Cell Death Discovery

Article	Citations
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases	311
A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer	294
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes	185
Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma	142
Ferroptosis in liver disease: new insights into disease mechanisms	126
Progress in understanding the role of lncRNA in programmed cell death	115
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury	114
Recent progress in ferroptosis: inducers and inhibitors	109
Role of interleukins in the pathogenesis of pulmonary fibrosis	108
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice	91
ROS induces NETosis by oxidizing DNA and initiating DNA repair	78
snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology	74
Role of the nervous system in cancers: a review	70
The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis	70
The role of ferroptosis in breast cancer patients: a comprehensive analysis	69
O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer	68
The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer	68
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells	68
Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury	66
Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma	66
GPX4-independent ferroptosis—a new strategy in disease’s therapy	64
Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis	62
Mitochondrial event as an ultimate step in ferroptosis	61
NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin	59
Periodontitis-level butyrate-induced ferroptosis in periodontal ligament fibroblasts by activation of ferritinophagy	58

Liquid biopsies and cancer omics	56
SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?	56
Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice	55
Implication of ferroptosis in aging	55
Glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment	54
Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model	54
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway	54
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis	53
Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy	53
Role of ferroptosis on tumor progression and immunotherapy	51
Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress	48
Human pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing	48
Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer	48
m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis	47
Emerging roles of ferroptosis in cardiovascular diseases	47
Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis	47
Long COVID: an estrogen-associated autoimmune disease?	46
Molecular mechanism of cell ferroptosis and research progress in regulation of ferroptosis by noncoding RNAs in tumor cells	45
Platinum drugs and taxanes: can we overcome resistance?	44
METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice	44
The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells	44
Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis	44
IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury	43
RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner	43
Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis	43
Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice	43
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients	42
The role of CXCL family members in different diseases	42
Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis	42
PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway	42
Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis	41
Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis	41
Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI	41
LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome	41
Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury	40
Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related ge	40
Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1	40
Effect of endothelial progenitor cell-derived extracellular vesicles on endothelial cell ferroptosis and atherosclerotic vascular endothelial injury	40
Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy	40
Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3	39
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells	39
Cell pyroptosis in health and inflammatory diseases	39
Genome-scale CRISPR-Cas9 knockout screening in hepatocellular carcinoma with lenvatinib resistance	38
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner	38
Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis	38
Long-term SARS-CoV-2 RNA shedding and its temporal association to IgG seropositivity	38
Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway	38
KLF4 transcription factor in tumorigenesis	37
Drug toxicity assessment: cell proliferation versus cell death	37
Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis	37

Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer	36
Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor	36
Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins	36
Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury	35
IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m6A/FOXM1 manner	35
Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI	35
YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis	35
MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models	35
Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment	34
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis	34
Hippo signaling pathway and respiratory diseases	34
ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking	33
Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance	33
Overexpression of circRNA SNRK targets miR-103-3p to reduce apoptosis and promote cardiac repair through GSK3β/β-catenin pathway in rats with myocardial infarction	33
SIRT1 attenuates renal fibrosis by repressing HIF-2α	33
Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases	33
LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside	33
Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages	32
Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205	32
METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism	32
Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis	32
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling	32
METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246	32
Hypoxic TAM-derived exosomal miR-155-5p promotes RCC progression through HuR-dependent IGF1R/AKT/PI3K pathway	32
Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review	32
CircRNA circ-NNT mediates myocardial ischemia/reperfusion injury through activating pyroptosis by sponging miR-33a-5p and regulating USP46 expression	32
Research progress on the tsRNA classification, function, and application in gynecological malignant tumors	32
Radiation-induced liver injury and hepatocyte senescence	32
Targeting pyroptosis as a preventive and therapeutic approach for stroke	31
RNA-binding protein 39: a promising therapeutic target for cancer	31
Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4	31
ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma	31
mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway	31
FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner	31
ACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis	30
Single cell RNA sequencing for breast cancer: present and future	30
LHPP suppresses colorectal cancer cell migration and invasion in vitro and in vivo by inhibiting Smad3 phosphorylation in the TGF-β pathway	30
Cancer-associated fibroblasts induce growth and radioresistance of breast cancer cells through paracrine IL-6	30
Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow	30
Emerging multifaceted roles of BAP1 complexes in biological processes	30
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy	30
Targeting CK2 in cancer: a valuable strategy or a waste of time?	30
Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients	29
Oxeiptosis: a novel pathway of melanocytes death in response to oxidative stress in vitiligo	29
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis	29
Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases	29
Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the Xc--GPX4 system	29
Transcriptional and genetic alterations of cuproptosis-related genes correlated to malignancy and immune-infiltrate of esophageal carcinoma	29
HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction	28
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients	28
TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells	28
Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease	28
YWHAZ interacts with DAAM1 to promote cell migration in breast cancer	28
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling	28
Canagliflozin protects against cisplatin-induced acute kidney injury by AMPK-mediated autophagy in renal proximal tubular cells	28
Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging	28
MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma	28
Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models	28
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer	27
tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application	27
Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance	27
Long noncoding RNAs: fine-tuners hidden in the cancer signaling network	27
The roles of osteoprotegerin in cancer, far beyond a bone player	27
BMSC-derived exosomes from congenital polydactyly tissue alleviate osteoarthritis by promoting chondrocyte proliferation	27
CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis	27
Regulatory T cell and macrophage crosstalk in acute lung injury: future perspectives	27
Ferroptosis and the bidirectional regulatory factor p53	27
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis	27
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2	27
GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway	27
ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability	27
Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway	26
m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability	26
Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis	26
Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells	26
Zika virus infection induces endoplasmic reticulum stress and apoptosis in placental trophoblasts	26
BMP signaling is a therapeutic target in ovarian cancer	26
CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis	26
miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin	26
NLRP3 associated with chronic kidney disease progression after ischemia/reperfusion-induced acute kidney injury	26

