Pharmacology Research & Perspectives

Article	Citations
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	96
A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants	94
Polypharmacology of clinical sodium glucose co‐transport protein 2 inhibitors and relationship to suspected adverse drug reactions	85
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	59
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a1 receptor) antagonist	52
FDA regulatory considerations for oncology drug development	49
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	44
Corrigendum	38
A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	36
Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	36
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	31
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The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	30
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	28
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	28
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	27
Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation	23
Effect of a common missense variant in LIPA gene on fatty liver disease and lipid phenotype: New perspectives from a single‐center observational study	22
Histamine in cancer immunology and immunotherapy. Current status and new perspectives	22
Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected literature	21
Benefits and adverse effects of sacubitril/valsartan in patients with chronic heart failure: A systematic review and meta‐analysis	21
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	21
Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care	21
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Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	19

Binding interactions with sevelamer and polystyrene sulfonate in vitro	19
Highlights of basic and clinical pharmacology from Africa	19
Hearing loss: The final frontier of pharmacology	19
CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	18
Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants	18
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Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals	17
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [14C] encor	17
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights	17
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons	16
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	16
Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics	16
Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	16
Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low‐toxic DNA staining dye	16
Stathmin dynamics modulate the activity of eribulin in breast cancer cells	16
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials	15
Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes	15
Pharmacology Research & Perspectives calls for pharmacology education papers	15
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study	15
Polypharmacy and mortality association by chronic kidney disease status: The REasons for Geographic And Racial Differences in Stroke Study	15
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Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients	14
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Lumbriculus variegatus: A novel organism for in vivo pharmacology education	14
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats	14
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice	14
The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial	14
Not first‐line antihypertensive agents, but still effective—The efficacy and safety of imidazoline receptor agonists: A network meta‐analysis	14
Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake	13
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring	13
Exploring Australian pharmacists' views toward reducing the risk of medicines‐related harm in aged care residents	13
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload	13
Issue Information	13
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [14C]Binimetinib 45 mg in Healthy Male Participants	13
Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins	13
Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants	13
Information overdose: Student performance and perceptions of pharmacology resources on exams	12
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity	12
Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study	12
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	12
Concurrent Prescribing of Opioids and Sedative‐Hypnotic Drugs for Long‐Term Use in Australian General Practice: A Cross‐Sectional Analysis Using MedicineInsight	12
The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats	12
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice	12
Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women	12
Issue Information	12
Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial	12
A first‐in‐human oral dose study of mesdopetam (IRL790) to assess its safety, tolerability, and pharmacokinetics in healthy male volunteers	12
Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells	12
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients	12
Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism	12

Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data	11
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital	11
Opioid and analgesic utilization in Ireland in 2000 and 2015: A repeated cross‐sectional study	11
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	11
EVT‐701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti‐tumor activity in models of solid cancers	11
Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists	11
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia	11
Involvement of Piezo 1 mechanoceptors in vascular stiffness in isolated small resistance arteries of male and female Dahl salt‐sensitive hypertensive rats	11
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials	11
Health service use and costs associated with fluoroquinolone‐related tendon injuries	11
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia	10
Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis	10
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers	10
The N‐Acetyltransferase 2 Polymorphism and Susceptibility to Inflammatory Bowel Disease: A Case–Control Study	10
Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers	10
Corrigendum	10
Critical insights to COVID‐19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology	10
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects	10
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	10
In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether	9
Spermidine and spermine exert protective effects within the lung	9
Pharmacology Research & Perspectives: A Decade of Progress	9
Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase	9
Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers	9
Issue Information	9
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes,	9
Pharmacokinetics and safety of TCMCB07, a melanocortin‐4 antagonist peptide in dogs	9
Synthesis, in vitro bioassays, and computational study of heteroaryl nitazoxanide analogs	8
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	8
Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs	8
Comparison of the mathematical equation and trapezoidal approach for 24 h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care se	8
Effects of sevoflurane and adenosine receptor antagonist on the sugammadex‐induced recovery from rocuronium‐induced neuromuscular blockade in rodent phrenic nerve–hemidiaphragm tissue specimens	8
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	8
New insights into the role of melatonin in diabetic cardiomyopathy	8
An overview of diagnosis and management of drug‐induced hypomagnesemia	8
Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	8
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	8
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β‐hydroxycortisol/cortisol	8
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	8
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes	8
Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium‐dependent, non‐D2 receptor‐dependent, manner	8
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	7
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	7
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	7
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Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	7
The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	7
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	7
Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals’ preferences	7
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	7
A Clinical Practice‐Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin	7
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	7
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	7
Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta‐analysis	7
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	7
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	7
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Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	7
The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker	6
Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?	6
Metopimazine is primarily metabolized by a liver amidase in humans	6
Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance	6
Jadomycins: A potential chemotherapy for multi‐drug resistant metastatic breast cancer	6
Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology	6
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants	6
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease	6
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool	6
The endocannabinoid system in appetite regulation and treatment of obesity	6
Effectiveness of edaravone in preventing contrast‐induced nephropathy in high‐risk patients undergoing coronary angiography: A randomized, double‐blind trial	6
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	6
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	6
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HDAC4/5 Inhibitor, LMK‐235 Improves Animal Voluntary Movement in MPTP‐Induced Parkinson's Disease Model	6
Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring	6
Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans	6
Cognitive and negative symptoms in schizophrenia with L‐Carnosine adjuvant therapy – A randomized double‐blind placebo‐controlled study	6
Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet‐fed rabbits	5
Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways	5
Distinct atrial remodeling in patients with subclinical atrial fibrillation: Lessons from computed tomographic images	5
Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach	5

Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents	5
Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy	5
Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor‐dependent contractions of guinea pig gastric fundus smooth muscle	5
Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and	5
COP27 climate change conference: Urgent action needed for Africa and the world	5
Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis	5
Seeking the exclusive binding region of phenylalkylamine derivatives on human T‐type calcium channels via homology modeling and molecular dynamics simulation approach	5
NMDA Receptor–Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin	5
Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4‐chloro‐2‐[2‐(2‐chloro‐phenoxy)‐acetylamino]‐benzoic acid	5
Food–drug interactions risk management: An emergent piece of pharmacovigilance systems	5
An exploratory first‐in‐man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2‐ and 1‐week interval in patients with metastatic castration resistant prostate cancer	5
Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic review	5
The influence of SARS‐CoV‐2 infection on expression of drug‐metabolizing enzymes and transporters in a hACE2 murine model	5
Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping	5
Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs	5
Co‐created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus	5
Utility of salivary mycophenolic acid concentration monitoring: Modeling and Monte Carlo validation approach	5
Preclinical anti‐angiogenic and anti‐cancer activities of BAY1143269 in glioblastoma via targeting oncogenic protein expression	5
Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency	5
Real clinical impact of drug–drug interactions of immunosuppressants in transplant patients	5
PET imaging to assess fibroblast activation protein inhibitor biodistribution: A training program adapted to pharmacology education	5
Management of pharmacovigilance during the COVID‐19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the EU DisCoVeRy clinical	5
The use of GA‐RxODE (Genetics Algorithms and Running simulations from Ordinary Differential Equations‐based model) method to optimize bioequivalence studies	5
Effects of a ritonavir‐containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects	5