OOIR: Observatory of International Research

Papers

(The median citation count of Frontiers of Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma	61
Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial	60
Decellularized extracellular matrix mediates tissue construction and regeneration	60
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution	50
Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis	49
SARS-CoV-2 variants, immune escape, and countermeasures	46
Integrated analysis of gut microbiome and host immune responses in COVID-19	46
Mechanism of insulin resistance in obesity: a role of ATP	39
Discovery and repurposing of artemisinin	36
Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial	35
Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic	34
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	34
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?	32
Orlistat induces ferroptosis-like cell death of lung cancer cells	32
Zooming in and out of ferroptosis in human disease	30
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells	29
Unusual global outbreak of monkeypox: what should we do?	28
Clinical characteristics and risk factors for mortality in cancer patients with COVID-19	27
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	25
Astrocytes in depression and Alzheimer’s disease	23
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	21
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	21
Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018	20
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia	20
Innate immune responses in RNA viral infection	20

A review of the safety and efficacy of current COVID-19 vaccines	20
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	20
Hyperglycemic memory in diabetic cardiomyopathy	19
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	19
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease	18
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population	18
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	15
Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach	15
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	14
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia	13
Proteins moonlighting in tumor metabolism and epigenetics	13
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	13
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial	13
Laboratory diagnosis for malaria in the elimination phase in China: efforts and challenges	12
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis	12
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples	12
Prefrontal cortical circuits in anxiety and fear: an overview	12
Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition	11
Progress and challenges in RET-targeted cancer therapy	11
Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia	11
Multi-target combinatory strategy to overcome tumor immune escape	11
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	11
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia	10
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	10
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	10
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	9
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field	9
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	9
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection	9
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	9
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer: a meta-analysis and systemic review of ran	9
Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway	9
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	9
Plasma transthyretin is a nutritional biomarker in human morbidities	9
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	9
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	8
Prohibitin regulates mTOR pathway via interaction with FKBP8	8
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	8
Primary cilia in hard tissue development and diseases	8
The development and benefits of metformin in various diseases	8
Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)	8
Translational application of neuroimaging in major depressive disorder: a review of psychoradiological studies	8
5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I	8
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2	8
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma	8
The critical importance of epigenetics in autoimmune-related skin diseases	7
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	7
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	7
Emerging immunological strategies: recent advances and future directions	7
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	7

Targeting “undruggable” c-Myc protein by synthetic lethality	7
DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis	7
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	7
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	7
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	6
Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation	6
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	6
Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy for acute lym	6
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	6
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	6
Four-protein model for predicting prognostic risk of lung cancer	6
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	6
Base editors: development and applications in biomedicine	6
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	5
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	5
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	5
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	5
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo	5
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	5
Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study	4
Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma	4
Microorganism-derived biological macromolecules for tissue engineering	4
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation	4
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	4
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	4
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma	4
Unraveling the complex roles of macrophages in obese adipose tissue: an overview	4
Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease	4
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	4
Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR	4
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	4
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges	4
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	4
Acupuncture for the management of dry eye disease	4
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets	4
Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair	4
Pathological progression of osteoarthritis: a perspective on subchondral bone	4
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	4
Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking	4
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma	4
COVID-19: why not learn from the past?	3
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	3
Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming	3
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	3
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	3
Liver cell therapies: cellular sources and grafting strategies	3
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia	3
Clinical applications of neurolinguistics in neurosurgery	3
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies	3
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats	3
Update on Mayer—Rokitansky—Küster—Hauser syndrome	3
Passive antibody therapy in emerging infectious diseases	3
Chimeric antigen receptor T cell therapies for acute myeloid leukemia	3
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1	3
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation	3
Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia	3
Advances in tissue state recognition in spinal surgery: a review	3
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	3
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling	3
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods	3
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast cancer was similar in node-negative diseases: a single-center study of 800 patients	3
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	3
Phase separation in cGAS-STING signaling	3
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	3
New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study	3
Mycophenolate mofetil or tacrolimus compared with azathioprine in long-term maintenance treatment for active lupus nephritis	3
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)	3
Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia	3
H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis	3
Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis	3
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	3
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	3