Signal Transduction and Targeted Therapy

(The median citation count of Signal Transduction and Targeted Therapy is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Pyroptosis: mechanisms and diseases909
Inflammation and tumor progression: signaling pathways and targeted intervention819
The role of m6A modification in the biological functions and diseases784
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study750
The JAK/STAT signaling pathway: from bench to clinic726
Therapeutic siRNA: state of the art708
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells666
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives664
Microbiota in health and diseases616
Exosomes: key players in cancer and potential therapeutic strategy593
The updated landscape of tumor microenvironment and drug repurposing581
Pattern recognition receptors in health and diseases572
Ferroptosis: mechanisms and links with diseases557
Viral vector platforms within the gene therapy landscape544
Therapeutic peptides: current applications and future directions542
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities542
COVID-19: immunopathogenesis and Immunotherapeutics495
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects461
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets447
Antibody drug conjugate: the “biological missile” for targeted cancer therapy421
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential412
A systematic review of SARS-CoV-2 vaccine candidates397
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials396
Application of exosomes as liquid biopsy in clinical diagnosis390
Targeting PI3K/Akt signal transduction for cancer therapy371
Targeting tumor-associated macrophages to synergize tumor immunotherapy345
FGF/FGFR signaling in health and disease344
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome344
The signal pathways and treatment of cytokine storm in COVID-19342
SARS-CoV-2 Omicron variant: recent progress and future perspectives337
Circulating tumor cells: biology and clinical significance337
Targeted therapy for hepatocellular carcinoma329
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development329
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity325
The interaction between ferroptosis and lipid metabolism in cancer316
Targeting macrophages in cancer immunotherapy307
Copper homeostasis and cuproptosis in health and disease305
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy299
Overcoming cancer therapeutic bottleneck by drug repurposing293
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics293
Extracellular matrix and its therapeutic potential for cancer treatment284
KRAS mutation: from undruggable to druggable in cancer281
Notch signaling pathway: architecture, disease, and therapeutics272
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches272
Stem cell-based therapy for human diseases271
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy268
Liquid–liquid phase separation in human health and diseases266
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation263
G protein-coupled receptors: structure- and function-based drug discovery260
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer255
Lactate metabolism in human health and disease249
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention239
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin239
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial233
Chitinase-3 like-protein-1 function and its role in diseases232
Advances in targeted therapy for esophageal cancer230
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments230
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1230
Targeting circular RNAs as a therapeutic approach: current strategies and challenges226
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling217
Regulated cell death (RCD) in cancer: key pathways and targeted therapies217
Wnt/β-catenin signaling in cancers and targeted therapies216
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications212
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy211
Advances in COVID-19 mRNA vaccine development210
Signaling pathways and targeted therapy for myocardial infarction209
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19206
Overview of lethal human coronaviruses206
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents203
NAD+ metabolism, stemness, the immune response, and cancer201
Regulating tumor suppressor genes: post-translational modifications200
Osteoarthritis: pathogenic signaling pathways and therapeutic targets198
Targeted protein degradation: mechanisms, strategies and application196
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy196
Alternative splicing and cancer: a systematic review191
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression191
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance188
From purines to purinergic signalling: molecular functions and human diseases187
mRNA-based therapeutics: powerful and versatile tools to combat diseases187
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation184
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases184
Comparison of nonhuman primates identified the suitable model for COVID-19183
Targeting TGFβ signal transduction for cancer therapy181
Emerging new therapeutic antibody derivatives for cancer treatment180
Macrophages in immunoregulation and therapeutics180
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial175
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2175
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat174
COVID-19 vaccine development: milestones, lessons and prospects173
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions171
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing169
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration167
Neoantigens: promising targets for cancer therapy166
Radiotherapy combined with immunotherapy: the dawn of cancer treatment166
COVID-19 in early 2021: current status and looking forward163
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases162
Protein kinase CK2: a potential therapeutic target for diverse human diseases160
Trends in insulin resistance: insights into mechanisms and therapeutic strategy159
T cell receptor (TCR) signaling in health and disease158
Structural biology of SARS-CoV-2: open the door for novel therapies152
The sirtuin family in health and disease151
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms150
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response147
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway145
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy142
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples142
The BET family in immunity and disease142
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events141
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms141
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives140
Targeting integrin pathways: mechanisms and advances in therapy140
Intercellular mitochondrial transfer as a means of tissue revitalization140
Targeting non-coding RNAs to overcome cancer therapy resistance138
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies132
Epigenetic regulation of aging: implications for interventions of aging and diseases131
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19131
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals130
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention129
Action mechanisms and research methods of tRNA-derived small RNAs127
Emerging role of tumor cell plasticity in modifying therapeutic response126
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies126
Recent progress in targeted delivery vectors based on biomimetic nanoparticles126
The biological applications of DNA nanomaterials: current challenges and future directions125
