OOIR: Observatory of International Research

Papers

(The median citation count of Frontiers of Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	96
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	60
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	59
Revisiting China’s response to coronavirus disease 2019	59
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	50
Betaine: an exercise mimetics for healthy aging?	34
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	34
ALKBH5 exacerbates psoriatic dermatitis in mice by promoting angiogenesis	31
Unusual global outbreak of monkeypox: what should we do?	31
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	31
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	30
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	29
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	28
Factors involved in human healthy aging: insights from longevity individuals	27
Burning lactic acid: a road to revitalizing antitumor immunity	26
Regulations of m6A and other RNA modifications and their roles in cancer	26
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	22
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	22
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	19
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	18
Human pangenome: far-reaching implications in precision medicine	18
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	18
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	17
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation	17
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation	17

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19	16
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	16
GID complex regulates the differentiation of neural stem cells by destabilizing TET2	16
Research progress on molecular mechanism and future perspectives of leonurine	16
The nature of cancer	16
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data	15
Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives	15
Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study	15
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis	15
Long-acting lenacapavir is a breakthrough for preventing HIV infection, but HIV vaccine research must continue	14
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies	14
Emerging immunological strategies: recent advances and future directions	14
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome	14
A critical perspective on patient activation through integrative healthcare counseling in oncology	13
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	13
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	12
Myeloid cells: key players in tumor microenvironments	12
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	12
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	12
Anti-angiogenic therapy as a beacon of hope in the battle against pulmonary NUT midline carcinoma	12
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	12
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	12
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	11
Heterogeneity of the tumor immune microenvironment and clinical interventions	11
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	11
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	11
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells	11
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	10
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	10
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	10
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	10
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	10
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	10
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	10
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	10
TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer	9
Hyperglycemic memory in diabetic cardiomyopathy	9
Flavivirus-infected hosts attract more mosquitoes to bite	9
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	9
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression	9
Advancing pediatric care before birth	9
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	9
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19	9
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	9
Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke	9
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial	8
Astrocytes in depression and Alzheimer’s disease	8
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients	8
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy	8
Innovation-driven trend shaping COVID-19 vaccine development in China	8

Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader—Willi syndrome	8
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy	7
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity	7
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	7
Update on Mayer—Rokitansky—Küster—Hauser syndrome	7
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia	7
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway	7
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	7
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	7
Progress and challenges in RET-targeted cancer therapy	7
Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review	7
Immune landscape and response to oncolytic virus-based immunotherapy	7
Tonic signaling in CAR-T therapy: the lever long enough to move the planet	7
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	6
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	6
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	6
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	6
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	6
Unlocking the potential of bispecific ADCs for targeted cancer therapy	6
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	6
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	6
Interactions between remote ischemic conditioning and post-stroke sleep regulation	6
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	6
lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy, leading to atherogenesis	6
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	6
Cellular senescence in age-related musculoskeletal diseases	6
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma	6
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	6
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)	5
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	5
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia	5
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives	5
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	5
lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complex IV axis	5
Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination	5
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution	5
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study	5
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report	5
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment	5
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years	5
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	4
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	4
Intracellular checkpoints for NK cell cancer immunotherapy	4
Multifaceted function of B cells in tumorigenesis	4
lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression	4
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	4
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	4
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids	4
Primary assessment of the diversity of Omicron sublineages and the epidemiologic features of autumn/winter 2022 COVID-19 wave in Chinese mainland	4
Primary cilia in hard tissue development and diseases	4
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	4
Passive antibody therapy in emerging infectious diseases	4
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	4
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation	4
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China	4
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	4
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	3
HOXB13 in cancer development: molecular mechanisms and clinical implications	3
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	3
Decellularized extracellular matrix mediates tissue construction and regeneration	3
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies	3
Neurokinin-1 receptor antagonists in the current management of chemotherapy-induced nausea and vomiting	3
Determining the biomarkers and pathogenesis of myocardial infarction combined with ankylosing spondylitis via a systems biology approach	3
Holistic Integrative Medicine Declaration	3
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	3
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	3
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	3
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	3
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	3
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	3
Plasma transthyretin is a nutritional biomarker in human morbidities	3