(The TQCC of Cells is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives512
Osteoblast-Osteoclast Communication and Bone Homeostasis484
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells401
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis378
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping355
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications337
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19274
Structure and Function of Human Matrix Metalloproteinases273
Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration265
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles265
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing259
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death249
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment242
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem238
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy234
Management of Rheumatoid Arthritis: An Overview234
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability219
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview212
Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19209
Hyaluronic Acid: Redefining Its Role208
Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee204
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review204
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management202
Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases202
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction201
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets201
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation198
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma190
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives185
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications180
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine174
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis171
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics170
Microglia: Agents of the CNS Pro-Inflammatory Response168
COVID-19: Characteristics and Therapeutics168
PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions161
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair159
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment157
Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease156
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease153
The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer153
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis153
Macrophages in Lung Injury, Repair, and Fibrosis150
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs149
The Role of MSC in Wound Healing, Scarring and Regeneration149
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis148
Hypoxia-Driven Immune Escape in the Tumor Microenvironment148
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19144
Noninvasive Diagnosis of NAFLD and NASH143
Lysosomal Biology and Function: Modern View of Cellular Debris Bin140
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer139
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer139
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?137
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2135
Cardiovascular Manifestations of COVID-19 Infection135
Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses133
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis133
Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies130
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer129
Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance128
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer127
Extracellular ATP: A Feasible Target for Cancer Therapy122
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations122
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation121
COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance121
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS119
The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma118
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review118
Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization116
The RHO Family GTPases: Mechanisms of Regulation and Signaling116
Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing112
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications110
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness109
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy108
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease106
Necroptosis in Immuno-Oncology and Cancer Immunotherapy106
Effects of Salinity Stress on Chloroplast Structure and Function106
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer105
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer104
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy102
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization102
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate101
Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation101
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?100
Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer99
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use99
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders99
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes99
Future Directions in the Treatment of Osteosarcoma98
The Role of Mitochondria in Oocyte Maturation97
Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story97
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening97
Hedgehog Signaling and Truncated GLI1 in Cancer96
Perivascular Inflammation in Pulmonary Arterial Hypertension95
Regulation of TNF-Induced Osteoclast Differentiation95
The Role of PPARs in Disease95
DNA Damage: From Threat to Treatment95
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases94
Inflammatory Chemokines in Atherosclerosis93
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications93
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance92
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging92
Mitochondria in Health and Diseases92
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis92
γδ T Cells: The Ideal Tool for Cancer Immunotherapy92
Neuroprotective Natural Products for Alzheimer’s Disease91
Role of Protein Glycosylation in Host-Pathogen Interaction91
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control90
Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development89
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease88
Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure88
Role of EGFR in the Nervous System87
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation87
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives87
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer86
Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases86
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers86
The Role of Th17 Response in COVID-1986
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants85
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ85
Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress85
Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases84
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now84
Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc83
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response83
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold83
Myeloid Cells in Glioblastoma Microenvironment82
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection82
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases82
A Review on Notch Signaling and Colorectal Cancer81
Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer80
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients80
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling80
Microglia Phenotypes in Aging and Neurodegenerative Diseases79
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments79
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review79
Beyond Activation: Characterizing Microglial Functional Phenotypes78
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression78
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling78
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility78
Macrophage Modification Strategies for Efficient Cell Therapy77
Hepatitis B Virus Entry into Cells77
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO77
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?77
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses77
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease76
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study76
The Endothelium as a Driver of Liver Fibrosis and Regeneration76
Neuron-Astrocyte Interactions in Parkinson’s Disease76
Retinoic Acid and Its Derivatives in Skin75
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis75
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma75
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications74
Metabolome Changes in Cerebral Ischemia74
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches74
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy73
Molecular Mechanisms of mtDNA-Mediated Inflammation73
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma73
Cardiac Fibrosis and Fibroblasts73
Identifying the Therapeutic Significance of Mesenchymal Stem Cells73
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation73
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health73
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease72
Neurofibromin Structure, Functions and Regulation72
Interconnections between Inflammageing and Immunosenescence during Ageing72
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease72
Molecular Markers and Targets in Melanoma72
Vascular Dysfunction in Preeclampsia72
Calcium Signaling Regulates Autophagy and Apoptosis71
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future71
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies71
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis71
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma71
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut70
Aprotinin Inhibits SARS-CoV-2 Replication70
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review70
The Roles of Ubiquitin in Mediating Autophagy70
The Emerging Roles of Exosomes as EMT Regulators in Cancer69
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches69
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders69
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies69
Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects68
IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer68
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab68
PPAR Beta/Delta and the Hallmarks of Cancer67
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications67
The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis66
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles66
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration66
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms66
Role of Human Mesenchymal Stem Cells in Regenerative Therapy66
The Emerging Role of the Lysosome in Parkinson’s Disease66
Neuron-Glia Interactions in Neurodevelopmental Disorders66
The Role of Hyaluronic Acid in Cartilage Boundary Lubrication66
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival66
Annexin A2 in Inflammation and Host Defense65
Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery65
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo65
Significance of NETs Formation in COVID-1965
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells65
GBA Variants and Parkinson Disease: Mechanisms and Treatments65
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure65
Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth65
Regulation of the Actin Cytoskeleton in Podocytes64
Advances in Understanding of the Role of Lipid Metabolism in Aging64
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction64
SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway64
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.64
Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance64
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology64
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review64
High Mobility Group Box-1 and Blood–Brain Barrier Disruption64
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications64
Platelet-Leukocyte Interplay in Cancer Development and Progression63
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction63
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond63
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins63
The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation63
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements62
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions62
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging62
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies62
An Insight into GPCR and G-Proteins as Cancer Drivers62
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)62
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line62
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression61
Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options61
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention61
Is There a Role for Immunotherapy in Prostate Cancer?61
Macrophage as a Peripheral Pain Regulator61
Emerging Role of cAMP/AMPK Signaling61
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity61
Canonical and Noncanonical Autophagy as Potential Targets for COVID-1960
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy60
Peroxisome Metabolism in Cancer60
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection60
IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells59
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress59
Adipose Tissue-Derived Mesenchymal Stem Cells59
Schwann Cell Role in Selectivity of Nerve Regeneration59
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration59
Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol59
Role of Mitochondria in Cancer Stem Cell Resistance59
Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis59
Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells59
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review59
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance59
Involvement of Actin and Actin-Binding Proteins in Carcinogenesis59
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review58
MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer’s Disease58