Acta Neuropathologica Communications

Article	Citations
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation	242
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease	151
Macrophages and microglia: the cerberus of glioblastoma	122
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus	122
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease	113
An update on the neurological short tandem repeat expansion disorders and the emergence of long-read sequencing diagnostics	100
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease	99
Neuroinflammation and protein pathology in Parkinson’s disease dementia	99
Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients	96
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies	95
Roles of neuropathology-associated reactive astrocytes: a systematic review	89
CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations	84
Perspective of mesenchymal transformation in glioblastoma	74
Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)	73
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome	72
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches	67
Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis	62
Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease	59
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study	59
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies	56
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease	53
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease	50
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain	48
Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease	47
Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model	46

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF	45
Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease	43
Synaptic tau: A pathological or physiological phenomenon?	43
Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling	43
Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development	43
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease	41
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease	39
Alzheimer’s disease brain contains tau fractions with differential prion-like activities	39
Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing	38
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s	38
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease	38
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study	38
Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice	38
Altered ribosomal function and protein synthesis caused by tau	37
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease	37
RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury	37
Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels	37
Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy	37
Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease	36
Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease	36
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease	36
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology	36
Clinical and mutational profiles of adult medulloblastoma groups	36
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects	35
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter	35
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro	35
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy	34
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease	34
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders	34
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research	34
Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes	34
Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery	33
TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations	33
EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression	33
Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma	32
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients	32
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury	31
DNA methylation as a diagnostic tool	31
Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study	31
Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma	31
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling	30
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions	30
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature	30
Sex-specific DNA methylation differences in Alzheimer’s disease pathology	29
BDNF-dependent modulation of axonal transport is selectively impaired in ALS	29
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models	29
Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons	29
The degree of astrocyte activation is predictive of the incubation time to prion disease	29
Glioma cells require one-carbon metabolism to survive glutamine starvation	29
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants	29

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study	29
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions	28
Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease	28
Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity	28
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation	28
The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy	28
Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases	28
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration	28
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease	27
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies	27
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation	27
STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks	27
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice	27
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia	27
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation	27
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology	26
Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation	26
Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS	26
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment	26
Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review	26
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs	26
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures	26
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease	25
In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery	25
Generation of human chronic wasting disease in transgenic mice	25
The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role	25
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model	25
Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice	25
C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease	25
Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons	24
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease	24
Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs	24
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response	24
Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease	24
Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas	24
Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas	23
NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy	23
The polyG diseases: a new disease entity	23
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice	23
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression	23
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice	23
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression	23
The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons	23
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate	23
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates	22
Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment	22
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice	21
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers	21
Early onset senescence and cognitive impairment in a murine model of repeated mTBI	21
Three-dimensional vascular microenvironment landscape in human glioblastoma	21
Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis	21
Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology	21
Prenatal alcohol exposure is a leading cause of interneuronopathy in humans	21
Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation	21
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia	21
Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns	20
White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition	20
Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain	20
Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities	20
Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis	20
The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”	20
Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study	20
Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits	20
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein	19
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis	19
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions	19
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease	19
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein	19
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease	19
Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review	19
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy	19
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex	19
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia	19
Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis	18
Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain	18
The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis	18
Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization	18
Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina	18
Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms	18
Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons	18

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss	18
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue	18
Myelin in Alzheimer’s disease: culprit or bystander?	18
Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release	18
Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change	18
Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice	18
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease	18
Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice	18
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition	18
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease	18
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2	17
Deep learning from multiple experts improves identification of amyloid neuropathologies	17
C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation	17
Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration	17
Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology	17
Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population	17
Novel rapid intraoperative qualitative tumor detection by a residual convolutional neural network using label-free stimulated Raman scattering microscopy	17
Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability	17
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration	17
Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival	17
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain	16
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice	16
Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury	16
Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease	16
TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome	16
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome	16
Sporadic multiple meningiomas harbor distinct driver mutations	16
Ischemic stroke causes Parkinson’s disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein	16
Loss of presenilin function enhances tau phosphorylation and aggregation in mice	16
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain	16
Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)	16
Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases	16
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models	16
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis	16
AQP4 labels a subpopulation of white matter-dependent glial radial cells affected by pediatric hydrocephalus, and its expression increased in glial microvesicles released to the cerebrospinal fluid in	16
Interpretable deep learning of myelin histopathology in age-related cognitive impairment	16
Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations	16
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques	16
Resilience of females to acute blood–brain barrier damage and anxiety behavior following mild blast traumatic brain injury	15
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease	15
Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome	15
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies	15
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice	15
Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators	15
Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain	15
Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature	15
Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas	15
Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients	15
Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells	15
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation	15
Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in gli	15
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies	15
Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature	15