OOIR: Observatory of International Research

Papers

(The median citation count of Frontiers of Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	67
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	67
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	39
Revisiting China’s response to coronavirus disease 2019	37
Unusual global outbreak of monkeypox: what should we do?	34
Betaine: an exercise mimetics for healthy aging?	30
Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Stud	27
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	26
Lactate and lactylation in tumor immunity	26
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	25
ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis	25
Burning lactic acid: a road to revitalizing antitumor immunity	24
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	24
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	23
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	23
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	21
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	21
Regulations of m6A and other RNA modifications and their roles in cancer	21
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	20
Factors involved in human healthy aging: insights from longevity individuals	20
Human pangenome: far-reaching implications in precision medicine	20
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	19
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	18
The nature of cancer	18
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	18

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	18
Research progress on molecular mechanism and future perspectives of leonurine	17
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	17
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	17
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	17
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	17
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	16
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	15
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	15
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	15
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue	15
Myeloid cells: key players in tumor microenvironments	14
Insights into potential therapeutic approaches for long COVID	14
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	14
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	14
Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma	14
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	14
A critical perspective on patient activation through integrative healthcare counseling in oncology	14
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	13
Heterogeneity of the tumor immune microenvironment and clinical interventions	13
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	13
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	12
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	12
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	12
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	12
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	12
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	12
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	11
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	11
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	11
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	11
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	11
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	10
China’s biosafety/biosecurity governance: evolution, challenges, and architecture design	10
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	10
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	10
Flavivirus-infected hosts attract more mosquitoes to bite	10
Advancing pediatric care before birth	10
Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	9
Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review	9
Progress and challenges in RET-targeted cancer therapy	9
Innovation-driven trend shaping COVID-19 vaccine development in China	9
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	9
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	9
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	8
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	8
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	8
RRS1 regulates proliferation, migration, and invasion of HTR-8/SVneo human trophoblasts	8
Immune landscape and response to oncolytic virus-based immunotherapy	8
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	8

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	8
Update on Mayer—Rokitansky—Küster—Hauser syndrome	7
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	7
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	7
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	7
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	7
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	7
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	7
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	7
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	7
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	7
Cellular senescence in age-related musculoskeletal diseases	7
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	6
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	6
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	6
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	6
Perspective on strengthening dementia prevention and control system: a comprehensive framework for national health	6
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	6
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	6
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	6
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	6
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	6
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	6
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	6
Unlocking the potential of bispecific ADCs for targeted cancer therapy	6
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	6
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	6
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	5
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	5
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	5
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	5
Intracellular checkpoints for NK cell cancer immunotherapy	5
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	5
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	5
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	5
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	5
Multifaceted function of B cells in tumorigenesis	5
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	5
Passive antibody therapy in emerging infectious diseases	5
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	5
Predictive biomarkers for immunotherapy in nasopharyngeal carcinoma: from tumor microenvironment to macroenvironment	5
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	4
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	4
Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach	4
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	4
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	4
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	4
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	4
HOXB13 in cancer development: molecular mechanisms and clinical implications	4
Plasma transthyretin is a nutritional biomarker in human morbidities	4
Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting	4
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	4
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	4
Holistic Integrative Medicine Declaration	4
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	4