OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Research is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Tumoricidal Efficacy of Artesunate-Eluting Microsphere: Differential Role of Bax/Bak in Orchestration of Cell Death Pathways	211
Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel	141
Erratum to “An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery”	118
Label-Free Prediction of Fluorescently Labeled Fibrin Networks	112
Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations	93
Zein and Trimethyl Chitosan-Based Core–Shell Nanoparticles for Quercetin Oral Delivery to Enhance Absorption by Paracellular Pathway in Obesity Mice	92
Coacervate-mediated novel pancreatic cancer drug Aleuria Aurantia lectin delivery for augmented anticancer therapy	92
Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration	90
The Strontium Ion Reprograms Monocyte Subsets via TRPM2 Channel Regulation to Enhance Osseointegration	89
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots	86
Strategies to Overcome Hurdles in Cancer Immunotherapy	81
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration	75
Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects	73
An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy	68
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles	65
Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Oxidative Damage via the miR-191-5p/DAPK1/AKT Axis in Type 2 Diabetes	63
High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds	61
Cellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor	60
Optimized Epigallocatechin Gallate Delivery and Adipogenesis Inhibition through Fluorescent Mesoporous Nanocarriers	57
Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate	55
Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and	54
Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system	54
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System	53
Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury	53
A Novel Lipopeptide–Functionalized Metal–Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway	53

Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection	52
Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment	51
Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration	49
Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy	48
Harnessing the Intradermal Delivery of Hair Follicle Dermal Papilla Cell Spheroids for Hair Follicle Regeneration in Nude Mice	48
Customized Sized Manganese Sulfide Nanospheres as Efficient T ₁ MRI Contrast Agents for Enhanced Tumor Theranostics	47
NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes	46
Dual-Channel NIR Fluorescence Imaging for Precise Delineation of Gastric Tumor Margins	46
Simultaneously Modulating HIF-1α and HIF-2α and Optimizing Macrophage Polarization through the Biomimetic Gene Vector toward the Treatment of Osteoarthritis	46
Genetically Encoded Fluorescence Resonance Energy Transfer Biosensor for Live-Cell Visualization of Lamin A Phosphorylation at Serine 22	45
Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3	45
An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery	44
mRNA nanodelivery systems: targeting strategies and administration routes	44
The worldwide patent landscape of dental implant technology	42
Advances in the development of tubular structures using extrusion-based 3D cell-printing technology for vascular tissue regenerative applications	41
The hydrogen storage nanomaterial MgH ₂ improves irradiation-induced male fertility impairment by suppressing oxidative stress	40
Injection laryngoplasty of human adipose-derived stem cell spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx	38
Paris polyphylla var. yunnanensis Leaf-Derived Extracellular Vesicles-like Particles Enhance Periodontal Regeneration	38
Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization	37
Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer	37
Modulation of bioactive calcium phosphate micro/nanoparticle size and shape during in situ synthesis of photo-crosslinkable gelatin methacryloyl based nanocomposite hydrogels for 3D bioprinting and ti	37
A New Perspective on Precision Medicine: The Power of Digital Organoids	37
Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants	36
Regeneration of a Rabbit Segmental Defect with a New Bone Therapy: Autologous Blood Coagulum with Bone Morphogenetic Protein 6 and Synthetic Ceramics	36
Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy	36
Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy	35
Homotypic Membrane Vesicle-Formulated VAN@ΔagrMVsfor Methicillin- Resistant Staphylococcus aureus Biofilm Clearance	35
Label-Free Enrichment of Highly Metastatic Tumor-Initiating Cells up to a Monoclonal State	35
Rediscovery of poly(ethylene glycol)s as a cryoprotectant for mesenchymal stem cells	35
Solubilized chlorin e6-layered double hydroxide complex for anticancer photodynamic therapy	34
Recent advances in optical imaging through deep tissue: imaging probes and techniques	34
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis	34
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration	33
Decellularized Extracellular Matrix Scaffolds for Soft Tissue Augmentation: From Host–Scaffold Interactions to Bottlenecks in Clinical Translation	33
Application of bioactive glasses in various dental fields	33
Low-Molecular-Weight PEGs for Cryopreservation of Stem Cell Spheroids	33
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri-implant	33
PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery	32
Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research	32
