Signal Transduction and Targeted Therapy

Article	Citations
Greasy hair against obesity	1907
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	1677
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	1572
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	1285
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	1147
Moving towards precision psychiatry: the hard nut of depression	1134
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis	1040
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics	940
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	916
Identification of glutamine as a potential therapeutic target in dry eye disease	877
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance	872
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	848
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	822
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma	821
Dopamine as a teaching signal: understanding its role in shaping individual behavior	794
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	786
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	734
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	732
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	731
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study	720
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	719
Correction: The Hippo signalling pathway and its implications in human health and diseases	715
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	713
Sensory neurons: unveiling the symphony of wound healing	706
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	706

PD-1 and LAG-3: synergistic fostering of T cell exhaustion	695
Signal pathways of melanoma and targeted therapy	691
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT	644
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5	623
A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease	606
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	578
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	572
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	568
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	564
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	561
Animal models for COVID-19: advances, gaps and perspectives	544
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies	542
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	540
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	540
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	524
Phototherapy in cancer treatment: strategies and challenges	503
Neutrophil extracellular traps in homeostasis and disease	501
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	496
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	493
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine	490
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	490
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination	471
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies	469
D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma	467
“Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis	461
Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis	459
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN	456
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection	447
Top(ological-operon) secret behind the long-range transcriptional coupling	442
Omicron spike protein: a clue for viral entry and immune evasion	438
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters	435
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression	427
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss	425
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth	424
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy	419
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism	418
Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver	402
Beyond borders: the choroid plexus-immune communication during neuroinflammation	401
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis	397
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant	396
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors	395
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy	392
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy	370
SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes	353
Platelets and diseases: signal transduction and advances in targeted therapy	352
Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair	350
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects	346
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron	341
Harnessing innate immune pathways for therapeutic advancement in cancer	335
Microbiota in health and diseases	330

The RING finger protein family in health and disease	328
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases	323
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	320
Mind-body control: a new perspective on motor neuron function	319
Base editing: a promising tool to rescue spinal muscular atrophy	313
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis	305
Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape	302
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine	300
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes	299
Persistent SARS-CoV-2 infection in asymptomatic young adults	298
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus	297
High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming	295
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants	294
IRE1α: a gatekeeper of chemotherapy-induced immunogenicity in triple-negative breast cancer	292
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors	288
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia	282
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations	281
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury	271
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors	271
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation	268
sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster	267
Linking B cell metabolism to immune regulation: the neurotransmitter GABA	260
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease	259
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread	258
Nascent mRNA damage: depot and disposal	256
DNA framework signal amplification platform-based high-throughput systemic immune monitoring	256
Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors	253
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection	252
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	252
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity	251
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression	249
Small molecules in the treatment of COVID-19	248
Molecular insights of exercise therapy in disease prevention and treatment	245
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance	240
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation	239
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis	237
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases	236
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer	236
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury	230
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy	228
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization	228
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome	226
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets	225
Mitochondrial heterogeneity in diseases	224
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study	224
Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies	221
Lactate metabolism in human health and disease	220
Targeting PI3K/Akt signal transduction for cancer therapy	219
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	214
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	211
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer	209
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2	209
Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma	208
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control	203
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice	202
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study	198
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness	197
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting	197
Single-cell genomics: the human biomolecular and cell atlases	196
Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function	196
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules	194
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection	194
Back to pluripotency: fully chemically induced reboot of human somatic cells	193
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy	193
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle	191
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus	191
ELANE: an emerging lane to selective anticancer therapy	191
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling	189
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors	188
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing	188
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism	182
Combination therapy for HCC: from CRISPR screening to the design of clinical therapies	180
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication	180
Current landscape of innovative drug development and regulatory support in China	180
Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells	176
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics	175
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants	175
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation	173
Programmable synthetic receptors: the next-generation of cell and gene therapies	172
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1	172

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer	171
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation	171
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration	170
Liquid biomarkers associate with TGF-β Type I receptor and hypoxia in kidney cancer	170
Glioblastoma at the crossroads: current understanding and future therapeutic horizons	170
mRNA-based therapeutics: powerful and versatile tools to combat diseases	169
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	168
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	167
Signaling pathways and targeted therapies for psoriasis	167
Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing	164
Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance	163
Activated STING: an ion channel to trigger non-interferon-related functions	161
Time’s up: mutation rate and lifespan	160
Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution	157
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs	153
Checkpoint blockade therapy in Hodgkin lymphoma: improved response through combination with JAK inhibition	153
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications	153
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation	153
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein	151
Signaling pathways in obesity: mechanisms and therapeutic interventions	151
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy	147
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes	146
Redox regulation: mechanisms, biology and therapeutic targets in diseases	145
T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape	145
Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity	144
Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study	144
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies	142
Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial	142
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation	139
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone	139
Balancing memory in sleep: firing barrages as a circuit breaker for reactivation	137
Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis	136
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts	135
Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells	131
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates	131
Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance	130
Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial	129
Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis	129
Bat organoid platform: revolutionizing zoonotic virus research and pandemic preparedness	128
Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial	127
Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells	127
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages	127
Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like	125
Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines	124
ALYREF mediates RNA m5C modification to promote hepatocellular carcinoma progression	124
To metabolomics and beyond: a technological portfolio to investigate cancer metabolism	124
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis	123
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential	123
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials	122
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis	122
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future	121
Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study	121
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy	120
Artificial intelligence in cancer target identification and drug discovery	120
The biological applications of DNA nanomaterials: current challenges and future directions	120
Targeted protein degradation: advances in drug discovery and clinical practice	119
Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic	118
Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome	115
Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial	115
NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity	114
Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern	114
SLC7A11: a new regulator in diabetic wound healing	114
Correction: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism	113
A systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver	112
The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation	112
Neoadjuvant oncolytic virus orienx010 and toripalimab in resectable acral melanoma: a phase Ib trial	111
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling	110
The gasdermin family: emerging therapeutic targets in diseases	110
XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal c	109
Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial	109
Cross-neutralization and cross-protection among SARS-CoV-2 viruses bearing different variant spikes	109
Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)	108
CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection	108
Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase II trial	108
Redox signaling-governed drug-tolerant persister cancer cell: a key spark of treatment failure	107
Progression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance	107
Human cross-tissue cell atlases: unprecedented resources towards systematic understanding of physiology and diseases	106
Artificial intelligence propels lung cancer screening: innovations and the challenges of explainability and reproducibility	105
Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa	103
Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism	103
Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies	102
IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells	101
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection	101
DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice	101
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes	100
Uveal melanoma with a GNA11/GNAQ mutation secretes VEGF for systemic spread	99
A multicenter single-arm clinical study of Chinese children’s cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol	99
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1	98
DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation	98
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness	98
Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study	97
The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing	96
Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial)	96
A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment	94
Intratumoural microbiota: a new frontier in cancer development and therapy	93