OOIR: Observatory of International Research

Papers

(The H4-Index of npj Systems Biology and Applications is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Measuring criticality in control of complex biological networks	105
Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma	84
Causality-aware graph neural networks for functional stratification and phenotype prediction at scale	83
Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model	64
Leveraging public AI tools to explore systems biology resources in mathematical modeling	62
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML	56
Optimization of nutrient utilization efficiency and productivity for algal cultures under light and dark cycles using genome-scale model process control	54
Patient-specific modeling of G2/M cell cycle dynamics reveals prognostic dynamical regimes driven by copy number alterations	49
Calibrating tissue level PDE models of ligand dynamics using single cell and spatial transcriptomics data	44
Severe testing with high-dimensional omics data for enhancing biomedical scientific discovery	41
Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer	40
Drug-tolerant persisters to TRAIL emerge from a dose-dependent surface in a cell-state continuum of sensitivity	39
Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies	35
Data-driven universal insights into tumorigenesis via hallmark networks	34
Network-based transfer of pan-cancer immunotherapy responses to guide breast cancer prognosis	34
Extracellular matrix-driven patient stratification and network modeling reveal distinct molecular grades with potential clinical implications	33
Author Correction: Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms	32
Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation	31
Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation	30
Revisiting the evolution of bow-tie architecture in signaling networks	30
Modelling HIV-1 control and remission	28
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders	27
sciCAN: single-cell chromatin accessibility and gene expression data integration via cycle-consistent adversarial network	27
Quantitative cancer-immunity cycle modeling for predicting disease progression in advanced metastatic colorectal cancer	26
Leveraging quantitative systems pharmacology modeling for elranatamab regimen optimization in relapsed or refractory multiple myeloma	25

Data-driven synthetic microbes for sustainable future	25
Classification of NSCLC subtypes using lung microbiome from resected tissue based on machine learning methods	25