OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacology Research & Perspectives is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Issue Information	101
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues	92
Modeling time‐delayed concentration‐QT effects with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5a₁ receptor) antagonist	49
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus	34
Cross‐modal embedding integrator for disease‐gene/protein association prediction using a multi‐head attention mechanism	32
A549 Alveolar Carcinoma Spheroids as a Cytotoxicity Platform for Carboxyl‐ and Amine‐Polyethylene Glycol Gold Nanoparticles	31
The potencies and neurotoxicity of intrathecal levobupivacaine in a rat spinal model: Effects of concentration	30
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics	29
Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance	25
	24
Corrigendum	24
Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care	22
Patient safety in home care: A multicenter cross‐sectional study about medication errors and medication management of nurses	22
FDA regulatory considerations for oncology drug development	21
Pharmacogenomics Education and Knowledge Assessment in Healthcare Curricula: A Scoping Review of the Middle East and North Africa Region	21
The blockade of the TGF‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity	20
	20
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation	20
Nucleoside analog GS‐441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid‐19	20
Jordanian community pharmacists' perceptions and experiences with continuing professional development – A comprehensive analysis	19
Highlights of basic and clinical pharmacology from Africa	19
The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele‐Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma R	19
Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants	19
Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross‐Sectional Study	18
Comparative Efficacy of Different Targeted Therapies in Patients With Moderate‐to‐Severe Ulcerative Colitis: Systematic Review/Network Meta‐Analysis and Mechanistic Overview	18

CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation	17
	17
Impact of a computerized physician order entry system on medication safety in pediatrics—The AVOID study	17
Gastrin‐Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus	17
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights	17
Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor	17
A phase I, single‐center, open‐label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [¹⁴C] encor	16
Deciphering the Language of Assessment in Pharmacology Summative Written Assessments	16
Hearing loss: The final frontier of pharmacology	16
Antioxidant potential of chlorogenic acid in Age‐Related eye diseases	16
Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials	15
Introducing a Professional Development Skill Building Platform Into a Biomedical Sciences Graduate Program Curriculum in Pharmacology	15
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Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low‐toxic DNA staining dye	15
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study	14
The efficacy of Jujube syrup on the prevention of drug‐induced hepatotoxicity in pulmonary tuberculosis patients: A pilot randomized double‐blind placebo‐controlled clinical trial	14
Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics	14
	14
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice	14
Information overdose: Student performance and perceptions of pharmacology resources on exams	13
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients	13
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats	13
Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes	13
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [¹⁴C]Binimetinib 45 mg in Healthy Male Participants	12
The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats	12
Concurrent Prescribing of Opioids and Sedative‐Hypnotic Drugs for Long‐Term Use in Australian General Practice: A Cross‐Sectional Analysis Using MedicineInsight	12
Role of G protein‐coupled receptor kinases (GRKs) in β₂‐adrenoceptor‐mediated glucose uptake	12
A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics	12
Not first‐line antihypertensive agents, but still effective—The efficacy and safety of imidazoline receptor agonists: A network meta‐analysis	12
Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants	11
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice	11
Accounting for Time‐Varying Confounding in a Self‐Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen‐Related Events	11
Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study	11
Issue Information	11
Dynamic muscle paralytic effects of a novel botulinum toxin A free of neurotoxin‐associated proteins	11
Clinical drug interactions between linezolid and other antibiotics: For adverse drug event monitoring	10
Exploring Australian pharmacists' views toward reducing the risk of medicines‐related harm in aged care residents	10
Issue Information	10
Differential effects of glucose‐dependent insulinotropic polypeptide receptor/glucagon‐like peptide‐1 receptor heteromerization on cell signaling when expressed in HEK‐293 cells	10
Massive presence of off‐label medicines in Danish neonatal departments: A nationwide survey using national hospital purchase data	10
Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A_2A and A_2B receptor agonists	10
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions	10
The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload	10
Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial	10
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity	10
Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID‐19: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials	9
Upadacitinib‐Induced Hemolysis in a Patient With Glucose‐6‐Phosphate Dehydrogenase Deficiency—A Possible Adverse Drug Reaction	9
Involvement of Piezo 1 mechanoceptors in vascular stiffness in isolated small resistance arteries of male and female Dahl salt‐sensitive hypertensive rats	9
Cannabinoid‐Induced Hyperphagia is Mediated by Increased Meal Frequency and the Orexin‐1 Receptor in Male Rats	9
Trends in Lipid‐Lowering Agent Consumption in Croatia: A 25‐Year Observational Study	9

Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450	9
