OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Pathology Clinical Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease	30
DNA methylation‐based profiling of bone and soft tissue tumours: a validation study of the ‘DKFZ Sarcoma Classifier’	29
Higher prevalence of pulmonary macrothrombi in SARS‐CoV‐2 than in influenza A: autopsy results from ‘Spanish flu’ 1918/1919 in Switzerland to Coronavirus disease 2019	27
Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases	26
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma	26
Characterisation of cardiac pathology in 23 autopsies of lethalCOVID‐19	26
Spatial analysis of tumor‐infiltrating lymphocytes in histological sections using deep learning techniques predicts survival in colorectal carcinoma	25
Detection of tumor‐derived cell‐free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid	23
Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer	23
Variability in grading of ductal carcinoma in situ among an international group of pathologists	22
Semantic annotation for computational pathology: multidisciplinary experience and best practice recommendations	22
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer	21
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients	21
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer	21
Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features	20
Identification of NTRK gene fusions in lung adenocarcinomas in the Chinese population	20
The ethical challenges of artificial intelligence‐driven digital pathology	19
Explainability and causability in digital pathology	19
Immune cell infiltrates as prognostic biomarkers in pancreatic ductal adenocarcinoma: a systematic review and meta‐analysis	18
Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types	17
Quick Annotator: an open‐source digital pathology based rapid image annotation tool	16
More than just acral melanoma: the controversies of defining the disease	15
TFE3 activation in a TSC1‐altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms	15
Reliable computational quantification of liver fibrosis is compromised by inherent staining variation	14
Dysbalance of ACE2 levels – a possible cause for severe COVID‐19 outcome in COPD	14

Analysis of a novel immune checkpoint, Siglec‐15, in pancreatic ductal adenocarcinoma	14
The prognostic marker elastin correlates with epithelial–mesenchymal transition and vimentin‐positive fibroblasts in gastric cancer	13
Prognostic value of patient‐derived xenograft engraftment in pediatric sarcomas	13
KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway	13
Tertiary lymphoid structures favor outcome in resected esophageal squamous cell carcinoma	13
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors	12
Diagnostic and prognostic implications of a three‐antibody molecular subtyping algorithm for non‐muscle invasive bladder cancer	12
MYC amplifications are common events in childhood osteosarcoma	12
Intra‐ and extra‐cranial BCOR‐ITD tumours are separate entities within the BCOR‐rearranged family	12
CD24 is a surrogate for ‘immune‐cold’ phenotype in aggressive large B‐cell lymphoma	12
PD‐L1 and PD‐L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules	12
The presence of tumour‐infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma	11
Understanding the ethical and legal considerations of Digital Pathology	11
pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical p	11
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors	11
A combination of stromal PD‐L1 and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal ca	10
Malignant transformation of salivary gland pleomorphic adenoma: proof of principle	10
Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy	10
Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants	10
KRAS mutations and endometriosis burden of disease	9
A distinct repertoire of cancer‐associated fibroblasts is enriched in cribriform prostate cancer	9
p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study	9
Tumor‐associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer	9
Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8⁺ T cell infiltrate	9
Tumor‐associated macrophages and risk of recurrence in stage III colorectal cancer	9
A series of COVID‐19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza	8
Characterizing the tumor microenvironment in rare renal cancer histological types	8
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy	8
STING pathway expression in low‐grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?	8
Optimization of deep learning models for the prediction of gene mutations using unsupervised clustering	8
Deep learning‐based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis	7
Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation	7
Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?	7
Clinicopathological characteristics of Epstein–Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization cri	7
Post‐operative mortality and recurrence patterns in pancreatic cancer according to KRAS mutation and CDKN2A, p53, and SMAD4 expression	6
High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma	6
Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours	6
c‐MYC and p53 expression highlight starry‐sky pattern as a favourable prognostic feature in R‐CHOP‐treated diffuse large B‐cell lymphoma	6
