OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pathology Clinical Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Assessment of clinical trial protocols for pathology content using the SPIRIT‐Path guidelines highlights areas for improvement	47
Clinicopathological features and cancer transcriptomic profiling of poorly cohesive gastric carcinoma subtypes	43
A novel telomere biology disease‐associated gastritis identified through a whole exome sequencing‐driven approach	41
Immune checkpoint CD161/LLT1‐associated immunological landscape and diagnostic value in oral squamous cell carcinoma	39
Issue Information	37
Tumor‐associated macrophages and risk of recurrence in stage III colorectal cancer	33
Characterizing the tumor microenvironment in rare renal cancer histological types	27
Issue Information	27
The prognostic marker elastin correlates with epithelial–mesenchymal transition and vimentin‐positive fibroblasts in gastric cancer	24
Gastric cancer immune microenvironment score predicts neoadjuvant chemotherapy efficacy and prognosis	23
Translational practice of fluorescence in situ hybridisation to identify neuroblastic tumours with TERT rearrangements	22
Identification and therapeutic evaluation of ALK rearrangements in non‐small‐cell lung cancer	21
Leveraging deep learning to discover interpretable cellular spatial biomarkers for prognostic predictions based on hepatocellular carcinoma histology	20
Spatial analysis of tumor‐infiltrating lymphocytes in histological sections using deep learning techniques predicts survival in colorectal carcinoma	19
KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway	19
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy	19
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Issue Information	16
Authors' reply: Re: Koga et al. Retrieval‐augmented generation versus document‐grounded generation: a key distinction in large language models	15
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KRAS mutations and endometriosis burden of disease	14
Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers	14
Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study	14
Somatic whole exome sequencing of colorectal carcinoma in young patients from sub‐Saharan Africa reveals novel insights	14
Cancer‐associated fibroblast expression of glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer	14

Altered cytoplasmic and nuclear ADP‐ribosylation levels analyzed with an improved ADP‐ribose binder are a prognostic factor in renal cell carcinoma	13
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Engineering the future of 3D pathology	13
Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis	12
Low‐burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation	12
The ethical challenges of artificial intelligence‐driven digital pathology	11
Issue Information	11
Myeloid sarcoma shows a high frequency of mutations activating the MAPK/ERK pathway and association with clonal hematopoiesis	11
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p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study	10
Issue Information	10
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma	10
Issue Information	9
Automated annotations of epithelial cells and stroma in hematoxylin–eosin‐stained whole‐slide images using cytokeratin re‐staining	9
Cell‐by‐cell quantification of the androgen receptor in benign and malignant prostate leads to a better understanding of changes linked to cancer initiation and progression	9
Real‐life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization	9
Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types	8
pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical p	8
A prognostic six‐gene expression risk‐score derived from proteomic profiling of the metastatic colorectal cancer secretome	8
Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials	8
Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer	8
Exosome‐derived ANXA9 functions as an oncogene in breast cancer	7
First proficiency testing for NGS‐based and combined NGS‐ and FISH‐based detection of FGFR2 fusions in intrahepatic cholangiocarcinoma	7
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Issue Information	7
DNA methylation profile discriminates sporadic giant cell granulomas of the jaws and cherubism from their giant cell‐rich histological mimics	6
Genomic heterogeneity at baseline is associated with T790M resistance mutations in EGFR‐mutated lung cancer treated with the first‐/second‐generation tyrosine kinase inhibitors	6
PD‐L1 and PD‐L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules	6
Issue Information	6
Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric aden	6
Sarcomatoid areas of urothelial carcinoma are enriched for CD163‐positive antigen‐presenting cells	6
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors	6
The effectiveness of neoadjuvant chemoradiotherapy in oesophageal adenocarcinoma with presence of extracellular mucin, signet‐ring cells, and/or poorly cohesive cells	6
MMR deficiency is frequent in colorectal carcinomas with diffuse SLFN11 immunostaining: clinicopathologic and molecular study of 31 cases identified among 3,300 tumors	6
Closing the loop – the role of pathologists in digital and computational pathology research	6
Accounting for intensity variation in image analysis of large‐scale multiplexed clinical trial datasets	6
Assessing the impact of deep‐learning assistance on the histopathological diagnosis of serous tubal intraepithelial carcinoma (STIC) in fallopian tubes	6