Signal Transduction and Targeted Therapy

(The TQCC of Signal Transduction and Targeted Therapy is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Pyroptosis: mechanisms and diseases863
Inflammation and tumor progression: signaling pathways and targeted intervention766
The role of m6A modification in the biological functions and diseases737
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study704
Therapeutic siRNA: state of the art676
The JAK/STAT signaling pathway: from bench to clinic667
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells660
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives632
Exosomes: key players in cancer and potential therapeutic strategy574
The updated landscape of tumor microenvironment and drug repurposing562
Microbiota in health and diseases542
Pattern recognition receptors in health and diseases528
Ferroptosis: mechanisms and links with diseases523
Viral vector platforms within the gene therapy landscape520
COVID-19: immunopathogenesis and Immunotherapeutics486
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities484
Therapeutic peptides: current applications and future directions483
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer466
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects436
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2434
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets428
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential397
A systematic review of SARS-CoV-2 vaccine candidates392
Antibody drug conjugate: the “biological missile” for targeted cancer therapy388
Application of exosomes as liquid biopsy in clinical diagnosis382
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials381
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome336
The signal pathways and treatment of cytokine storm in COVID-19333
FGF/FGFR signaling in health and disease328
Targeting tumor-associated macrophages to synergize tumor immunotherapy326
Targeting PI3K/Akt signal transduction for cancer therapy322
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development317
SARS-CoV-2 Omicron variant: recent progress and future perspectives316
Circulating tumor cells: biology and clinical significance316
Targeted therapy for hepatocellular carcinoma312
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity301
Targeting macrophages in cancer immunotherapy298
The interaction between ferroptosis and lipid metabolism in cancer294
Overcoming cancer therapeutic bottleneck by drug repurposing292
Extracellular matrix and its therapeutic potential for cancer treatment270
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics270
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches269
Copper homeostasis and cuproptosis in health and disease267
KRAS mutation: from undruggable to druggable in cancer266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation257
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy253
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy252
G protein-coupled receptors: structure- and function-based drug discovery249
Notch signaling pathway: architecture, disease, and therapeutics248
Liquid–liquid phase separation in human health and diseases246
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer244
Stem cell-based therapy for human diseases243
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin237
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer230
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial227
Lactate metabolism in human health and disease222
Advances in targeted therapy for esophageal cancer221
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1220
Targeting circular RNAs as a therapeutic approach: current strategies and challenges217
Chitinase-3 like-protein-1 function and its role in diseases216
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention215
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling213
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy208
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis207
Overview of lethal human coronaviruses203
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19203
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents197
NAD+ metabolism, stemness, the immune response, and cancer195
Wnt/β-catenin signaling in cancers and targeted therapies195
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications194
Regulated cell death (RCD) in cancer: key pathways and targeted therapies194
Regulating tumor suppressor genes: post-translational modifications192
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy190
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments190
Advances in COVID-19 mRNA vaccine development190
Signaling pathways and targeted therapy for myocardial infarction186
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance185
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression184
Alternative splicing and cancer: a systematic review183
Comparison of nonhuman primates identified the suitable model for COVID-19180
Osteoarthritis: pathogenic signaling pathways and therapeutic targets177
Targeting TGFβ signal transduction for cancer therapy177
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation176
From purines to purinergic signalling: molecular functions and human diseases175
Targeted protein degradation: mechanisms, strategies and application174
mRNA-based therapeutics: powerful and versatile tools to combat diseases172
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases172
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial171
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2169
Emerging new therapeutic antibody derivatives for cancer treatment165
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat163
COVID-19 in early 2021: current status and looking forward162
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration159
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing158
COVID-19 vaccine development: milestones, lessons and prospects157
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases156
Radiotherapy combined with immunotherapy: the dawn of cancer treatment154
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions150
Macrophages in immunoregulation and therapeutics149
Protein kinase CK2: a potential therapeutic target for diverse human diseases148
Trends in insulin resistance: insights into mechanisms and therapeutic strategy146
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms145
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response142
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms141
Structural biology of SARS-CoV-2: open the door for novel therapies141
T cell receptor (TCR) signaling in health and disease141
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples140
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events138
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway137
Intercellular mitochondrial transfer as a means of tissue revitalization135
The BET family in immunity and disease132
Targeting non-coding RNAs to overcome cancer therapy resistance132
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives132
Neoantigens: promising targets for cancer therapy132
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy131
The sirtuin family in health and disease131
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals128
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19125
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies124
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies123
Emerging role of tumor cell plasticity in modifying therapeutic response122
Epigenetic regulation of aging: implications for interventions of aging and diseases121
Action mechanisms and research methods of tRNA-derived small RNAs120
Recent progress in targeted delivery vectors based on biomimetic nanoparticles118
Signal pathways of melanoma and targeted therapy118
