Cell Discovery

(The TQCC of Cell Discovery is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-08-01 to 2023-08-01.)
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro1322
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-21034
Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations610
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing474
Inflammasome activation and regulation: toward a better understanding of complex mechanisms361
Lysosome biology in autophagy308
Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China300
Bi-directional differentiation of single bronchioalveolar stem cells during lung repair220
Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro212
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro198
SARS-CoV-2 detection with CRISPR diagnostics166
The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing152
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro146
SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2136
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility134
Efficient generation of mouse models with the prime editing system119
SARS-CoV-2 cell tropism and multiorgan infection114
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes112
Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human112
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2111
Emerging roles of ATG proteins and membrane lipids in autophagosome formation110
Single-copy sensitive, field-deployable, and simultaneous dual-gene detection of SARS-CoV-2 RNA via modified RT–RPA95
Activation and targeting of ATG8 protein lipidation89
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine81
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages80
Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients73
Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response71
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension68
Emerging functions of branched ubiquitin chains67
Plasma membrane integrity in health and disease: significance and therapeutic potential64
Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss63
Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis62
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression56
SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region56
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication56
Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics56
Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo55
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination54
Autophagosome biogenesis and human health53
Defining an evolutionarily conserved role of GW182 in circular RNA degradation51
Atomic structure of human TOM core complex50
Generation of human blastocyst-like structures from pluripotent stem cells50
Antihypertensive drugs are associated with reduced fatal outcomes and improved clinical characteristics in elderly COVID-19 patients49
Author Correction: Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing46
Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement44
A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer43
The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes43
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines43
Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m1A-methylated IGF1R39
A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases39
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo38
Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules37
SARS-CoV-2 infection in the mouse olfactory system37
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy37
Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro36
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy32
In vivo chemical reprogramming of astrocytes into neurons32
Genome-wide association study of COVID-19 severity among the Chinese population32
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease31
CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila31
Targeted exon skipping with AAV-mediated split adenine base editors31
RGS12 is required for the maintenance of mitochondrial function during skeletal development30
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence30
Immune memory in convalescent patients with asymptomatic or mild COVID-1930
More than one antibody of individual B cells revealed by single-cell immune profiling30
Mendelian neurodegenerative disease genes involved in autophagy29
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter29
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor29
Antenna arrangement and energy-transfer pathways of PSI–LHCI from the moss Physcomitrella patens29
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos28
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients28
Dysregulated hematopoiesis in bone marrow marks severe COVID-1927
KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge27
Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells27
A novel approach to remove the batch effect of single-cell data27
Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 201926
Infection of human sweat glands by SARS-CoV-225
Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation25
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis24
Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm11224
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies24
Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis23
Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays23
Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy22
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome22
An in vivo strategy for knockdown of circular RNAs22
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq22
Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals22
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing22
Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture21
A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease21
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans21
Rett mutations attenuate phase separation of MeCP220
Dysfunction of dimorphic sperm impairs male fertility in the silkworm20
Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase20
Structure of the human RNA polymerase I elongation complex20
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini20
Analysis of m6A RNA methylation in Caenorhabditis elegans20
Cas9 has no exonuclease activity resulting in staggered cleavage with overhangs and predictable di- and tri-nucleotide CRISPR insertions without template donor20
Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection19
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing19
The Asprosin-OLFR734 hormonal signaling axis modulates male fertility19
A bioenergetic shift is required for spermatogonial differentiation19
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-1919
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment19
Structural insights into assembly of human mitochondrial translocase TOM complex18
Screened AAV variants permit efficient transduction access to supporting cells and hair cells18
TAZ is required for chondrogenesis and skeletal development18
Single-particle cryo-EM structural studies of the β2AR–Gs complex bound with a full agonist formoterol18
Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes18
Identification of an intraocular microbiota18
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment18
3D landscape of Hepatitis B virus interactions with human chromatins18
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 118
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization17
RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates17
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming17
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses17
A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein17
Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication17
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries17