Cells

Article	Citations
Management of Rheumatoid Arthritis: An Overview	366
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19	315
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview	300
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives	296
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review	290
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation	278
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma	240
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine	221
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs	221
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis	204
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair	202
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease	201
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis	200
Macrophages in Lung Injury, Repair, and Fibrosis	200
COVID-19: Characteristics and Therapeutics	194
The Role of MSC in Wound Healing, Scarring and Regeneration	190
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment	187
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?	187
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis	168
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health	168
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer	161
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review	155
Effects of Salinity Stress on Chloroplast Structure and Function	152
The RHO Family GTPases: Mechanisms of Regulation and Signaling	151
Extracellular ATP: A Feasible Target for Cancer Therapy	150

Cardiovascular Manifestations of COVID-19 Infection	149
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2	147
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity	147
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes	143
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control	142
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations	137
The Role of Mitochondria in Oocyte Maturation	136
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease	135
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications	129
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer	128
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ	127
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis	126
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications	125
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy	124
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization	124
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis	122
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation	121
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases	120
The Role of Oxidative Stress in Atherosclerosis	120
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements	119
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease	119
Beyond Activation: Characterizing Microglial Functional Phenotypes	119
Future Directions in the Treatment of Osteosarcoma	117
Regulation of TNF-Induced Osteoclast Differentiation	117
Microglia Phenotypes in Aging and Neurodegenerative Diseases	116
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate	115
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling	114
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression	113
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening	113
Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress	112
Calcium Signaling Regulates Autophagy and Apoptosis	110
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO	109
Neuroprotective Natural Products for Alzheimer’s Disease	108
Inflammatory Chemokines in Atherosclerosis	108
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments	104
Retinoic Acid and Its Derivatives in Skin	101
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles	101
Interconnections between Inflammageing and Immunosenescence during Ageing	101
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma	100
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling	99
Vascular Dysfunction in Preeclampsia	99
Molecular Markers and Targets in Melanoma	97
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies	95
Emerging Role of cAMP/AMPK Signaling	95
Neuron-Astrocyte Interactions in Parkinson’s Disease	95
The Role of Th17 Response in COVID-19	94
Myeloid Cells in Glioblastoma Microenvironment	94
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses	94
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies	93
GBA Variants and Parkinson Disease: Mechanisms and Treatments	93

Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants	92
Molecular Mechanisms of mtDNA-Mediated Inflammation	91
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis	91
Macrophage-Mediated Inflammation in Skin Wound Healing	90
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response	90
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection	89
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival	89
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	89
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease	89
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches	89
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility	88
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut	87
Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease	87
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress	87
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications	86
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma	85
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction	85
Cardiac Fibrosis and Fibroblasts	85
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future	85
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration	84
Adipose Tissue-Derived Mesenchymal Stem Cells	83
An Insight into GPCR and G-Proteins as Cancer Drivers	83
Various AAV Serotypes and Their Applications in Gene Therapy: An Overview	83
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients	82
BECLIN1: Protein Structure, Function and Regulation	82
The Emerging Role of the Lysosome in Parkinson’s Disease	82
Role of Human Mesenchymal Stem Cells in Regenerative Therapy	82
S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation	81
Current Understanding of Asthma Pathogenesis and Biomarkers	81
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications	80
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration	80
Sex-Specific Differences in Glioblastoma	80
Diabetic Macular Edema: Current Understanding, Molecular Mechanisms and Therapeutic Implications	79
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis	79
Vascularization Strategies in Bone Tissue Engineering	79
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines	78
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line	78
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review	78
Crosstalk of Autophagy and Apoptosis	78
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction	78
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging	78
Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics	78
Advances in Understanding of the Role of Lipid Metabolism in Aging	78
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches	77
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond	77
Multifunctional Role of S100 Protein Family in the Immune System: An Update	76
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration	76
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)	75
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention	75
Mesenchymal Stem Cell-Derived Secretome: A Potential Therapeutic Option for Autoimmune and Immune-Mediated Inflammatory Diseases	75
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.	75
Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options	74
Macrophage as a Peripheral Pain Regulator	74
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure	74
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction	74
The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke	73
Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction	73
The Interplay between Glioblastoma and Its Microenvironment	73
Mast Cells: A New Frontier for Cancer Immunotherapy	73
Interaction of Mitochondrial Calcium and ROS in Neurodegeneration	73
NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes	72
Significance of NETs Formation in COVID-19	72
Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol	71
An Epigenetic Role of Mitochondria in Cancer	71
The Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation	71
High Mobility Group Box-1 and Blood–Brain Barrier Disruption	71
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	71
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum	71
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (Oryza sativa L.)	70
NAC Transcription Factor Family Regulation of Fruit Ripening and Quality: A Review	70
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities	70
Quasar: Easy Machine Learning for Biospectroscopy	70
Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics	70
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review	69
Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria	69
The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness	69
Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas	69
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Progress, Challenges, and Prospects	69
The Role of the Immune System in the Development of Endometriosis	68
Iron: An Essential Element of Cancer Metabolism	68

