Cells

Article	Citations
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives	496
Osteoblast-Osteoclast Communication and Bone Homeostasis	464
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells	399
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis	366
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping	354
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications	324
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19	268
Structure and Function of Human Matrix Metalloproteinases	263
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles	261
Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration	259
Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing	250
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death	243
The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem	235
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment	235
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy	227
Management of Rheumatoid Arthritis: An Overview	218
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability	215
Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19	207
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction	200
Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee	198
Hyaluronic Acid: Redefining Its Role	197
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management	197
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets	196
Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases	195
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation	194

High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review	192
Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma	185
Influence of Nitrogen and Phosphorus on Microalgal Growth, Biomass, Lipid, and Fatty Acid Production: An Overview	184
Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications	175
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives	173
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics	169
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine	165
Microglia: Agents of the CNS Pro-Inflammatory Response	165
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis	164
COVID-19: Characteristics and Therapeutics	163
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism	159
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair	158
PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions	157
Immunotherapy, Inflammation and Colorectal Cancer	153
Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease	153
Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment	151
The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer	150
Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis	149
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease	147
Hypoxia-Driven Immune Escape in the Tumor Microenvironment	146
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19	143
Macrophages in Lung Injury, Repair, and Fibrosis	143
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis	142
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs	142
The Role of MSC in Wound Healing, Scarring and Regeneration	142
Noninvasive Diagnosis of NAFLD and NASH	139
Lysosomal Biology and Function: Modern View of Cellular Debris Bin	139
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer	137
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer	136
Cardiovascular Manifestations of COVID-19 Infection	134
Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2	134
HSP70 Multi-Functionality in Cancer	132
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?	129
New Onset of Autoimmune Diseases Following COVID-19 Diagnosis	129
Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies	128
Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses	128
Role and Mechanisms of Mitophagy in Liver Diseases	127
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer	126
Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance	124
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer	124
ER Stress Responses: An Emerging Modulator for Innate Immunity	123
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations	121
COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance	120
Extracellular ATP: A Feasible Target for Cancer Therapy	119
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS	117
The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma	116
Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization	115
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation	114
The RHO Family GTPases: Mechanisms of Regulation and Signaling	111
Insights into the Interactions among Roots, Rhizosphere, and Rhizobacteria for Improving Plant Growth and Tolerance to Abiotic Stresses: A Review	110

Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness	109
Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing	108
Immune Infiltrates in Breast Cancer: Recent Updates and Clinical Implications	107
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy	106
Necroptosis in Immuno-Oncology and Cancer Immunotherapy	105
Effects of Salinity Stress on Chloroplast Structure and Function	104
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer	103
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer	102
DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types	102
The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization	100
Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation	99
GSK-3 and Tau: A Key Duet in Alzheimer’s Disease	99
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use	98
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes	98
Chronic Diabetic Wounds and Their Treatment with Skin Substitutes	97
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy	97
Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer	96
Future Directions in the Treatment of Osteosarcoma	96
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate	95
DNA Damage: From Threat to Treatment	95
Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System	95
Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story	94
Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria	94
Hedgehog Signaling and Truncated GLI1 in Cancer	94
The Role of Mitochondria in Oocyte Maturation	94
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases	92
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?	92
The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging	92
The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders	92
Inflammatory Chemokines in Atherosclerosis	92
Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis	91
Molecular and Hormonal Mechanisms Regulating Fleshy Fruit Ripening	91
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications	91
The Role of PPARs in Disease	91
Mitochondria in Health and Diseases	90
Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes	90
γδ T Cells: The Ideal Tool for Cancer Immunotherapy	89
Regulation of TNF-Induced Osteoclast Differentiation	89
Neuroprotective Natural Products for Alzheimer’s Disease	89
Role of Protein Glycosylation in Host-Pathogen Interaction	88
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance	88
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases	88
Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases	88
Perivascular Inflammation in Pulmonary Arterial Hypertension	87
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives	87
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis	87
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers	86
Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development	86
Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure	85
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control	85
The Role of Th17 Response in COVID-19	84
Spermine: Its Emerging Role in Regulating Drought Stress Responses in Plants	84
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation	83
Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases	83
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease	83
Transient Receptor Potential Canonical (TRPC) Channels: Then and Now	82
Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection	82
Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases	82
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response	82
Role of EGFR in the Nervous System	82
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ	81
Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc	81
Biostimulants for the Regulation of Reactive Oxygen Species Metabolism in Plants under Abiotic Stress	81
Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma	80
Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold	79
Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer	79
Myeloid Cells in Glioblastoma Microenvironment	79
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer	79
A Review on Notch Signaling and Colorectal Cancer	78
Macrophage Modification Strategies for Efficient Cell Therapy	78
ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients	78
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases	78
Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review	78
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling	77
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility	77
The Cuprizone Model: Dos and Do Nots	76
GSK3: A Kinase Balancing Promotion and Resolution of Inflammation	76
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling	75
Microglia Phenotypes in Aging and Neurodegenerative Diseases	74
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma	74

Metabolome Changes in Cerebral Ischemia	74
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses	74
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study	74
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments	74
Hepatitis B Virus Entry into Cells	74
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma	73
Neuron-Astrocyte Interactions in Parkinson’s Disease	73
Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications	73
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	73
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease	73
Retinoic Acid and Its Derivatives in Skin	73
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO	73
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches	72
The Endothelium as a Driver of Liver Fibrosis and Regeneration	72
Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation	72
Molecular Mechanisms of mtDNA-Mediated Inflammation	72
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression	72
Molecular Markers and Targets in Melanoma	71
Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease	71
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy	70
Beyond Activation: Characterizing Microglial Functional Phenotypes	70
Aprotinin Inhibits SARS-CoV-2 Replication	70
Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis	70
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies	70
Vascular Dysfunction in Preeclampsia	70
Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review	70
Identifying the Therapeutic Significance of Mesenchymal Stem Cells	70
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis	70
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future	70
Neurofibromin Structure, Functions and Regulation	69
Interconnections between Inflammageing and Immunosenescence during Ageing	69
Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders	69
Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease	69
The Emerging Roles of Exosomes as EMT Regulators in Cancer	68
Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC	68
Cardiac Fibrosis and Fibroblasts	68
Calcium Signaling Regulates Autophagy and Apoptosis	67
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut	67
PPAR Beta/Delta and the Hallmarks of Cancer	67
Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects	67
IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer	66
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies	66
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches	66
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma	66
Neuron-Glia Interactions in Neurodevelopmental Disorders	66
Hybrid Epithelial/Mesenchymal State in Cancer Metastasis: Clinical Significance and Regulatory Mechanisms	66
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	65
Annexin A2 in Inflammation and Host Defense	65
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles	65
The Roles of Ubiquitin in Mediating Autophagy	65
Human γδ TCR Repertoires in Health and Disease	65
The Emerging Role of the Lysosome in Parkinson’s Disease	64
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab	64
Extracellular Vesicles as Delivery Vehicles of Specific Cellular Cargo	64
The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration	64
Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling	64
The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis	64
Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells	64
Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance	64
Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery	64
Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth	64
Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology	64
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications	63
The Role of Hyaluronic Acid in Cartilage Boundary Lubrication	63
Signaling Pathways and Key Genes Involved in Regulation of foam Cell Formation in Atherosclerosis	63
Regulation of the Actin Cytoskeleton in Podocytes	63
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review	63
High Mobility Group Box-1 and Blood–Brain Barrier Disruption	63
Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure	62
Role of Human Mesenchymal Stem Cells in Regenerative Therapy	62
TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions	62
Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction	62
SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway	62
Platelet-Leukocyte Interplay in Cancer Development and Progression	62
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health	62
3D Printed Conductive Nanocellulose Scaffolds for the Differentiation of Human Neuroblastoma Cells	62
Significance of NETs Formation in COVID-19	62
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival	62
Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications	62
Emerging Role of cAMP/AMPK Signaling	61
Comparative Study between Exogenously Applied Plant Growth Hormones versus Metabolites of Microbial Endophytes as Plant Growth-Promoting for Phaseolus vulgaris L.	61
Is There a Role for Immunotherapy in Prostate Cancer?	61
circRNAs Signature as Potential Diagnostic and Prognostic Biomarker for Diabetes Mellitus and Related Cardiovascular Complications	61
The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation	61
Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins	61
Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line	61
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis	61
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19	60
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging	60
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection	60
Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies	60
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance	59
Advances in Understanding of the Role of Lipid Metabolism in Aging	59
Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond	59
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy	59