OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation	136
Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis	94
Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application	85
Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast	70
Self-assembling peptide scaffolds in the clinic	63
Neural stem cell delivery via porous collagen scaffolds promotes neuronal differentiation and locomotion recovery in spinal cord injury	58
The bright side of fibroblasts: molecular signature and regenerative cues in major organs	58
Towards stem cell therapies for skeletal muscle repair	57
Immune modulation of hair follicle regeneration	56
Longevity leap: mind the healthspan gap	54
Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries	54
Innervation: the missing link for biofabricated tissues and organs	53
Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine	48
Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering	48
Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds	48
Overcoming kidney organoid challenges for regenerative medicine	48
Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis	46
Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure	45
Macrophages in heterotopic ossification: from mechanisms to therapy	43
Challenges and translational considerations of mesenchymal stem/stromal cell therapy for Parkinson’s disease	42
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice	41
Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms	38
The evolving definition of salivary gland stem cells	35
Skeletal muscle differentiation of human iPSCs meets bioengineering strategies: perspectives and challenges	34
The jam session between muscle stem cells and the extracellular matrix in the tissue microenvironment	34

3D in vitro M2 macrophage model to mimic modulation of tissue repair	33
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin	32
Regenerative medicine meets mathematical modelling: developing symbiotic relationships	29
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19	29
Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease	28
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes	27
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration	27
Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling	25
Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury	25
Cellularized small-caliber tissue-engineered vascular grafts: looking for the ultimate gold standard	24
Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration	24
The genetic basis of inter-individual variation in recovery from traumatic brain injury	24
Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing	23
TP63 basal cells are indispensable during endoderm differentiation into proximal airway cells on acellular lung scaffolds	23
Metformin accelerates zebrafish heart regeneration by inducing autophagy	23
The clinical potential of articular cartilage-derived progenitor cells: a systematic review	23
Targets identified from exercised heart: killing multiple birds with one stone	22
Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients	21
Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue	20
Immunomodulation for optimal cardiac regeneration: insights from comparative analyses	19
An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial	19
Mussel-inspired multifunctional surface through promoting osteogenesis and inhibiting osteoclastogenesis to facilitate bone regeneration	19
Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing	19
Looking backward to move forward: a meta-analysis of stem cell therapy in amyotrophic lateral sclerosis	18
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis	18
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	18
Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review	18
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue	16
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy	16
Mammals fail to regenerate organs when wound contraction drives scar formation	16
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis	15
Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic	15
Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury	15
Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment	15
FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia	15
Stem cell-based therapy for COVID-19 and ARDS: a systematic review	15
Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis	15
Vasculogenesis in kidney organoids upon transplantation	14
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair	14
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	14
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)	14
Vitrification of particulated articular cartilage via calculated protocols	14
Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury	14
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration	14
Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	14
3D bioprinting using a new photo-crosslinking method for muscle tissue restoration	14
Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit	14
Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction	13
Inhibition of nuclear factor (erythroid-derived 2)-like 2 promotes hepatic progenitor cell activation and differentiation	13
Harnessing 3D collagen hydrogel-directed conversion of human GMSCs into SCP-like cells to generate functionalized nerve conduits	13

Clinically relevant small-molecule promotes nerve repair and visual function recovery	13
Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury	13
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	12
Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration	12
Pain sensing neurons promote tissue regeneration in adult mice	12
Towards a bioengineered uterus: bioactive sheep uterus scaffolds are effectively recellularized by enzymatic preconditioning	12
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation	12
Hippo-Yap/Taz signalling in zebrafish regeneration	11
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease	11
Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration	10
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage	10
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	10
Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development	10
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis	10
Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration	10
The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds	10
Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord	10
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	9
Bio-artificial pleura using autologous dermal fibroblast sheets to mitigate air leaks during thoracoscopic lung resection	9
Process analysis of pluripotent stem cell differentiation to megakaryocytes to make platelets applying European GMP	9
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	9
The stem cell revolution: on the role of CD164 as a human stem cell marker	9
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	9
DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration	9
VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone	9
Esophageal regeneration following surgical implantation of a tissue engineered esophageal implant in a pediatric model	9
A cross-species analysis of systemic mediators of repair and complex tissue regeneration	9
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	9
Tendon and multiomics: advantages, advances, and opportunities	9
Prolonged field care for traumatic extremity injuries: defining a role for biologically focused technologies	9
In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration	8
Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration	8
Stem cell preservation for regenerative therapies: ethical and governance considerations for the health care sector	8
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis	8
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	8
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression	8
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	8
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells	8
Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	8
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration	8
Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration	8
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β	8
Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva	8
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties	8
Modelling urea cycle disorders using iPSCs	8
Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue	7
Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers	7
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn	7
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	7
Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis	7
Myocardial fibrosis reversion via rhACE2-electrospun fibrous patch for ventricular remodeling prevention	7
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates	7
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	7
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model	7
Epicardial slices: an innovative 3D organotypic model to study epicardial cell physiology and activation	7
GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells	7
Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential	7
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease	7
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	7
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium	7
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	7