OOIR: Observatory of International Research

Papers

(The TQCC of Frontiers of Medicine is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	75
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	58
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	55
Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain	55
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	50
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	47
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	43
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors	42
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	41
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China	39
Rare tumors: a blue ocean of investigation	38
COVID-19: why not learn from the past?	36
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian heart	28
Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy	28
Novel mutation c.1210-3C > G in cis with a poly-T tract of 5T affects CFTR mRNA splicing in a Chinese patient with cystic fibrosis	28
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	27
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	26
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	25
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	23
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	22
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	20
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma	20
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	19
Erratum to: Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	18
A review of the safety and efficacy of current COVID-19 vaccines	18

ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	17
PAK5-mediated PKM2 phosphorylation is critical for anaerobic glycolysis in endometriosis	16
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	15
Base editors: development and applications in biomedicine	14
Phase separation in cGAS-STING signaling	14
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	14
Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture	13
Passive antibody therapy in emerging infectious diseases	13
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	13
Mechanism of insulin resistance in obesity: a role of ATP	12
Update on Mayer—Rokitansky—Küster—Hauser syndrome	12
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	12
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	12
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	12
HOXB13 in cancer development: molecular mechanisms and clinical implications	11
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	11
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma	11
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	11
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	11
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	11
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	11
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	11
Heterogeneity of the tumor immune microenvironment and clinical interventions	10
Interactions between remote ischemic conditioning and post-stroke sleep regulation	10
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections	10
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	10
Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking	10
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	10
Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions	9
Myeloid cells: key players in tumor microenvironments	9
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	9
A novel variant in the GJB6 gene in a large Chinese family with a unique phenotype of Clouston syndrome	9
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	9
Prevalence of antifolate drug resistance markers in Plasmodium vivax in China	9
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control	9
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	9
Disparities in 36 cancers across 185 countries: secondary analysis of global cancer statistics	8
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	8
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods	8
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling	8
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats	8
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	8
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	7
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	7
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	7
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	7
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	7
Intracellular concentration of ADA2 is a marker for monocyte differentiation and activation	7
Unusual global outbreak of monkeypox: what should we do?	6
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome	6

Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	6
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges	6
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies	6
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	6
Plasma transthyretin is a nutritional biomarker in human morbidities	6
Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac	6
Revisiting China’s response to coronavirus disease 2019	6
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	6
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	6