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1–Orai1 Signaling and Calcium Overload-Induced Mitochondrial Damage of Follicular Helper T Cells in Lupus	31
From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds	30
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy	30
Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization	29
Distinct Roles of Matrigel Enabled the Production of Expandable Hepatoblast and Polarized Hepatocyte Organoids from Human Embryonic Stem Cells under 3-Dimensional Suspension Conditions	29
Non-interfacial self-assembly of synthetic protocells	29
Erratum to “Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA”	29
Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models	29
Intranasal Nanoliposomes Delivering Interferon Lambda with Enhanced Mucosal Retention as an Antiviral	28
Impact of Culture Duration on the Properties and Functionality of Yeast-Derived Extracellular Vesicles	28
Boron Nanocomposites for Boron Neutron Capture Therapy and in Biomedicine: Evolvement and Challenges	28

Res@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency	28
Surface-mediated high antioxidant and anti-inflammatory effects of astaxanthin-loaded ultrathin graphene oxide film that inhibits the overproduction of intracellular reactive oxygen species	27
Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment	26
Targeted H ₂ S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane	26
Lipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure	26
Optimization of the clinically approved Mg-Zn alloy system through the addition of Ca	26
Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies	26
Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid	26
A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management	26
Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds	26
Biomimetic Marine-Sponge-Derived Spicule-Microparticle-Mediated Biomineralization and YAP/TAZ Pathway for Bone Regeneration In Vivo	26
Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering	25
Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment	25
Evaluating the validity of lightweight talar replacement designs: rational models and topologically optimized models	25
Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation	25
Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming	25
Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate	25
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin	25
Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma	24
Nanotherapeutic System with Effective Microwave Sensitization and Pyroptosis Programming Enable Synergistic Microwave-Immunotherapy in Bladder Cancer	24
Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field	24
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration	23
Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis	23
A novel DNA double-strand breaks biosensor based on fluorescence resonance energy transfer	23
Smart and versatile biomaterials for cutaneous wound healing	22
Progress of tissue adhesives based on proteins and synthetic polymers	22
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae	22
Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects	22
Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity	22
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization	22
Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival	22
Development of NK Cell-Drug Conjugates via Membrane-installed Liposomes for Pancreatic Cancer Treatment	21
A Self-Assembling Senolytic Prodrug with Enhanced Bioavailability and Selective Activation for Targeting Senescent Retinal Pigment Epithelium	21
A systematic study on the use of multifunctional nanodiamonds for neuritogenesis and super-resolution imaging	21
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment	21
The role of cellular traction forces in deciphering nuclear mechanics	21
Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques	21
Hyaluronic Acid-Functionalized Bismuth Vanadate/Molybdenum Disulfide Nanoheterojunctions Achieve Efficient Phototherapy of Hypoxic Tumor	21
Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation	21
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophag	21
Correction: Non-interfacial self-assembly of synthetic protocells	20
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy	20
Erratum to “Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment”	19
Application of molecular dynamics simulation in self-assembled cancer nanomedicine	19
Inducing in situ M2 Macrophage Polarization for Tendinopathy Therapy through Microneedle Patch Mediated Instant/Sustained Delivery of Rosmarinic Acid	19
Hybrid Homodimeric Prodrug Nanoassemblies for Low-Toxicity and Synergistic Chemophotodynamic Therapy of Melanoma	19
Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration	19
Hydrogel in the Treatment of Traumatic Brain Injury	19
Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level	19
3D biofabrication of diseased human skin models in vitro	19
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model	19
Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers	19
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair	19
Epigallocatechin Gallate Attenuates CaOx Crystal-Induced Renal Tubular Injury to Inhibit CaOx Nephrolithiasis via GRP94/PI3K/AKT Signaling	18
Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy	18
Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals	18
In Silico Target Discovery of Kaempferol: Therapeutic Effect of Kaempferol on Atopic Dermatitis through Regulation of Aryl Hydrocarbon Receptor	18
Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy	18
Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery	18