OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Research is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The Strontium Ion Reprograms Monocyte Subsets via TRPM2 Channel Regulation to Enhance Osseointegration	280
Erratum to “An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery”	212
Construction of a Bioactive ECM Interface Enables Concurrent Suppression of Foreign Body Reaction, Inflammation, and Promotion of Urethral Regeneration	157
A Peptide Inhibitor of Lymphocyte Activation Gene-3 Interaction with Fibrinogen-like Protein 1 Synergizes with Programmed Death-Ligand 1 Blockade to Restore T Cell Activity and Inhibit Tumor Growth	134
Label-Free Prediction of Fluorescently Labeled Fibrin Networks	130
Strategies to Overcome Hurdles in Cancer Immunotherapy	106
Tumoricidal Efficacy of Artesunate-Eluting Microsphere: Differential Role of Bax/Bak in Orchestration of Cell Death Pathways	105
Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations	103
Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration	98
Prominent Alveolar Bone Graft Substitute Derived from Silk Fibroin/Hyaluronic Acid/Demineralized Dentin Matrix Hybrid Hydrogel	98
Zein and Trimethyl Chitosan-Based Core–Shell Nanoparticles for Quercetin Oral Delivery to Enhance Absorption by Paracellular Pathway in Obesity Mice	96
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots	92
Enhanced Chondrogenic Differentiation of Electrically Primed Human Mesenchymal Stem Cells for the Regeneration of Osteochondral Defects	89
An injectable, in situ forming and NIR-responsive hydrogel persistently reshaping tumor microenvironment for efficient melanoma therapy	83
Focused Ultrasound-Triggered Burst Release and Enrichment of Engineered Bacteria for Tumor Therapy	82
Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and	78
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles	76
Optimized Epigallocatechin Gallate Delivery and Adipogenesis Inhibition through Fluorescent Mesoporous Nanocarriers	75
Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury	70
Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate	70
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System	69
Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment	69
Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration	64
Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Oxidative Damage via the miR-191-5p/DAPK1/AKT Axis in Type 2 Diabetes	63
High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds	60

Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system	59
Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection	59
A Novel Lipopeptide–Functionalized Metal–Organic Framework for Periodontitis Therapy through the Htra1/FAK/YAP Pathway	55
Radiation-Activated Cobalt-Based Zeolite Imidazolate Frameworks for Tumor Multitherapy	54
A New Perspective on Precision Medicine: The Power of Digital Organoids	54
Harnessing the Intradermal Delivery of Hair Follicle Dermal Papilla Cell Spheroids for Hair Follicle Regeneration in Nude Mice	54
Simultaneously Modulating HIF-1α and HIF-2α and Optimizing Macrophage Polarization through the Biomimetic Gene Vector toward the Treatment of Osteoarthritis	54
Customized Sized Manganese Sulfide Nanospheres as Efficient T ₁ MRI Contrast Agents for Enhanced Tumor Theranostics	53
An Ultrasoft and Flexible PDMS-Based Balloon-Type Implantable Device for Controlled Drug Delivery	49
Genetically Encoded Fluorescence Resonance Energy Transfer Biosensor for Live-Cell Visualization of Lamin A Phosphorylation at Serine 22	49
Engineering Glioma-Cell-Derived Exosomes as Trojan Horse for Precisely Targeted Chemotherapy of Glioblastoma	48
Modulation of bioactive calcium phosphate micro/nanoparticle size and shape during in situ synthesis of photo-crosslinkable gelatin methacryloyl based nanocomposite hydrogels for 3D bioprinting and ti	48
Advances in the development of tubular structures using extrusion-based 3D cell-printing technology for vascular tissue regenerative applications	47
Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer	47
Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3	46
Control of maleic acid-propylene diepoxide hydrogel for 3D printing application for flexible tissue engineering scaffold with high resolution by end capping and graft polymerization	46
Dual-Channel NIR Fluorescence Imaging for Precise Delineation of Gastric Tumor Margins	46
Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration	46
Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy	45
Biomimetic Layered Double Hydroxide-Molybdenum Disulfide Encapsulated with Bovine Serum Albumin: A Multifaceted Nanotherapy for Inflammatory Bowel Disease	45
The worldwide patent landscape of dental implant technology	45
Paris polyphylla var. yunnanensis Leaf-Derived Extracellular Vesicle-Like Particles Enhance Periodontal Regeneration	45
mRNA nanodelivery systems: targeting strategies and administration routes	45
