Signal Transduction and Targeted Therapy

Article	Citations
Pyroptosis: mechanisms and diseases	943
Inflammation and tumor progression: signaling pathways and targeted intervention	858
The role of m6A modification in the biological functions and diseases	810
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study	778
The JAK/STAT signaling pathway: from bench to clinic	765
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives	687
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells	679
Microbiota in health and diseases	675
Exosomes: key players in cancer and potential therapeutic strategy	608
The updated landscape of tumor microenvironment and drug repurposing	601
Pattern recognition receptors in health and diseases	596
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	584
Ferroptosis: mechanisms and links with diseases	579
Therapeutic peptides: current applications and future directions	568
Viral vector platforms within the gene therapy landscape	565
COVID-19: immunopathogenesis and Immunotherapeutics	504
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets	475
Antibody drug conjugate: the “biological missile” for targeted cancer therapy	451
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential	427
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials	411
Targeting PI3K/Akt signal transduction for cancer therapy	408
A systematic review of SARS-CoV-2 vaccine candidates	398
Application of exosomes as liquid biopsy in clinical diagnosis	398
Targeting tumor-associated macrophages to synergize tumor immunotherapy	357
FGF/FGFR signaling in health and disease	355

Circulating tumor cells: biology and clinical significance	352
SARS-CoV-2 Omicron variant: recent progress and future perspectives	350
The signal pathways and treatment of cytokine storm in COVID-19	350
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome	349
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity	343
Targeted therapy for hepatocellular carcinoma	340
Copper homeostasis and cuproptosis in health and disease	340
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development	335
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	330
Targeting macrophages in cancer immunotherapy	323
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics	313
Extracellular matrix and its therapeutic potential for cancer treatment	304
KRAS mutation: from undruggable to druggable in cancer	302
Notch signaling pathway: architecture, disease, and therapeutics	301
Stem cell-based therapy for human diseases	299
Overcoming cancer therapeutic bottleneck by drug repurposing	298
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy	281
Liquid–liquid phase separation in human health and diseases	278
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer	276
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches	275
Lactate metabolism in human health and disease	271
G protein-coupled receptors: structure- and function-based drug discovery	270
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation	268
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer	267
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention	266
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments	251
Chitinase-3 like-protein-1 function and its role in diseases	237
Targeting circular RNAs as a therapeutic approach: current strategies and challenges	236
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1	236
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial	234
Advances in targeted therapy for esophageal cancer	234
Advances in COVID-19 mRNA vaccine development	229
Regulated cell death (RCD) in cancer: key pathways and targeted therapies	227
Signaling pathways and targeted therapy for myocardial infarction	226
Wnt/β-catenin signaling in cancers and targeted therapies	224
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications	224
Osteoarthritis: pathogenic signaling pathways and therapeutic targets	222
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling	222
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy	214
Macrophages in immunoregulation and therapeutics	212
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19	207
NAD+ metabolism, stemness, the immune response, and cancer	206
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy	205
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents	205
Targeted protein degradation: mechanisms, strategies and application	202
mRNA-based therapeutics: powerful and versatile tools to combat diseases	201
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases	199
Alternative splicing and cancer: a systematic review	195
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression	195
From purines to purinergic signalling: molecular functions and human diseases	194

