancer	2
Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival	2
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma	2
Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance	2
Development and evaluation of the screening performance of a low-cost high-risk screening strategy for breast cancer	2
Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment	2
Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of <i>KRAS</i>-mutant colorectal cancer	2
A truncated protein product of the germline variant of the <i>DUOX2</i> gene leads to adenomatous polyposis	2
Commensal microbiota in the digestive tract: a review of its roles in carcinogenesis and radiotherapy	2
Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing	2
Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial	2