OOIR: Observatory of International Research

Papers

(The H4-Index of npj Systems Biology and Applications is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Measuring criticality in control of complex biological networks	99
Severe testing with high-dimensional omics data for enhancing biomedical scientific discovery	76
Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies	73
Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma	58
Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model	54
Leveraging public AI tools to explore systems biology resources in mathematical modeling	51
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML	50
Optimization of nutrient utilization efficiency and productivity for algal cultures under light and dark cycles using genome-scale model process control	45
Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer	44
Causality-aware graph neural networks for functional stratification and phenotype prediction at scale	39
Calibrating tissue level PDE models of ligand dynamics using single cell and spatial transcriptomics data	39
Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation	36
Network-based transfer of pan-cancer immunotherapy responses to guide breast cancer prognosis	34
Revisiting the evolution of bow-tie architecture in signaling networks	34
Data-driven universal insights into tumorigenesis via hallmark networks	30
Extracellular matrix-driven patient stratification and network modeling reveal distinct molecular grades with potential clinical implications	30
Quantitative cancer-immunity cycle modeling for predicting disease progression in advanced metastatic colorectal cancer	29
Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation	29
Classification of NSCLC subtypes using lung microbiome from resected tissue based on machine learning methods	27
Leveraging quantitative systems pharmacology modeling for elranatamab regimen optimization in relapsed or refractory multiple myeloma	27
Modelling HIV-1 control and remission	26
Author Correction: Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms	25
sciCAN: single-cell chromatin accessibility and gene expression data integration via cycle-consistent adversarial network	25
Data-driven synthetic microbes for sustainable future	25
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders	25