Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 149. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization1458
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance1431
Greasy hair against obesity1374
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine1198
Correction: The Hippo signalling pathway and its implications in human health and diseases1025
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis1002
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells959
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection844
CD4 T cell contact drives macrophage cell cycle G0-G1 transition834
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver743
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster697
Sensory neurons: unveiling the symphony of wound healing665
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE644
Moving towards precision psychiatry: the hard nut of depression597
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis580
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis577
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics572
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5565
Identification of glutamine as a potential therapeutic target in dry eye disease565
PD-1 and LAG-3: synergistic fostering of T cell exhaustion559
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity557
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion540
A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease530
Phototherapy in cancer treatment: strategies and challenges527
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry516
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis486
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages476
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT473
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity462
Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers462
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms461
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies444
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration436
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study433
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates425
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study419
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells417
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study416
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer416
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders414
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects405
Signal pathways of melanoma and targeted therapy400
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases391
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications385
Animal models for COVID-19: advances, gaps and perspectives378
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance373
Neutrophil extracellular traps in homeostasis and disease372
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness362
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination359
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure359
Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis355
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism350
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss349
Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver342
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis331
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression328
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy317
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth316
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN313
Exploiting a chink in the armor: engineering broadly neutralizing monoclonal antibodies for SARS-like viruses303
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy299
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy299
Top(ological-operon) secret behind the long-range transcriptional coupling298
Omicron spike protein: a clue for viral entry and immune evasion292
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron290
Beyond borders: the choroid plexus-immune communication during neuroinflammation289
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters286
SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes274
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors271
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects266
Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair257
Harnessing innate immune pathways for therapeutic advancement in cancer256
The RING finger protein family in health and disease248
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases245
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies245
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions244
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant241
Microbiota in health and diseases241
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma236
Base editing: a promising tool to rescue spinal muscular atrophy235
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes233
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine231
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread230
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis228
Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape226
Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma223
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer222
Mind-body control: a new perspective on motor neuron function222
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection220
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry220
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease219
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury215
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity215
HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients215
Mitochondrial heterogeneity in diseases213
Persistent SARS-CoV-2 infection in asymptomatic young adults211
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation208
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis207
Small molecules in the treatment of COVID-19206
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury205
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors203
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus203
Linking B cell metabolism to immune regulation: the neurotransmitter GABA199
sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster198
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation198
IRE1α: a gatekeeper of chemotherapy-induced immunogenicity in triple-negative breast cancer197
Nascent mRNA damage: depot and disposal197
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression196
DNA framework signal amplification platform-based high-throughput systemic immune monitoring193
Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies189
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy189
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants188
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia188
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases188
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors187
Lactate metabolism in human health and disease185
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study184
Molecular insights of exercise therapy in disease prevention and treatment183
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy183
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy179
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities177
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets175
Targeting PI3K/Akt signal transduction for cancer therapy172
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization170
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome170
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism165
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle165
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules164
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer163
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice161
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing161
New regulators of systemic iron homeostasis160
Correction: A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins159
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1159
Combination therapy for HCC: from CRISPR screening to the design of clinical therapies157
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection157
Single-cell genomics: the human biomolecular and cell atlases157
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study156
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control155
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation155
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness154
Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells152
Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma152
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication152
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia152
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq152
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants149
Programmable synthetic receptors: the next-generation of cell and gene therapies149
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy149
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