Label-Free Enrichment of Highly Metastatic Tumor-Initiating Cells up to a Monoclonal State	43
Surface Engineering of MXenes for Biomedical Uses: Functionalization Strategies and Application Trends	43
Transdermal Delivery of Chinese Medicinal Formula Mitigates Pediatric Constipation by Modulating Intestinal Endocrine and Metabolic Homeostasis	41
Regeneration of a Rabbit Segmental Defect with a New Bone Therapy: Autologous Blood Coagulum with Bone Morphogenetic Protein 6 and Synthetic Ceramics	41
A drug delivery system constructed by a fusion peptide capturing exosomes targets to titanium implants accurately resulting the enhancement of osseointegration peri-implant	41
Rediscovery of poly(ethylene glycol)s as a cryoprotectant for mesenchymal stem cells	41
Near-Infrared-Triggered “Bridge-and-Attack” Strategy via a Bioinspired Copper–Polyphenol Nanoarchitectonics Platform for Vascular Normalization-Enhanced Cuproptosis-Immunotherapy of Triple-Negative Br	40
Chicken Embryo Extract Remodeling of Extracellular Matrix Sustains Self-Renewal and Differentiation for Scaffold-Free Cell Sheet Formation	40
Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants	39
Homotypic Membrane Vesicle-Formulated VAN@ ^Δagr MVs for Methicillin-Resistant Staphylococcus aureus Bi	39
Decellularized Extracellular Matrix Scaffolds for Soft Tissue Augmentation: From Host–Scaffold Interactions to Bottlenecks in Clinical Translation	39
Recent advances in optical imaging through deep tissue: imaging probes and techniques	37
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis	37
Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy	37
Non-interfacial self-assembly of synthetic protocells	37
Low-Molecular-Weight PEGs for Cryopreservation of Stem Cell Spheroids	36
Oxidative Stress and Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy	36
Erratum to “Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA”	36
Intranasal Nanoliposomes Delivering Interferon Lambda with Enhanced Mucosal Retention as an Antiviral	36
Autotaxin-Scavenging Nanoliposomes for Prolonged Colon Retention and Autophagy-Mediated Mucosal Immune Restoration in Colitis	35
Rescue Radiosensitization of Pancreatic Cancer via PD-L1/TGF-β1 Dual-Blockade Nanotherapy as Evaluated in 3-Dimensional Microtumors	35
Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy	35
Mesenchymal Stem Cell-Derived Exosomes Inhibit Stim1–Orai1 Signaling and Calcium Overload-Induced Mitochondrial Damage of Follicular Helper T Cells in Lupus	33
Impact of Culture Duration on the Properties and Functionality of Yeast-Derived Extracellular Vesicles	33
Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds	33
Boron Nanocomposites for Boron Neutron Capture Therapy and in Biomedicine: Evolvement and Challenges	33
From Hemostasis to Angiogenesis: A Self-Healing Hydrogel Loaded with Copper Sulfide-Based Nanoenzyme for Whole-Process Management of Diabetic Wounds	32

Distinct Roles of Matrigel Enabled the Production of Expandable Hepatoblast and Polarized Hepatocyte Organoids from Human Embryonic Stem Cells under 3-Dimensional Suspension Conditions	32
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy	32
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration	32
Erratum to “Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment”	31
Targeted H ₂ S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane	31
Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models	31
Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research	31
Res@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency	31
PEG-mediated transduction of rAAV as a platform for spatially confined and efficient gene delivery	31
Biomimetic Gradient Microporous Scaffold with a Triply Periodic Minimal Surface Enhances Osseointegration by Modulating Macrophage Polarization	31
Visible-Light-Curable Catechol-Reinforced Gelatin Bioglue for Rapid Hemostasis and Engineered Tissue Assembly	30
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin	29
Lipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure	29
Optimization of the clinically approved Mg-Zn alloy system through the addition of Ca	29
Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation	29
Biomimetic Marine-Sponge-Derived Spicule-Microparticle-Mediated Biomineralization and YAP/TAZ Pathway for Bone Regeneration In Vivo	29
Molecular Targeting of Intracellular Bacteria by Homotypic Recognizing Nanovesicles for Infected Pneumonia Treatment	29
Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid	29
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae	28
A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management	28
Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment	28
Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate	28
Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming	28
Nervonic Acid from Malania oleifera Reverses Parkinson’s Disease by Regulating Oxidative Stress, Neuroinflammation, and Gut Microbiota	27
