Pharmacology Research & Perspectives

Article	Citations
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist	94
Anticholinergic drugs and risk of dementia: Time for action?	93
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	83
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	56
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline	55
Modulation of TNF‐α, interleukin‐6, and interleukin‐10 by nebivolol–valsartan and nebivolol–lisinopril polytherapy in SHR rats	49
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Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta‐analysis	36
A meta‐analysis and cost‐minimization analysis of bivalirudin versus heparin in high‐risk patients for percutaneous coronary intervention	36
Calibration and validation of the rabbit model of electrolytic‐mediated arterial thrombosis against the standard‐of‐care anticoagulant apixaban	36
Issue Information	32
Statin withdrawal and treating COVID‐19 patients	30
Pattern and predictors of medication use among adults in southwestern Nigeria: A community‐based cross‐sectional study	30
Pharmacological hypothesis: A recombinant probiotic for taming bacterial β‐glucuronidase in drug‐induced enteropathy	28
The abrupt pathological deterioration of cisplatin‐induced acute kidney injury: Emerging of a critical time point	24
Issue Information	24
Deprived social status is associated with decreased use of oral chemotherapy in patients with metastatic colorectal cancer: A retrospective cohort study on administrative databases in a French Univers	23
Commentary on Health service use and costs associated with fluoroquinolone‐related tendon injuries	22
Effects of sevoflurane and adenosine receptor antagonist on the sugammadex‐induced recovery from rocuronium‐induced neuromuscular blockade in rodent phrenic nerve–hemidiaphragm tissue specimens	21
A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants	21
Issue Information	21
Impact of amiodarone use on metoprolol concentrations, α‐OH‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study	20
Determination of a vancomycin nephrotoxicity threshold and assessment of target attainment in hematology patients	20
EOS789, pan‐phosphate transporter inhibitor, ameliorates the progression of kidney injury in anti‐GBM‐induced glomerulonephritis rats	19
Dose rationale for gabapentin and tramadol in pediatric patients with chronic pain	19

Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	18
Population pharmacokinetic of paracetamol and atorvastatin with co‐administration of semaglutide	17
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	17
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	17
2‐Deoxyglucose and hydroxychloroquine HPLC‐MS–MS analytical methods and pharmacokinetic interactions after oral co‐administration in male rats	16
Issue Information	16
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis	16
Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions	16
The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	16
Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string	15
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	15
The role of plasma concentrations and drug characteristics of beta‐blockers in fall risk of older persons	15
Issue Information	15
Genes ingenuity pathway analysis unveils smoothelin‐like 1 (SMTNL1) as a key regulatory protein involved in sodium pentobarbital‐induced growth inhibition in breast cancer	15
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	14
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions	14
Defined daily doses in pediatric dosing‐ a theoretical example	13
Phenotype versus genotype to optimize cancer dosing in the clinical setting—focus on 5‐fluorouracil and tyrosine kinase inhibitors	13
Evaluation of OCT2‐mediated drug–drug interactions between ulotaront and metformin in subjects with schizophrenia	13
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	13
The role of histamine H1 receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats	13
What is the evidence that a pharmacy team working in an acute or emergency medicine department improves outcomes for patients: A systematic review	13
The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses	13
Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox	12
Phase I Study of the Safety, Tolerability, and Pharmacokinetics of Inhaled Voriconazole in Healthy Volunteers and Subjects With Stable Asthma	12
Teneurin C‐Terminal Associated Peptide (TCAP)‐1 Attenuates Restraint Stress‐Induced Corticosterone Increases in Male Mice and Rats	12
Combined docking and machine learning identify key molecular determinants of ligand pharmacological activity on β2 adrenoceptor	12
The prescribing safety assessment: Looking to the future	12
Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	12
FDA regulatory considerations for oncology drug development	12
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	12
A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	12
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	12
What do We Mean by an Inclusive Pharmacology Education?	12
Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir	11
Morphine stimulates cervical cancer cells and alleviates cytotoxicity of chemotherapeutic drugs via opioid receptor‐dependent and ‐independent mechanisms	11
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Bioequivalence study of low dose drospirenone/ethinyl estradiol 3 mg/0.03 mg film tablets under fasting conditions in Turkish healthy female subjects	11
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β‐hydroxycortisol/cortisol	11
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	11
A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata	11
High prevalence of medication errors in a secondary‐level Lithuanian hospital: A prospective cross‐sectional observational study	11
Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification	11
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	11
Has the human biological interaction with SARS‐CoV2 variants entered a pliant “Faustian bargain”?	11
miRNA and leptin signaling in metabolic diseases and at extreme environments	11
Effects of vasoactive substances on biomechanics of small resistance arteries of male and female Dahl salt‐sensitive rats	11
New insights into the role of melatonin in diabetic cardiomyopathy	10
An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup	10
Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium‐dependent, non‐D2 receptor‐dependent, manner	10

Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	10
The 5‐HT2C receptor as a therapeutic target for alcohol and methamphetamine use disorders: A pilot study in treatment‐seeking individuals	10
Impact of pharmaceutical care for asthma patients on health‐related outcomes: An umbrella review	10
A framework for economic evaluation of therapeutic drug monitoring—guided dosing in oncology	10
Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies	10
Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic	10
Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation	10
Strategies to apply 3Rs in preclinical testing	10
2‐Deoxy‐d‐glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation	9
Alleviation of cisplatin‐induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase‐3 activity	9
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	9
A randomized, double‐blind, comparative study of the pharmacodynamics and pharmacokinetics of GP40141 (romiplostim biosimilar) and reference romiplostim in healthy male volunteers	9
Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids	9
Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage	9
Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses	9
Modulation of vascular contraction via soluble guanylate cyclase signaling in a novel ex vivo method using rat precision‐cut liver slices	9
Hypothalamic cannabinoid signaling: Consequences for eating behavior	9
Drug repurposing strategies of relevance for Parkinson’s disease	9
Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration	9
The evaluation of digital educational game use in pharmacology teaching process	9
Issue Information	8
Histamine in cancer immunology and immunotherapy. Current status and new perspectives	8
Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway	8
Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals’ preferences	8
Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells	8
Corrigendum	8
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	8
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	8
Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs	8
Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damage	8
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	8
“LONG COVID”—A hypothesis for understanding the biological basis and pharmacological treatment strategy	8
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	7
Analgesic effects of medicinal plants and phytochemicals on chemotherapy‐induced neuropathic pain through glial modulation	7
Antimicrobial stewardship: Prescribing across the primary care health professions	7
Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice	7
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	7
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8	7
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	7
Epigenetics in obesity: Mechanisms and advances in therapies based on natural products	7
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats	7
Real‐world treatment outcomes of immune checkpoint inhibitors used off‐label in oncology: A comprehensive cancer institution experience	7
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Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study	7
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	7
Prevalence and determinants of attention deficit/hyperactivity disorder (ADHD) medication use during pregnancy: Results from the Quebec Pregnancy/Children Cohort	7
A systematic review on experimental studies about patient adherence to treatment	7
Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature	6
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Issue Information	6
Evaluating adverse events in databases	6
Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects	6
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Tamsulosin and risk of priapism: A causality assessment using Austin Bradford Hill Criteria	6
Exposure–response modeling of peficitinib efficacy in patients with rheumatoid arthritis	6
Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor	6
Community pharmacists workforce readiness to deliver vaccination services: A cross‐sectional study from Jordan	6
Characteristics and completeness of spontaneous reports by reporter's role in Germany: An analysis of the EudraVigilance database using the example of opioid‐associated abuse, dependence, o	6
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	6
Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals	6
Hearing loss: The final frontier of pharmacology	6
Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018	6
Clinical considerations on monkeypox antiviral medications: An overview	6
Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	6
Effect of nivasorexant (ACT‐539313), a selective orexin‐1‐receptor antagonist, on multiple cytochrome P450 probe substrates in vitro and in vivo using a cocktail approach in heal	5
Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA‐8010 in healthy subjects: First‐in‐human phase I study	5
Highlights of basic and clinical pharmacology from Africa	5
Binding interactions with sevelamer and polystyrene sulfonate in vitro	5
CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	5
Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study	5
Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review	5
Dexamethasone promotes breast cancer stem cells in obese and not lean mice	5
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Sensitivity of dose‐estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack‐Matthew Nomogram	5
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14C] encor	5
Palliative effects of carnosol on lung‐deposited pollutant particles‐induced thrombogenicity and vascular injury in mice	5
Issue Information	5
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Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	5
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	5

Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans	5
Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	5
Impact of schizophrenia relapse definition on the comparative effectiveness of oral versus injectable antipsychotics: A systematic review and meta‐analysis of observational studies	5
Validity, sensitivity and specificity of a measure of medication adherence instrument among patients taking oral anticoagulants	5
Issue Information	5
The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	5
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	5
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	5
Principles for inclusive implementation of the undergraduate pharmacology core curriculum	5