OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death Discovery is 71. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model	588
MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway	303
AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression	268
Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion	258
Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death	248
N6-methyladenosine: a key regulator in ocular disease mechanisms and treatment	241
Matrix metalloproteinase-10 promotes kidney fibrosis by transactivating β-catenin signaling	186
USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression	185
The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics	171
Retraction Note to: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast	164
GILT stabilizes cofilin to promote the metastasis of prostate cancer	154
Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis	154
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1	151
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma	150
MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1	147
IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10	142
Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42	138
Replication stress primes a trophectoderm fate in embryonic stem cells	137
Radiobiological characterisation of a 28 MeV proton beam delivered by the MC-40 cyclotron	135
An electrophysiological and proteomics roadmap for human induced glutamatergic neurons: fine-tuning of culture conditions for pathophysiological studies	127
ATP binding to lysozyme and superfolder GFP amyloid fibrils induces aggregate remodeling and attenuates their cytotoxicity	126
Transcriptional activation of PINK1 by MyoD1 mediates mitochondrial homeostasis to induce renal calcification in pediatric nephrolithiasis	123
FKBP5 isoforms shape immune pathways related to tumor tolerance	120
Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis	116
Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis	115

ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues	115
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins	115
Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis	114
Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation	112
RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation	110
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury	109
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism	107
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction	105
The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation	105
FOXM1 inhibition primes terminal differentiation of human iPSC-derived hepatocytes	104
Exosomal circRNAs: key modulators in breast cancer progression	104
Dual control of liver regeneration by Nr1d1 homeostasis and Klf2 checkpoint	103
Smoking-induced microbial dysbiosis: a key driver of systemic diseases and emerging therapeutic opportunities	102
Oncometabolite signatures from tumor-stroma crosstalk as potential non-invasive biomarkers	101
CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH	99
Epitranscriptomic control of cancer: the emerging roles of m⁵C and ac⁴C RNA modifications	98
CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma	93
Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials	92
Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis	89
Stem cell-derived intestinal organoids: a novel modality for IBD	88
Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications	87
Absence of Rnf126 causes male infertility with multiple morphological abnormalities of the sperm flagella	87
The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer	87
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis	87
Cellular senescence of renal tubular epithelial cells in acute kidney injury	87
New insights into constitutive neutrophil death	86
STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction	85
Diverse functions of NLRP3 inflammasome in PANoptosis and diseases	84
Lipids associated with autophagy: mechanisms and therapeutic targets	83
Targeting mitochondrial autophagy for anti-aging	81
USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target	81
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44	81
Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma	81
Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions	79
Tissue microenvironment induces tissue specificity of ILC2	79
Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma	78
MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway	77
In vitro cytotoxic mechanisms of Pt(O,O′-acac)(γ-acac)(DMS): mitochondrial dysfunction and impaired autophagy in U251 cell line	77
Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity	77
Differential effects of HDAC inhibitors in the RhoI255d mouse model for autosomal dominant retinitis pigmentosa	77
Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress	76
Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy	76
CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila	75
Neddylation inhibition induces DNA double-strand breaks, hampering tumor growth in vivo, and promotes radiosensitivity in PAX3–FOXO1 rhabdomyosarcoma	74
NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes	73
Correction: Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis	73
Modulation of stress granules by lobeline increases cell death in hypoxia and impacts the ability of glioblastoma cells to secrete extracellular vesicles	71