OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Research is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations	118
MXene-Derived Multifunctional Biomaterials: New Opportunities for Wound Healing	87
Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament–Bone Junction Repair	79
Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic endometriosis therapy	73
Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment	73
P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging	70
Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold	66
Two-Dimensional “Nanotanks” Release “Gas Bombs” through Photodynamic Cascades to Promote Diabetic Wound Healing	65
Ultrasonic-controlled drug release prevents pro-tumorigenic transition and improves sequential targeting effect to enhance treatment of residual HCC	65
Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field	61
Recent Advancements in Biomaterials for Chimeric Antigen Receptor T Cell Immunotherapy	58
Evaluation of Integrity of Allogeneic Bone Processed with High Hydrostatic Pressure: A Pilot Animal Study	49
Nanotherapeutic System with Effective Microwave Sensitization and Pyroptosis Programming Enable Synergistic Microwave-Immunotherapy in Bladder Cancer	47
Strategies to Overcome Hurdles in Cancer Immunotherapy	46
Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects	45
Pulmonary Delivery of Anti-microRNA Oligonucleotide and Glycyrrhizic Acid Using Ternary Peptide Micelles for the Treatment of Acute Lung Injury	45
Evaluating the validity of lightweight talar replacement designs: rational models and topologically optimized models	44
Coacervate-mediated novel pancreatic cancer drug Aleuria Aurantia lectin delivery for augmented anticancer therapy	44
Shape-memory collagen scaffold combined with hyaluronic acid for repairing intervertebral disc	43
Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis	43
A novel DNA double-strand breaks biosensor based on fluorescence resonance energy transfer	43
A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement	41
Self-curling 3D oriented scaffolds from fish scales for skeletal muscle regeneration	39
Progress of tissue adhesives based on proteins and synthetic polymers	37
Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding	36

Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT	36
A novel and cost-effective method for high-throughput 3D culturing and rhythmic assessment of hiPSC-derived cardiomyocytes using retroreflective Janus microparticles	35
Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection	35
An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy	34
Enhancing Cancer Therapy: Boron-Rich Polyboronate Ester Micelles for Synergistic Boron Neutron Capture Therapy and PD-1/PD-L1 Checkpoint Blockade	34
High-Frequency Optical Coherence Elastography for Gingival Tissue Characterization: Variability in Stiffness and Response to Physiological Conditions	33
Additively manufactured titanium scaffolds and osteointegration - meta-analyses and moderator-analyses of in vivo biomechanical testing	31
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization	31
Fabrication of 3D printed bi-layered scaffold carboxymethyl chitosan/oxidized xanthan gum, biphasic calcium phosphate for osteochondral regeneration	30
Antibacterial Immunonegative Coating with Biocompatible Materials on a Nanostructured Titanium Plate for Orthopedic Bone Fracture Surgery	30
The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery	30
Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival	30
Erratum to “An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery”	30
Aspirin in the Form of Microneedle Repairs DNA and Reduces Inflammation in Persistent Skin Damage	29
Cell Membrane-Coated Nanotherapeutics for the Targeted Treatment of Acute and Chronic Colitis	29
Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs	28
Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity	28
Manufacturing Uniform Cerebral Organoids for Neurological Disease Modeling and Drug Evaluation	28
Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration	27
Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis	27
Current aspects of small extracellular vesicles in pain process and relief	26
Polydopamine-Cloaked Nanoarchitectonics of Prussian Blue Nanoparticles Promote Functional Recovery in Neonatal and Adult Ischemic Stroke Models	26
Emerging biomaterials for tumor immunotherapy	25
Emerging 3D bioprinting applications in plastic surgery	25
Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate	25
Harnessing Nanotechnology for Gout Therapy: Colchicine-Loaded Nanoparticles Regulate Macrophage Polarization and Reduce Inflammation	25
PEDF-Enriched Extracellular Vesicle for Vessel Normalization to Potentiate Immune Checkpoint Blockade Therapy	24
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration	24
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration	24
Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects	24
De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation	24
Combining Gut Microbiota Modulation and Enzymatic-Triggered Colonic Delivery by Prebiotic Nanoparticles Improves Mouse Colitis Therapy	23
Recent advances in surface-mounted metal–organic framework thin film coatings for biomaterials and medical applications: a review	23
Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications	23
GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances	23
Smart and versatile biomaterials for cutaneous wound healing	22
Versatile and marvelous potentials of polydeoxyribonucleotide for tissue engineering and regeneration	21
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae	21
CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease	20
3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review	20
Cellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor	20
NIR-Triggered Release of Nitric Oxide by Upconversion-Based Nanoplatforms to Enhance Osteogenic Differentiation of Mesenchymal Stem Cells for Osteoporosis Therapy	20
A methylprednisolone-loaded and core-shell nanofiber-covered stent-graft to prevent inflammation and reduce degradation in aortic dissection	20
Recent Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Engineering Strategies for Precise Strike Therapy against Tumor	19
Erratum to “Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment”	19
si-Tgfbr1-loading liposomes inhibit shoulder capsule fibrosis via mimicking the protective function of exosomes from patients with adhesive capsulitis	19
Reactive Oxygen Species-Responsive Chitosan–Bilirubin Nanoparticles Loaded with Statin for Treatment of Cerebral Ischemia	19
Insulin-Like Growth Factor 2 Secreted from Mesenchymal Stem Cells with High Glutathione Levels Alleviates Osteoarthritis via Paracrine Rejuvenation of Senescent Chondrocytes	19
Metallic Copper-Based Dual-Enzyme Biomimetic Nanoplatform for Mild Photothermal Enhancement of Anticancer Catalytic Activity	19
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model	19

The Extracellular Matrix Promotes Diabetic Oral Wound Healing by Modulating the Microenvironment	18
Improvement of Charcot-Marie-Tooth Phenotype with a Nanocomplex Treatment in Two Transgenic Models of CMT1A	18
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment	18
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair	18
Polydopamine-based Nanoadjuvants Promote a Positive Feedback Loop for Cancer Immunotherapy via Overcoming Photothermally Boosted T Cell Exhaustion	18
CD62E- and ROS-Responsive ETS Improves Cartilage Repair by Inhibiting Endothelial Cell Activation through OPA1-Mediated Mitochondrial Homeostasis	18
Biomimetic hydrogel blanket for conserving and recovering intrinsic cell properties	18
Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate	17
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy	17
Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure” formation via FN-ITG β1-FAK-mTOR signaling cascade	17
Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway	17
Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system	16
Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas	16
Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties for Infected Wound Healing	16
3D biofabrication of diseased human skin models in vitro	16
Time-Released Black Phosphorus Hydrogel Accelerates Myocardial Repairing through Antioxidant and Motivates Macrophage Polarization Properties	16
NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy	16
Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury	16
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles	15
A Novel Lipopeptide–Functionalized Metal–Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway	15
Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis	15
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System	15
Optimized Epigallocatechin Gallate Delivery and Adipogenesis Inhibition through Fluorescent Mesoporous Nanocarriers	15
Hydrogel in the Treatment of Traumatic Brain Injury	14
Immunoregulation in Skull Defect Repair with a Smart Hydrogel Loaded with Mesoporous Bioactive Glasses	14
An In Situ Sustained-Release Chitosan Hydrogel to Attenuate Renal Fibrosis by Retaining Klotho Expression	14
Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and	13
Correction: Non-interfacial self-assembly of synthetic protocells	13
Custom-Made Ce–Mn Bimetallic Nanozyme for the Treatment of Intervertebral Disc Degeneration by Inhibiting Oxidative Stress and Modulating Macrophage M1/M2 Polarization	13
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophag	13
An efficient strategy to recellularization of a rat aorta scaffold: an optimized decellularization, detergent removal, and Apelin-13 immobilization	13
High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds	13
Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy	13