OOIR: Observatory of International Research

Papers

(The median citation count of npj Regenerative Medicine is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization	88
Combinatorial extracellular matrix tissue chips for optimizing mesenchymal stromal cell microenvironment and manufacturing	75
Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons	71
Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval	61
Author Correction: Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate	60
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A	59
Author Correction: The bright side of fibroblasts: molecular signature and regenerative cues in major organs	58
Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration	57
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing	53
Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes	49
Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence	44
Implication of CXCR2-Src axis in the angiogenic and osteogenic effects of FP-TEB	42
Non-canonical muscle stem cells and other lessons from regenerative vertebrates	40
Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels	39
The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway	37
Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish	35
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment	34
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy	33
Infected wound repair correlates with collagen I induction and NOX2 activation by cold atmospheric plasma	31
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms	31
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration	30
Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease	29
Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts	28
Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside	28
Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas	28

Adipose-derived dual cell therapy enhances arteriogenesis and limb preservation through vascular integration in critical limb ischemia	27
MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice	27
Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration	26
Harnessing bioengineered myeloid progenitors for precision immunotherapies	26
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice	26
Immunomodulatory and anabolic biphasic scaffold with hierarchical biomimetic structure directed osteochondral defect repair	25
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration	25
A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish	25
Telomere shortening in laminopathic dilated cardiomyopathy	25
Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction	25
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors	25
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells	25
Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing	25
Clinically relevant small-molecule promotes nerve repair and visual function recovery	24
Dissecting the boundary of quiescence and activation of murine melanocyte stem cells in the hair follicle niche	24
Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice	24
Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration	23
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization	23
Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs	22
The specialist in regeneration—the Axolotl—a suitable model to study bone healing?	22
Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response	20
Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice	20
Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms	20
Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon	19
Epimorphic regeneration in the mammalian tympanic membrane	19
Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease	19
Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells	19
Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function	19
Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept	18
Heart ventricle regeneration in the lizard Eublepharis macularius, the leopard gecko	18
Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice	18
Author Correction: Disease exacerbation in human DMD MYOrganoids enables gene therapy evaluation and unveils persistence of fibrotic activity	18
Author Correction: Patients seeking stem cell therapies—a prospective qualitative analysis from a Regenerative Medicine Consult Service	17
Preclinical efficacy and safety of AAVrh10-based plakophilin-2 gene therapy (LX2020) as a treatment for arrhythmogenic cardiomyopathy	17
A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration	17
Regeneration of tracheal neotissue in partially decellularized scaffolds	17
Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible	17
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation	17
Author Correction: Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants	17
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration	17
Systemic factors associated with antler growth promote complete wound healing	16
Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart	16
Immune-mediated regeneration of cell-free vascular grafts in an ovine model	16
Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures	16
Injectable decellularized cartilage matrix hydrogel encapsulating urine-derived stem cells for immunomodulatory and cartilage defect regeneration	16
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation	15
Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression	15
Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury	15
Rational engineering of lung alveolar epithelium	15
Intrinsic muscle stem cell dysfunction underlies functional deficits in models of type 1 diabetes	15

CYR61 delivery promotes angiogenesis during bone fracture repair	15
A two-way street – cellular metabolism and myofibroblast contraction	15
An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish	15
Early resistance rehabilitation improves functional regeneration following segmental bone defect injury	15
Engineered extracellular vesicle-encapsulated CHIP as novel nanotherapeutics for treatment of renal fibrosis	15
Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction	14
Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model	13
Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors	13
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration	13
Enforced mesenchymal stem cell tissue colonization counteracts immunopathology	13
Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	13
Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles	13
Ferric citrate and apo-transferrin enable erythroblast maturation with β-globin from hemogenic endothelium	13
hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model	12
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans	12
Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment	12
Genetic compensation response contributes to Pleurodeles waltl limb regeneration	12
BMP3 inhibits TGFβ2-mediated myofibroblast differentiation during wound healing of the embryonic cornea	12
Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds	12
Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation	12
Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing	12
Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy	12
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration	12
Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice	12
Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration	11
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI	11
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing	11
Circulating beta-2-microglobulin promotes revascularization via TGFBR2 after spinal cord injury	11
Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)	11
Label-free in-line characterization of immune cell culture using quantitative phase imaging	11
Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation	10
Integrin-specific hydrogels for growth factor-free vasculogenesis	10
ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis	10
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues	10
Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs	10
Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation	10
Neuronal activation in the axolotl brain promotes tail regeneration	10
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment	10
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells	9
Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti	9
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration	9
Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration	9
Single cell transcriptomics of human kidney organoid endothelium reveals vessel growth processes and arterial maturation upon transplantation	9
Role of umbilical cord mesenchymal stromal cells in skin rejuvenation	9
Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse	9
The impact of bilateral injuries on the pathophysiology and functional outcomes of volumetric muscle loss	9
Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration	9
Implementing systems thinking and data science in the training of the regenerative medicine workforce	8
Perspectives on the cost of goods for hPSC banks for manufacture of cell therapies	8
Deer antler ASCs exosomes ameliorate osteoarthritis via miR-140/MMP13 axis-mediated dual modulation of inflammation and cartilage regeneration	8
Topical application of synthetic melanin promotes tissue repair	8
Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis	8
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line	8
CD73 overexpression in ADSCs accelerates bladder repair by regulating the NFκB/NLRP3/caspase-1 signaling axis in neurogenic bladder rats	8
Activated Hedgehog signaling in keratocytes leads to stromal stiffness and impairs corneal regeneration	8
A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model	8
Janus porous polylactic acid membranes with versatile metal–phenolic interface for biomimetic periodontal bone regeneration	8
Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum	8