Emerging new therapeutic antibody derivatives for cancer treatment	189
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	189
Targeting TGFβ signal transduction for cancer therapy	186
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation	186
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	184
Comparison of nonhuman primates identified the suitable model for COVID-19	184
COVID-19 vaccine development: milestones, lessons and prospects	181
Neoantigens: promising targets for cancer therapy	180
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial	178
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing	175
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2	175
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat	175
Radiotherapy combined with immunotherapy: the dawn of cancer treatment	172
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration	171
Trends in insulin resistance: insights into mechanisms and therapeutic strategy	171
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases	166
COVID-19 in early 2021: current status and looking forward	165
T cell receptor (TCR) signaling in health and disease	163
Protein kinase CK2: a potential therapeutic target for diverse human diseases	162
The sirtuin family in health and disease	161
Structural biology of SARS-CoV-2: open the door for novel therapies	157
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway	157
Targeting integrin pathways: mechanisms and advances in therapy	154
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms	152
The blood–brain barrier: structure, regulation, and drug delivery	149
Intercellular mitochondrial transfer as a means of tissue revitalization	148
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response	147
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy	146
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives	145
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples	144
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events	143
The BET family in immunity and disease	142
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms	142
Targeting non-coding RNAs to overcome cancer therapy resistance	141
Epigenetic regulation of aging: implications for interventions of aging and diseases	141
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions	137
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies	136
Recent progress in targeted delivery vectors based on biomimetic nanoparticles	136
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response	136
Targeting fibrosis: mechanisms and clinical trials	134
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19	134
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention	133
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals	132
Signal pathways of melanoma and targeted therapy	132
The biological applications of DNA nanomaterials: current challenges and future directions	131
Emerging role of tumor cell plasticity in modifying therapeutic response	130
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota	124
Inflammation and aging: signaling pathways and intervention therapies	124
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	124
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer	123
Human organoids in basic research and clinical applications	121
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations	117
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics	117
The glycosylation in SARS-CoV-2 and its receptor ACE2	117
Inflammasomes as therapeutic targets in human diseases	116
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties	116
CRISPR/Cas9 therapeutics: progress and prospects	115
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)	114
Progress in the mechanism and targeted drug therapy for COPD	114
The Hippo signalling pathway and its implications in human health and diseases	113
Role of neuroinflammation in neurodegeneration development	112
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion	112
The STING1 network regulates autophagy and cell death	112
Small molecule metabolites: discovery of biomarkers and therapeutic targets	109
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future	108
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair	108
Signaling pathways in obesity: mechanisms and therapeutic interventions	107
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins	106
Targeting p53 pathways: mechanisms, structures, and advances in therapy	105
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients	105
Molecular regulations of circadian rhythm and implications for physiology and diseases	105
Omicron: increased transmissibility and decreased pathogenicity	104
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy	102
Colorectal liver metastasis: molecular mechanism and interventional therapy	102
Functional characterization of SOX2 as an anticancer target	101
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src	101
Artificial intelligence in cancer target identification and drug discovery	100
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis	100
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages	100
Alternative approaches to target Myc for cancer treatment	99

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression	99
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome	98
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	98
Monkeypox: epidemiology, pathogenesis, treatment and prevention	98
RNA modifications: importance in immune cell biology and related diseases	97
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics	97
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis	96
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis	95
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis	95
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines	95
Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2	95
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation	95
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials	95
COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm	93
ACE2-independent infection of T lymphocytes by SARS-CoV-2	93
AlphaFold2 and its applications in the fields of biology and medicine	93
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)	92
Signaling pathways and intervention therapies in sepsis	91
Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19	91
T cells in health and disease	91
Signaling pathways of chronic kidney diseases, implications for therapeutics	91
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer	90
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases	89
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins	89
SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies	87
CD146, from a melanoma cell adhesion molecule to a signaling receptor	87
Functional hair follicle regeneration: an updated review	87
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	87
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity	86
Natural killer cell homing and trafficking in tissues and tumors: from biology to application	86
Signaling pathways in rheumatoid arthritis: implications for targeted therapy	85
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions	84
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence	84
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy	84
Nanomedicine in cancer therapy	84
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys	84
The role of histone modifications: from neurodevelopment to neurodiseases	83
Overview of current targeted therapy in gallbladder cancer	83
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma	83
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development	82
Kidney fibrosis: from mechanisms to therapeutic medicines	82
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1	82
Vaccine adjuvants: mechanisms and platforms	81
Immunosenescence: molecular mechanisms and diseases	80
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy	79
Spatiotemporal control of CRISPR/Cas9 gene editing	79
Engineered exosomes from different sources for cancer-targeted therapy	77
Clinical and translational values of spatial transcriptomics	77
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine	77
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting	74
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study	74
Targeting lysosomes in human disease: from basic research to clinical applications	74
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes	74
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need	74
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance	74
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling	73
The role of histone methylation in the development of digestive cancers: a potential direction for cancer management	73
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies	73
Signaling pathways and therapeutic interventions in gastric cancer	72
Mitochondrial dynamics in health and disease: mechanisms and potential targets	71
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy	71
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets	71
Neurological complications and infection mechanism of SARS-CoV-2	71
Dynamic blood single-cell immune responses in patients with COVID-19	71
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design	71
Omicron adopts a different strategy from Delta and other variants to adapt to host	71
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules	70
The key roles of cancer stem cell-derived extracellular vesicles	69
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway	69
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response	69
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications	69
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients	69
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding	68
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends	68
GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages	67
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease	67
ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage	67
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants	66
Spinal cord injury: molecular mechanisms and therapeutic interventions	66
Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice	65
Liquid–liquid phase separation in tumor biology	65
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy	64
Smart nanoparticles for cancer therapy	64
Ribosome biogenesis in disease: new players and therapeutic targets	64
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects	64
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies	64
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma	63
GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies	63
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment	63
Application of 3D bioprinting in the prevention and the therapy for human diseases	62
Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective	62
Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19	62
Mesenchymal stem cell therapy for severe COVID-19	62
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis	62
Targeting epigenetic regulators to overcome drug resistance in cancers	62