OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Pathology Clinical Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
SWI/SNF‐deficiency defines highly aggressive undifferentiated endometrial carcinoma	38
Replacement and desmoplastic histopathological growth patterns in cutaneous melanoma liver metastases: frequency, characteristics, and robust prognostic value	35
Endometrial stromal sarcomas with BCOR‐rearrangement harbor MDM2 amplifications	31
Combined CCNE1 high‐level amplification and overexpression is associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma	30
Higher prevalence of pulmonary macrothrombi in SARS‐CoV‐2 than in influenza A: autopsy results from ‘Spanish flu’ 1918/1919 in Switzerland to Coronavirus disease 2019	27
Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease	26
DNA methylation‐based profiling of bone and soft tissue tumours: a validation study of the ‘DKFZ Sarcoma Classifier’	26
Characterisation of cardiac pathology in 23 autopsies of lethal COVID‐19	26
Prognostic assessment of resected colorectal liver metastases integrating pathological features, RAS mutation and Immunoscore	24
Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation	23
Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases	23
Hypothesis‐free deep survival learning applied to the tumour microenvironment in gastric cancer	21
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma	20
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients	20
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer	19
Spatial analysis of tumor‐infiltrating lymphocytes in histological sections using deep learning techniques predicts survival in colorectal carcinoma	19
Semantic annotation for computational pathology: multidisciplinary experience and best practice recommendations	19
Detection of tumor‐derived cell‐free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid	19
Sarcoma and the 100,000 Genomes Project: our experience and changes to practice	19
Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population	17
Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer	17
The ethical challenges of artificial intelligence‐driven digital pathology	16
Variability in grading of ductal carcinoma in situ among an international group of pathologists	16
Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features	15
Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer	15

Significance of tumour regression in lymph node metastases of gastric and gastro‐oesophageal junction adenocarcinomas	15
Immune cell infiltrates as prognostic biomarkers in pancreatic ductal adenocarcinoma: a systematic review and meta‐analysis	15
Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response	14
An analysis of HER2 amplification in cervical adenocarcinoma: correlation with clinical outcomes and the International Endocervical Adenocarcinoma Criteria and Classification	14
TFE3 activation in a TSC1‐altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms	13
Expression of invadopodia markers can identify oral lesions with a high risk of malignant transformation	12
Dysbalance of ACE2 levels – a possible cause for severe COVID‐19 outcome in COPD	12
Analysis of a novel immune checkpoint, Siglec‐15, in pancreatic ductal adenocarcinoma	12
Quick Annotator: an open‐source digital pathology based rapid image annotation tool	12
Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma	11
More than just acral melanoma: the controversies of defining the disease	11
Loss of NF2 defines a genetic subgroup of non‐FOS‐rearranged osteoblastoma	11
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer	11
Intra‐ and extra‐cranial BCOR‐ITD tumours are separate entities within the BCOR‐rearranged family	10
CD24 is a surrogate for ‘immune‐cold’ phenotype in aggressive large B‐cell lymphoma	10
Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types	10
Explainability and causability in digital pathology	10
MYC amplifications are common events in childhood osteosarcoma	10
Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants	10
Prognostic value of patient‐derived xenograft engraftment in pediatric sarcomas	10
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors	10
Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8⁺ T cell infiltrate	9
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors	9
pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical p	9
PD‐L1 and PD‐L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules	9
Diagnostic and prognostic implications of a three‐antibody molecular subtyping algorithm for non‐muscle invasive bladder cancer	9
The presence of tumour‐infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma	9
Tertiary lymphoid structures favor outcome in resected esophageal squamous cell carcinoma	8
A combination of stromal PD‐L1 and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal ca	8
Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy	8
Malignant transformation of salivary gland pleomorphic adenoma: proof of principle	8
A series of COVID‐19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza	8
An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours	8
Reliable computational quantification of liver fibrosis is compromised by inherent staining variation	8
Greater utility of molecular subtype rather than epithelial‐to‐mesenchymal transition (EMT) markers for prognosis in high‐risk non‐muscle‐invasive (HGT1) bladder cancer	8
