OOIR: Observatory of International Research

Papers

(The TQCC of Cell Discovery is 21. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Generation of live mice from haploid ESCs with germline-DMR deletions or switch	181
The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay	164
Two long-lasting human monoclonal antibodies cross-react with monkeypox virus A35 antigen	141
Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice	129
Pig blastocyst-like structure models from embryonic stem cells	118
Publisher Correction: SGF29 nuclear condensates reinforce cellular aging	118
Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis	103
Structure basis for sugar specificity of gustatory receptors in insects	93
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting	90
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities	87
The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation	86
Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1	80
Calcium influx-induced lytic cell death disrupts skin immune homeostasis	76
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control	65
Intercellular genetic tracing by alternative synthetic Notch signaling	65
Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	64
Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma	61
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2	61
EGFR blockade confers sensitivity to cabozantinib in hepatocellular carcinoma	61
Human SERPINA3 induces neocortical folding and improves cognitive ability in mice	58
Author Correction: The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance	56
Non-adjuvanted interferon-armed RBD protein nasal drops protect airway infection from SARS-CoV-2	55
SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration	54
Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque	54
Rapid screening of TCR-pMHC interactions by the YAMTAD system	54

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	53
RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus	52
Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins	51
Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant	50
PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy	49
Progressive evolution of secondary aquatic adaptation in hippos and cetaceans	48
Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration	47
Structural insights into cyanobacterial RuBisCO assembly coordinated by two chaperones Raf1 and RbcX	47
A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors	47
Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists	46
In vivo treatment of tyrosinaemia with hypercompact Cas12f1	45
Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution	44
Author Correction: Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	43
MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation	43
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex	42
Publisher Correction: TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential	42
Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy	41
Simultaneous de novo calling and phasing of genetic variants at chromosome-scale using NanoStrand-seq	40
Human zygotic genome activation is initiated from paternal genome	39
DdCBE-mediated mitochondrial base editing in human 3PN embryos	38
Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis	38
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis	38
Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq	38
A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD	37
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing	37
Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells	37
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase	37
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication	37
Author Correction: Postsynaptic lncRNA Sera/Pkm2 pathway orchestrates the transition from social competition to rank by remodeling the neural ensemble in mPFC	37
Structural and functional insights into the helicase protein E5 of Mpox virus	36
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	36
Publisher Correction: Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	36
Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	35
Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury	35
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma	35
Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly	35
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	34
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq	34
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant	34
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries	34
Hypercompact TnpB and truncated TnpB systems enable efficient genome editing in vitro and in vivo	33
A spatiotemporal transcriptomic atlas of mouse placentation	33
Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487	33
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	33
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication	32
Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy	32
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists	32
CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor	31
Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor	31
Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study	31

KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge	31
Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues	31
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	31
Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis	31
40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice	30
DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism	30
Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy	30
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome	30
Structural insights into human brain–gut peptide cholecystokinin receptors	30
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy	29
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication	29
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates	29
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs	29
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety	29
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis	29
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients	28
Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors	28
Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells	28
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines	28
A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders	28
Programmable broad-spectrum resistance to bacterial blight using targeted insertion in rice	28
Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum	27
Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics	27
Structural insights into human ABCD3-mediated peroxisomal acyl-CoA translocation	27
Derivation of transgene-free bat induced pluripotent stem cells amenable to chimera formation in mice, pigs, and chicks	27
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue	27
Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy	27
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites	27
Author Correction: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer	27
Cryo-EM structure of PML RBCC dimer reveals CC-mediated octopus-like nuclear body assembly mechanism	27
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation	26
Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2	25
The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum	25
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease	25
Structural characterization reveals substrate recognition by the taurine transporter TauT	24
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	24
Prediction of overall survival in stage II and III colon cancer through machine learning of rapidly-acquired proteomics	24
LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination	24
Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis	24
Author Correction: TMEM151A variants cause paroxysmal kinesigenic dyskinesia	24
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	24
Artificial intelligence defines protein-based classification of thyroid nodules	24
Author Correction: A genetically encoded ratiometric indicator for tryptophan	24
Proximity editing to identify RNAs in phase-separated RNA binding protein condensates	23
Identification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants	23
Structural insights into assembly of human mitochondrial translocase TOM complex	23
Genome-wide association study of COVID-19 severity among the Chinese population	23
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses	23
Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes	23
Humoral responses in naive or SARS-CoV-2 experienced individuals vaccinated with an inactivated vaccine	23
Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas	22
Author Correction: Artificial intelligence defines protein-based classification of thyroid nodules	22
Resetting histone modifications during human prenatal germline development	22
Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury	22
High-precision mapping reveals rare N6-deoxyadenosine methylation in the mammalian genome	21
Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression	21
In-cell structural insight into the stability of sperm microtubule doublet	21
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation	21
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding	21
Designed allosteric protein logic	21
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	21
The activation mechanism and antibody binding mode for orphan GPR20	21
Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine	21