OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation	178
Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application	102
Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast	84
Longevity leap: mind the healthspan gap	79
Self-assembling peptide scaffolds in the clinic	77
The bright side of fibroblasts: molecular signature and regenerative cues in major organs	68
Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries	67
Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering	63
Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis	54
3D in vitro M2 macrophage model to mimic modulation of tissue repair	53
Macrophages in heterotopic ossification: from mechanisms to therapy	53
Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds	52
The evolving definition of salivary gland stem cells	50
Challenges and translational considerations of mesenchymal stem/stromal cell therapy for Parkinson’s disease	48
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice	48
Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms	45
The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment	42
Skeletal muscle differentiation of human iPSCs meets bioengineering strategies: perspectives and challenges	38
Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease	38
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin	36
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	34
Regenerative medicine meets mathematical modelling: developing symbiotic relationships	34
Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing	33
Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling	33
Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury	31

The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	31
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	30
Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard	29
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19	29
The genetic basis of inter-individual variation in recovery from traumatic brain injury	28
Mussel-inspired multifunctional surface through promoting osteogenesis and inhibiting osteoclastogenesis to facilitate bone regeneration	28
The clinical potential of articular cartilage-derived progenitor cells: a systematic review	27
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue	27
Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing	27
Targets identified from exercised heart: killing multiple birds with one stone	26
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	26
An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial	26
TP63 basal cells are indispensable during endoderm differentiation into proximal airway cells on acellular lung scaffolds	25
Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue	24
Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration	24
Metformin accelerates zebrafish heart regeneration by inducing autophagy	24
Immunomodulation for optimal cardiac regeneration: insights from comparative analyses	23
Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review	22
Harnessing 3D collagen hydrogel-directed conversion of human GMSCs into SCP-like cells to generate functionalized nerve conduits	21
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	20
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue	20
Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit	20
3D bioprinting using a new photo-crosslinking method for muscle tissue restoration	19
Looking backward to move forward: a meta-analysis of stem cell therapy in amyotrophic lateral sclerosis	19
Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke	19
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration	19
Vasculogenesis in kidney organoids upon transplantation	18
VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone	18
Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	18
Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury	18
Hippo-Yap/Taz signalling in zebrafish regeneration	18
Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury	18
Mammals fail to regenerate organs when wound contraction drives scar formation	18
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)	18
FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia	18
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage	18
Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction	17
Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment	17
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy	17
Pain sensing neurons promote tissue regeneration in adult mice	17
Clinically relevant small-molecule promotes nerve repair and visual function recovery	17
Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic	17
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury	16
Vitrification of particulated articular cartilage via calculated protocols	16
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis	16
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair	15
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	15
Stem cell-based therapy for COVID-19 and ARDS: a systematic review	15
Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	15
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	15

Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation	14
Towards a bioengineered uterus: bioactive sheep uterus scaffolds are effectively recellularized by enzymatic preconditioning	14
The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds	14
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	14
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	14
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	14
Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation	13
Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration	13
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	13
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	13
Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord	13
In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration	13
The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation	13
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	13
Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva	13
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	13
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	13
Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development	13
A cross-species analysis of systemic mediators of repair and complex tissue regeneration	13
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis	13
Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration	12
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	12
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice	12
Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration	12
Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis	11
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	11
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression	11
Prolonged field care for traumatic extremity injuries: defining a role for biologically focused technologies	11
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties	11
Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	11
Topical application of synthetic melanin promotes tissue repair	11
Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration	11
Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection	11
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	11
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	11
3D printing titanium grid scaffold facilitates osteogenesis in mandibular segmental defects	10
Stem cell preservation for regenerative therapies: ethical and governance considerations for the health care sector	10
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice	10
Tendon and multiomics: advantages, advances, and opportunities	10
Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention	10
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates	10
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model	10
Esophageal regeneration following surgical implantation of a tissue engineered esophageal implant in a pediatric model	10
Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue	10
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	10
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	10
The stem cell revolution: on the role of CD164 as a human stem cell marker	9
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	9
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	9
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	9
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease	9
CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells	9
Modelling urea cycle disorders using iPSCs	9
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β	9
Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential	9
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP	9
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	9
Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy	8
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn	8
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis	8
A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog	8
DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation	8
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease	8
Epicardial slices: an innovative 3D organotypic model to study epicardial cell physiology and activation	8
Enhanced peripheral nerve regeneration by mechano-electrical stimulation	8
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration	8
Concerns about cell therapy for intervertebral disc degeneration	8
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes	8
Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue	8
PDGF inhibits BMP2-induced bone healing	8