OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Intensive Care is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling	162
Nutritional therapy for the prevention of post-intensive care syndrome	95
Long-term recovery of sensorimotor functions and prediction of participation in survivors of critical illness: a prospective cohort study	61
The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020	50
Dose–response relationship between transfusion and the incidence of infection in critically ill patients: a systematic review and dose–response meta-analysis	49
Post-resuscitation diastolic blood pressure is a prognostic factor for outcomes of cardiac arrest patients: a multicenter retrospective registry-based analysis	47
Acute lung injury and post-cardiac arrest syndrome: a narrative review	42
Brain death: a clinical overview	39
Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW)	36
Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses	35
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?	35
Calculated left ventricular outflow tract diameter for critically ill patients	33
Current corticosteroid therapeutic strategy for community-acquired pneumonia in adults: indications, dosage, and timing	29
Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study	27
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study	27
External validation and comparative performance of the SLANT score for neuroprognostication in out-of-hospital cardiac arrest survivors undergoing targeted temperature management: insights from an Asi	26
Management of endothelial dysfunction in septic shock: role of albumin administration	24
Effects of a multicomponent sleep enhancement protocol on delirium incidence in elderly critically ill surgical patients: a randomized controlled trial	24
Early systemic insults following severe sepsis-associated encephalopathy of critically ill patients: association with mortality and awakening—an analysis of the OUTCOMEREA database	22
Extracorporeal membrane oxygenation for COVID-19-related acute respiratory distress syndrome: a narrative review	22
Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study	22
The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation	22
Classifying diarrhea in critically ill patients through various criteria: a cohort study	21
Ultraprotective versus apneic ventilation in acute respiratory distress syndrome patients with extracorporeal membrane oxygenation: a physiological study	20
Recommendations for long-term outcomes in sepsis and septic shock: a comparison between Japanese and international guidelines	19

Circulating and urinary microRNAs profile for predicting renal recovery from severe acute kidney injury	19
New avenues of sepsis research: obtaining perspective by analyzing and comparing SSCG 2021 and J-SSCG 2020	19
Acute pulmonary edema after subarachnoid hemorrhage: risk factors and comorbidities—an analysis of a nationwide database from the United States	18
The optimal glycemic target in critically ill patients: an updated network meta-analysis	18
One-year outcomes in sepsis: a prospective multicenter cohort study in Japan	18
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis	17
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohor	17
Descriptive statistics and risk factor analysis of children with community-acquired septic shock	17
Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients	16
Current status of palliative care delivery and self-reported practice in ICUs in Japan: a nationwide cross-sectional survey of physician directors	16
Post-intensive care syndrome follow-up system after hospital discharge: a narrative review	16
Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study	16
Correction: One-year outcomes in sepsis: a prospective multicenter cohort study in Japan	15
Exploring METRNL as a novel biomarker in sepsis: diagnostic potential and secretion mechanism	15
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium	15
Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: a retrospective cohort study using Japanese claims data	14
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study	14
Construction of a predictive model and prognosis of left ventricular systolic dysfunction in patients with sepsis based on the diagnosis using left ventricular global longitudinal strain	14
The method to identify invasive mechanical ventilation with Japanese claim data	14
UNLOADERS-PVAD Weaning Score: predicting post-weaning adverse events in cardiogenic shock patients supported by microaxial flow pump	14
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomise	14
Changes in gene expression in healthcare workers during night shifts: implications for immune response and health risks	13
Impact of the COVID-19 pandemic on critical care utilization in Japan: a nationwide inpatient database study	13
Longitudinal proteomic analysis of pathophysiology in plasma and bronchoalveolar lavage fluid of patients with ARDS	13
Strategies for discontinuing vasopressin and norepinephrine during the recovery phase of shock: a single-center retrospective study	13
Incidence and outcomes of in-hospital cardiac arrest in Japan 2011–2017: a nationwide inpatient database study	13
Prone positioning in ARDS patients supported with VV ECMO, what we should explore?	13
Autophagy and autophagic cell death in sepsis: friend or foe?	12
Association between the timing of ICU admission and mortality in patients with hospital-onset sepsis: a nationwide prospective cohort study	12
Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis	12
Erythropoietin as a critical prognostic indicator in ICU patients with sepsis: a prospective observational study	12
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study	11
Effectiveness of systemic thrombolysis on clinical outcomes in high-risk pulmonary embolism patients with venoarterial extracorporeal membrane oxygenation: a nationwide inpatient database study	11
External validation of 5A score model for predicting in-hospital mortality among the accidental hypothermia patients: JAAM-Hypothermia study 2018–2019 secondary analysis	11
Association between the triglyceride–glucose index and the risk of acute kidney injury in critically ill patients with acute pancreatitis: a retrospective study	11
Re-evaluating albumin use in traumatic brain injury	11
Prognostic significance of delirium subtypes in critically ill medical and surgical patients: a secondary analysis of a prospective multicenter study	11
Is it time to reconsider the administration of thiamine alone or in combination with vitamin C in critically ill patients? A meta-analysis of clinical trial studies	11
