OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	200
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	166
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	144
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	138
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	107
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	105
A spatiotemporal transcriptomic atlas of mouse placentation	102
Human zygotic genome activation is initiated from paternal genome	93
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing	84
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	79
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	75
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	74
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	74
Structural characterization reveals substrate recognition by the taurine transporter TauT	72
Developing an erythrocyte‒MHC-I conjugate for cancer treatment	72
A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline	70
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	65
The building blocks of embryo models: embryonic and extraembryonic stem cells	64
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	64
RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation	63
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1	62
TMEM151A variants cause paroxysmal kinesigenic dyskinesia	61
Structural insight into PIF6-mediated red light signal transduction of plant phytochrome B	61
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses	61
Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo	60

Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	59
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	58
Author Correction: Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart	56
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	53
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy	52
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	51
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection	51
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses	49
Mechanistic insights into the acetyl-CoA recognition by SLC33A1	48
Reprogramming an RNA-guided archaeal TnpB endonuclease for genome editing	48
Author Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	48
Packaged release and targeted delivery of cytokines by migrasomes in circulation	48
COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan	47
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss	46
Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15	46
Structural basis for the activity regulation of Medicago calcium channel CNGC15	44
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway	44
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	44
Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals	44
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure	43
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	43
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability	43
Proteogenomic insights into the biology and treatment of pan-melanoma	43
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	41
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores	41
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	40
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies	40
Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment	40
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	40
A tissue specific-infection mouse model of SARS-CoV-2	40
Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes	39
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	39
Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism	39
Author Correction: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	39
Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury	38
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas	38
Structural basis for promiscuity in ligand recognition by yjdF riboswitch	38
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	37
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	37
Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung	36
Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia	36
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	35
Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome	35
Molecular basis for the activation of thyrotropin-releasing hormone receptor	35
Identification of neutralizing nanobodies protecting against poxvirus infection	35
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	35
Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis	34
Discovery of new genetic loci for male sexual orientation in Han population	33
Structure of small HBV surface antigen reveals mechanism of dimer formation	33
The second messenger c-di-AMP controls natural competence via ComFB signaling protein	33

Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	33
Synthetic macrolides overcoming MLSBK-resistant pathogens	33
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	33
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis	33
High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2	31
RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus	31
Common signatures of neutrophils in diverse disease conditions	31
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	31
Author Correction: The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance	31
Intercellular genetic tracing by alternative synthetic Notch signaling	31
Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant	30
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	30
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase	30
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	30
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau	29
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	29
Structural and functional insights into the helicase protein E5 of Mpox virus	29
Targeting miR-337 mitigates disuse-induced bone loss	29
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	29
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	29
Inhibiting hedgehog signal by a patched-1 antibody	28
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	28
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites	28
New mouse genetic model of breast cancer from IKKα defects in dendritic cells revealed by single-cell RNA sequencing	28
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	28
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	28
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	28
WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity	28
Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs	27
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2	27
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution	27
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	27
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	26
In-cell structural insight into the stability of sperm microtubule doublet	26
CRISPR signal conductor 2.0 for redirecting cellular information flow	26
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	26
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	26
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	26
Integration of 3D bioprinting and multi-algorithm machine learning identified glioma susceptibilities and microenvironment characteristics	26
Multi-modal molecular determinants of clinically relevant osteoporosis subtypes	25
Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A	25
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma	25
The −KTS isoform of Wt1 induces the transformation of Leydig cells into granulosa-like cells	25
Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression	25
Structure of the human RNA polymerase I elongation complex	25
Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1	25
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	25
Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression	25
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	24
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	23
Structure of infective Getah virus at 2.8 Å resolution determined by cryo-electron microscopy	23
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance	23
Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development	23
IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy	23
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	23