Pharmacist intervention to improve adherence to medication among heart failure patients at North East Ethiopia hospital	9
Effect of cyclosporin A on respiratory viral replication in fully differentiated ex vivo human airway epithelia	9
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients	9
	9
Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism	9
Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women	9
Evidence‐based safety profile of oral ketorolac in adults: Systematic review and meta‐analysis	8
Opioid and analgesic utilization in Ireland in 2000 and 2015: A repeated cross‐sectional study	8
Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic,	8
Team‐Based Learning in the Meta Horizon Workroom: A Pilot Study on Its Potential Effectiveness for Pharmacology Teaching	8
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial	8
The Use of Proton Pump Inhibitors Among Adults in Norway—A Nationwide Drug Utilization Study	8
Critical insights to COVID‐19 disease and potential treatments using a systems analysis approach that integrates physiology, pharmacology, and clinical pharmacology	7
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects	7
Comparison of the mathematical equation and trapezoidal approach for 24 h area under the plasma concentration‐time curve calculation in patients who received intravenous vancomycin in an acute care se	7
Pharmacology Research & Perspectives: A Decade of Progress	7
Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects	7
The N‐Acetyltransferase 2 Polymorphism and Susceptibility to Inflammatory Bowel Disease: A Case–Control Study	7
Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats	7
Aromatase Inhibitors and Dementia Risk: Putting Safety Into Perspective	7
Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats	7
Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers	7
Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes,	7
Corrigendum	7
The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases	7
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes	7
Development and evaluation of an escape room based on general pharmacokinetics: Students' perceptions of its motivational climate	7
Treatment of [99mTc]Tc‐hydroxy‐diphosphonate ([99mTc]Tc‐HDP) extravasation using hyaluronidase	7
In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether	7
Absorption, metabolism, and excretion of [¹⁴C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers	7
The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment	7
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells	7
A humanized anti‐cocaine mAb antagonizes the cardiovascular effects of cocaine in rats	7
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database	7
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor	6
Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model	6
Plasma concentration of atorvastatin metabolites correlates with low‐density lipoprotein cholesterol reduction in patients with coronary heart disease	6
The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis	6
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Reflections on the Core Concepts of Physiology and Pharmacology	6
Supporting Pediatric RSV Clinical Trials Through Close Epidemiological Surveillance During the SARS‐CoV‐2 Pandemic	6
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue	6
Telmisartan and losartan: The marked differences between their chemical and pharmacological properties may explain the difference in therapeutic efficacy in hospitalized patients with COVID‐19	6
Evaluation and optimization of sample size of neonates and infants for pediatric clinical studies on cefiderocol using a model‐based approach	6
Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist	6
From Psychiatry to Oncology: Exploring the Anti‐Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment	6
Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways	6
New insights into the role of melatonin in diabetic cardiomyopathy	6
Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer	6
Effectiveness of edaravone in preventing contrast‐induced nephropathy in high‐risk patients undergoing coronary angiography: A randomized, double‐blind trial	5
Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance	5
Association of Pharmacologic Markers of Anti‐Tumor Necrosis Factor‐α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis	5
NMDA Receptor–Mediated Ca²⁺ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin	5
Metopimazine is primarily metabolized by a liver amidase in humans	5
Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways	5
A Randomized, Open‐Label, Single‐Dose, Parallel‐Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia	5
Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System	5
The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies	5
Nicotine addiction and the influence of life adversity and acute stress on PYY: Prediction of early smoking relapse	5
Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring	5
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease	5
Co‐created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus	5
The effects of apixaban on clot characteristics in atrial fibrillation: A novel pharmacodynamic biomarker	5
Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?	5
Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease	5
HDAC4/5 Inhibitor, LMK‐235 Improves Animal Voluntary Movement in MPTP‐Induced Parkinson's Disease Model	5
Vasoactivity of Rac GTPase , Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibi	5
Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans	5
	5
A Clinical Practice‐Based Comparison of Conventional and Individualized Dosing Strategies for Therapeutic Enoxaparin	5
Pharmacology and Regulation of Appetite and Food Intake	5
Cognitive and negative symptoms in schizophrenia with L‐Carnosine adjuvant therapy – A randomized double‐blind placebo‐controlled study	5
Enhancing Student Comprehension of Glucose Metabolism Visualization Through Virtual Simulation Platform: An Educational Approach	5
Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool	5
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants	5
A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra‐Long‐Acting β₂‐Agonists Used for Asthma and COPD	5
The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors	5
The endocannabinoid system in appetite regulation and treatment of obesity	5
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