A distinct repertoire of cancer‐associated fibroblasts is enriched in cribriform prostate cancer	8
Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?	7
Characterizing the tumor microenvironment in rare renal cancer histological types	7
KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway	7
Understanding the ethical and legal considerations of Digital Pathology	7
The prognostic marker elastin correlates with epithelial–mesenchymal transition and vimentin‐positive fibroblasts in gastric cancer	7
Digital image analysis in pathologist‐selected regions of interest predicts survival more accurately than whole‐slide analysis: a direct comparison study in 153 gastric carcinomas	6
Optimization of deep learning models for the prediction of gene mutations using unsupervised clustering	6
Tumor‐associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer	6
Deep learning‐based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis	6
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy	6
STING pathway expression in low‐grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?	6
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell car	6
Tumor‐associated macrophages and risk of recurrence in stage III colorectal cancer	6
Identifying fibroblast growth factor receptor genetic alterations using RNA‐based assays in patients with metastatic or locally advanced, surgically unresectable, urothelial carcinoma who may benefit	5

PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways	5
Post‐operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression	5
c‐MYC and p53 expression highlight starry‐sky pattern as a favourable prognostic feature in R‐CHOP‐treated diffuse large B‐cell lymphoma	5
Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation	5
p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study	5
The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies	4
Pathologic T1 and T2 encapsulated invasive carcinomas arising from mucinous cystic neoplasms of the pancreas have favorable prognosis and might be treated conservatively	4
Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric aden	4
PRR11 unveiled as a top candidate biomarker within the RBM3‐regulated transcriptome in pancreatic cancer	4
Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours	4
Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups	4
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity	4
Recommendations for cellular and molecular pathology input into clinical trials: a systematic review and meta‐aggregation	4
CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways	4
Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E‐stained images: achieving state‐of‐the‐art predictive performance with fewer data using Swin Transformer	4
Whole‐exome sequencing analysis of juvenile papillomatosis and coexisting breast carcinoma	4
PRAME protein expression in DICER1‐related tumours	4
High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma	4
Clinicopathological characteristics of Epstein–Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization cri	4
A prognostic six‐gene expression risk‐score derived from proteomic profiling of the metastatic colorectal cancer secretome	3
CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer	3
KRAS mutations and endometriosis burden of disease	3
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations	3
Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma	3
Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?	3
Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast	3
First proficiency testing for NGS‐based and combined NGS‐ and FISH‐based detection of FGFR2 fusions in intrahepatic cholangiocarcinoma	3
Automated annotations of epithelial cells and stroma in hematoxylin–eosin‐stained whole‐slide images using cytokeratin re‐staining	3
Severity of arterial and/or arteriolar sclerosis in IgA nephropathy and the effects of renin–angiotensin system inhibitors on its prognosis	3
Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry	3
Identifying primary tumor site of origin for liver metastases via a combination of handcrafted and deep learning features	2
Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention	2
Increased diagnostic sensitivity of palpation‐guided thyroid nodule fine‐needle aspiration cytology by BRAF V600E‐mutation analysis	2
Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study	2
Exosome‐derived ANXA9 functions as an oncogene in breast cancer	2
Development of multiple AI pipelines that predict neoadjuvant chemotherapy response of breast cancer using H&E‐stained tissues	2
Identification of a prognostic signature in colorectal cancer using combinatorial algorithm‐driven analysis	2
AI‐based intra‐tumor heterogeneity score of Ki67 expression as a prognostic marker for early‐stage ER+/HER2− breast cancer	2
Application of direct stochastic optical reconstruction microscopy (dSTORM) to the histological analysis of human glomerular disease	2
Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas	2
CD70 and PD‐L1 (CD274) co‐expression predicts poor clinical outcomes in patients with pleural mesothelioma	2
CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer	2
	2
High cyclin E1 protein, but not gene amplification, is prognostic for basal‐like breast cancer	2
NTRK gene aberrations in triple‐negative breast cancer: detection challenges using IHC, FISH, RT‐PCR, and NGS	2