GSK-3β manipulates ferroptosis sensitivity by dominating iron homeostasis	25
The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway	25
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA	25
The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects	25
miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE	25
ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway	25
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways	25
N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability	25
Role of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma	25
Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice	25
A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma	25
LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B	25
N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner	24
Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma	24
Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway	24
NLRP3 inflammasome promoted the malignant progression of prostate cancer via the activation of caspase-1	24
Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells	24
Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer	24
Regulatory T cells (Tregs) in liver fibrosis	24
The emerging role of WWP1 in cancer development and progression	24
Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling	24
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury	24
Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma	23
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis	23
Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role	23
Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture models	23
Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression	23
MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia	23
MiRNA-132/212 regulates tight junction stabilization in blood–brain barrier after stroke	23
Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets	23
ALKBH5-mediated N6-methyladenosine modification of TRERNA1 promotes DLBCL proliferation via p21 downregulation	23
Ferroptosis: a new approach for immunotherapy	23
The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson’s disease is promoted by conserved oxidation sites	22
Carcinoma associated fibroblasts small extracellular vesicles with low miR-7641 promotes breast cancer stemness and glycolysis by HIF-1α	22
Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer	22
Zika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids	22
Targeting tumor innervation: premises, promises, and challenges	22
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis	22
Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer	22
The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting	22
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro	22
T cells in idiopathic pulmonary fibrosis: crucial but controversial	22
EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway	22
Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysis	22
Different types of cell death and their shift in shaping disease	22
Mitochondrial DNA leakage exacerbates odontoblast inflammation through gasdermin D-mediated pyroptosis	22
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner	22
Biological functions and clinical significance of long noncoding RNAs in bladder cancer	22
Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein	21
MicroRNA-181a–2–3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson’s disease by inhibiting EGR1 and NOX4	21
Inflammation in myocardial infarction: roles of mesenchymal stem cells and their secretome	21
SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA	21
Single-cell RNA transcriptome reveals the intra-tumoral heterogeneity and regulators underlying tumor progression in metastatic pancreatic ductal adenocarcinoma	21
Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions	21
N6-methyladenosine (m6A) methyltransferase METTL3-mediated LINC00680 accelerates osteoarthritis through m6A/SIRT1 manner	21
HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer	21
Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer	21
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice	21
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress	21
Gut microbiota and microbiota-derived metabolites promotes endometriosis	21
Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation	21
Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization	21
Integrated analysis of high-throughput sequencing data reveals the key role of LINC00467 in the invasion and metastasis of testicular germ cell tumors	21
Pro-angiognetic and pro-osteogenic effects of human umbilical cord mesenchymal stem cell-derived exosomal miR-21-5p in osteonecrosis of the femoral head	21
Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis	20
Androgen receptor regulates eIF5A2 expression and promotes prostate cancer metastasis via EMT	20
N6-methyladenosine (m6A) methyltransferase KIAA1429 accelerates the gefitinib resistance of non-small-cell lung cancer	20
Nrf2: a dark horse in doxorubicin-induced cardiotoxicity	20
microRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis	20
The role of integrin family in bone metabolism and tumor bone metastasis	20
DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9	20
Role of K63-linked ubiquitination in cancer	20
Cell death affecting the progression of gastric cancer	20
Immune dysregulation in sepsis: experiences, lessons and perspectives	20
RCN1 induces sorafenib resistance and malignancy in hepatocellular carcinoma by activating c-MYC signaling via the IRE1α–XBP1s pathway	20
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling	20
NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosis	20
A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment	20
MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling	19
Synergistic mechanism between the endoplasmic reticulum and mitochondria and their crosstalk with other organelles	19
LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2	19
LncRNA XIST accelerates burn wound healing by promoting M2 macrophage polarization through targeting IL-33 via miR-19b	19
miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting β-catenin/SOX9/TGF-β1 pathway	19
The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury	19
Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation	19
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma	19
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer	19
microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeti	19
CircETFA upregulates CCL5 by sponging miR-612 and recruiting EIF4A3 to promote hepatocellular carcinoma	19
Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models	19
TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis	19
Molecular mechanism of m6A methylation of circDLC1 mediated by RNA methyltransferase METTL3 in the malignant proliferation of glioma cells	19
MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3	19
MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma	19
Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression	19