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response125
The blood–brain barrier: structure, regulation, and drug delivery125
Signal pathways of melanoma and targeted therapy124
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota121
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions121
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer120
Targeting fibrosis: mechanisms and clinical trials119
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations113
Progress in the mechanism and targeted drug therapy for COPD111
The glycosylation in SARS-CoV-2 and its receptor ACE2111
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties110
Inflammasomes as therapeutic targets in human diseases109
The STING1 network regulates autophagy and cell death108
Inflammation and aging: signaling pathways and intervention therapies108
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion106
CRISPR/Cas9 therapeutics: progress and prospects106
Human organoids in basic research and clinical applications105
The interactions between cGAS-STING pathway and pathogens105
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)105
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients104
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair104
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics104
Angiogenic signaling pathways and anti-angiogenic therapy for cancer104
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins103
Signaling pathways in obesity: mechanisms and therapeutic interventions102
Molecular regulations of circadian rhythm and implications for physiology and diseases101
Omicron: increased transmissibility and decreased pathogenicity101
Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients101
Functional characterization of SOX2 as an anticancer target99
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src99
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis99
Colorectal liver metastasis: molecular mechanism and interventional therapy98
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages98
The Hippo signalling pathway and its implications in human health and diseases98
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy97
Alternative approaches to target Myc for cancer treatment96
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer96
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome96
Monkeypox: epidemiology, pathogenesis, treatment and prevention95
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation94
Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-294
Targeting p53 pathways: mechanisms, structures, and advances in therapy94
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression94
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis94
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis94
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines93
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis93
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future92
Role of neuroinflammation in neurodegeneration development92
COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm91
Artificial intelligence in cancer target identification and drug discovery91
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials90
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)90
ACE2-independent infection of T lymphocytes by SARS-CoV-289
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer89
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics88
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins88
Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-1988
Signaling pathways and intervention therapies in sepsis88
RNA modifications: importance in immune cell biology and related diseases88
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases86
Small molecule metabolites: discovery of biomarkers and therapeutic targets86
SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies86
CD146, from a melanoma cell adhesion molecule to a signaling receptor85
Functional hair follicle regeneration: an updated review84
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys84
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions84
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy84
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity83
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma83
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy82
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A181
Overview of current targeted therapy in gallbladder cancer80
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence80
The role of histone modifications: from neurodevelopment to neurodiseases79
AlphaFold2 and its applications in the fields of biology and medicine79
Signaling pathways of chronic kidney diseases, implications for therapeutics79
Natural killer cell homing and trafficking in tissues and tumors: from biology to application79
T cells in health and disease78
Signaling pathways in rheumatoid arthritis: implications for targeted therapy76
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development76
Clinical and translational values of spatial transcriptomics75
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine75
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need74
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy74
Spatiotemporal control of CRISPR/Cas9 gene editing74
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance73
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes73
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting72
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling72
Vaccine adjuvants: mechanisms and platforms72
Kidney fibrosis: from mechanisms to therapeutic medicines71
Nanomedicine in cancer therapy71
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design71
Dynamic blood single-cell immune responses in patients with COVID-1971
Neurological complications and infection mechanism of SARS-CoV-271
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy71
The role of histone methylation in the development of digestive cancers: a potential direction for cancer management71
Engineered exosomes from different sources for cancer-targeted therapy70
Targeting lysosomes in human disease: from basic research to clinical applications69
The key roles of cancer stem cell-derived extracellular vesicles69
Immunosenescence: molecular mechanisms and diseases68
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications67
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules67
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study67
Signaling pathways and therapeutic interventions in gastric cancer67
Omicron adopts a different strategy from Delta and other variants to adapt to host67
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding67
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients67
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response67
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway66
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies64
Liquid–liquid phase separation in tumor biology64
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants64
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy64
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies64
Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice63
GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies63
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma63
GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages63
ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage62
Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-1962
Mesenchymal stem cell therapy for severe COVID-1962
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis62
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment62
Ribosome biogenesis in disease: new players and therapeutic targets61