OOIR: Observatory of International Research

Papers

(The TQCC of Frontiers of Medicine is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma	61
Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial	60
Decellularized extracellular matrix mediates tissue construction and regeneration	60
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution	50
Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis	49
SARS-CoV-2 variants, immune escape, and countermeasures	46
Integrated analysis of gut microbiome and host immune responses in COVID-19	46
Mechanism of insulin resistance in obesity: a role of ATP	39
Discovery and repurposing of artemisinin	36
Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial	35
Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic	34
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	34
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?	32
Orlistat induces ferroptosis-like cell death of lung cancer cells	32
Zooming in and out of ferroptosis in human disease	30
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells	29
Unusual global outbreak of monkeypox: what should we do?	28
Clinical characteristics and risk factors for mortality in cancer patients with COVID-19	27
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	25
Astrocytes in depression and Alzheimer’s disease	23
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	21
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	21
Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018	20
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia	20
Innate immune responses in RNA viral infection	20

A review of the safety and efficacy of current COVID-19 vaccines	20
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	20
Hyperglycemic memory in diabetic cardiomyopathy	19
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	19
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease	18
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population	18
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	15
Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach	15
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	14
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia	13
Proteins moonlighting in tumor metabolism and epigenetics	13
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	13
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial	13
Laboratory diagnosis for malaria in the elimination phase in China: efforts and challenges	12
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis	12
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples	12
Prefrontal cortical circuits in anxiety and fear: an overview	12
Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition	11
Progress and challenges in RET-targeted cancer therapy	11
Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia	11
Multi-target combinatory strategy to overcome tumor immune escape	11
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	11
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	10
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia	10
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	10
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	9
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	9
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field	9
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	9
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection	9
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	9
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer: a meta-analysis and systemic review of ran	9
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway	9
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	9
Plasma transthyretin is a nutritional biomarker in human morbidities	9
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	8
Prohibitin regulates mTOR pathway via interaction with FKBP8	8
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	8
Primary cilia in hard tissue development and diseases	8
The development and benefits of metformin in various diseases	8
Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)	8
Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies	8
5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I	8
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2	8
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma	8
The critical importance of epigenetics in autoimmune-related skin diseases	7
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	7
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	7
Emerging immunological strategies: recent advances and future directions	7
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	7

Targeting “undruggable” c-Myc protein by synthetic lethality	7
DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis	7
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	7
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	7