Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 120. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Pyroptosis: mechanisms and diseases829
Inflammation and tumor progression: signaling pathways and targeted intervention726
The role of m6A modification in the biological functions and diseases710
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study669
Therapeutic siRNA: state of the art661
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells649
The JAK/STAT signaling pathway: from bench to clinic639
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives600
Exosomes: key players in cancer and potential therapeutic strategy559
The updated landscape of tumor microenvironment and drug repurposing549
Pattern recognition receptors in health and diseases505
Microbiota in health and diseases504
Viral vector platforms within the gene therapy landscape503
Ferroptosis: mechanisms and links with diseases498
COVID-19: immunopathogenesis and Immunotherapeutics478
Therapeutic peptides: current applications and future directions459
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer457
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities454
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2431
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects419
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets410
A systematic review of SARS-CoV-2 vaccine candidates392
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential380
Application of exosomes as liquid biopsy in clinical diagnosis373
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials371
Antibody drug conjugate: the “biological missile” for targeted cancer therapy365
The signal pathways and treatment of cytokine storm in COVID-19331
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome330
FGF/FGFR signaling in health and disease319
Targeting tumor-associated macrophages to synergize tumor immunotherapy314
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development312
SARS-CoV-2 Omicron variant: recent progress and future perspectives310
Targeted therapy for hepatocellular carcinoma303
Targeting PI3K/Akt signal transduction for cancer therapy299
Circulating tumor cells: biology and clinical significance298
Overcoming cancer therapeutic bottleneck by drug repurposing287
Targeting macrophages in cancer immunotherapy287
The interaction between ferroptosis and lipid metabolism in cancer283
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity279
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches266
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation255
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics254
KRAS mutation: from undruggable to druggable in cancer251
Extracellular matrix and its therapeutic potential for cancer treatment251
G protein-coupled receptors: structure- and function-based drug discovery241
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy238
Liquid–liquid phase separation in human health and diseases236
Copper homeostasis and cuproptosis in health and disease236
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin236
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy233
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer231
Notch signaling pathway: architecture, disease, and therapeutics228
Stem cell-based therapy for human diseases224
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial222
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer218
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1214
Targeting circular RNAs as a therapeutic approach: current strategies and challenges213
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling212
Advances in targeted therapy for esophageal cancer211
Lactate metabolism in human health and disease208
Chitinase-3 like-protein-1 function and its role in diseases207
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis203
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19203
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy201
Overview of lethal human coronaviruses201
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention192
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents188
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications187
NAD+ metabolism, stemness, the immune response, and cancer186
Regulating tumor suppressor genes: post-translational modifications185
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy185
Wnt/β-catenin signaling in cancers and targeted therapies185
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance183
Advances in COVID-19 mRNA vaccine development181
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression179
Comparison of nonhuman primates identified the suitable model for COVID-19179
Alternative splicing and cancer: a systematic review177
Signaling pathways and targeted therapy for myocardial infarction176
Regulated cell death (RCD) in cancer: key pathways and targeted therapies174
Targeting TGFβ signal transduction for cancer therapy173
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation172
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial170
From purines to purinergic signalling: molecular functions and human diseases169
Targeted protein degradation: mechanisms, strategies and application166
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2165
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments165
mRNA-based therapeutics: powerful and versatile tools to combat diseases165
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat162
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases159
COVID-19 in early 2021: current status and looking forward159
Osteoarthritis: pathogenic signaling pathways and therapeutic targets154
Emerging new therapeutic antibody derivatives for cancer treatment154
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration153
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing152
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases151
Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells148
COVID-19 vaccine development: milestones, lessons and prospects148
Radiotherapy combined with immunotherapy: the dawn of cancer treatment144
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response142
Protein kinase CK2: a potential therapeutic target for diverse human diseases141
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms141
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples140
Structural biology of SARS-CoV-2: open the door for novel therapies139
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms138
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions138
A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia135
Trends in insulin resistance: insights into mechanisms and therapeutic strategy133
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events133
T cell receptor (TCR) signaling in health and disease132
Intercellular mitochondrial transfer as a means of tissue revitalization132
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway129
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives127
The BET family in immunity and disease127
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals126
Macrophages in immunoregulation and therapeutics123
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy123
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19122
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies121
The sirtuin family in health and disease121
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies120
0.030365943908691