Signal Transduction and Targeted Therapy

Papers
(The H4-Index of Signal Transduction and Targeted Therapy is 125. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Pyroptosis: mechanisms and diseases1076
Inflammation and tumor progression: signaling pathways and targeted intervention1001
The JAK/STAT signaling pathway: from bench to clinic941
The role of m6A modification in the biological functions and diseases931
Microbiota in health and diseases836
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives769
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities737
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells692
Pattern recognition receptors in health and diseases685
Therapeutic peptides: current applications and future directions674
Ferroptosis: mechanisms and links with diseases647
Viral vector platforms within the gene therapy landscape646
Antibody drug conjugate: the “biological missile” for targeted cancer therapy549
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets527
Targeting PI3K/Akt signal transduction for cancer therapy506
Copper homeostasis and cuproptosis in health and disease444
Targeting tumor-associated macrophages to synergize tumor immunotherapy416
Circulating tumor cells: biology and clinical significance406
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity404
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy394
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics392
SARS-CoV-2 Omicron variant: recent progress and future perspectives381
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome380
Stem cell-based therapy for human diseases380
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments367
The signal pathways and treatment of cytokine storm in COVID-19365
Notch signaling pathway: architecture, disease, and therapeutics365
Extracellular matrix and its therapeutic potential for cancer treatment361
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development356
Targeting macrophages in cancer immunotherapy354
KRAS mutation: from undruggable to druggable in cancer353
Lactate metabolism in human health and disease349
Macrophages in immunoregulation and therapeutics341
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy340
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention338
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer328
Osteoarthritis: pathogenic signaling pathways and therapeutic targets319
Liquid–liquid phase separation in human health and diseases313
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer308
G protein-coupled receptors: structure- and function-based drug discovery305
Regulated cell death (RCD) in cancer: key pathways and targeted therapies292
Signaling pathways and targeted therapy for myocardial infarction281
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches276
Wnt/β-catenin signaling in cancers and targeted therapies273
Targeting circular RNAs as a therapeutic approach: current strategies and challenges262
Advances in COVID-19 mRNA vaccine development261
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1258
Targeted protein degradation: mechanisms, strategies and application254
mRNA-based therapeutics: powerful and versatile tools to combat diseases250
The blood–brain barrier: Structure, regulation and drug delivery245
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases244
Neoantigens: promising targets for cancer therapy241
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy235
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions232
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions229
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy227
NAD+ metabolism, stemness, the immune response, and cancer226
Radiotherapy combined with immunotherapy: the dawn of cancer treatment225
The sirtuin family in health and disease225
Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents221
Targeting integrin pathways: mechanisms and advances in therapy220
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling220
Trends in insulin resistance: insights into mechanisms and therapeutic strategy218
Emerging new therapeutic antibody derivatives for cancer treatment218
From purines to purinergic signalling: molecular functions and human diseases215
Role of neuroinflammation in neurodegeneration development211
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation209
COVID-19 vaccine development: milestones, lessons and prospects208
Alternative splicing and cancer: a systematic review207
Angiogenic signaling pathways and anti-angiogenic therapy for cancer202
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing201
T cell receptor (TCR) signaling in health and disease197
Targeting TGFβ signal transduction for cancer therapy196
Inflammation and aging: signaling pathways and intervention therapies194
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance193
Epigenetic regulation of aging: implications for interventions of aging and diseases186
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases184
Protein kinase CK2: a potential therapeutic target for diverse human diseases181
Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial181
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration181
Structural biology of SARS-CoV-2: open the door for novel therapies176
Targeting non-coding RNAs to overcome cancer therapy resistance175
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2175
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy175
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future171
Small molecule metabolites: discovery of biomarkers and therapeutic targets168
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway166
Intercellular mitochondrial transfer as a means of tissue revitalization165
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response165
COVID-19 in early 2021: current status and looking forward165
Targeting p53 pathways: mechanisms, structures and advances in therapy162
The Hippo signalling pathway and its implications in human health and diseases161
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives161
Targeting fibrosis: mechanisms and clinical trials158
The BET family in immunity and disease156
The biological applications of DNA nanomaterials: current challenges and future directions153
T cells in health and disease153
Human organoids in basic research and clinical applications151
CRISPR/Cas9 therapeutics: progress and prospects150
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events149
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies148
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics147
Recent progress in targeted delivery vectors based on biomimetic nanoparticles146
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response145
Signal pathways of melanoma and targeted therapy145
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19145
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms144
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations142
Mitochondrial dynamics in health and disease: mechanisms and potential targets141
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention141
Signaling pathways in obesity: mechanisms and therapeutic interventions139
AlphaFold2 and its applications in the fields of biology and medicine136
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota134
Kidney fibrosis: from mechanisms to therapeutic medicines133
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)133
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets133
Nanomedicine in cancer therapy132
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer131
Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties131
Vaccine adjuvants: mechanisms and platforms130
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion130
Immunosenescence: molecular mechanisms and diseases127
Artificial intelligence in cancer target identification and drug discovery126
Inflammasomes as therapeutic targets in human diseases125
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics125
1.0243110656738