OOIR: Observatory of International Research

Papers

(The median citation count of Frontiers of Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	82
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	72
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	39
Unusual global outbreak of monkeypox: what should we do?	37
Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Stud	34
Revisiting China’s response to coronavirus disease 2019	31
Betaine: an exercise mimetics for healthy aging?	29
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	29
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	28
ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis	28
Lactate and lactylation in tumor immunity	28
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	27
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	27
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	26
Burning lactic acid: a road to revitalizing antitumor immunity	24
Factors involved in human healthy aging: insights from longevity individuals	23
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	23
Human pangenome: far-reaching implications in precision medicine	22
Regulations of m6A and other RNA modifications and their roles in cancer	22
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	21
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	21
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	21
The nature of cancer	21
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	20
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	19

Research progress on molecular mechanism and future perspectives of leonurine	19
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue	18
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	18
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	17
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	17
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	17
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	16
A critical perspective on patient activation through integrative healthcare counseling in oncology	16
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	16
Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma	16
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	16
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	15
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	15
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	15
Insights into potential therapeutic approaches for long COVID	15
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	14
Myeloid cells: key players in tumor microenvironments	14
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	14
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	14
Heterogeneity of the tumor immune microenvironment and clinical interventions	14
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	13
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	13
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	13
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	13
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	13
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	12
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	12
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	12
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	11
Flavivirus-infected hosts attract more mosquitoes to bite	11
China’s biosafety/biosecurity governance: evolution, challenges, and architecture design	11
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	11
Advancing pediatric care before birth	11
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	11
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	10
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	10
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	10
Innovation-driven trend shaping COVID-19 vaccine development in China	10
Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	10
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	10
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	9
Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review	9
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	9
RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts	9
Progress and challenges in RET-targeted cancer therapy	9
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	9
Immune landscape and response to oncolytic virus-based immunotherapy	9
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	8
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	8
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	8

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	8
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	8
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	8
Cellular senescence in age-related musculoskeletal diseases	8
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	8
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	8
Update on Mayer—Rokitansky—Küster—Hauser syndrome	8
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	8
Perspective on strengthening dementia prevention and control system: a comprehensive framework for national health	8
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	7
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	7
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	7
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	7
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	7
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	7
Unlocking the potential of bispecific ADCs for targeted cancer therapy	7
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	7
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	6
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	6
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	6
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	6
Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment	6
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	6
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	6
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	6
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	6
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	5
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	5
Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach	5
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	5
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	5
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	5
Passive antibody therapy in emerging infectious diseases	5
HOXB13 in cancer development: molecular mechanisms and clinical implications	5
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	5
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	5
Multifaceted function of B cells in tumorigenesis	5
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	5
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	5
Holistic Integrative Medicine Declaration	5
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	5
Intracellular checkpoints for NK cell cancer immunotherapy	5
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	5
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	4
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	4
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis	4
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	4
Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study	4
Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy adjustments	4
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression	4
Innovation and development of stent retrievers in acute ischemic stroke	4
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	4
Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women	4
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	4
Artificial intelligence methods available for cancer research	4
Particulate matter exposure and end-stage renal disease risk in IgA nephropathy	4
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer	4
Pathological progression of osteoarthritis: a perspective on subchondral bone	4
Suboptimal reporting of randomized controlled trials on non-pharmacological therapies in Chinese medicine	4
Albumin-bound paclitaxel plus anlotinib in patients with recurrent, platinum-resistant primary epithelial ovarian cancer (A-Plus): a phase II, single-arm, prospective study	4
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	4
Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis	4
Plasma transthyretin is a nutritional biomarker in human morbidities	4
Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting	4
NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway	4
Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing the release of microparticles	4
Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation	4
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015	4
Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo	4
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	4