Monocyte Recruitment, Specification, and Function in Atherosclerosis	68
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review	68
Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications	68
Progesterone Actions and Resistance in Gynecological Disorders	68
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy	68
Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells	68
Macrophages, Chronic Inflammation, and Insulin Resistance	68
Sustainable Agriculture through Multidisciplinary Seed Nanopriming: Prospects of Opportunities and Challenges	68
Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells	67
Novel Peptide Therapeutic Approaches for Cancer Treatment	67
Toll-Like Receptor Signaling in the Establishment and Function of the Immune System	67
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance	67
Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate	67
The Relationship between the Antioxidant System and Proline Metabolism in the Leaves of Cucumber Plants Acclimated to Salt Stress	67
Characterization of Apis mellifera Gastrointestinal Microbiota and Lactic Acid Bacteria for Honeybee Protection—A Review	67
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression	67
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies	66
Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions	66
The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion	66
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease	66
The Role of GDF15 as a Myomitokine	65
The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles	65
The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications	65
Ischemia–Reperfusion Injury in Lung Transplantation	64
Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines	64
Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response	64
Hippo Signaling Pathway in Gliomas	64
SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2	64
Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening	64
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells	64
Updates on the Role of ABSCISIC ACID INSENSITIVE 5 (ABI5) and ABSCISIC ACID-RESPONSIVE ELEMENT BINDING FACTORs (ABFs) in ABA Signaling in Different Developmental Stages in Plants	64
Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders	64
HDAC6 in Diseases of Cognition and of Neurons	64
Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration	63
The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation	63
Major Depression: One Brain, One Disease, One Set of Intertwined Processes	63
CD8+ T Cells in Atherosclerosis	63
Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)	63
Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes	63
Epigenetic Regulation of Cellular Senescence	62
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders	62
Current Strategies for Exosome Cargo Loading and Targeting Delivery	62
The Role of Prostaglandins in Different Types of Cancer	62
Lithium and Therapeutic Targeting of GSK-3	62
Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances	62
Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids	62
Progression of Metastasis through Lymphatic System	61
Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation	61
Hidradenitis Suppurativa: Where We Are and Where We Are Going	61
The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology	61
Molecular Mechanisms and Regulation of Mammalian Mitophagy	61
Prognostic Cancer Gene Expression Signatures: Current Status and Challenges	61
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways	61
Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications	60
The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth	60
HDL in Atherosclerotic Cardiovascular Disease: In Search of a Role	60
Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury	60
The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders	60
Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge	60
Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models	60
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids	59
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells	59
Mechanistic Insights into the Link between Gut Dysbiosis and Major Depression: An Extensive Review	59
KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease	59
PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer	59
Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling	59
Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways	59
Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy	59
Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators	59
Inflammation: A Target for Treatment in Spinal Cord Injury	59
Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches	58
The Role of Inflammation in CKD	58
Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: From Research Perspectives to Clinical Practice	58
Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development	58
Siglec Ligands	58
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review	58
The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity	57
Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease	57
Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA	57
Discovery, Function, and Therapeutic Targeting of Siglec-8	57
The Transcription Factor NF-κB in Stem Cells and Development	57
Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma	56
GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis	56
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease	56
Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration	56
Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation	56
Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine	56
Biomarkers of Radiotherapy-Induced Immunogenic Cell Death	56
Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism	56
The Role of Epithelial Damage in the Pulmonary Immune Response	56
A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases	56
Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging	56
Exosome-Mediated Immunosuppression in Tumor Microenvironments	56
Pathological Functions of LRRK2 in Parkinson’s Disease	55
The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications	55