OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death Discovery is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression	438
Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin	171
Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42	168
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1	157
TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer	156
Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death	132
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44	115
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism	109
CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH	102
Transcriptional activation of PINK1 by MyoD1 mediates mitochondrial homeostasis to induce renal calcification in pediatric nephrolithiasis	101
Retraction Note to: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast	96
IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10	92
OASIS/CREB3L1 is a factor that responds to nuclear envelope stress	92
GILT stabilizes cofilin to promote the metastasis of prostate cancer	84
N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction	84
Current insights into the expression and functions of tumor-derived immunoglobulins	83
The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer	82
MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1	81
Targeting NAD+: is it a common strategy to delay heart aging?	81
New insights into constitutive neutrophil death	81
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer	76
Tissue microenvironment induces tissue specificity of ILC2	75
The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics	74
SMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer	72
Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications	70

An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth	69
Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI	67
ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues	66
Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasion	65
Exosomal circRNAs: key modulators in breast cancer progression	64
A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression	63
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis	63
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury	62
PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway	62
Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis	61
Stem cell-derived intestinal organoids: a novel modality for IBD	61
Lipids associated with autophagy: mechanisms and therapeutic targets	60
Exploring necroptosis: mechanistic analysis and antitumor potential of nanomaterials	60
DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma	59
The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury	59
Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma	58
Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review	58
Cellular senescence of renal tubular epithelial cells in acute kidney injury	58
The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer	56
USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target	56
CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma	56
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway	55
Comprehensive analysis of cellular metrics: From proliferation to mitochondrial membrane potential and cell death in a single sample	55
Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress	54
Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3	54
MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma	54
Polyploidy mitigates the impact of DNA damage while simultaneously bearing its burden	53
Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide	53
Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4	53
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies	53
Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes	53
LncRNA XIST accelerates burn wound healing by promoting M2 macrophage polarization through targeting IL-33 via miR-19b	53