The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies	6
Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E‐stained images: achieving state‐of‐the‐art predictive performance with fewer data using Swin Transformer	6
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell car	6
PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways	6
Whole‐exome sequencing analysis of juvenile papillomatosis and coexisting breast carcinoma	5
PRR11 unveiled as a top candidate biomarker within the RBM3‐regulated transcriptome in pancreatic cancer	5
A prognostic six‐gene expression risk‐score derived from proteomic profiling of the metastatic colorectal cancer secretome	5
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity	5
Automated annotations of epithelial cells and stroma in hematoxylin–eosin‐stained whole‐slide images using cytokeratin re‐staining	5
PRAME protein expression in DICER1‐related tumours	5
Identifying primary tumor site of origin for liver metastases via a combination of handcrafted and deep learning features	4
CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer	4

Engineering the future of 3D pathology	4
Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric aden	4
Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast	4
Exosome‐derived ANXA9 functions as an oncogene in breast cancer	4
CD70 and PD‐L1 (CD274) co‐expression predicts poor clinical outcomes in patients with pleural mesothelioma	4
Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups	4
PD‐L1 expression in megakaryocytes and its clinicopathological features in primary myelofibrosis patients	4
DecreasedCD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma	4
Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry	4
Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial	4
Pathologic T1 and T2 encapsulated invasive carcinomas arising from mucinous cystic neoplasms of the pancreas have favorable prognosis and might be treated conservatively	4
Validation of the prognostic value of CD3 and CD8 cell densities analogous to the Immunoscore® by stage and location of colorectal cancer: an independent patient cohort study	4
Recommendations for cellular and molecular pathology input into clinical trials: a systematic review and meta‐aggregation	4
CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways	4
Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma	3
Severity of arterial and/or arteriolar sclerosis in IgA nephropathy and the effects of renin–angiotensin system inhibitors on its prognosis	3
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations	3
Development of multiple AI pipelines that predict neoadjuvant chemotherapy response of breast cancer using H&E‐stained tissues	3
Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?	3
Application of direct stochastic optical reconstruction microscopy (dSTORM) to the histological analysis of human glomerular disease	3
First proficiency testing for NGS‐based and combined NGS‐ and FISH‐based detection of FGFR2 fusions in intrahepatic cholangiocarcinoma	3
Real‐life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization	3
Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis	3
Cancer‐associated fibroblast expression of glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer	3
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The epigenetic modifier lysine methyltransferase 2C is frequently mutated in gastric remnant carcinoma	2
RAD51 as a biomarker for homologous recombination deficiency in high‐grade serous ovarian carcinoma: robustness and interobserver variability of the RAD51 test	2
CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer	2
AI‐based intra‐tumor heterogeneity score of Ki67 expression as a prognostic marker for early‐stage ER+/HER2− breast cancer	2
The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple‐negative breast cancers	2
NTRK gene aberrations in triple‐negative breast cancer: detection challenges using IHC, FISH, RT‐PCR, and NGS	2
Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention	2
Prediction of immunochemotherapy response for diffuse large B‐cell lymphoma using artificial intelligence digital pathology	2
Increased diagnostic sensitivity of palpation‐guided thyroid nodule fine‐needle aspiration cytology by BRAF V600E‐mutation analysis	2
Immunohistochemical characteristics and potential therapeutic regimens of hepatoid adenocarcinoma of the stomach: a study of 139 cases	2
High cyclin E1 protein, but not gene amplification, is prognostic for basal‐like breast cancer	2
Immune checkpoint CD161/LLT1‐associated immunological landscape and diagnostic value in oral squamous cell carcinoma	2
Cell‐by‐cell quantification of the androgen receptor in benign and malignant prostate leads to a better understanding of changes linked to cancer initiation and progression	2
The effectiveness of neoadjuvant chemoradiotherapy in oesophageal adenocarcinoma with presence of extracellular mucin, signet‐ring cells, and/or poorly cohesive cells	2
Identification of a prognostic signature in colorectal cancer using combinatorial algorithm‐driven analysis	2
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Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas	2
Digital image analysis allows objective stratification of patients with silent PIT1‐lineage pituitary neuroendocrine tumors	2