OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death Discovery is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis	489
Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model	289
MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway	246
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44	230
AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression	227
PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway	201
Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion	174
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction	164
An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth	147
Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death	147
STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction	146
ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues	141
Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma	139
Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation	137
N6-methyladenosine: a key regulator in ocular disease mechanisms and treatment	135
New insights into constitutive neutrophil death	132
CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma	127
RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation	125
Matrix metalloproteinase-10 promotes kidney fibrosis by transactivating β-catenin signaling	118
USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression	117
The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics	117
Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials	116
Retraction Note to: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast	114
MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1	112
GILT stabilizes cofilin to promote the metastasis of prostate cancer	107

Absence of Rnf126 causes male infertility with multiple morphological abnormalities of the sperm flagella	106
Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis	104
Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications	104
Epitranscriptomic control of cancer: the emerging roles of m⁵C and ac⁴C RNA modifications	104
USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target	103
Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma	102
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1	99
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism	98
Lipids associated with autophagy: mechanisms and therapeutic targets	97
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma	95
Dual control of liver regeneration by Nr1d1 homeostasis and Klf2 checkpoint	95
Diverse functions of NLRP3 inflammasome in PANoptosis and diseases	95
Oncometabolite signatures from tumor-stroma crosstalk as potential non-invasive biomarkers	94
CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH	94
Transcriptional activation of PINK1 by MyoD1 mediates mitochondrial homeostasis to induce renal calcification in pediatric nephrolithiasis	93
The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer	88
Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis	87
FKBP5 isoforms shape immune pathways related to tumor tolerance	87
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis	87
Exosomal circRNAs: key modulators in breast cancer progression	86
Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis	81
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins	80
The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation	80
Stem cell-derived intestinal organoids: a novel modality for IBD	79
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury	79
Radiobiological characterisation of a 28 MeV proton beam delivered by the MC-40 cyclotron	78
Targeting mitochondrial autophagy for anti-aging	78
Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis	77
Smoking-induced microbial dysbiosis: a key driver of systemic diseases and emerging therapeutic opportunities	76
The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer	76
Tissue microenvironment induces tissue specificity of ILC2	76
Cellular senescence of renal tubular epithelial cells in acute kidney injury	76
Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42	75
IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10	75
Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions	74
Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity	73
Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC	72
Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes	71
BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1	71
MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway	71
MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling	70
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins	70
Differential effects of HDAC inhibitors in the RhoI255d mouse model for autosomal dominant retinitis pigmentosa	69
The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury	69