Signal Transduction and Targeted Therapy

Article	Citations
Novel pyroptosis-independent functions of gasdermins	1194
Sensory neurons: unveiling the symphony of wound healing	1142
Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-2	1080
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage	1053
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma	1052
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment	923
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	862
D614G and SARS-CoV-2 replication fitness	806
Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery	770
Greasy hair against obesity	716
Four-wheel-drive immune protection	688
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity	638
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	619
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders	607
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants	521
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor	475
New case of HIV cure: joined forces of haploidentical stem cells and HLA-mismatched cord blood	466
Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway	463
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity	457
Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation	447
RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation	446
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling	443
“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers	439
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	434
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice	413

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys	402
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	391
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enh	390
Mutated trimeric RBD vaccines: a platform against variants of concern	386
Epstein-Barr virus infection: the leading cause of multiple sclerosis	386
Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment	385
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response	365
Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents	364
A bivalent recombinant vaccine: a promising strategy against both SARS-CoV-2 variants and wild type of the virus	360
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity	358
Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity	355
Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer	354
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment	339
Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy	325
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers	324
Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant	320
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation	316
ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer	315
Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection	308
Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis	304
SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency	301
CRISPRing the hypertrophic cardiomyopathy: correcting one pathogenic variant at a time	300
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	294
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications	292
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies	290
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway	281
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis	279
Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores	269
Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers	268
Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents	265
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer	256
Highly efficient gene editing and single cell analysis of hematopoietic stem/progenitor cells from X-linked sideroblastic anemia patients	253
Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro	242
Unexpected little helpers: microbiota stimulate systemic antiviral defenses	241
The beginning of a new era: pioneering direct screens for RNA modulators	239
Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit	236
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study	234
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy	234
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma	231
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease	230
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models	229
STING cg16983159 methylation: a key factor for glioblastoma immunosuppression	228
STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway	222
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients	218
SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies	212
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity	212
Pre-activated macrophage membrane-encased aggregation-induced emission featuring nanoparticles: a novel possibility for tuberculosis treatment	210
Longitudinal dynamics of antibody responses in recovered COVID-19 patients	209
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	203
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism	198

Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma	197
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study	197
A novel alternative for pyrogen detection based on a transgenic cell line	197
Ketogenic diet: new avenues to overcome colorectal cancer	196
SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway	196
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	195
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	193
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition	193
Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies	188
Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes	187
Beyond the code: the role of histone methylation in cancer resistance and therapy	187
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis	186
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation	183
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	182
SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)	181
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation	179
Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19	178
Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization	177
Myeloid cells in COVID-19 microenvironment	177
LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury	175
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses	173
An emerging artificial nanomachine: a nanoengine with a reversible clutch	172
Cancer metastasis chemoprevention prevents circulating tumour cells from germination	169
Supporting tumor therapy by exercise: boosting T cell immunity by myokines	167
For the sake of longevity: eating less and eating at the right time	165
Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity	164
Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response	164
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer	163
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	163
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation	159
COVID-19 vaccine development: milestones, lessons and prospects	155
Signal pathways of melanoma and targeted therapy	155
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)	155
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc	154
Advances in COVID-19 mRNA vaccine development	153
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	152
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets	149
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity	149
Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia	145
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells	142
CD5: from antiquated T cell marker to immunotherapy’s new hope	142
Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment	141
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques	139
Segregating memories: targeting microenvironment of neuronal ensembles	139
SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis	138
Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease	136
Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy	136
FAP senescence: a critical event in muscle regeneration	134
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin	134
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing	134
Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy	132
Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma	132
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial	131
The regulation of protein translation and its implications for cancer	130
Animal models for COVID-19: advances, gaps and perspectives	130
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	130
Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation	129
Scalable biomimetic SARS-CoV‑2 nanovaccines with robust protective immune responses	129
Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma	128
An mRNA vaccine with broad-spectrum neutralizing protection against Omicron variant sublineages BA.4/5 -included SARS-CoV-2	127
A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues	127
The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression	125
Biofilms and exopolysaccharides in Pseudomonas aeruginosa: pathogenesis, immune evasion, and lung–brain signaling during pneumonia	125
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial	123
Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study	122
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm	122
RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern	121
Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study	120
Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α	118
Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease	115
Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease	114
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study	112
RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy	111
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	111
Moving towards precision psychiatry: the hard nut of depression	110
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation	110
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	110
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors	109
Mef2d: a novel transcription factor in type 2 allergic lung inflammation	109
Mesenchymal stem cell therapy for severe COVID-19	108

Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis	108
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma	106
A microglial compliment: controlling neuronal function from within	106
PD-1 and LAG-3: synergistic fostering of T cell exhaustion	105
Carbon nanotube promotes contraction and electrical activity of neonatal cardiomyocytes by targeting sodium/calcium exchanger NCX1	104
One step at a time: new insights into double-stranded ribonucleic acid virus assembly	104
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB	104
Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling	104
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment	103
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets	102
Immunological and metabolic characteristics of the Omicron variants infection	100
Lung microbiome: new insights into the pathogenesis of respiratory diseases	100
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	99
Mitochondrial dysfunction: mechanisms and advances in therapy	99
Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies	97
Therapeutic cancer vaccines: advancements, challenges and prospects	97
Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy	97
Stem cell-based therapy for human diseases	96
The IL-17 family in diseases: from bench to bedside	95
Small molecule metabolites: discovery of biomarkers and therapeutic targets	95
Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis	95
Oncolytic virotherapy: basic principles, recent advances and future directions	94
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	94
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer	93
Targeting strategies for bone diseases: signaling pathways and clinical studies	93
A bacteria-based system expressing anti-TNF-α nanobody for enhanced cancer immunotherapy	92
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	91
A new wave of innovations within the DNA damage response	90
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management	90
Radiopharmaceuticals and their applications in medicine	89
Aptamer blocking S-TLR4 interaction selectively inhibits SARS-CoV-2 induced inflammation	89
In defence of ferroptosis	88
Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy	87
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	87
Trends in insulin resistance: insights into mechanisms and therapeutic strategy	86
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics	86
TET2 cascade: a novel regulator of chromatin structure and leukaemogenesis	85
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	84
Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers	83
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT	83
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	83
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis	81
The loss of epigenetic information: not only consequences but a cause of mammalian aging	80
Clinical and translational values of spatial transcriptomics	78
A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma	78
Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis	77
Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7	77
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids	76
Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression	76
PINK1-mediated Drp1S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission	76
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products	75
Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome	75
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients	75
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases	75
Spliceosomal repression: unleashing human cell totipotency	75
High-resolution aging niche of human adipose tissues	74
Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer	74
Pyrotinib plus capecitabine could significantly improve overall survival in HER2-positive metastatic breast cancer	72
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota	72
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1	72
Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines	72
The chemokine CCL17 is a novel therapeutic target for cardiovascular aging	72
NOL7 facilitates melanoma progression and metastasis	72
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	72
A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants	71
Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial	71
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins	71
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	71
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	70
Structural biology of SARS-CoV-2: open the door for novel therapies	70
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	69
Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma	69
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies	69
Cryo-EM advances in RNA structure determination	69
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions	69
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion	69
VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance	68
Immunosenescence: molecular mechanisms and diseases	68
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases	67
Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma	67
Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C	65
Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis	65
Targeting epigenetic regulators to overcome drug resistance in cancers	65
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies	65
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets	64
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability	64
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model	63
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils	63
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer	63
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression	63
Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study	62
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	62
Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration	62
Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction	62
Signaling pathways of chronic kidney diseases, implications for therapeutics	62