OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	114
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	90
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	87
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	78
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	70
Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval	61
Combinatorial extracellular matrix tissue chips for optimizing mesenchymal stromal cell microenvironment and manufacturing	58
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	58
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease	57
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties	56
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	52
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	50
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	44
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	42
Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels	42
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	39
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	39
Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	36
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	36
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	36
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	36
Pain sensing neurons promote tissue regeneration in adult mice	34
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration	33
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice	32
Stem cell-based therapy for COVID-19 and ARDS: a systematic review	31

Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	31
Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas	31
Harnessing bioengineered myeloid progenitors for precision immunotherapies	31
Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside	31
MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice	30
Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells	29
Clinically relevant small-molecule promotes nerve repair and visual function recovery	28
A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish	28
Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction	28
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis	28
Metformin accelerates zebrafish heart regeneration by inducing autophagy	27
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	27
Human adipose-derived stromal/stem cells expressing doublecortin improve cartilage repair in rabbits and monkeys	26
Hippo-Yap/Taz signalling in zebrafish regeneration	26
The specialist in regeneration—the Axolotl—a suitable model to study bone healing?	25
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice	24
Epimorphic regeneration in the mammalian tympanic membrane	24
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)	24
Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs	24
Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function	23
Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering	23
Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response	23
Macrophages in heterotopic ossification: from mechanisms to therapy	22
Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration	22
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	21
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	21
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	20
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	20
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	20
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	20
The bright side of fibroblasts: molecular signature and regenerative cues in major organs	20
Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	20
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation	19
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	19
Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries	19
Regeneration of tracheal neotissue in partially decellularized scaffolds	19
Author Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	19
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	19
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	19
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	19
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation	18
Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart	18
Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy	18
Author Correction: Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	18
Immune-mediated regeneration of cell-free vascular grafts in an ovine model	17
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair	17
Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva	17
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration	17
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	17
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease	17

Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard	16
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	16
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation	16
Systemic factors associated with antler growth promote complete wound healing	16
Longevity leap: mind the healthspan gap	15
Early resistance rehabilitation improves functional regeneration following segmental bone defect injury	15
Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development	15
Rational engineering of lung alveolar epithelium	15
Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures	15
Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression	15
Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis	14
Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium	14
Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing	14
A two-way street – cellular metabolism and myofibroblast contraction	14
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	14
CYR61 delivery promotes angiogenesis during bone fracture repair	14
Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction	14
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration	13
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression	13
Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	13
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model	13
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	12
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	12
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	12
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	12
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy	12
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes	12
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	12
Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury	12
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	12
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue	12
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	12
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles	12
Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis	11
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	11
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	11
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	11
CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells	11
A therapeutic vascular conduit to support in vivo cell-secreted therapy	11
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	11
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	11
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration	11
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	11
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice	11
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates	10
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	10
The stem cell revolution: on the role of CD164 as a human stem cell marker	10
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI	10
Towards a bioengineered uterus: bioactive sheep uterus scaffolds are effectively recellularized by enzymatic preconditioning	10
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing	10
Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)	10
Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice	10
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury	10
Role of umbilical cord mesenchymal stromal cells in skin rejuvenation	9
Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum	9
The impact of bilateral injuries on the pathophysiology and functional outcomes of volumetric muscle loss	9
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β	9
Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs	9
An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial	9
Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti	9
Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis	9
Integrin-specific hydrogels for growth factor-free vasculogenesis	9
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues	9
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	9
Topical application of synthetic melanin promotes tissue repair	9
Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration	9
Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration	9
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment	9
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse	9