Acta Neuropathologica Communications

Article	Citations
Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication	176
Correction to: Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease	155
Pleomorphic xanthoastrocytoma in the multiverse of epigenomics: is it time to recognize the variants?	151
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve	126
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice	103
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids	89
NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells	79
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype	78
Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation	75
Correction to: Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas	68
Mical modulates Tau toxicity via cysteine oxidation in vivo	67
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients	63
Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration	62
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice	62
Tau seeding in cases of multiple sclerosis	60
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions	59
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons	58
Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data	57
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI	55
Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights	53
Single-cell spatial proteomic imaging for human neuropathology	52
Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination	51
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value	50
Machine learning quantification of Amyloid-β deposits in the temporal lobe of 131 brain bank cases	48
Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation	48

High-grade astrocytoma with piloid features: a single-institution case series and literature review	47
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease	46
Exogenous interleukin 33 enhances the brain’s lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice	45
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia	43
The genomic alterations in glioblastoma influence the levels of CSF metabolites	42
SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature	42
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study	42
A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma	41
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC), new name and new problems: an illustration of one case with atypical morphology and biology	41
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion	40
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice	40
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2	39
Differential vulnerability of the dentate gyrus to tauopathies in dementias	39
EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma	39
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders	39
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease	39
Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ	38
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant	36
The role of neuromuscular ultrasound in diagnostics of peripheral neuropathies induced by cytostatic agents or immunotherapies	35
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression	35
Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors	35
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration	35
ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation	35
ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics	35
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s	35
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau	35
Correction to: Interplay between androgen and CXCR4 chemokine signaling in myelin repair	34
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor	34
Enhancing mitosis quantification and detection in meningiomas with computational digital pathology	34
Regional vulnerability of brain white matter in vanishing white matter	34
Myelin in Alzheimer’s disease: culprit or bystander?	33
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease	33
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs	33
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis	33
Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration	33
Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications	33
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration	32
Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma	32
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations	32
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report	32
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition	32
Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome	32
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis	32
Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei	31
Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling	31
DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma	31
Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement	31
Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease	30
MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects	29
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds	29

The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome	29
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction	29
Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons	29
Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology	28
Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded prote	28
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist	28
Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model	28
Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes	27
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation	27
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models	27
A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin	27
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy b	26
Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases	26
Retraction Note: Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive fun	26
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice	26
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease	26
Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles	25
Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization	25
Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis	24
Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas	24
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects	24
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment	24
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B	24
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia	24
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias	24
Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons	24
Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination	24
APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology	24
In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration	24
Publisher Correction to: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation	24
De novo pathogenic variant in SETX causes a rapidly progressive neurodegenerative disorder of early childhood-onset with severe axonal polyneuropathy	23
Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice	23
Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions	23
Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease	23
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma	23
Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy	23
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity	23
Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation	23
Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors	22
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice	22
Blocking peptidyl arginine deiminase 4 confers neuroprotective effect in the post-ischemic brain through both NETosis-dependent and -independent mechanisms	22
Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates	22
Upregulation of carbonic anhydrase 1 beneficial for depressive disorder	22
MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy	22
Epitranscriptomic analysis reveals clinical and molecular signatures in glioblastoma	22
DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment	21
Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain	21
Intracranial mesenchymal tumor with (novel) COX14::PTEN rearrangement	21
Curative timed NK cell-based immunochemotherapy aborts brain tumour recurrence driven by mesenchymal glioma stem cells	21
TDP43 pathology in chronic traumatic encephalopathy retinas	21
Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy	21
Progesterone receptor distribution in the human hypothalamus and its association with suicide	21
Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids	21
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays	21
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors	21
Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant	21
Pediatric high-grade gliomas with concomitant RB1 and SETD2 alterations and Li-Fraumeni syndrome	20
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse	20
Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis	20
Current molecular understanding of central nervous system schwannomas	20
Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states	20
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease	20
Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks	20
Generation of human chronic wasting disease in transgenic mice	19
Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease	19
Cortical microvascular raspberries and ageing: an independent but not exclusive relationship	19
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis	19
miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4	19
ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease	19
The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease	19
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma	19
A patient-derived cell model for malignant transformation in IDH-mutant glioma	19
Investigating genotype-phenotype correlation of limb-girdle muscular dystrophy R8: association of clinical severity, protein biological function and protein oligomerization	19
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma	19
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue	18
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis	18
Development and characterization of novel anti-acetylated tau monoclonal antibodies to probe pathogenic tau species in Alzheimer’s disease	18
Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease	18
Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsies	18
Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!	18

Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition	18
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation	18
Antemortem detection of Parkinson’s disease pathology in peripheral biopsies using artificial intelligence	18
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease	18
Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mapping	18
TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis	17
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease	17
PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth	17
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion	17
The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies	17
Trem2-deficiency aggravates and accelerates age-related myelin degeneration	17
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice	17
Quantitative multiplex immunohistochemistry with colorimetric staining (QUIVER) may still benefit from MILAN	17
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease	17
The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration	17
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain	17
Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic	17
Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence	17
Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing	16
Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development an	16
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis	16
Correction to: High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease	16
Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review	16
Autophagy is affected in patients with hypokalemic periodic paralysis: an involvement in vacuolar myopathy?	16
RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein	15
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway	15
Correction: Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas	15
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse	15
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects	15
Plasma proteome profiling identifies changes associated to AD but not to FTD	15
Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion	15
Interface astrogliosis in contact sport head impacts and military blast exposure	15
On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells	15
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy	15
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study	15
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells	15
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease	15
Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage	15
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease	14
Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies	14
Correction to: Dynamic profiling of medulloblastoma surfaceome	14
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias	14
Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants	14
Correction to: Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators	14
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors	14
Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19	14
IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation	14
Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury	14
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection	14
CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours	14
Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis	14
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence	14