Transdermal Delivery of Hyaluronate-Conjugated Formyl Peptide Receptor 2 Agonistic Peptide Ameliorates Bleomycin-Induced Skin Fibrosis	27
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization	27
Autophagy-Modulated Sonodynamic Therapy Triggers Mitochondrial Catastrophe for Potent Immunogenic Tumor Eradication	27
Liposome-Encapsulated Rutin Attenuates Cisplatin-Induced Ototoxicity via Suppression of P53-Associated Oxidative Injury	26
Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma	26
Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival	26
Nanotherapeutic System with Effective Microwave Sensitization and Pyroptosis Programming Enable Synergistic Microwave-Immunotherapy in Bladder Cancer	26
Biomimetic-Nanoparticle-Enhanced Photothermal Immunotherapy: Targeted Delivery of Near-Infrared Region II Agents and Immunoadjuvants for Tumor Immunogenicity	26
Injectable Poloxamer and Hyaluronic Acid Hydrogel for Sustained Co-Delivery of Dexamethasone and Lidocaine Ameliorates Neuropathic Pain	26
A novel DNA double-strand breaks biosensor based on fluorescence resonance energy transfer	25
Smart and versatile biomaterials for cutaneous wound healing	25
High yield engineered nanovesicles from ADSC with enriched miR-21-5p promote angiogenesis in adipose tissue regeneration	25
Research Progress on Extracellular Matrix-Based Composite Materials in Antibacterial Field	25
Functional insights from targeted imaging BACE1: the first near-infrared fluorescent probe for Alzheimer’s disease diagnosis	25
Progress of tissue adhesives based on proteins and synthetic polymers	25
A degradable nanoplatform integrating glucose oxidase and copper selenide for near-infrared-enhanced multimodal synergistic therapy in lung cancer	24
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy	24
A Self-Assembling Senolytic Prodrug with Enhanced Bioavailability and Selective Activation for Targeting Senescent Retinal Pigment Epithelium	24
Erratum to “Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment”	23
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model	23
Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation	23
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment	23
The role of cellular traction forces in deciphering nuclear mechanics	23
A systematic study on the use of multifunctional nanodiamonds for neuritogenesis and super-resolution imaging	23
Development of Natural Killer Cell–Drug Conjugates via Membrane-Installed Liposomes for Pancreatic Cancer Treatment	23
Hyaluronic Acid-Functionalized Bismuth Vanadate/Molybdenum Disulfide Nanoheterojunctions Achieve Efficient Phototherapy of Hypoxic Tumor	23
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophag	23
Correction: Non-interfacial self-assembly of synthetic protocells	23
Hydrogel in the Treatment of Traumatic Brain Injury	23
Hybrid Homodimeric Prodrug Nanoassemblies for Low-Toxicity and Synergistic Chemophotodynamic Therapy of Melanoma	22
Inducing In Situ M ₂ Macrophage Polarization for Tendinopathy Therapy through Microneedle Patch-Mediated Instant/Sustained Delivery of Rosmarinic Aci	22
Application of molecular dynamics simulation in self-assembled cancer nanomedicine	22
Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers	22
3D biofabrication of diseased human skin models in vitro	22
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair	22
Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy	22
Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration	22
Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level	21
E-Selectin-Targeted Nanomicelles via Sialic Acid Conjugation for Anti-Inflammatory Efficacy and Alleviating the Progression of Metabolic-Associated Steatotic Liver Disease	21
Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy	21
Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals	21
In Silico Target Discovery of Kaempferol: Therapeutic Effect of Kaempferol on Atopic Dermatitis through Regulation of Aryl Hydrocarbon Receptor	20
Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery	20
Restoring Zinc Homeostasis via a Bimetallic Nanozyme to Amplify Ferroptosis and Antitumor Immunity for Prostate Cancer Treatment	20
MXene/Doxorubicin Complex-Loaded Supramolecular Hydrogels for Near Infrared-Triggered Synergistic Cancer Therapy	20
The complex of miRNA2861 and cell-penetrating, dimeric α-helical peptide accelerates the osteogenesis of mesenchymal stem cells	19
Fe-curcumin nanozyme-mediated immunosuppression and anti-inflammation in experimental autoimmune uveitis	19
The triply periodic minimal surface-based 3D printed engineering scaffold for meniscus function reconstruction	19
Highly Durable, Stretchable Multielectrode Array for Electro-mechanical Co-stimulation of Cells	19
Epigallocatechin Gallate Attenuates CaOx Crystal-Induced Renal Tubular Injury to Inhibit CaOx Nephrolithiasis via GRP94/PI3K/AKT Signaling	19
Photothermal therapy of copper incorporated nanomaterials for biomedicine	19