OOIR: Observatory of International Research

Papers

(The TQCC of Acta Crystallographica Section D-Structural Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Completion of partial structures using Patterson maps with the CrysFormer machine-learning model	933
Cryo-EM single-particle analysis expanding towards increasingly native samples	91
Using graphlet degree vectors to predict atomic displacement parameters in protein structures	73
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope	68
EMhub: a web platform for data management and on-the-fly processing in scientific facilities	57
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing	54
Limiting the effects of radiation damage in MicroED through dose selection during data processing	47
Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library	40
Scotty : lattice coincidences in the Protein Data Bank	36
PETIMOT : a novel framework for inferring protein motions from sparse data using SE(3)-equivariant graph neural networks	36
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody	31
Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases	30
Identifying and avoiding radiation damage in macromolecular crystallography	23
Structural studies of NAD ⁺ -dependent methanol dehydrogenase 1 from Bacillus methanolicus MGA3	23
Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement	22
Crystal structure of DNA polymerase I from Thermus phage G20c	21
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals	21
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites	20
Interactive segmentation of membrane and membrane-mimic densities in cryo-EM maps	20
Biochemical and structural characterization of a tail-spike protein with depolymerase activity identified in a marine podovirus	20
Structures of permuted halves of a modern ribose-binding protein	20
Optimal 1TEL–target protein linker character is target protein-dependent. Corrigendum	19
Analysis and validation of overall N -glycan conformation in Privateer	19
A cryo-EM processing pipeline for microtubules using CryoSPARC	18
Validation of helical symmetry parameters in the EMDB	18

An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent	18
The crystal structure of the N-terminal domain of the backbone pilin LrpA reveals a new closure-and-twist motion for assembling dynamic pili in Ligilactobacillus ruminis	17
Biophysical Chemistry, Second Edition. By Dagmar Klostermeier and Markus G. Rudolph. CRC Press, Boca Raton, 2025, pp. 944. ISBN 9781032060835. Price GBP 57.39 (hardback)	17
Experimental estimation of copper-site geometry reproducibility in biologically relevant redox and saccharide-bound states of a model lytic polysaccharide monooxygenase	16
Overall protein structure quality assessment using hydrogen-bonding parameters	16
Structural basis for the fast maturation of pcStar, a photoconvertible fluorescent protein. Erratum	15
Miroslav Z. Papiz (1955–2026)	15
Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor	15
Structure of the Arabidopsis receptor kinase SRF6 ectodomain determined from crystals obtained using the LRR crystallization screen	15
Crystal structure of coagulation factor XII N-terminal domains 1–5	14
Time-resolved serial femtosecond crystallography on fatty-acid photodecarboxylase: lessons learned	14
Structural studies of β-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus	14
A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands	13
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhib	13
Statistical analyses of the oxidized P-clusters in MoFe proteins using the bond-valence method: towards their electron transfer in nitrogenases	13
Medical contrast agents as promising tools for biomacromolecular SAXS experiments	13
Radiation damage in sub-Ångström resolution macromolecular crystallography: a low-dose study	13
Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase	13
Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples	12
Alexei Vagin (1944–2023)	12
Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix . By Howard Markel. W. W. Norton & Co., 2021. Hardback, pp. 608.	12
Michael James (1940–2023)	12
The T ₂ structure of polycrystalline cubic human insulin	12
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket	12
Structures of variants of Escherichia coli flavodiiron-type nitric oxide reductase reveal changes in the di-iron site	11
Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase from Bradyrhizobium sp.	11
Raynals , an online tool for the analysis of dynamic light scattering	11
Preparation and characterization of inactivated tick-borne encephalitis virus samples for single-particle imaging at the European XFEL	11
Direct phasing algorithm for protein crystals with high solvent content using low-resolution diffraction data	11
Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets	11
The LH–DH module of bacterial replicative helicases is the common binding site for DciA and other helicase loaders	11
Structural study of Nicotiana benthamiana NADPH-dependent thioredoxin reductase C and its molecular mechanism of interaction with 2-Cys peroxiredoxin	11
Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis	11
Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE	11
Dose-dependent structural and electron-density features in the lytic polysaccharide monooxygenase Nc AA9D	10
Structural mechanism of Escherichia coli cyanase	10
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy	10
Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin	10
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects	9
A short story of the long road to cryo-EM in Portugal	9
Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies	9
The High-Pressure Freezing Laboratory for Macromolecular Crystallography (HPMX), an ancillary tool for the macromolecular crystallography beamlines at the ESRF	9
Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome	9
Alphafuser : a parsimonious approach to predicting higher-order protein complexes	9
Accelerating crystal structure determination with iterative AlphaFold prediction	9
Dependence of crystallographic atomic displacement parameters on temperature (25–150 K) for complexes of horse liver alcohol dehydrogenase	9
Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans	9
Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase	9
Buccaneer model building with neural network fragment selection	9
Correcting systematic errors in diffraction data with modern scaling algorithms	8

VitroJet: new features and case studies	8
Restoration of the 3D structure of insect flight muscle from a rotationally averaged 2D X-ray diffraction pattern	8
Simulating neutron protein crystallography experiments: applications to the development of the NMX instrument at ESS	8
Tomo Live : an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows	8
Atypical homodimerization revealed by the structure of the ( S )-enantioselective haloalkane dehalogenase DmmarA from Mycobacteriu	8
Errors in structural biology are not the exception	8
Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules	8
X-ray beam effects on metallo-peptides reflect redox events: insights from X-ray absorption spectroscopy measurements on metal complexes of truncated amyloid-β peptides	7
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase	7
Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn ₄ Ca cofac	7
Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements	7
Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions	7
Phosphatidylinositol transfer protein α binds microcolins in its open conformation	7
Coupled on-line in crystallo UV–Vis absorption spectroscopy and X-ray crystallography to compare specific radiation damage in metal-containing proteins a	7
Protein–macrocycle polymorphism: crystal form IV of the Ralstonia solanacearum lectin–sulfonato-calix[8]arene complex	7
Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals	7
An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM	7
Dynamics and Kinetics in Structural Biology: Unravelling Function Through Time-Resolved Structural Analysis. By Keith Moffat and Eaton E. Lattman. Wiley, New York, 2023, pp.	7