Signal Transduction and Targeted Therapy

Article	Citations
Greasy hair against obesity	1716
Cocktails of defined chemical compounds: sufficient to induce totipotency in embryonic stem cells	1561
Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection	1405
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver	1179
Robust neutralizing antibody response to the XBB.1.5 trivalent recombinant protein vaccine booster	1088
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE	1007
Moving towards precision psychiatry: the hard nut of depression	982
Correction: Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis	956
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies	818
Dietary restriction interventions: lifespan benefits need resilience and are limited by immune compromise and genetics	818
Boosting liver regeneration: kinase inhibitor as a new tool to prevent liver failure	760
PD-1 and LAG-3: synergistic fostering of T cell exhaustion	752
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5	715
A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease	710
Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion	686
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine	681
Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry	679
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages	658
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis	657
Next-generation mpox vaccines: efficacy of mRNA-1769 compared to modified vaccinia virus Ankara in non-human primates	656
Massively parallel interrogation of human functional variants modulating cancer immunosurveillance	655
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study	651
Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis	649
Animal models for COVID-19: advances, gaps and perspectives	648
Correction: The Hippo signalling pathway and its implications in human health and diseases	645

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells	634
CD4 T cell contact drives macrophage cell cycle G0-G1 transition	595
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer	595
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study	551
Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study	550
Identification of glutamine as a potential therapeutic target in dry eye disease	536
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects	535
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis	511
Sensory neurons: unveiling the symphony of wound healing	504
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases	489
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders	488
Signal pathways of melanoma and targeted therapy	479
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness	478
Phototherapy in cancer treatment: strategies and challenges	477
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance	471
Neutrophil extracellular traps in homeostasis and disease	462
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms	458
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration	454
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT	446
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications	443
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy	439
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth	439
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors	432
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies	427
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy	425
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN	423
Top(ological-operon) secret behind the long-range transcriptional coupling	413
Omicron spike protein: a clue for viral entry and immune evasion	403
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters	389
From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism	387
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination	377
D-lactate and glycerol as potential biomarkers of sorafenib activity in hepatocellular carcinoma	370
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron	370
Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver	360
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant	359
Platelets and diseases: signal transduction and advances in targeted therapy	355
Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair	351
Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis	350
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis	348
Beyond borders: the choroid plexus-immune communication during neuroinflammation	344
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma	340
Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy	336
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects	331
Harnessing innate immune pathways for therapeutic advancement in cancer	329
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression	316
SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes	315
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases	315
The RING finger protein family in health and disease	306
Microbiota in health and diseases	302
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss	301

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions	299
Base editing: a promising tool to rescue spinal muscular atrophy	295
Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes	291
Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine	285
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis	284
Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape	281
Mind-body control: a new perspective on motor neuron function	276
Persistent SARS-CoV-2 infection in asymptomatic young adults	275
Metaplastic epithelial cells: origination from stem cells and promotion of intestinal inflammation	274
sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster	272
Nascent mRNA damage: depot and disposal	268
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury	261
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations	259
IRE1α: a gatekeeper of chemotherapy-induced immunogenicity in triple-negative breast cancer	251
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors	248
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants	247
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors	245
Waning humoral immune responses to inactivated SARS-CoV-2 vaccines in patients with severe liver disease	243
Multicenter phase 1/2 study of onatasertib, a dual TORC1/2 inhibitor, combined with the PD-1 antibody toripalimab in advanced solid tumors	240
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression	240
Linking B cell metabolism to immune regulation: the neurotransmitter GABA	239
Small molecules in the treatment of COVID-19	238
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread	235
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis	235
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus	234
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation	232
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization	232
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury	228
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection	227
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity	227
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer	227
Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies	227
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia	227
Lactate metabolism in human health and disease	225
DNA framework signal amplification platform-based high-throughput systemic immune monitoring	223
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy	219
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities	216
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome	216
Mitochondrial heterogeneity in diseases	216
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy	215
Targeting PI3K/Akt signal transduction for cancer therapy	215
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases	214
Molecular insights of exercise therapy in disease prevention and treatment	212
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy	210
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study	209
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets	209
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules	205
Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control	204
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus	200
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation	198
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection	194
Glioblastoma at the crossroads: current understanding and future therapeutic horizons	191
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice	184
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness	183
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia	183
Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study	181
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling	180
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants	178
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting	178
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy	178
RNA interfering machinery: new insight into the Dicer-2 complexes in the dsRNA-processing cycle	177
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer	177
Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function	175
Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma	174
Single-cell genomics: the human biomolecular and cell atlases	174
Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells	172
Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics	172
Programmable synthetic receptors: the next-generation of cell and gene therapies	169
Current landscape of innovative drug development and regulatory support in China	168
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer	167
Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism	164
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19	163
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication	162
Combination therapy for HCC: from CRISPR screening to the design of clinical therapies	162
Back to pluripotency: fully chemically induced reboot of human somatic cells	159
Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration	159
Angiogenic signaling pathways and anti-angiogenic therapy for cancer	157
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer	157
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors	157
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing	157

RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation	156
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1	156