Frontiers of Medicine

Article	Citations
Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel study	61
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia	60
Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis	60
Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study	51
Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain	51
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions	50
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma	49
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian heart	43
Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance	39
Novel mutation c.1210-3C > G in cis with a poly-T tract of 5T affects CFTR mRNA splicing in a Chinese patient with cystic fibrosis	36
Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai, China	35
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches	34
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria	32
Update on Mayer—Rokitansky—Küster—Hauser syndrome	30
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China	28
Rare tumors: a blue ocean of investigation	27
COVID-19: why not learn from the past?	25
Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy	23
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma	21
Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors	21
Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5	21
A review of the safety and efficacy of current COVID-19 vaccines	20
Echocardiographic Measurements in Normal Chinese Adults (EMINCA) II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography	20
Erratum to: Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	20
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers	19

PAK5-mediated PKM2 phosphorylation is critical for anaerobic glycolysis in endometriosis	18
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance	18
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke	15
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer	15
Renin-angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension	14
Phase separation in cGAS-STING signaling	13
ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification	13
Base editors: development and applications in biomedicine	13
Passive antibody therapy in emerging infectious diseases	12
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors	12
Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages	12
Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture	12
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis	11
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice	11
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19	11
Recurrent eosinophilia with a novel homozygous ARPC1B mutation	10
Mechanism of insulin resistance in obesity: a role of ATP	10
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis	10
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma	10
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity	10
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions	9
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ	9
Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF	9
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections	9
Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis	9
Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking	8
Interactions between remote ischemic conditioning and post-stroke sleep regulation	8
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges	8
A novel variant in the GJB6 gene in a large Chinese family with a unique phenotype of Clouston syndrome	8
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study	8
Prevalence of antifolate drug resistance markers in Plasmodium vivax in China	8
Heterogeneity of the tumor immune microenvironment and clinical interventions	8
Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics	8
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications	8
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats	7
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma	7
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial	7
Biosensor-based assay of exosome biomarker for early diagnosis of cancer	7
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation	7
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China	7
Intracellular concentration of ADA2 is a marker for monocyte differentiation and activation	7
Targeting “undruggable” c-Myc protein by synthetic lethality	7
Progress on early diagnosing Alzheimer’s disease	7
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective	7
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients (‘CCC-Integrat	7
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients	6
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies	6
R158Q and G212S, novel pathogenic compound heterozygous variants in SLC12A3 of Gitelman syndrome	6
SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic	6
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control	6

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?	6
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation	6
The adoption of repeated measurement of variance analysis and Shapiro—Wilk test	6
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma	6
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling	6
Unusual global outbreak of monkeypox: what should we do?	6
Plasma transthyretin is a nutritional biomarker in human morbidities	5
Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac	5
Revisiting China’s response to coronavirus disease 2019	5
Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis: a single-center, prospective study in China	5
Holistic Integrative Medicine Declaration	5
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells	4
Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis	4
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer	4
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models	4
Disparities in 36 cancers across 185 countries: secondary analysis of global cancer statistics	4
Decellularized extracellular matrix mediates tissue construction and regeneration	4
Integrated analysis of gut microbiome and host immune responses in COVID-19	4
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies	4
Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis	4
Epigenetic modifiers: catalytic or noncatalytic, that is the question	4
Prevalence of anemia of varying severity, geographic variations, and association with metabolic factors among women of reproductive age in China: a nationwide, population-based study	4
Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial	4
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults	4
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families	4
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer	4
A distinct “repair” role of regulatory T cells in fracture healing	4
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis	4
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods	4
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study	3
Regulations of m6A and other RNA modifications and their roles in cancer	3
Effects and mechanisms of acupuncture on women related health	3
Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults	3
Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai	3
The critical importance of epigenetics in autoimmune-related skin diseases	3
EEG-controlled functional electrical stimulation rehabilitation for chronic stroke: system design and clinical application	3
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis	3
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature	3
Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions	3
Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICU quality data from 2015 to 2020	3
Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant	3
H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis	3
Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospective analysis	3
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis	3
Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic	3
Penetrance estimation of PRRT2 variants in paroxysmal kinesigenic dyskinesia and infantile convulsions	3
Unlocking the potential of bispecific ADCs for targeted cancer therapy	3
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament	3
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution	3
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target	3
A new perspective in pyroptosis: lifting the veil on GSDMA activation	3
Artificial intelligence methods available for cancer research	3
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial	3
Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)	3
Clinical applications of neurolinguistics in neurosurgery	3
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy	3
Erratum to: Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC	3
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial	3
The novel anthraquinone compound Kanglexin prevents endothelial-to-mesenchymal transition in atherosclerosis by activating FGFR1 and suppressing integrin β1/TGFβ signaling	3
Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2	3
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019	3
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis	3
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections	2
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy	2
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors	2
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside	2
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant	2
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance of multiple diseases	2
Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia	2
Answer for questions of repeated measurements of variance analysis and distribution test of data — Authors’ reply	2
NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway	2
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease	2
Discovery and repurposing of artemisinin	2
18F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma	2
EBV-associated lymphoproliferative disease post-CAR-T cell therapy	2
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia	2
Advances in tissue state recognition in spinal surgery: a review	2
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis	2
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China	2
The development and benefits of metformin in various diseases	2

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression	2
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer	2
SARS-CoV-2 variants, immune escape, and countermeasures	2
Fine-tuning cell organelle dynamics during mitosis by small GTPases	2
Characterization of chromatin accessibility in psoriasis	2
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression	2
Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia	2
Human pangenome: far-reaching implications in precision medicine	2
Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents	2
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis	2
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center	2
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015	2