Cells

Article	Citations
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives	512
Osteoblast-Osteoclast Communication and Bone Homeostasis	484
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells	401
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis	378
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping	355
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications	337
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19	274
Structure and Function of Human Matrix Metalloproteinases	273
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles	265
Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration	265
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing	259
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death	249
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment	242
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem	238
Management of Rheumatoid Arthritis: An Overview	234
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy	234
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability	219
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview	212
Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19	209
Hyaluronic Acid: Redefining Its Role	208
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review	204
Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee	204
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management	202
Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases	202
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction	201

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets	201
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation	198
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma	190
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives	185
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications	180
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine	174
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis	171
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics	170
Microglia: Agents of the CNS Pro-Inflammatory Response	168
COVID-19: Characteristics and Therapeutics	168
PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions	161
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair	159
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment	157
Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease	156
The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer	153
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis	153
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease	153
Macrophages in Lung Injury, Repair, and Fibrosis	150
The Role of MSC in Wound Healing, Scarring and Regeneration	149
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs	149
Hypoxia-Driven Immune Escape in the Tumor Microenvironment	148
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis	148
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19	144
Noninvasive Diagnosis of NAFLD and NASH	143
Lysosomal Biology and Function: Modern View of Cellular Debris Bin	140
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer	139
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer	139
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?	137
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2	135
Cardiovascular Manifestations of COVID-19 Infection	135
Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses	133
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis	133
Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies	130
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer	129
Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance	128
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer	127
Extracellular ATP: A Feasible Target for Cancer Therapy	122
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations	122
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation	121
COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance	121
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS	119
The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma	118
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review	118
The RHO Family GTPases: Mechanisms of Regulation and Signaling	116
Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization	116
Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing	112
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications	110
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness	109
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy	108
Necroptosis in Immuno-Oncology and Cancer Immunotherapy	106

Effects of Salinity Stress on Chloroplast Structure and Function	106
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease	106
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer	105
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer	104
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy	102
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization	102
Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation	101
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate	101
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?	100
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use	99
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders	99
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes	99
Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer	99
Future Directions in the Treatment of Osteosarcoma	98
Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story	97
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening	97
The Role of Mitochondria in Oocyte Maturation	97
Hedgehog Signaling and Truncated GLI1 in Cancer	96
The Role of PPARs in Disease	95
DNA Damage: From Threat to Treatment	95
Perivascular Inflammation in Pulmonary Arterial Hypertension	95
Regulation of TNF-Induced Osteoclast Differentiation	95
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases	94
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications	93
Inflammatory Chemokines in Atherosclerosis	93
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging	92
Mitochondria in Health and Diseases	92
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis	92
γδ T Cells: The Ideal Tool for Cancer Immunotherapy	92
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance	92
Role of Protein Glycosylation in Host-Pathogen Interaction	91
Neuroprotective Natural Products for Alzheimer’s Disease	91
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control	90
Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development	89
Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure	88
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease	88
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives	87
Role of EGFR in the Nervous System	87
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation	87
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers	86
The Role of Th17 Response in COVID-19	86
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer	86
Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases	86
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ	85
Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress	85
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants	85
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now	84
Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases	84
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response	83
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold	83
Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc	83
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection	82
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases	82
Myeloid Cells in Glioblastoma Microenvironment	82
A Review on Notch Signaling and Colorectal Cancer	81
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients	80
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling	80
Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer	80
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments	79
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review	79
Microglia Phenotypes in Aging and Neurodegenerative Diseases	79
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling	78
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility	78
Beyond Activation: Characterizing Microglial Functional Phenotypes	78
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression	78
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	77
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses	77
Macrophage Modification Strategies for Efficient Cell Therapy	77
Hepatitis B Virus Entry into Cells	77
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO	77
Neuron-Astrocyte Interactions in Parkinson’s Disease	76
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease	76
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study	76
The Endothelium as a Driver of Liver Fibrosis and Regeneration	76
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis	75
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma	75
Retinoic Acid and Its Derivatives in Skin	75
Metabolome Changes in Cerebral Ischemia	74
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches	74
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications	74

The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma	73
Cardiac Fibrosis and Fibroblasts	73
Identifying the Therapeutic Significance of Mesenchymal Stem Cells	73
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation	73
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health	73
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy	73
Molecular Mechanisms of mtDNA-Mediated Inflammation	73
Interconnections between Inflammageing and Immunosenescence during Ageing	72
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease	72
Molecular Markers and Targets in Melanoma	72
Vascular Dysfunction in Preeclampsia	72
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease	72
Neurofibromin Structure, Functions and Regulation	72
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis	71
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma	71
Calcium Signaling Regulates Autophagy and Apoptosis	71
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future	71
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies	71
The Roles of Ubiquitin in Mediating Autophagy	70
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review	70
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut	70
Aprotinin Inhibits SARS-CoV-2 Replication	70
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies	69
The Emerging Roles of Exosomes as EMT Regulators in Cancer	69
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches	69
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders	69
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab	68
Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects	68
IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer	68
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications	67
PPAR Beta/Delta and the Hallmarks of Cancer	67
Neuron-Glia Interactions in Neurodevelopmental Disorders	66
The Role of Hyaluronic Acid in Cartilage Boundary Lubrication	66
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival	66
The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis	66
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles	66
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration	66
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	66
Role of Human Mesenchymal Stem Cells in Regenerative Therapy	66
The Emerging Role of the Lysosome in Parkinson’s Disease	66
Annexin A2 in Inflammation and Host Defense	65
Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery	65
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo	65
Significance of NETs Formation in COVID-19	65
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells	65
GBA Variants and Parkinson Disease: Mechanisms and Treatments	65
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure	65
Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth	65
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review	64
High Mobility Group Box-1 and Blood–Brain Barrier Disruption	64
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications	64
Regulation of the Actin Cytoskeleton in Podocytes	64
Advances in Understanding of the Role of Lipid Metabolism in Aging	64
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction	64
SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway	64
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.	64
Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance	64
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology	64
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins	63
The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation	63
Platelet-Leukocyte Interplay in Cancer Development and Progression	63
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction	63
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond	63
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)	62
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line	62
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements	62
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions	62
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging	62
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies	62
An Insight into GPCR and G-Proteins as Cancer Drivers	62
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity	61
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression	61
Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options	61
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention	61
Is There a Role for Immunotherapy in Prostate Cancer?	61
Macrophage as a Peripheral Pain Regulator	61
Emerging Role of cAMP/AMPK Signaling	61
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19	60
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy	60
Peroxisome Metabolism in Cancer	60
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection	60
Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells	59
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review	59
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance	59
Involvement of Actin and Actin-Binding Proteins in Carcinogenesis	59
IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells	59
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress	59
Adipose Tissue-Derived Mesenchymal Stem Cells	59
Schwann Cell Role in Selectivity of Nerve Regeneration	59
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration	59
Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol	59
Role of Mitochondria in Cancer Stem Cell Resistance	59
Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis	59
MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer’s Disease	58
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review	58