Signal Transduction and Targeted Therapy

Article	Citations
Molecular principles of metastasis: a hallmark of cancer revisited	997
Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study	941
Pyroptosis: mechanisms and diseases	796
Comprehensive review of targeted therapy for colorectal cancer	789
The role of m6A modification in the biological functions and diseases	684
Inflammation and tumor progression: signaling pathways and targeted intervention	676
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells	644
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study	641
Therapeutic siRNA: state of the art	639
The JAK/STAT signaling pathway: from bench to clinic	600
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives	577
The updated landscape of tumor microenvironment and drug repurposing	532
Exosomes: key players in cancer and potential therapeutic strategy	530
Pattern recognition receptors in health and diseases	485
Viral vector platforms within the gene therapy landscape	483
Ferroptosis: mechanisms and links with diseases	479
COVID-19: immunopathogenesis and Immunotherapeutics	472
Microbiota in health and diseases	455
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer	446
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	430
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2	429
Therapeutic peptides: current applications and future directions	429
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects	401
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets	391
A systematic review of SARS-CoV-2 vaccine candidates	390

Application of exosomes as liquid biopsy in clinical diagnosis	368
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential	367
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials	364
Antibody drug conjugate: the “biological missile” for targeted cancer therapy	334
The signal pathways and treatment of cytokine storm in COVID-19	328
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome	323
FGF/FGFR signaling in health and disease	310
Targeting tumor-associated macrophages to synergize tumor immunotherapy	307
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development	306
Targeted therapy for hepatocellular carcinoma	296
SARS-CoV-2 Omicron variant: recent progress and future perspectives	294
Overcoming cancer therapeutic bottleneck by drug repurposing	281
Targeting PI3K/Akt signal transduction for cancer therapy	280
Circulating tumor cells: biology and clinical significance	278
Targeting macrophages in cancer immunotherapy	278
The interaction between ferroptosis and lipid metabolism in cancer	272
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity	263
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches	260
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation	249
Extracellular matrix and its therapeutic potential for cancer treatment	233
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin	233
G protein-coupled receptors: structure- and function-based drug discovery	230
KRAS mutation: from undruggable to druggable in cancer	230
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy	230
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics	224
Liquid–liquid phase separation in human health and diseases	222
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer	219
Copper homeostasis and cuproptosis in health and disease	218
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial	218
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	217
Notch signaling pathway: architecture, disease, and therapeutics	212
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling	211
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1	211
Targeting circular RNAs as a therapeutic approach: current strategies and challenges	208
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer	204
Advances in targeted therapy for esophageal cancer	203
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19	203
Chitinase-3 like-protein-1 function and its role in diseases	201
Overview of lethal human coronaviruses	198
Stem cell-based therapy for human diseases	198
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy	196
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis	191
Lactate metabolism in human health and disease	185
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications	184
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents	181
Regulating tumor suppressor genes: post-translational modifications	180
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	179
NAD+ metabolism, stemness, the immune response, and cancer	179
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy	178
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention	178

Comparison of nonhuman primates identified the suitable model for COVID-19	177
Wnt/β-catenin signaling in cancers and targeted therapies	176
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression	175
Alternative splicing and cancer: a systematic review	173
Targeting TGFβ signal transduction for cancer therapy	170
Advances in COVID-19 mRNA vaccine development	168
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial	167
Signaling pathways and targeted therapy for myocardial infarction	165
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2	164
From purines to purinergic signalling: molecular functions and human diseases	163
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation	162
Targeted protein degradation: mechanisms, strategies and application	157
COVID-19 in early 2021: current status and looking forward	157
Regulated cell death (RCD) in cancer: key pathways and targeted therapies	157
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat	156
mRNA-based therapeutics: powerful and versatile tools to combat diseases	155
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration	150
Emerging new therapeutic antibody derivatives for cancer treatment	149
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases	148
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing	146
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments	143
Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells	142
COVID-19 vaccine development: milestones, lessons and prospects	142
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response	141
Osteoarthritis: pathogenic signaling pathways and therapeutic targets	139
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples	139
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms	138
Protein kinase CK2: a potential therapeutic target for diverse human diseases	137
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms	137
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases	136
Radiotherapy combined with immunotherapy: the dawn of cancer treatment	135
A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia	134
Structural biology of SARS-CoV-2: open the door for novel therapies	132
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events	130
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	127
T cell receptor (TCR) signaling in health and disease	126
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway	126
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals	126
The BET family in immunity and disease	125
Intercellular mitochondrial transfer as a means of tissue revitalization	125
Trends in insulin resistance: insights into mechanisms and therapeutic strategy	125
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives	123
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies	119
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19	117
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies	117
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy	117
Emerging role of tumor cell plasticity in modifying therapeutic response	114
Action mechanisms and research methods of tRNA-derived small RNAs	113
Signal pathways of melanoma and targeted therapy	112
The sirtuin family in health and disease	110
Targeting non-coding RNAs to overcome cancer therapy resistance	110
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention	110
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota	109
The biological applications of DNA nanomaterials: current challenges and future directions	108
Recent progress in targeted delivery vectors based on biomimetic nanoparticles	108
The glycosylation in SARS-CoV-2 and its receptor ACE2	106
Neoantigens: promising targets for cancer therapy	104
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer	104
The STING1 network regulates autophagy and cell death	102
Progress in the mechanism and targeted drug therapy for COPD	102
Inflammasomes as therapeutic targets in human diseases	100
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations	100
Macrophages in immunoregulation and therapeutics	100
Correction: Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study	100
Epigenetic regulation of aging: implications for interventions of aging and diseases	99
The interactions between cGAS-STING pathway and pathogens	98
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins	97
Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients	94
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties	94
Omicron: increased transmissibility and decreased pathogenicity	93
Targeting fibrosis: mechanisms and clinical trials	93
Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2	92
Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines	91
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages	90
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response	90
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients	89
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair	89
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy	88
Functional characterization of SOX2 as an anticancer target	88
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome	87

