OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Sheep blastocyst-like structure models derived from stem cells	397
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	322
tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells	144
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	126
Human zygotic genome activation is initiated from paternal genome	107
GV-971 remodels the gut microbiota-bile acid-FXR axis to ameliorate obesity and metabolic dysfunction	103
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	102
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	102
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	90
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	89
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	87
A spatiotemporal transcriptomic atlas of mouse placentation	82
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	82
Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system	78
Structural characterization reveals substrate recognition by the taurine transporter TauT	74
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	73
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	73
The building blocks of embryo models: embryonic and extraembryonic stem cells	71
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	71
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	70
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	70
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	69
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis	69
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	67
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	66

Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	66
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	64
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	64
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	62
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	61
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	60
Receptor hyper-flexibility of human bitter receptor TAS2R4 revealed by cryo-EM structures in apo and tripeptide-bound states	59
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	59
Packaged release and targeted delivery of cytokines by migrasomes in circulation	57
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	57
A tissue specific-infection mouse model of SARS-CoV-2	55
Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming	55
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	54
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	51
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	51
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	51
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	51
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	50
Proteogenomic insights into the biology and treatment of pan-melanoma	50
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	49
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	49
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	49
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	48
Structural basis for the activity regulation of Medicago calcium channel CNGC15	47
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	47
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	46
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	46
Author Correction: Longitudinal single-cell and TCR repertoire profiling characterizes clonal entrapment in patients with pMMR/MSS locally advanced rectal cancer	44
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	43
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	43
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	42
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	42
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	41
Spatial single-cell landscape of tumor-associated macrophages and their crosstalk with the tumor microenvironment	41
Structural basis for a central permeation pathway in the P2X1 receptor	40
Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma	39
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	38
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	37
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	36
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	35
A spatiotemporal gating hypothesis for psilocybin plasticity: reconciling the 5-HT₂A-TrkB mechanistic paradox	35
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	35
Identification of a novel deeply quiescent neural stem cell population in the subventricular zone: a potential source for brain repair	35
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	35
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	34
Molecular basis for the activation of thyrotropin-releasing hormone receptor	34
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	34
Synthetic macrolides overcoming MLSBK-resistant pathogens	34
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	34

Identification of neutralizing nanobodies protecting against poxvirus infection	33
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	33
Structure of small HBV surface antigen reveals mechanism of dimer formation	33
ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression	33
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	33
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	32
Common signatures of neutrophils in diverse disease conditions	32
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	32
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	32
Structural and functional insights into the helicase protein E5 of Mpox virus	32
Intercellular genetic tracing by alternative synthetic Notch signaling	32
Targeting miR-337 mitigates disuse-induced bone loss	32
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	31
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	31
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	31
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	31
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	30
Inhibiting hedgehog signal by a patched-1 antibody	30
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	29
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	29
In-cell structural insight into the stability of sperm microtubule doublet	28
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	27
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	27
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	27
Structural basis of human zinc-activated channel (ZAC) signaling and modulation	27
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	27
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	27
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	26
Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia	26
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	26
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	26
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	26
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	26
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	26
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	26
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	26
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	26
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	25
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	25
Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies	25
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	25
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	25
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	25
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	25
Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25