Cell Discovery

Article	Citations
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro	175
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes	164
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility	159
SARS-CoV-2 cell tropism and multiorgan infection	154
Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response	127
Emerging functions of branched ubiquitin chains	109
Plasma membrane integrity in health and disease: significance and therapeutic potential	107
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages	100
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression	98
CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor	98
Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine	97
Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss	95
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis	90
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy	88
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension	85
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication	81
Generation of human blastocyst-like structures from pluripotent stem cells	76
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease	72
KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge	68
SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region	67
Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination	64
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines	64
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor	63
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies	62
Dysregulated hematopoiesis in bone marrow marks severe COVID-19	54

A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases	53
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo	53
In vivo chemical reprogramming of astrocytes into neurons	52
Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma	49
SARS-CoV-2 infection in the mouse olfactory system	49
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients	47
Genome-wide association study of COVID-19 severity among the Chinese population	46
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter	45
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos	45
Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells	42
Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome	42
Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture	40
Identification of an intraocular microbiota	39
Antenna arrangement and energy-transfer pathways of PSI–LHCI from the moss Physcomitrella patens	39
Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos	38
Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing	38
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans	38
Structure and dynamics of the EGFR/HER2 heterodimer	38
Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection	38
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3	37
Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNA-seq	37
RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models	37
Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming	37
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini	37
Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis	36
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant	36
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis	35
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis	34
Immune memory in convalescent patients with asymptomatic or mild COVID-19	34
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2	33
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm	32
Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing	32
Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy	31
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1	31
Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals	31
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication	30
Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models	30
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma	30
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries	30
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2	30
Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s	29
TAZ is required for chondrogenesis and skeletal development	29
Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection	29
Infection of human sweat glands by SARS-CoV-2	29
Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression	28
Integrated proteogenomic characterization of medullary thyroid carcinoma	28
Chilling-induced phosphorylation of IPA1 by OsSAPK6 activates chilling tolerance responses in rice	28
Structural insights into assembly of human mitochondrial translocase TOM complex	28
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury	28
CRISPR-edited CART with GM-CSF knockout and auto secretion of IL6 and IL1 blockers in patients with hematologic malignancy	28

Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2	28
SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment	27
A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease	27
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma	26
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis	26
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses	26
Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly	26
Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB	25
Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy	25
Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infection	25
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization	25
Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity	25
Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)	25
3D landscape of Hepatitis B virus interactions with human chromatins	25
PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation	25
Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines	25
Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication	25
High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation	24
TMEM151A variants cause paroxysmal kinesigenic dyskinesia	24
Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern	24
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis	24
SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells	23
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2	23
DdCBE-mediated mitochondrial base editing in human 3PN embryos	23
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19	23
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5	23
Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues	23
m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation	23
Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma	23
Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells	22
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells	22
Structural insights into human CCAN complex assembled onto DNA	22
RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates	22
Efficient and precise generation of Tay–Sachs disease model in rabbit by prime editing system	22
Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics	21
LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis	21
Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma	21
The Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance	21
Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter	21
Single-cell RNA-Seq reveals transcriptional heterogeneity and immune subtypes associated with disease activity in human myasthenia gravis	21
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE	21
Structure of the human RNA polymerase I elongation complex	21
The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay	21
Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35	21
A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species	21
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration	20
Structure-based evidence for the enhanced transmissibility of the dominant SARS-CoV-2 B.1.1.7 variant (Alpha)	20
Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state	20
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses	20
Rapid screening of TCR-pMHC interactions by the YAMTAD system	20
The Omicron BA.2.2.1 subvariant drove the wave of SARS-CoV-2 outbreak in Shanghai during spring 2022	20
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming	20
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD	20
Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3	20
Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2	20
Neutralization of SARS-CoV-2 BQ.1.1, CH.1.1, and XBB.1.5 by breakthrough infection sera from previous and recent waves in China	20
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma	20
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype	20
The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1	19
Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling	19
Molecular insights into the human ABCB6 transporter	19
Artificial intelligence defines protein-based classification of thyroid nodules	19
BRD4-targeting PROTAC as a unique tool to study biomolecular condensates	19
Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells	19
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity	19
Loss of function of CMPK2 causes mitochondria deficiency and brain calcification	19
Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque	19
A differentiation roadmap of murine placentation at single-cell resolution	19
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis	19
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling	19
Cryo-EM structures of human TMEM120A and TMEM120B	19
A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration	19
Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2	18
Structural insight into the substrate recognition and transport mechanism of the human LAT2–4F2hc complex	18
Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq	18
Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying	18
Cell-in-cell structure mediates in-cell killing suppressed by CD44	18
High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform	18
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy	18
Dynamics of histone acetylation during human early embryogenesis	18

