OOIR: Observatory of International Research

Papers

(The TQCC of Acta Crystallographica Section D-Structural Biology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing	824
Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library	97
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope	81
Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase	71
Cryo-EM single-particle analysis expanding towards increasingly native samples	63
Limiting the effects of radiation damage in MicroED through dose selection during data processing	60
Completion of partial structures using Patterson maps with the CrysFormer machine-learning model	57
EMhub: a web platform for data management and on-the-fly processing in scientific facilities	53
Using graphlet degree vectors to predict atomic displacement parameters in protein structures	46
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody	42
Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases	37
Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites	31
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals	31
Data collection from crystals grown in microfluidic droplets	30
Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement	23
Structures of permuted halves of a modern ribose-binding protein	23
Structural studies of NAD ⁺ -dependent methanol dehydrogenase 1 from Bacillus methanolicus MGA3	23
Crystal structure of DNA polymerase I from Thermus phage G20c	21
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases	21
Identifying and avoiding radiation damage in macromolecular crystallography	20
Validation of helical symmetry parameters in the EMDB	19
Raw diffraction data are our ground truth from which all subsequent workflows develop	19
The crystal structure of the N-terminal domain of the backbone pilin LrpA reveals a new closure-and-twist motion for assembling dynamic pili in Ligilactobacillus ruminis	19
Biophysical Chemistry, Second Edition. By Dagmar Klostermeier and Markus G. Rudolph. CRC Press, Boca Raton, 2025, pp. 944. ISBN 9781032060835. Price GBP 57.39 (hardback)	19
Overall protein structure quality assessment using hydrogen-bonding parameters	18

An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent	18
Training undergraduate research assistants with an outcome-oriented and skill-based mentoring strategy	18
A cryo-EM processing pipeline for microtubules using CryoSPARC	18
Analysis and validation of overall N-glycan conformation in Privateer	18
Statistical analyses of the oxidized P-clusters in MoFe proteins using the bond-valence method: towards their electron transfer in nitrogenases	18
Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase	17
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor	16
Crystal structure of coagulation factor XII N-terminal domains 1–5	15
Time-resolved serial femtosecond crystallography on fatty-acid photodecarboxylase: lessons learned	15
Medical contrast agents as promising tools for biomacromolecular SAXS experiments	15
Structural studies of β-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus	14
Alexei Vagin (1944–2023)	14
Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix. By Howard Markel. W. W. Norton & Co., 2021. Hardback, pp. 608. ISBN 978-1324002239.	14
Radiation damage in sub-Ångström resolution macromolecular crystallography: a low-dose study	14
Michael James (1940–2023)	14
A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands	14
Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples	14
Structural study of Nicotiana benthamiana NADPH-dependent thioredoxin reductase C and its molecular mechanism of interaction with 2-Cys peroxiredoxin	13
Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam	13
Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803	12
Preparation and characterization of inactivated tick-borne encephalitis virus samples for single-particle imaging at the European XFEL	12
Direct phasing algorithm for protein crystals with high solvent content using low-resolution diffraction data	12
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket	12
Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE	12
The T₂ structure of polycrystalline cubic human insulin	12
Knowledge-based prediction of DNA hydration using hydrated dinucleotides as building blocks	11
The LH–DH module of bacterial replicative helicases is the common binding site for DciA and other helicase loaders	11
Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects	11
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy	11
Structural mechanism of Escherichia coli cyanase	11
Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase fromBradyrhizobiumsp.	11
Structures of variants of Escherichia coli flavodiiron-type nitric oxide reductase reveal changes in the di-iron site	11
Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis	11
Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin	11
Raynals , an online tool for the analysis of dynamic light scattering	11
Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets	11
Dependence of crystallographic atomic displacement parameters on temperature (25–150 K) for complexes of horse liver alcohol dehydrogenase	10
Protonation states of hen egg-white lysozyme observed using D/H contrast neutron crystallography	10
Alphafuser : a parsimonious approach to predicting higher-order protein complexes	10
Native glycosylation and binding of the antidepressant paroxetine in a low-resolution crystal structure of human myeloperoxidase	10
Accelerating crystal structure determination with iterative AlphaFold prediction	10
Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans	10
Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies	10
A short story of the long road to cryo-EM in Portugal	10
Correcting systematic errors in diffraction data with modern scaling algorithms	9
VitroJet: new features and case studies	9
Buccaneer model building with neural network fragment selection	9
Tomo Live : an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows	9
Errors in structural biology are not the exception	9
Dynamics and Kinetics in Structural Biology: Unravelling Function Through Time-Resolved Structural Analysis. By Keith Moffat and Eaton E. Lattman. Wiley, New York, 2023, pp. 288. ISBN 978-1-119	9

Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules	9
Restoration of the 3D structure of insect flight muscle from a rotationally averaged 2D X-ray diffraction pattern	9
The High-Pressure Freezing Laboratory for Macromolecular Crystallography (HPMX), an ancillary tool for the macromolecular crystallography beamlines at the ESRF	9
Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase	9
Atypical homodimerization revealed by the structure of the (S)-enantioselective haloalkane dehalogenase DmmarA from Mycobacterium marinum	9
Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn₄Ca cofactor in dark-adapted photosystem II structu	8
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase	8
Structural features of chloroplast trigger factor determined at 2.6 Å resolution	8
Protein–macrocycle polymorphism: crystal form IV of the Ralstonia solanacearum lectin–sulfonato-calix[8]arene complex	8
Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals	8
X-ray beam effects on metallo-peptides reflect redox events: insights from X-ray absorption spectroscopy measurements on metal complexes of truncated amyloid-β peptides	8
Coupled on-line in crystallo UV–Vis absorption spectroscopy and X-ray crystallography to compare specific radiation damage in metal-containing proteins a	8
Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2-vWa construct improves crystal order and diffraction limits	8
XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures	8
Deep-learning methods for contrast enhancement and artifact reduction in cryo-electron tomography: a systematic analysis of the state of the art and proposed improvements	8
Phosphatidylinositol transfer protein α binds microcolins in its open conformation	8
Post-translational modifications in the Protein Data Bank	8
Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography	8
Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions	8