OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death Discovery is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Smoking-induced microbial dysbiosis: a key driver of systemic diseases and emerging therapeutic opportunities	451
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins	285
Stem cell-derived intestinal organoids: a novel modality for IBD	232
The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics	223
Dual control of liver regeneration by Nr1d1 homeostasis and Klf2 checkpoint	220
Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis	203
Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma	192
Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials	181
MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway	167
Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis	160
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism	144
USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target	138
Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion	137
PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway	136
An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth	135
Matrix metalloproteinase-10 promotes kidney fibrosis by transactivating β-catenin signaling	132
The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer	128
Cellular senescence of renal tubular epithelial cells in acute kidney injury	127
Targeting mitochondrial autophagy for anti-aging	124
N6-methyladenosine: a key regulator in ocular disease mechanisms and treatment	123
USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression	116
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury	114
Lipids associated with autophagy: mechanisms and therapeutic targets	113
RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation	112
New insights into constitutive neutrophil death	111

CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma	108
Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications	104
The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer	102
Diverse functions of NLRP3 inflammasome in PANoptosis and diseases	102
The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury	99
Tissue microenvironment induces tissue specificity of ILC2	99
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis	96
Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation	95
Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions	94
Exosomal circRNAs: key modulators in breast cancer progression	93
Retraction Note to: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast	92
IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10	92
AXL tyrosine kinase inhibitor TP-0903 induces ROS trigger neuroblastoma cell apoptosis via targeting the miR-335-3p/DKK1 expression	92
Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42	91
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis	91
Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death	90
Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma	89
FKBP5 isoforms shape immune pathways related to tumor tolerance	89
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44	85
Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis	83
The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation	81
Transcriptional activation of PINK1 by MyoD1 mediates mitochondrial homeostasis to induce renal calcification in pediatric nephrolithiasis	78
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1	78
STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction	78
Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model	78
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction	77
Radiobiological characterisation of a 28 MeV proton beam delivered by the MC-40 cyclotron	75
Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis	75
Absence of Rnf126 causes male infertility with multiple morphological abnormalities of the sperm flagella	74
MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1	74
CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH	73
CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila	73
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma	73
ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues	73
GILT stabilizes cofilin to promote the metastasis of prostate cancer	73
YAP is required for prostate development, regeneration, and prostate stem cell function	72
VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson’s disease	72
Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC	72
Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress	72
Long non-coding RNA MAFG-AS1 promotes proliferation and metastasis of breast cancer by modulating STC2 pathway	70
BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1	70
Polyploidy mitigates the impact of DNA damage while simultaneously bearing its burden	70
Targeting Txnip-mediated metabolic reprogramming has therapeutic potential for osteoarthritis	70
Gemcitabine elaidate and ONC201 combination therapy for inhibiting pancreatic cancer in a KRAS mutated syngeneic mouse model	68