OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons	91
Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval	77
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	75
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	64
Combinatorial extracellular matrix tissue chips for optimizing mesenchymal stromal cell microenvironment and manufacturing	62
A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization	61
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	60
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	59
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	53
Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes	51
Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	45
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	40
Non-canonical muscle stem cells and other lessons from regenerative vertebrates	40
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	38
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	35
Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels	34
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	34
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	32
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	32
Adipose-derived dual cell therapy enhances arteriogenesis and limb preservation through vascular integration in critical limb ischemia	31
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration	31
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease	31
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	31
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice	28
Harnessing bioengineered myeloid progenitors for precision immunotherapies	28

Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas	28
Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts	28
MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice	27
Telomere shortening in laminopathic dilated cardiomyopathy	27
Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside	27
Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair	27
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors	26
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	26
Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration	26
Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice	25
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells	25
Clinically relevant small-molecule promotes nerve repair and visual function recovery	25
Dissecting the boundary of quiescence and activation of murine melanocyte stem cells in the hair follicle niche	25
A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish	25
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	24
Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing	24
Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction	24
The specialist in regeneration—the Axolotl—a suitable model to study bone healing?	22
Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration	22
Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs	22
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice	21
Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms	21
Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response	20
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	19
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	19
Epimorphic regeneration in the mammalian tympanic membrane	19
Author Correction: Disease exacerbation in human DMD MYOrganoids enables gene therapy evaluation and unveils persistence of fibrotic activity	19
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	19
Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function	19
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	19
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	19
Impaired bone healing upon neutrophil-specific adrenoreceptor beta 2 knockout in non-osteoporotic and osteoporotic mice	19
Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice	18
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	18
Heart ventricle regeneration in the lizard Eublepharis macularius, the leopard gecko	18
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	17
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	17
Author Correction: Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	17
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation	17
Regeneration of tracheal neotissue in partially decellularized scaffolds	17
Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy	17
Immune-mediated regeneration of cell-free vascular grafts in an ovine model	17
An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish	16
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation	16
Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures	16
Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart	16
Systemic factors associated with antler growth promote complete wound healing	16
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	16
CYR61 delivery promotes angiogenesis during bone fracture repair	15
Rational engineering of lung alveolar epithelium	15

Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression	15
Early resistance rehabilitation improves functional regeneration following segmental bone defect injury	15
Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis	15
Intrinsic muscle stem cell dysfunction underlies functional deficits in models of type 1 diabetes	15
A two-way street – cellular metabolism and myofibroblast contraction	15
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	14
Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	14
Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction	14
Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing	13
Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium	13
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	13
Genetic compensation response contributes to Pleurodeles waltl limb regeneration	13
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	13
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model	13
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles	13
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	13
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	13
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration	13
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	13
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	13
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	13
Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration	12
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration	12
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI	12
Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation	12
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	12
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	12
Label-free in-line characterization of immune cell culture using quantitative phase imaging	12
Circulating beta-2-microglobulin promotes revascularization via TGFBR2 after spinal cord injury	12
Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation	11
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing	11
Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)	11
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues	11
Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice	11
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	11
Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs	11
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	10
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment	10
Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration	10
Neuronal activation in the axolotl brain promotes tail regeneration	10
Integrin-specific hydrogels for growth factor-free vasculogenesis	10
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse	9
Role of umbilical cord mesenchymal stromal cells in skin rejuvenation	9
The impact of bilateral injuries on the pathophysiology and functional outcomes of volumetric muscle loss	9
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration	9
Engineering the oxygen microenvironment for pancreatic islet transplants	9
Single cell transcriptomics of human kidney organoid endothelium reveals vessel growth processes and arterial maturation upon transplantation	9
Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis	9
Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration	8
CD73 overexpression in ADSCs accelerates bladder repair by regulating the NFκB/NLRP3/caspase-1 signaling axis in neurogenic bladder rats	8
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	8
Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti	8
Deer antler ASCs exosomes ameliorate osteoarthritis via miR-140/MMP13 axis-mediated dual modulation of inflammation and cartilage regeneration	8
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line	8
Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	8
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	8
Topical application of synthetic melanin promotes tissue repair	8
Activated Hedgehog signaling in keratocytes leads to stromal stiffness and impairs corneal regeneration	8
Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum	8