OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Research is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The Strontium Ion Reprograms Monocyte Subsets via TRPM2 Channel Regulation to Enhance Osseointegration	256
Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations	199
Erratum to “An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery”	149
Tumoricidal Efficacy of Artesunate-Eluting Microsphere: Differential Role of Bax/Bak in Orchestration of Cell Death Pathways	132
Construction of a Bioactive ECM Interface Enables Concurrent Suppression of Foreign Body Reaction, Inflammation, and Promotion of Urethral Regeneration	125
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots	121
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration	105
Strategies to Overcome Hurdles in Cancer Immunotherapy	102
Zein and Trimethyl Chitosan-Based Core–Shell Nanoparticles for Quercetin Oral Delivery to Enhance Absorption by Paracellular Pathway in Obesity Mice	100
Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel	100
A Peptide Inhibitor of Lymphocyte Activation Gene-3 Interaction with Fibrinogen-like Protein 1 Synergizes with Programmed Death-Ligand 1 Blockade to Restore T Cell Activity and Inhibit Tumor Growth	100
Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects	94
Label-Free Prediction of Fluorescently Labeled Fibrin Networks	90
Coacervate-mediated novel pancreatic cancer drug Aleuria Aurantia lectin delivery for augmented anticancer therapy	89
An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy	85
Optimized Epigallocatechin Gallate Delivery and Adipogenesis Inhibition through Fluorescent Mesoporous Nanocarriers	78
Cellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor	73
Focused Ultrasound-Triggered Burst Release and Enrichment of Engineered Bacteria for Tumor Therapy	72
High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds	72
Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and	71
Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment	70
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System	67
Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury	67
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles	61
Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Oxidative Damage via the miR-191-5p/DAPK1/AKT Axis in Type 2 Diabetes	61

A Novel Lipopeptide–Functionalized Metal–Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway	60
Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system	59
Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection	58
Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate	57
Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy	55
Harnessing the Intradermal Delivery of Hair Follicle Dermal Papilla Cell Spheroids for Hair Follicle Regeneration in Nude Mice	55
Modulation of bioactive calcium phosphate micro/nanoparticle size and shape during in situ synthesis of photo-crosslinkable gelatin methacryloyl based nanocomposite hydrogels for 3D bioprinting and ti	52
NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes	52
Paris polyphylla var. yunnanensis Leaf-Derived Extracellular Vesicle-Like Particles Enhance Periodontal Regeneration	49
Customized Sized Manganese Sulfide Nanospheres as Efficient T ₁ MRI Contrast Agents for Enhanced Tumor Theranostics	48
Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3	48
Genetically Encoded Fluorescence Resonance Energy Transfer Biosensor for Live-Cell Visualization of Lamin A Phosphorylation at Serine 22	48
Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization	47
Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy	47
Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration	45
Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer	45
Biomimetic Layered Double Hydroxide-Molybdenum Disulfide Encapsulated with Bovine Serum Albumin: A Multifaceted Nanotherapy for Inflammatory Bowel Disease	44
Advances in the development of tubular structures using extrusion-based 3D cell-printing technology for vascular tissue regenerative applications	44
Dual-Channel NIR Fluorescence Imaging for Precise Delineation of Gastric Tumor Margins	44
Surface Engineering of MXenes for Biomedical Uses: Functionalization Strategies and Application Trends	44
A New Perspective on Precision Medicine: The Power of Digital Organoids	44
Engineering Glioma-Cell-Derived Exosomes as Trojan Horse for Precisely Targeted Chemotherapy of Glioblastoma	43
The worldwide patent landscape of dental implant technology	43
mRNA nanodelivery systems: targeting strategies and administration routes	43
An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery	42
Simultaneously Modulating HIF-1α and HIF-2α and Optimizing Macrophage Polarization through the Biomimetic Gene Vector toward the Treatment of Osteoarthritis	42
Homotypic Membrane Vesicle-Formulated VAN@ ^Δagr MVs for Methicillin-Resistant Staphylococcus aureus Bi	42
Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants	41
Label-Free Enrichment of Highly Metastatic Tumor-Initiating Cells up to a Monoclonal State	41
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri-implant	40
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis	39
Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy	39
Solubilized chlorin e6-layered double hydroxide complex for anticancer photodynamic therapy	39
Rediscovery of poly(ethylene glycol)s as a cryoprotectant for mesenchymal stem cells	39
Chicken Embryo Extract Remodeling of Extracellular Matrix Sustains Self-Renewal and Differentiation for Scaffold-Free Cell Sheet Formation	39
Decellularized Extracellular Matrix Scaffolds for Soft Tissue Augmentation: From Host–Scaffold Interactions to Bottlenecks in Clinical Translation	38
Regeneration of a Rabbit Segmental Defect with a New Bone Therapy: Autologous Blood Coagulum with Bone Morphogenetic Protein 6 and Synthetic Ceramics	38
Transdermal delivery of Chinese medicinal formula mitigates pediatric constipation by modulating intestinal endocrine and metabolic homeostasis	38
Recent advances in optical imaging through deep tissue: imaging probes and techniques	36
Application of bioactive glasses in various dental fields	36
Non-interfacial self-assembly of synthetic protocells	35
Distinct Roles of Matrigel Enabled the Production of Expandable Hepatoblast and Polarized Hepatocyte Organoids from Human Embryonic Stem Cells under 3-Dimensional Suspension Conditions	35
Erratum to “Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA”	35
Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization	34
Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models	34
Intranasal Nanoliposomes Delivering Interferon Lambda with Enhanced Mucosal Retention as an Antiviral	34
Res@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency	33
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1–Orai1 Signaling and Calcium Overload-Induced Mitochondrial Damage of Follicular Helper T Cells in Lupus	32
PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery	31
Targeted H ₂ S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane	31

Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research	31
Autotaxin-Scavenging Nanoliposomes for Prolonged Colon Retention and Autophagy-Mediated Mucosal Immune Restoration in Colitis	30
Oxidative Stress and Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy	30
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration	30
Rescue Radiosensitization of Pancreatic Cancer via PD-L1/TGF-β1 Dual-Blockade Nanotherapy as Evaluated in 3-Dimensional Microtumors	30
Impact of Culture Duration on the Properties and Functionality of Yeast-Derived Extracellular Vesicles	30
Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy	30
Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds	29
Surface-mediated high antioxidant and anti-inflammatory effects of astaxanthin-loaded ultrathin graphene oxide film that inhibits the overproduction of intracellular reactive oxygen species	29
Boron Nanocomposites for Boron Neutron Capture Therapy and in Biomedicine: Evolvement and Challenges	29
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy	29
Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies	29
From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds	29
Low-Molecular-Weight PEGs for Cryopreservation of Stem Cell Spheroids	29
Biomimetic Marine-Sponge-Derived Spicule-Microparticle-Mediated Biomineralization and YAP/TAZ Pathway for Bone Regeneration In Vivo	28
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin	28
Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming	28
Lipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure	28
Erratum to “Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment”	27
Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment	27
Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation	27
Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment	26
Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate	26
Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid	26
Visible-Light-Curable Catechol-Reinforced Gelatin Bioglue for Rapid Hemostasis and Engineered Tissue Assembly	26
Optimization of the clinically approved Mg-Zn alloy system through the addition of Ca	26
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae	26
A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management	26
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization	26
A novel DNA double-strand breaks biosensor based on fluorescence resonance energy transfer	25
Progress of tissue adhesives based on proteins and synthetic polymers	25
Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival	25
Nanotherapeutic System with Effective Microwave Sensitization and Pyroptosis Programming Enable Synergistic Microwave-Immunotherapy in Bladder Cancer	25
Transdermal Delivery of Hyaluronate-Conjugated Formyl Peptide Receptor 2 Agonistic Peptide Ameliorates Bleomycin-Induced Skin Fibrosis	25
Nervonic Acid from Malania oleifera Reverses Parkinson’s Disease by Regulating Oxidative Stress, Neuroinflammation, and Gut Microbiota	25
Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma	24
Liposome-Encapsulated Rutin Attenuates Cisplatin-Induced Ototoxicity via Suppression of P53-Associated Oxidative Injury	24
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration	24
Injectable Poloxamer and Hyaluronic Acid Hydrogel for Sustained Co-Delivery of Dexamethasone and Lidocaine Ameliorates Neuropathic Pain	24
Autophagy-Modulated Sonodynamic Therapy Triggers Mitochondrial Catastrophe for Potent Immunogenic Tumor Eradication	24
Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity	24
Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis	24
Smart and versatile biomaterials for cutaneous wound healing	23
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy	23
Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field	23
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model	23
A Self-Assembling Senolytic Prodrug with Enhanced Bioavailability and Selective Activation for Targeting Senescent Retinal Pigment Epithelium	23
Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects	23
Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation	23
Correction: Non-interfacial self-assembly of synthetic protocells	23
The role of cellular traction forces in deciphering nuclear mechanics	22
Erratum to “Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment”	22
Hyaluronic Acid-Functionalized Bismuth Vanadate/Molybdenum Disulfide Nanoheterojunctions Achieve Efficient Phototherapy of Hypoxic Tumor	22
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment	22
Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques	22
A systematic study on the use of multifunctional nanodiamonds for neuritogenesis and super-resolution imaging	22
3D biofabrication of diseased human skin models in vitro	22
Hydrogel in the Treatment of Traumatic Brain Injury	21
Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration	21
Development of Natural Killer Cell–Drug Conjugates via Membrane-Installed Liposomes for Pancreatic Cancer Treatment	21
Hybrid Homodimeric Prodrug Nanoassemblies for Low-Toxicity and Synergistic Chemophotodynamic Therapy of Melanoma	21
Application of molecular dynamics simulation in self-assembled cancer nanomedicine	20
Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers	20
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair	20
Epigallocatechin Gallate Attenuates CaOx Crystal-Induced Renal Tubular Injury to Inhibit CaOx Nephrolithiasis via GRP94/PI3K/AKT Signaling	20
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophag	20
Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals	20
Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy	19
In Silico Target Discovery of Kaempferol: Therapeutic Effect of Kaempferol on Atopic Dermatitis through Regulation of Aryl Hydrocarbon Receptor	19
The complex of miRNA2861 and cell-penetrating, dimeric α-helical peptide accelerates the osteogenesis of mesenchymal stem cells	19
The triply periodic minimal surface-based 3D printed engineering scaffold for meniscus function reconstruction	19