Cells

Article	Citations
Osteoblast-Osteoclast Communication and Bone Homeostasis	549
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications	382
Management of Rheumatoid Arthritis: An Overview	304
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19	301
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy	273
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing	271
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review	256
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview	254
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives	240
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management	239
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability	238
Hyaluronic Acid: Redefining Its Role	236
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation	235
Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee	225
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets	223
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma	214
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction	207
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine	206
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis	187
Microglia: Agents of the CNS Pro-Inflammatory Response	184
COVID-19: Characteristics and Therapeutics	183
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis	182
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs	182
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair	181
Macrophages in Lung Injury, Repair, and Fibrosis	180

Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis	175
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease	174
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment	174
The Role of MSC in Wound Healing, Scarring and Regeneration	168
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?	159
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis	152
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19	149
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer	148
Cardiovascular Manifestations of COVID-19 Infection	144
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer	143
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review	140
Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance	140
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2	138
Extracellular ATP: A Feasible Target for Cancer Therapy	138
Effects of Salinity Stress on Chloroplast Structure and Function	136
The RHO Family GTPases: Mechanisms of Regulation and Signaling	131
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations	130
COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance	123
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control	122
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes	120
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders	120
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease	120
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications	119
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer	115
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy	115
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?	113
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization	113
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health	112
The Role of Mitochondria in Oocyte Maturation	112
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness	111
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications	111
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer	111
Necroptosis in Immuno-Oncology and Cancer Immunotherapy	110
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer	110
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis	110
DNA Damage: From Threat to Treatment	110
Future Directions in the Treatment of Osteosarcoma	109
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases	109
The Role of PPARs in Disease	109
Perivascular Inflammation in Pulmonary Arterial Hypertension	107
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate	107
Regulation of TNF-Induced Osteoclast Differentiation	106
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening	105
Inflammatory Chemokines in Atherosclerosis	104
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ	104
Hedgehog Signaling and Truncated GLI1 in Cancer	103
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease	102
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging	100
Neuroprotective Natural Products for Alzheimer’s Disease	100
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation	100

Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress	99
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression	98
Beyond Activation: Characterizing Microglial Functional Phenotypes	98
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity	97
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements	97
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling	97
Microglia Phenotypes in Aging and Neurodegenerative Diseases	96
The Role of Th17 Response in COVID-19	93
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis	93
Role of EGFR in the Nervous System	93
Calcium Signaling Regulates Autophagy and Apoptosis	92
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO	90
Myeloid Cells in Glioblastoma Microenvironment	90
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers	90
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling	89
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases	89
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants	89
Vascular Dysfunction in Preeclampsia	88
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments	87
The Role of Oxidative Stress in Atherosclerosis	87
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response	86
Retinoic Acid and Its Derivatives in Skin	86
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now	86
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection	85
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma	85
Molecular Mechanisms of mtDNA-Mediated Inflammation	84
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses	84
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study	84
Interconnections between Inflammageing and Immunosenescence during Ageing	84
Metabolome Changes in Cerebral Ischemia	84
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility	84
Neuron-Astrocyte Interactions in Parkinson’s Disease	83
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review	83
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation	82
Cardiac Fibrosis and Fibroblasts	82
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches	82
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients	82
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications	82
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	82
Molecular Markers and Targets in Melanoma	81
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease	81
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies	81
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease	81
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma	81
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut	80
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis	80
Neurofibromin Structure, Functions and Regulation	80
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies	79
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles	79
GBA Variants and Parkinson Disease: Mechanisms and Treatments	78
An Insight into GPCR and G-Proteins as Cancer Drivers	77
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review	77
The Roles of Ubiquitin in Mediating Autophagy	77
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications	76
The Emerging Role of the Lysosome in Parkinson’s Disease	76
Role of Human Mesenchymal Stem Cells in Regenerative Therapy	75
Emerging Role of cAMP/AMPK Signaling	75
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future	75
Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects	75
Advances in Understanding of the Role of Lipid Metabolism in Aging	75
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab	74
Neuron-Glia Interactions in Neurodevelopmental Disorders	74
Adipose Tissue-Derived Mesenchymal Stem Cells	73
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches	73
Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction	73
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line	73
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies	72
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications	72
Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options	72
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress	72
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival	72
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging	71
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins	71
Significance of NETs Formation in COVID-19	71
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders	71
BECLIN1: Protein Structure, Function and Regulation	71
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure	71
Vascularization Strategies in Bone Tissue Engineering	70
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond	70
Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)	70

Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells	70
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration	70
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo	70
Aprotinin Inhibits SARS-CoV-2 Replication	70
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration	69
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	69
Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery	69
The Role of Hyaluronic Acid in Cartilage Boundary Lubrication	69
Macrophage-Mediated Inflammation in Skin Wound Healing	69
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.	69
Sex-Specific Differences in Glioblastoma	68
Macrophage as a Peripheral Pain Regulator	68
NAC Transcription Factor Family Regulation of Fruit Ripening and Quality: A Review	68
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction	68
SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway	67
Multifunctional Role of S100 Protein Family in the Immune System: An Update	67
The Interplay between Glioblastoma and Its Microenvironment	67
Regulation of the Actin Cytoskeleton in Podocytes	67
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology	67
Current Understanding of Asthma Pathogenesis and Biomarkers	67
High Mobility Group Box-1 and Blood–Brain Barrier Disruption	67
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review	66
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction	66
The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke	66
Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics	66
Mesenchymal Stem Cell-Derived Secretome: A Potential Therapeutic Option for Autoimmune and Immune-Mediated Inflammatory Diseases	66
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions	66
Schwann Cell Role in Selectivity of Nerve Regeneration	65
Is There a Role for Immunotherapy in Prostate Cancer?	65
Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease	65
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression	65
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention	65
NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes	65
S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation	65
Dapagliflozin Restores Impaired Autophagy and Suppresses Inflammation in High Glucose-Treated HK-2 Cells	64
An Epigenetic Role of Mitochondria in Cancer	64
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review	64
Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways	64
Involvement of Actin and Actin-Binding Proteins in Carcinogenesis	64
The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion	64
The Relationship between the Antioxidant System and Proline Metabolism in the Leaves of Cucumber Plants Acclimated to Salt Stress	64
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines	63
Characterization of Apis mellifera Gastrointestinal Microbiota and Lactic Acid Bacteria for Honeybee Protection—A Review	63
Nano-Enhanced Cancer Immunotherapy: Immunology Encounters Nanotechnology	63
Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol	63
Mast Cells: A New Frontier for Cancer Immunotherapy	63
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration	63
Diabetic Macular Edema: Current Understanding, Molecular Mechanisms and Therapeutic Implications	63
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy	63
Peroxisome Metabolism in Cancer	62
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance	62
Toll-Like Receptor Signaling in the Establishment and Function of the Immune System	62
Hippo Signaling Pathway in Gliomas	62
Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas	62
Crosstalk of Autophagy and Apoptosis	62
Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines	61
Monocyte Recruitment, Specification, and Function in Atherosclerosis	61
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key	61
Iron: An Essential Element of Cancer Metabolism	61
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19	61
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review	61
Interaction of Mitochondrial Calcium and ROS in Neurodegeneration	61
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (Oryza sativa L.)	61
Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction	61
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review	61
Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells	60
Role of Tumor-Associated Myeloid Cells in Breast Cancer	60
Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response	60
The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation	60
Role of Mitochondria in Cancer Stem Cell Resistance	60
The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles	60
Ischemia–Reperfusion Injury in Lung Transplantation	60
Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond	60
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA	60
HDAC6 in Diseases of Cognition and of Neurons	60
The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer	59
The Role of GDF15 as a Myomitokine	59
Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications	59
Affecting HEK293 Cell Growth and Production Performance by Modifying the Expression of Specific Genes	59
Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers	59
Quasar: Easy Machine Learning for Biospectroscopy	59
Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine	59
Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria	59
Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility	59
Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration	59
SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2	59
Sustainable Agriculture through Multidisciplinary Seed Nanopriming: Prospects of Opportunities and Challenges	59
Mucopolysaccharidosis Type I: A Review of the Natural History and Molecular Pathology	58
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells	58
Lithium and Therapeutic Targeting of GSK-3	58
Progesterone Actions and Resistance in Gynecological Disorders	58
Novel Peptide Therapeutic Approaches for Cancer Treatment	58
Updates on the Role of ABSCISIC ACID INSENSITIVE 5 (ABI5) and ABSCISIC ACID-RESPONSIVE ELEMENT BINDING FACTORs (ABFs) in ABA Signaling in Different Developmental Stages in Plants	58
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum	58
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies	58