Signal Transduction and Targeted Therapy

Article	Citations
Greasy hair against obesity	1995
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	1753
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	1642
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	1337
Moving towards precision psychiatry: the hard nut of depression	1228
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis	1208
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics	1067
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	1004
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	982
A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease	961
Identification of glutamine as a potential therapeutic target in dry eye disease	946
Correction: The Hippo signalling pathway and its implications in human health and diseases	879
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	874
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	869
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	834
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	817
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	781
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	780
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma	769
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	769
Dopamine as a teaching signal: understanding its role in shaping individual behavior	764
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5	763
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	756
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT	749
PD-1 and LAG-3: synergistic fostering of T cell exhaustion	735

Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	735
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine	718
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	693
Sensory neurons: unveiling the symphony of wound healing	652
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	622
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study	602
Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	599
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	594
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies	590
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	570
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	570
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	570
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance	561
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	549
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	540
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	539
Animal models for COVID-19: advances, gaps and perspectives	534
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	530
Neutrophil extracellular traps in homeostasis and disease	529
Phototherapy in cancer treatment: strategies and challenges	518
Signal pathways of melanoma and targeted therapy	514
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination	511
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies	510
“Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis	502
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection	488
Top(ological-operon) secret behind the long-range transcriptional coupling	487
Omicron spike protein: a clue for viral entry and immune evasion	478
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth	476
Beyond borders: the choroid plexus-immune communication during neuroinflammation	470
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron	454
Platelets and diseases: signal transduction and advances in targeted therapy	451
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN	450
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters	448
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects	447
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy	438
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression	437
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy	429
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant	427
D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma	417
Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver	416
The RING finger protein family in health and disease	413
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism	395
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors	384
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis	382
SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes	380
Harnessing innate immune pathways for therapeutic advancement in cancer	365
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy	361
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss	358
Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair	356
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases	356

Microbiota in health and diseases	351
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	347
Mind-body control: a new perspective on motor neuron function	344
Base editing: a promising tool to rescue spinal muscular atrophy	340
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis	334
Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape	329
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine	323
High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming	323
IRE1α: a gatekeeper of chemotherapy-induced immunogenicity in triple-negative breast cancer	316
Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors	313
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection	312
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer	310
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance	303
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury	302
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes	297
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity	294
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation	293
sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster	292
Nascent mRNA damage: depot and disposal	285
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury	284
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus	275
Linking B cell metabolism to immune regulation: the neurotransmitter GABA	275
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia	275
Persistent SARS-CoV-2 infection in asymptomatic young adults	275
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression	272
DNA framework signal amplification platform-based high-throughput systemic immune monitoring	272
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread	271
Mitochondrial heterogeneity in diseases	269
Molecular insights of exercise therapy in disease prevention and treatment	268
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis	268
Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies	266
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations	266
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors	260
Small molecules in the treatment of COVID-19	252
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome	251
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases	248
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization	247
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	246
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease	245
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation	240
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants	238
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy	235
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study	235
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets	233
Targeting PI3K/Akt signal transduction for cancer therapy	233
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors	233
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	231
Lactate metabolism in human health and disease	228
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	225
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2	221
Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma	220
Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function	219
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting	219
Single-cell genomics: the human biomolecular and cell atlases	214
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules	213
Back to pluripotency: fully chemically induced reboot of human somatic cells	211
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors	210
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer	209
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing	207
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection	206
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism	206
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics	205
Liquid biomarkers associate with TGF-β Type I receptor and hypoxia in kidney cancer	205
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1	205
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy	204
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus	203
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation	201
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration	199
Programmable synthetic receptors: the next-generation of cell and gene therapies	198
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control	198
Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells	196
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study	196
Current landscape of innovative drug development and regulatory support in China	196
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation	194
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice	194
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants	190
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness	190
Glioblastoma at the crossroads: current understanding and future therapeutic horizons	190
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling	189
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	188

mRNA-based therapeutics: powerful and versatile tools to combat diseases	181
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle	180
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer	180
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication	179
Signaling pathways and targeted therapies for psoriasis	175
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	174
Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance	173
Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing	173
Activated STING: an ion channel to trigger non-interferon-related functions	173
Time’s up: mutation rate and lifespan	171
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes	167
Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution	167
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts	167
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation	167