Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)
ArticleCitations
Pyroptosis: mechanisms and diseases943
Inflammation and tumor progression: signaling pathways and targeted intervention858
The role of m6A modification in the biological functions and diseases810
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study778
The JAK/STAT signaling pathway: from bench to clinic765
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives687
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells679
Microbiota in health and diseases675
Exosomes: key players in cancer and potential therapeutic strategy608
The updated landscape of tumor microenvironment and drug repurposing601
Pattern recognition receptors in health and diseases596
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities584
Ferroptosis: mechanisms and links with diseases579
Therapeutic peptides: current applications and future directions568
Viral vector platforms within the gene therapy landscape565
COVID-19: immunopathogenesis and Immunotherapeutics504
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets475
Antibody drug conjugate: the “biological missile” for targeted cancer therapy451
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential427
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials411
Targeting PI3K/Akt signal transduction for cancer therapy408
A systematic review of SARS-CoV-2 vaccine candidates398
Application of exosomes as liquid biopsy in clinical diagnosis398
Targeting tumor-associated macrophages to synergize tumor immunotherapy357
FGF/FGFR signaling in health and disease355
Circulating tumor cells: biology and clinical significance352
The signal pathways and treatment of cytokine storm in COVID-19350
SARS-CoV-2 Omicron variant: recent progress and future perspectives350
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome349
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity343
Copper homeostasis and cuproptosis in health and disease340
Targeted therapy for hepatocellular carcinoma340
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development335
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy330
Targeting macrophages in cancer immunotherapy323
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics313
Extracellular matrix and its therapeutic potential for cancer treatment304
KRAS mutation: from undruggable to druggable in cancer302
Notch signaling pathway: architecture, disease, and therapeutics301
Stem cell-based therapy for human diseases299
Overcoming cancer therapeutic bottleneck by drug repurposing298
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy281
Liquid–liquid phase separation in human health and diseases278
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer276
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches275
Lactate metabolism in human health and disease271
G protein-coupled receptors: structure- and function-based drug discovery270
SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation268
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer267
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention266
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments251
Chitinase-3 like-protein-1 function and its role in diseases237
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1236
Targeting circular RNAs as a therapeutic approach: current strategies and challenges236
Advances in targeted therapy for esophageal cancer234
Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial234
Advances in COVID-19 mRNA vaccine development229
Regulated cell death (RCD) in cancer: key pathways and targeted therapies227
Signaling pathways and targeted therapy for myocardial infarction226
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications224
Wnt/β-catenin signaling in cancers and targeted therapies224
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling222
Osteoarthritis: pathogenic signaling pathways and therapeutic targets222
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy214
Macrophages in immunoregulation and therapeutics212
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19207
NAD+ metabolism, stemness, the immune response, and cancer206
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents205
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy205
Targeted protein degradation: mechanisms, strategies and application202
mRNA-based therapeutics: powerful and versatile tools to combat diseases201
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases199
Alternative splicing and cancer: a systematic review195
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression195
From purines to purinergic signalling: molecular functions and human diseases194
Emerging new therapeutic antibody derivatives for cancer treatment189
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance189
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation186
Targeting TGFβ signal transduction for cancer therapy186
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions184
Comparison of nonhuman primates identified the suitable model for COVID-19184
COVID-19 vaccine development: milestones, lessons and prospects181
Neoantigens: promising targets for cancer therapy180
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial178
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat175
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing175
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2175
Radiotherapy combined with immunotherapy: the dawn of cancer treatment172
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration171
Trends in insulin resistance: insights into mechanisms and therapeutic strategy171
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases166
COVID-19 in early 2021: current status and looking forward165
T cell receptor (TCR) signaling in health and disease163
Protein kinase CK2: a potential therapeutic target for diverse human diseases162
The sirtuin family in health and disease161
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway157
Structural biology of SARS-CoV-2: open the door for novel therapies157
Targeting integrin pathways: mechanisms and advances in therapy154
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms152
The blood–brain barrier: structure, regulation, and drug delivery149
Intercellular mitochondrial transfer as a means of tissue revitalization148
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response147
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy146
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives145
Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples144
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events143
The BET family in immunity and disease142
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms142
Epigenetic regulation of aging: implications for interventions of aging and diseases141
Targeting non-coding RNAs to overcome cancer therapy resistance141
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions137
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies136
Recent progress in targeted delivery vectors based on biomimetic nanoparticles136
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response136
Targeting fibrosis: mechanisms and clinical trials134
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19134
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention133
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals132
Signal pathways of melanoma and targeted therapy132
The biological applications of DNA nanomaterials: current challenges and future directions131
Emerging role of tumor cell plasticity in modifying therapeutic response130
Angiogenic signaling pathways and anti-angiogenic therapy for cancer124
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota124
Inflammation and aging: signaling pathways and intervention therapies124
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