OOIR: Observatory of International Research

Papers

(The H4-Index of npj Systems Biology and Applications is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies	95
Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma	75
Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes	64
Calibrating tissue level PDE models of ligand dynamics using single cell and spatial transcriptomics data	57
Causality-aware graph neural networks for functional stratification and phenotype prediction at scale	53
Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer	49
Optimization of nutrient utilization efficiency and productivity for algal cultures under light and dark cycles using genome-scale model process control	48
Severe testing with high-dimensional omics data for enhancing biomedical scientific discovery	45
Measuring criticality in control of complex biological networks	42
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML	38
Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model	37
Leveraging public AI tools to explore systems biology resources in mathematical modeling	34
Revisiting the evolution of bow-tie architecture in signaling networks	33
Classification of NSCLC subtypes using lung microbiome from resected tissue based on machine learning methods	31
Network-based transfer of pan-cancer immunotherapy responses to guide breast cancer prognosis	29
Data-driven universal insights into tumorigenesis via hallmark networks	28
Author Correction: Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms	28
Data-driven synthetic microbes for sustainable future	27
Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation	27
Extracellular matrix-driven patient stratification and network modeling reveal distinct molecular grades with potential clinical implications	26
Quantitative cancer-immunity cycle modeling for predicting disease progression in advanced metastatic colorectal cancer	26
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders	25
sciCAN: single-cell chromatin accessibility and gene expression data integration via cycle-consistent adversarial network	25
Modelling HIV-1 control and remission	25
Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation	24