Association of multiple sclerosis with mortality in sepsis: a population-level analysis	10
Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients	10
Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome	10
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study	10
The cardioprotective and anti-inflammatory effect of inhaled nitric oxide during Fontan surgery in patients with single ventricle congenital heart defects: a prospective randomized study	10
Onset timing and duration of augmented renal clearance in a mixed intensive care unit	10
Accuracy evaluation of mainstream and sidestream end-tidal carbon dioxide monitoring during noninvasive ventilation: a randomized crossover trial (MASCAT-NIV trial)	10
Rethinking diuretic use in acute kidney injury: effective prevention or false hope?	10
Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation	10
Evaluating the diagnostic performance of adult sepsis event criteria in the emergency department: impact of including isolated serum lactate elevations	10
A pilot multicenter randomized controlled trial on individualized blood pressure targets versus standard care among critically ill patients with shock	10
Combination of Cv-aCO2/Ca-vO2 and Pv-aCO2 as markers of resuscitation or microcirculation in patients with septic shock: a pilot study	9

Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disea	9
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data	9
Extracorporeal cardiopulmonary resuscitation with temperature management could improve the neurological outcomes of out-of-hospital cardiac arrest: a retrospective analysis of a nationwide multicenter	9
Prehospital tranexamic acid for trauma victims	9
Recovery of consciousness after acute brain injury: a narrative review	8
Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey	8
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials	8
A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis	8
Hemoglobin in cardiogenic shock: the lower, the poorer survival	8
Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock	8
Different definitions of feeding intolerance and their associations with outcomes of critically ill adults receiving enteral nutrition: a systematic review and meta-analysis	8
Author’s response to the letter “Japanese clinical practice guidelines for rehabilitation in critically ill patients 2023 (J-ReCIP 2023)”	8
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients	8
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database	8
Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database	7
Fundamental concepts and the latest evidence for esophageal pressure monitoring	7
Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease	7
Association between the plasma-to-red blood cell ratio and survival in geriatric and non-geriatric trauma patients undergoing massive transfusion: a retrospective cohort study	7
Ultrafiltration in Japanese critically ill patients with acute kidney injury on renal replacement therapy	7
Respiratory drive: a journey from health to disease	7
Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group	7
Long-term prevalence of PTSD symptom in family members of severe COVID-19 patients: a serial follow-up study extending to 18 months after ICU discharge	6
Prevention and management of critical care complications in cardiogenic shock: a narrative review	6
PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the	6
Respiratory physiotherapy for critically ill children: concern regarding a recommendation	6
Primary palliative care recommendations for critical care clinicians	6
Comparison of balanced and unbalanced crystalloids as resuscitation fluid in patients treated for cardiogenic shock	6
Exploring the scope of inspiratory muscle training in difficult weaning: reflections on the multicentre RCT	6
Effect of early intubation on patient-centered outcomes in urosepsis: a retrospective multicenter cohort study	6
Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive	6
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study	6
Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study	6
Granulomonocytapheresis for chronic inflammatory diseases and sepsis	6
Ability of the respiratory ECMO survival prediction (RESP) score to predict survival for patients with COVID-19 ARDS and non-COVID-19 ARDS: a single-center retrospective study	6
Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study	6
Predictors of and hospital-level variation in intensive care unit readmissions in Japan: a nationwide inpatient database study	6
The time cost of physiologically ineffective intravenous fluids in the emergency department: an observational pilot study employing wearable Doppler ultrasound	5
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients	5
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study	5
Hydrocortisone, ascorbic acid, and thiamine (HAT) for sepsis and septic shock: a meta-analysis with sequential trial analysis	5
Long-term outcome of COVID-19 patients treated with helmet noninvasive ventilation vs. high-flow nasal oxygen: a randomized trial	5
The impact of a preoperative nurse-led orientation program on postoperative delirium after cardiovascular surgery: a retrospective single-center observational study	5
Clinical utility of diaphragmatic ultrasound for mechanical ventilator liberation in adults: a systematic review and meta-analysis	5
Height status matters for risk of mortality in critically ill children	5
Association between initial intravenous fluid volume and the composite outcome of hemodialysis dependence at discharge or in-hospital mortality in inpatients with rhabdomyolysis	5
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study	5
Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry	5
Association between histological diaphragm atrophy and ultrasound diaphragm expiratory thickness in ventilated patients	5
Effects of normal saline versus lactated Ringer’s solution on organ function and inflammatory responses to heatstroke in rats	5
Preliminary application of the Sharesource connect data collection and analysis system in the management of continuous renal replacement therapy in the intensive care unit	5
Prognostic implication of venoarterial extracorporeal membrane oxygenation in acute myocardial infarction-related cardiogenic shock	5
Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)	5
Lacosamide dosing in patients receiving continuous renal replacement therapy	5
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury	5
Unit-to-unit transfer due to shortage of intensive care beds in Sweden 2015–2019 was associated with a lower risk of death but a longer intensive care stay compared to no transfer: a registry study	5