The biological applications of DNA nanomaterials: current challenges and future directions118
Targeting integrin pathways: mechanisms and advances in therapy116
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention116
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota114
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer113
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response112
Targeting fibrosis: mechanisms and clinical trials111
The glycosylation in SARS-CoV-2 and its receptor ACE2110
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations108
Progress in the mechanism and targeted drug therapy for COPD108
The STING1 network regulates autophagy and cell death106
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties103
Inflammasomes as therapeutic targets in human diseases103
The interactions between cGAS-STING pathway and pathogens102
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins100
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair100
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions99
Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients99
Functional characterization of SOX2 as an anticancer target98
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion98
Omicron: increased transmissibility and decreased pathogenicity97
The blood–brain barrier: structure, regulation, and drug delivery96
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients96
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src95
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)95
Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-294
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis94
Human organoids in basic research and clinical applications94
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy93
Molecular regulations of circadian rhythm and implications for physiology and diseases93
Colorectal liver metastasis: molecular mechanism and interventional therapy93
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines93
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages93
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression92
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics92
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome92
CRISPR/Cas9 therapeutics: progress and prospects91
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis91
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer90
Alternative approaches to target Myc for cancer treatment90
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis89
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis89
COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm89
Angiogenic signaling pathways and anti-angiogenic therapy for cancer88
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer88
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification87
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins87
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation87
Signaling pathways in obesity: mechanisms and therapeutic interventions86
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)85
The Hippo signalling pathway and its implications in human health and diseases85
Artificial intelligence in cancer target identification and drug discovery85
Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-1984
ACE2-independent infection of T lymphocytes by SARS-CoV-284
Inflammation and aging: signaling pathways and intervention therapies84
Monkeypox: epidemiology, pathogenesis, treatment and prevention83
SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies83
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics82
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys82
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions81
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma81
CD146, from a melanoma cell adhesion molecule to a signaling receptor80
RNA modifications: importance in immune cell biology and related diseases80
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy78
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity78
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials78
Overview of current targeted therapy in gallbladder cancer78
Targeting p53 pathways: mechanisms, structures, and advances in therapy77
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases77
Signaling pathways and intervention therapies in sepsis77
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A177
Functional hair follicle regeneration: an updated review77
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy77
Role of neuroinflammation in neurodegeneration development76
Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro75
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development75
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need74
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence73
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting73
Signaling pathways of chronic kidney diseases, implications for therapeutics72
Natural killer cell homing and trafficking in tissues and tumors: from biology to application71
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling71
Spatiotemporal control of CRISPR/Cas9 gene editing70
Dynamic blood single-cell immune responses in patients with COVID-1970
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine70
Small molecule metabolites: discovery of biomarkers and therapeutic targets70
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design69
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes69
Neurological complications and infection mechanism of SARS-CoV-269
The role of histone modifications: from neurodevelopment to neurodiseases69
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance69
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy68
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer68
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding67
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth67
The key roles of cancer stem cell-derived extracellular vesicles66
The role of histone methylation in the development of digestive cancers: a potential direction for cancer management66
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response66
Clinical and translational values of spatial transcriptomics66
Signaling pathways in rheumatoid arthritis: implications for targeted therapy66
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications66
Omicron adopts a different strategy from Delta and other variants to adapt to host65
Engineered exosomes from different sources for cancer-targeted therapy65
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future65
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients63
AlphaFold2 and its applications in the fields of biology and medicine63
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway63
Targeting lysosomes in human disease: from basic research to clinical applications63
Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-1962
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies62
Kidney fibrosis: from mechanisms to therapeutic medicines61
Mesenchymal stem cell therapy for severe COVID-1961
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma61
Liquid–liquid phase separation in tumor biology61
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules61
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy60
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis60
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy60
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis59
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer59
Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice59
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants59
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment59
GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages59
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-1959