Single-cell transcriptome reveals cellular hierarchies and guides p-EMT-targeted trial in skull base chordoma	18
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses	18
Human zygotic genome activation is initiated from paternal genome	18
Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses	17
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies	17
Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin	17
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase	17
Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations	17
PPARγ phase separates with RXRα at PPREs to regulate target gene expression	16
Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis	16
Proximity editing to identify RNAs in phase-separated RNA binding protein condensates	16
CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway	16
Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes	16
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation	16
Establishment of human distal lung organoids for SARS-CoV-2 infection	16
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis	16
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5	15
Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer	15
Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A	15
Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes	15
A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein	15
Cross-neutralization of SARS-CoV-2 Kappa and Delta variants by inactivated vaccine-elicited serum and monoclonal antibodies	15
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity	15
Potential of angiotensin II receptor blocker telmisartan in reducing mortality among hospitalized patients with COVID-19 compared with recommended drugs	15
Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein	15
Metagenomic discovery of novel CRISPR-Cas13 systems	15
The immune-suppressive landscape in lepromatous leprosy revealed by single-cell RNA sequencing	14
Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting	14
LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation	14
Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells	14
Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages	14
Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2	14
Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression	14
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection	14
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding	14
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase	14
Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations	14
Discovery of a cooperative mode of inhibiting RIPK1 kinase	14
Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling	14
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus	14
Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists	14
GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation	13
Structural identification of riluzole-binding site on human TRPC5	13
The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response	13
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis	13
Landscape of the RBD-specific IgG, IgM, and IgA responses triggered by the inactivated virus vaccine against the Omicron variant	13
Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema	13
Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair	13
Excess folic acid intake increases DNA de novo point mutations	13
Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs	13
2,3-Butanediol synthesis from glucose supplies NADH for elimination of toxic acetate produced during overflow metabolism	13
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants	13
HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation	13
Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity	13
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney	13
The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum	13
Dissecting the fate of Foxl2-expressing cells in fetal ovary using lineage tracing and single-cell transcriptomics	12
Structure of infective Getah virus at 2.8 Å resolution determined by cryo-electron microscopy	12
Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2	12
Cryo-EM structures of human calcium homeostasis modulator 5	12
CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion	12
Ribosomal RNA regulates chromosome clustering during mitosis	12
Distinct BCR repertoires elicited by SARS-CoV-2 RBD and S vaccinations in mice	12
Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera	12
Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells	12
Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2	12
Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel	12
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates	12
Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis	11
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication	11
hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants	11
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters	11
Spatiotemporal regulation of insulin signaling by liquid–liquid phase separation	11
In-cell structural insight into the stability of sperm microtubule doublet	11
Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z	11
A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy	10
Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening	10
Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury	10
Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors a	10
Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells	10
SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants	10
A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors	10
The asymmetrical ESR1 signaling in muscle progenitor cells determines the progression of adolescent idiopathic scoliosis	10
Proteomic characterization of Omicron SARS-CoV-2 host response	10
Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution	10
Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment	9
Molecular mechanism of substrate recognition by folate transporter SLC19A1	9
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver	9
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities	9
A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems	9
Identification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants	9
RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus	9
Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM	9
Structural insights into human brain–gut peptide cholecystokinin receptors	9
MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation	9