Frontiers of Medicine

Article	Citations
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	77
COVID-19: why not learn from the past?	61
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	55
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	55
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	49
Revisiting China’s response to coronavirus disease 2019	47
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	44
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	36
Unusual global outbreak of monkeypox: what should we do?	31
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	30
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	29
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	28
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	27
Regulations of m6A and other RNA modifications and their roles in cancer	27
Burning lactic acid: a road to revitalizing antitumor immunity	26
Factors involved in human healthy aging: insights from longevity individuals	25
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	24
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	23
Clinical applications of neurolinguistics in neurosurgery	22
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	22
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	22
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	20
Human pangenome: far-reaching implications in precision medicine	18
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	17
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	17

Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	16
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation	16
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	15
The nature of cancer	15
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial	14
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	14
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	14
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	14
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	13
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	13
Emerging immunological strategies: recent advances and future directions	13
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	13
Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study	13
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	13
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	12
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	12
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	12
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	12
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	12
Novel mutation c.1210-3C > G in cis with a poly-T tract of 5T affects CFTR mRNA splicing in a Chinese patient with cystic fibrosis	12
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	11
Myeloid cells: key players in tumor microenvironments	11
Heterogeneity of the tumor immune microenvironment and clinical interventions	11
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	11
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	11
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	11
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	10
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	10
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	10
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells	10
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	10
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	10
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	10
Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia	9
Advances in tissue state recognition in spinal surgery: a review	9
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	9
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	9
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	9
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	9
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	9
Hyperglycemic memory in diabetic cardiomyopathy	8
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	8
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	8
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	8
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	7
Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement	7
Astrocytes in depression and Alzheimer’s disease	7
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	7
Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	7
Flavivirus-infected hosts attract more mosquitoes to bite	7

Advancing pediatric care before birth	7
Immune landscape and response to oncolytic virus-based immunotherapy	7
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	6
Innovation-driven trend shaping COVID-19 vaccine development in China	6
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	6
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	6
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	6
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	6
Second unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte infusion	6
Progress and challenges in RET-targeted cancer therapy	6
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	6
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population	6
Mechanism of insulin resistance in obesity: a role of ATP	5
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	5
Update on Mayer—Rokitansky—Küster—Hauser syndrome	5
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	5
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	5
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	5
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	5
Orlistat induces ferroptosis-like cell death of lung cancer cells	5
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	5
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	5
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	5
Unlocking the potential of bispecific ADCs for targeted cancer therapy	4
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	4
Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia	4
Erratum to: Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo	4
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	4
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	4
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	4
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	4
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	4
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	4
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	4
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	4
Interactions between remote ischemic conditioning and post-stroke sleep regulation	4
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	4
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	4
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	4
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	4
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	4
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	4
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	4
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	4
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	3
Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination	3
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	3
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	3
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	3
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	3
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	3
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	3
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	3
Multifaceted function of B cells in tumorigenesis	3
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	3
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	3
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	3
HOXB13 in cancer development: molecular mechanisms and clinical implications	3
Plasma transthyretin is a nutritional biomarker in human morbidities	3
Passive antibody therapy in emerging infectious diseases	3
Primary cilia in hard tissue development and diseases	3
Intracellular checkpoints for NK cell cancer immunotherapy	3
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	3
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	3
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	3
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	3
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	3
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	3
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	3
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	3
Fine-tuning cell organelle dynamics during mitosis by small GTPases	2
Artificial intelligence methods available for cancer research	2
Decellularized extracellular matrix mediates tissue construction and regeneration	2
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	2
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	2
Four-protein model for predicting prognostic risk of lung cancer	2
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer	2
First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer: real-world multicenter study	2
Multi-target combinatory strategy to overcome tumor immune escape	2
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015	2

EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	2
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies	2
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	2
Holistic Integrative Medicine Declaration	2
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	2
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression	2
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer	2
Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation	2
Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo	2
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis	2
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	2
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	2
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	2
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	2
NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway	2
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples	2
Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing the release of microparticles	2
Pathological progression of osteoarthritis: a perspective on subchondral bone	2
Suboptimal reporting of randomized controlled trials on non-pharmacological therapies in Chinese medicine	2
Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy adjustments	2
Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis	2