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm	87
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion	86
Targeting integrin pathways: mechanisms and advances in therapy	85
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer	85
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)	85
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation	84
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification	84
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis	84
Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19	83
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression	83
Colorectal liver metastasis: molecular mechanism and interventional therapy	83
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis	83
SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies	83
Molecular regulations of circadian rhythm and implications for physiology and diseases	83
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins	82
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	81
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis	81
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis	80
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src	79
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys	79
Alternative approaches to target Myc for cancer treatment	78
Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1	78
ACE2-independent infection of T lymphocytes by SARS-CoV-2	78
Human organoids in basic research and clinical applications	77
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics	76
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics	76
Monkeypox: epidemiology, pathogenesis, treatment and prevention	76
NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1	75
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)	75
Immunological surrogate endpoints of COVID-2019 vaccines: the evidence we have versus the evidence we need	75
The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma	75
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions	75
CD146, from a melanoma cell adhesion molecule to a signaling receptor	75
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions	74
The blood–brain barrier: structure, regulation, and drug delivery	74
Overview of current targeted therapy in gallbladder cancer	74
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy	73
A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity	73
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials	73
Artificial intelligence in cancer target identification and drug discovery	72
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development	71
RNA modifications: importance in immune cell biology and related diseases	71
Functional hair follicle regeneration: an updated review	71
Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro	71
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence	70
Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling	70
PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC	69
Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting	69
Signaling pathways in obesity: mechanisms and therapeutic interventions	68
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	68
Signaling pathways and intervention therapies in sepsis	68
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer	68
Neurological complications and infection mechanism of SARS-CoV-2	67
CRISPR/Cas9 therapeutics: progress and prospects	67
Dynamic blood single-cell immune responses in patients with COVID-19	67
The Hippo signalling pathway and its implications in human health and diseases	67
Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design	66
Signaling pathways of chronic kidney diseases, implications for therapeutics	66
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	66
Spatiotemporal control of CRISPR/Cas9 gene editing	66
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases	66
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance	65
Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes	65
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy	64
Omicron adopts a different strategy from Delta and other variants to adapt to host	64
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding	64
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response	63
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications	63
Natural killer cell homing and trafficking in tissues and tumors: from biology to application	62
The key roles of cancer stem cell-derived extracellular vesicles	62
NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease	61
The role of histone modifications: from neurodevelopment to neurodiseases	61
Targeting p53 pathways: mechanisms, structures, and advances in therapy	61
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies	60
The role of histone methylation in the development of digestive cancers: a potential direction for cancer management	60
Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19	60
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients	59
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis	59
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway	59
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules	59
Advances in targeted therapy for malignant lymphoma	58
Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice	58
SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern	58
POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy	58
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19	58
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma	57
Clinical and translational values of spatial transcriptomics	57
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth	57
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19	57
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine	56
Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study	56
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis	56
Targeting lysosomes in human disease: from basic research to clinical applications	55
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment	55
Mesenchymal stem cell therapy for severe COVID-19	55