Frontiers of Medicine

Article	Citations
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection	1551
Coronavirus disease 2019 (COVID-19): a clinical update	273
Oxidative stress and diabetes: antioxidative strategies	234
Clinical characteristics of 19 neonates born to mothers with COVID-19	178
Biological properties and clinical applications of berberine	177
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain	169
COVID-19 containment: China provides important lessons for global response	104
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19	95
Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19	88
Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions	76
Deep learning in digital pathology image analysis: a survey	74
Application of artificial intelligence in surgery	70
Precision medicine in acute lymphoblastic leukemia	69
Factors influencing peak bone mass gain	65
Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies	60
Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial	60
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection	54
The role played by traditional Chinese medicine in preventing and treating COVID-19 in China	46
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma	45
Review of surgical robotic systems for keyhole and endoscopic procedures: state of the art and perspectives	42
China’s local governments are combating COVID-19 with unprecedented responses — from a Wenzhou governance perspective	39
Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis	38
Decellularized extracellular matrix mediates tissue construction and regeneration	38
Development of oncolytic virotherapy: from genetic modification to combination therapy	38
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution	37

SARS-CoV-2 variants, immune escape, and countermeasures	37
Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios	37
Integrated analysis of gut microbiome and host immune responses in COVID-19	36
Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis	35
Mechanism of insulin resistance in obesity: a role of ATP	34
Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases	32
Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial	32
Back to the spring of 2020: facts and hope of COVID-19 outbreak	30
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?	30
Discovery and repurposing of artemisinin	28
Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic	27
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	27
Clinical characteristics and risk factors for mortality in cancer patients with COVID-19	26
Metabolism and immunity in breast cancer	26
Orlistat induces ferroptosis-like cell death of lung cancer cells	25
Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study	25
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells	24
Advances on immune-related adverse events associated with immune checkpoint inhibitors	24
Molecular network-based intervention brings us closer to ending the HIV pandemic	24
Unusual global outbreak of monkeypox: what should we do?	23
Current applications of artificial intelligence for intraoperative decision support in surgery	22
Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase II oocytes	22
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	20
Traditional Chinese medicine for combating COVID-19	19
A review of the safety and efficacy of current COVID-19 vaccines	19
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	18
Human microbiome and prostate cancer development: current insights into the prevention and treatment	17
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	17
Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018	17
Innate immune responses in RNA viral infection	16
Recent advances in myeloid-derived suppressor cell biology	16
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia	16
Astrocytes in depression and Alzheimer’s disease	16
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma	15
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	15
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population	14
Phase- and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China	14
Artificial intelligence in radiotherapy: a technological review	14
Organ function support in patients with coronavirus disease 2019: Tongji experience	14
Artificial intelligence in gastroenterology: where are we heading?	14
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease	13
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	13
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4 signaling pathway	13
Laboratory diagnosis for malaria in the elimination phase in China: efforts and challenges	12
Applications of atomic force microscopy in immunology	12
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia	12
Proteins moonlighting in tumor metabolism and epigenetics	12
Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach	12
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	12
Zooming in and out of ferroptosis in human disease	12

Progress in systemic therapy for triple-negative breast cancer	12
State-of-the-art of intelligent minimally invasive surgical robots	11
Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia	11
Guidelines for navigation-assisted spine surgery	11
Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion tensor imaging studies	11
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial	11
Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study	11
2019 novel coronavirus outbreak: a quiz or final exam?	10
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples	10
Linking key intervention timings to rapid declining effective reproduction number to quantify lessons against COVID-19	10
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system	10
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	10
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	9
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis	9
Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study	9
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2	8
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer: a meta-analysis and systemic review of ran	8
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19	8
Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition	8
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	8
Prefrontal cortical circuits in anxiety and fear: an overview	8
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	8
Primary cilia in hard tissue development and diseases	8
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway	7
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	7
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection	7
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	7
Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies	7
Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2	7
Hyperglycemic memory in diabetic cardiomyopathy	7
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field	7
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma	7
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	7
Multi-target combinatory strategy to overcome tumor immune escape	7
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	7
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	7
Targeting “undruggable” c-Myc protein by synthetic lethality	7
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia	6
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	6
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	6
Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy for acute lym	6
Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma after chimeric antigen receptor T cell therapy	6
Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)	6
Taizhou’s COVID-19 prevention and control experience with telemedicine features	6
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	6
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	6
Four-protein model for predicting prognostic risk of lung cancer	5
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	5
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	5
Prohibitin regulates mTOR pathway via interaction with FKBP8	5
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	5
Emerging immunological strategies: recent advances and future directions	5
Plasma transthyretin is a nutritional biomarker in human morbidities	5
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	5
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets	4
5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I	4
DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis	4
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	4
Analysis of antibiotic usage for viral community-acquired pneumonia in adults	4
Progress and challenges in RET-targeted cancer therapy	4
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction	4
The critical importance of epigenetics in autoimmune-related skin diseases	4
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	4
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	4
Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of sex development	4
Development of an artificial intelligence diagnostic model based on dynamic uncertain causality graph for the differential diagnosis of dyspnea	4
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	4
Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking	4
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	4
Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy	3
Advances in tissue state recognition in spinal surgery: a review	3
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo	3
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	3
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats	3
New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study	3
Microorganism-derived biological macromolecules for tissue engineering	3
Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies: a prospe	3
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	3
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia	3
H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis	3

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	3
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma	3
Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming	3
Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia	3
Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head	3
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	3
Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma: a prospective cohort study	3
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	3
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast cancer was similar in node-negative diseases: a single-center study of 800 patients	3
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma	3
Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study	3
Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR	3