Signal Transduction and Targeted Therapy

(The H4-Index of Signal Transduction and Targeted Therapy is 125. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Pyroptosis: mechanisms and diseases909
Inflammation and tumor progression: signaling pathways and targeted intervention819
The role of m6A modification in the biological functions and diseases784
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study750
The JAK/STAT signaling pathway: from bench to clinic726
Therapeutic siRNA: state of the art708
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells666
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives664
Microbiota in health and diseases616
Exosomes: key players in cancer and potential therapeutic strategy593
The updated landscape of tumor microenvironment and drug repurposing581
Pattern recognition receptors in health and diseases572
Ferroptosis: mechanisms and links with diseases557
Viral vector platforms within the gene therapy landscape544
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities542
Therapeutic peptides: current applications and future directions542
COVID-19: immunopathogenesis and Immunotherapeutics495
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects461
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets447
Antibody drug conjugate: the “biological missile” for targeted cancer therapy421
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential412
A systematic review of SARS-CoV-2 vaccine candidates397
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials396
Application of exosomes as liquid biopsy in clinical diagnosis390
Targeting PI3K/Akt signal transduction for cancer therapy371
Targeting tumor-associated macrophages to synergize tumor immunotherapy345
FGF/FGFR signaling in health and disease344
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome344
The signal pathways and treatment of cytokine storm in COVID-19342
Circulating tumor cells: biology and clinical significance337
SARS-CoV-2 Omicron variant: recent progress and future perspectives337
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development329
Targeted therapy for hepatocellular carcinoma329
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity325
The interaction between ferroptosis and lipid metabolism in cancer316
Targeting macrophages in cancer immunotherapy307
Copper homeostasis and cuproptosis in health and disease305
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy299
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics293
Overcoming cancer therapeutic bottleneck by drug repurposing293
Extracellular matrix and its therapeutic potential for cancer treatment284
KRAS mutation: from undruggable to druggable in cancer281
Notch signaling pathway: architecture, disease, and therapeutics272
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches272
Stem cell-based therapy for human diseases271
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy268
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer266
Liquid–liquid phase separation in human health and diseases266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation263
G protein-coupled receptors: structure- and function-based drug discovery260
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer255
Lactate metabolism in human health and disease249
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention239
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin239
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial233
Chitinase-3 like-protein-1 function and its role in diseases232
Advances in targeted therapy for esophageal cancer230
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments230
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1230
Targeting circular RNAs as a therapeutic approach: current strategies and challenges226
Regulated cell death (RCD) in cancer: key pathways and targeted therapies217
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling217
Wnt/β-catenin signaling in cancers and targeted therapies216
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications212
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy211
Advances in COVID-19 mRNA vaccine development210
Signaling pathways and targeted therapy for myocardial infarction209
Overview of lethal human coronaviruses206
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19206
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents203
NAD+ metabolism, stemness, the immune response, and cancer201
Regulating tumor suppressor genes: post-translational modifications200
Osteoarthritis: pathogenic signaling pathways and therapeutic targets198
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy196
Targeted protein degradation: mechanisms, strategies and application196
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression191
Alternative splicing and cancer: a systematic review191
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance188
mRNA-based therapeutics: powerful and versatile tools to combat diseases187
From purines to purinergic signalling: molecular functions and human diseases187
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation184
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases184
Comparison of nonhuman primates identified the suitable model for COVID-19183
Targeting TGFβ signal transduction for cancer therapy181
Emerging new therapeutic antibody derivatives for cancer treatment180
Macrophages in immunoregulation and therapeutics180
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial175
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2175
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat174
COVID-19 vaccine development: milestones, lessons and prospects173
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions171
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing169
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration167
Neoantigens: promising targets for cancer therapy166
Radiotherapy combined with immunotherapy: the dawn of cancer treatment166
COVID-19 in early 2021: current status and looking forward163
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases162
Protein kinase CK2: a potential therapeutic target for diverse human diseases160
Trends in insulin resistance: insights into mechanisms and therapeutic strategy159
T cell receptor (TCR) signaling in health and disease158
Structural biology of SARS-CoV-2: open the door for novel therapies152
The sirtuin family in health and disease151
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms150
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response147
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway145
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples142
The BET family in immunity and disease142
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy142
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms141
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events141
Targeting integrin pathways: mechanisms and advances in therapy140
Intercellular mitochondrial transfer as a means of tissue revitalization140
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives140
Targeting non-coding RNAs to overcome cancer therapy resistance138
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies132
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19131
Epigenetic regulation of aging: implications for interventions of aging and diseases131
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals130
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention129
Action mechanisms and research methods of tRNA-derived small RNAs127
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies126
Recent progress in targeted delivery vectors based on biomimetic nanoparticles126
Emerging role of tumor cell plasticity in modifying therapeutic response126
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response125
The blood–brain barrier: structure, regulation, and drug delivery125
The biological applications of DNA nanomaterials: current challenges and future directions125