OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro	175
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes	164
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility	159
SARS-CoV-2 cell tropism and multiorgan infection	154
Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response	127
Emerging functions of branched ubiquitin chains	109
Plasma membrane integrity in health and disease: significance and therapeutic potential	107
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages	100
CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor	98
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression	98
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	97
Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss	95
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis	90
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy	88
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension	85
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication	81
Generation of human blastocyst-like structures from pluripotent stem cells	76
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease	72
KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge	68
SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region	67
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines	64
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	64
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor	63
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	62
Dysregulated hematopoiesis in bone marrow marks severe COVID-19	54

A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases	53
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo	53
In vivo chemical reprogramming of astrocytes into neurons	52
Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma	49
SARS-CoV-2 infection in the mouse olfactory system	49
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients	47
Genome-wide association study of COVID-19 severity among the Chinese population	46
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter	45
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos	45
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome	42
Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells	42
Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture	40
Antenna arrangement and energy-transfer pathways of PSI–LHCI from the moss Physcomitrella patens	39
Identification of an intraocular microbiota	39
Structure and dynamics of the EGFR/HER2 heterodimer	38
Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection	38
Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos	38
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing	38
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans	38
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini	37
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	37
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq	37
RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models	37
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	37
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant	36
Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis	36
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	35
Immune memory in convalescent patients with asymptomatic or mild COVID-19	34
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	34
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	33
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm	32
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	32
Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy	31
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1	31
Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals	31
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	30
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication	30
Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models	30
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	30
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries	30
Infection of human sweat glands by SARS-CoV-2	29
Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s	29
TAZ is required for chondrogenesis and skeletal development	29
Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection	29
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	28
CRISPR-edited CART with GM-CSF knockout and auto secretion of IL6 and IL1 blockers in patients with hematologic malignancy	28
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	28
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	28
Integrated proteogenomic characterization of medullary thyroid carcinoma	28
Chilling-induced phosphorylation of IPA1 by OsSAPK6 activates chilling tolerance responses in rice	28

Structural insights into assembly of human mitochondrial translocase TOM complex	28
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment	27
A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease	27
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses	26
Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly	26
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	26
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis	26
Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines	25
3D landscape of Hepatitis B virus interactions with human chromatins	25
Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB	25
Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy	25
Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication	25
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	25
Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)	25
Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infection	25
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization	25
PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation	25
TMEM151A variants cause paroxysmal kinesigenic dyskinesia	24
Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern	24
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis	24
High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation	24
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19	23
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	23
Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues	23
m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation	23
Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma	23
SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells	23
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2	23
DdCBE-mediated mitochondrial base editing in human 3PN embryos	23
RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates	22
Efficient and precise generation of Tay–Sachs disease model in rabbit by prime editing system	22
Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells	22
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells	22
Structural insights into human CCAN complex assembled onto DNA	22
Single-cell RNA-Seq reveals transcriptional heterogeneity and immune subtypes associated with disease activity in human myasthenia gravis	21
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE	21
Structure of the human RNA polymerase I elongation complex	21
The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay	21
Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35	21
A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species	21
Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics	21
LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis	21
Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma	21
The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance	21
Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter	21
The Omicron BA.2.2.1 subvariant drove the wave of SARS-CoV-2 outbreak in Shanghai during spring 2022	20
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming	20
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD	20
Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3	20
Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2	20
Neutralization of SARS-CoV-2 BQ.1.1, CH.1.1, and XBB.1.5 by breakthrough infection sera from previous and recent waves in China	20
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	20
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	20
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration	20
Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha)	20
Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state	20
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses	20
Rapid screening of TCR-pMHC interactions by the YAMTAD system	20