Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 130. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)
ArticleCitations
Novel pyroptosis-independent functions of gasdermins1194
Sensory neurons: unveiling the symphony of wound healing1142
Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-21080
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage1053
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma1052
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment923
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages862
D614G and SARS-CoV-2 replication fitness806
Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery770
Greasy hair against obesity716
Four-wheel-drive immune protection688
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity638
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells619
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders607
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants521
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor475
New case of HIV cure: joined forces of haploidentical stem cells and HLA-mismatched cord blood466
Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway463
An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity457
Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation447
RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation446
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling443
“Clone-specific” antibody-drug conjugates: an innovative strategy in the treatment of T-cell cancers439
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection434
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice413
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys402
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration391
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enh390
Epstein-Barr virus infection: the leading cause of multiple sclerosis386
Mutated trimeric RBD vaccines: a platform against variants of concern386
Tumor-derived miR-20b-5p promotes lymphatic metastasis of esophageal squamous cell carcinoma by remodeling the tumor microenvironment385
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response365
Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents364
A bivalent recombinant vaccine: a promising strategy against both SARS-CoV-2 variants and wild type of the virus360
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity358
Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity355
Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer354
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment339
Mitochondrial apoptosis: facilitator of NK cell-mediated immunotherapy325
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers324
Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant320
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation316
ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer315
Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection308
Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis304
SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency301
CRISPRing the hypertrophic cardiomyopathy: correcting one pathogenic variant at a time300
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis294
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications292
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies290
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway281
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis279
Caspase-7 and acid sphingomyelinase: partner repairmans of gasdermin and perforin pores269
Sera proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers268
Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents265
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer256
Highly efficient gene editing and single cell analysis of hematopoietic stem/progenitor cells from X-linked sideroblastic anemia patients253
Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro242
Unexpected little helpers: microbiota stimulate systemic antiviral defenses241
The beginning of a new era: pioneering direct screens for RNA modulators239
Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit236
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy234
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study234
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma231
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease230
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models229
STING cg16983159 methylation: a key factor for glioblastoma immunosuppression228
STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway222
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients218
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity212
SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies212
Pre-activated macrophage membrane-encased aggregation-induced emission featuring nanoparticles: a novel possibility for tuberculosis treatment210
Longitudinal dynamics of antibody responses in recovered COVID-19 patients209
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver203
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism198
QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study197
A novel alternative for pyrogen detection based on a transgenic cell line197
Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma197
SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway196
Ketogenic diet: new avenues to overcome colorectal cancer196
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness195
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition193
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster193
Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies188
Beyond the code: the role of histone methylation in cancer resistance and therapy187
Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes187
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis186
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation183
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure182
SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)181
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation179
Acetylshikonin inhibits inflammatory responses and Papain-like protease activity in murine model of COVID-19178
Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization177
Myeloid cells in COVID-19 microenvironment177
LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury175
Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses173
An emerging artificial nanomachine: a nanoengine with a reversible clutch172
Cancer metastasis chemoprevention prevents circulating tumour cells from germination169
Supporting tumor therapy by exercise: boosting T cell immunity by myokines167
For the sake of longevity: eating less and eating at the right time165
Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity164
Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response164
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates163
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer163
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation159
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)155
COVID-19 vaccine development: milestones, lessons and prospects155
Signal pathways of melanoma and targeted therapy155
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc154
Advances in COVID-19 mRNA vaccine development153
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE152
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets149
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity149
Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia145
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells142
CD5: from antiquated T cell marker to immunotherapy’s new hope142
Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment141
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques139
Segregating memories: targeting microenvironment of neuronal ensembles139
SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis138
Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease136
Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy136
FAP senescence: a critical event in muscle regeneration134
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin134
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing134
Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy132
Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma132
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial131
The regulation of protein translation and its implications for cancer130
Animal models for COVID-19: advances, gaps and perspectives130
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study130
0.058825969696045