Acta Neuropathologica Communications

Article	Citations
Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication	218
Correction to: Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease	168
Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype	165
Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation	119
Correction to: Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas	88
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients	87
Tau seeding in cases of multiple sclerosis	86
Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights	78
High-grade astrocytoma with piloid features: a single-institution case series and literature review	67
NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells	67
SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature	65
Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration	61
DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci	60
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value	55
Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination	53
Correction: Investigating genotype-phenotype correlation of limb-girdle muscular dystrophy R8: association of clinical severity, protein biological function and protein oligomerization	52
Mical modulates Tau toxicity via cysteine oxidation in vivo	50
Pleomorphic xanthoastrocytoma in the multiverse of epigenomics: is it time to recognize the variants?	50
Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation	48
Histomorphological variations in progressive multifocal leukoencephalopathy correlated with JCV replication in brain lesions: insights from 91 patients	48
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids	47
Machine learning quantification of Amyloid-β deposits in the temporal lobe of 131 brain bank cases	45
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease	45
The genomic alterations in glioblastoma influence the levels of CSF metabolites	45
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI	44

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve	44
Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data	43
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons	43
Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism	42
Single-cell spatial proteomic imaging for human neuropathology	42
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study	41
Exogenous interleukin 33 enhances the brain’s lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice	40
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia	40
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions	40
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice	39
Single-cell transcriptome sequencing reveals new epithelial-stromal associated mesenchymal-like subsets in recurrent gliomas	39
Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ	39
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC), new name and new problems: an illustration of one case with atypical morphology and biology	39
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice	39
Therapeutic potential of NGF-enriched extracellular vesicles in modulating neuroinflammation and enhancing peripheral nerve remyelination	38
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2	38
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion	38
A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma	38
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant	37
ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation	37
Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay	36
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression	36
ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics	36
Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors	36
Age-dependent interactions of APOE isoform 4 and Alzheimer’s disease neuropathology: findings from the NACC	35
EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma	35
Differential vulnerability of the dentate gyrus to tauopathies in dementias	35
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau	35
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s	34
Correction to: Interplay between androgen and CXCR4 chemokine signaling in myelin repair	34
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease	34
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders	34
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor	33
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease	33
Oedematic-atrophic astrocytes in hepatic encephalopathy	33
Regional vulnerability of brain white matter in vanishing white matter	33
Blood biomarker fingerprints in a cohort of patients with CHRNE-related congenital myasthenic syndrome	32
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report	32
Enhancing mitosis quantification and detection in meningiomas with computational digital pathology	32
Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement	32
Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells	32
Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling	31
Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei	31
Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease	30
Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis	30
DNA methylation profiling from cerebrospinal fluid as a diagnostic tool for pineoblastoma	30
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds	30
Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model	29
MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects	29
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration	29

Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis	29
The role of neuromuscular ultrasound in diagnostics of peripheral neuropathies induced by cytostatic agents or immunotherapies	28
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration	28
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome	27
Myelin in Alzheimer’s disease: culprit or bystander?	27
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations	27
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs	27
Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications	27
Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons	27
Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma	27
Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration	26
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models	26
Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils	26
Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology	26
Retraction Note: Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive fun	26
Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes	26
A case of primary optic pathway demyelination caused by oncocytic oligodendrogliopathy of unknown origin	26
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease	26
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B	25
Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded prote	25
Correction: Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids	25
Evaluation of Rho kinase inhibitor effects on neuroprotection and neuroinflammation in an ex-vivo retinal explant model	25
Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis	25
Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization	25
APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology	25
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction	25
Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas	25
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist	25
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment	24
ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice	24
Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases	24
Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles	24
Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation	24
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy b	24
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity	23
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias	23
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors	23
Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination	23
Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy	23
Inflammation alters myeloid cell and oligodendroglial iron-handling in multiple sclerosis	22
Blocking peptidyl arginine deiminase 4 confers neuroprotective effect in the post-ischemic brain through both NETosis-dependent and -independent mechanisms	22
Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation	22
Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury	22
Upregulation of carbonic anhydrase 1 beneficial for depressive disorder	22
Intracranial mesenchymal tumor with (novel) COX14::PTEN rearrangement	22
Epitranscriptomic analysis reveals clinical and molecular signatures in glioblastoma	22
Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions	22
De novo pathogenic variant in SETX causes a rapidly progressive neurodegenerative disorder of early childhood-onset with severe axonal polyneuropathy	21
Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease	21
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma	21
MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy	21
Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates	21
Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice	21
Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors	21
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects	21
Small molecule treatment alleviates photoreceptor cilia defects in LCA5-deficient human retinal organoids	21
miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4	20
Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain	20
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice	20
Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states	20
Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy	20
Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases	20
Pediatric high-grade gliomas with concomitant RB1 and SETD2 alterations and Li-Fraumeni syndrome	20
Curative timed NK cell-based immunochemotherapy aborts brain tumour recurrence driven by mesenchymal glioma stem cells	20
A patient-derived cell model for malignant transformation in IDH-mutant glioma	19
Investigating genotype-phenotype correlation of limb-girdle muscular dystrophy R8: association of clinical severity, protein biological function and protein oligomerization	19
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis	19
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays	19
Operationalizing postmortem pathology-MRI association studies in Alzheimer’s disease and related disorders with MRI-guided histology sampling	19
TDP43 pathology in chronic traumatic encephalopathy retinas	19
Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease	19
Progesterone receptor distribution in the human hypothalamus and its association with suicide	18
Imaging features and consideration of progression pattern of diffuse hemispheric gliomas, H3 G34-mutant	18
Cortical microvascular raspberries and ageing: an independent but not exclusive relationship	18
Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model	18
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse	18
Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis	18
Current molecular understanding of central nervous system schwannomas	18
ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease	18
Generation of human chronic wasting disease in transgenic mice	18

Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma	18
DNA methylation, combined with RNA sequencing, provide novel insight into molecular classification of chordomas and their microenvironment	18
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson’s disease	18
Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks	18
Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue	17
TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis	17
Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsies	17
Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease	17
Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!	17
Antemortem detection of Parkinson’s disease pathology in peripheral biopsies using artificial intelligence	17
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma	17
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation	17
The inflammatory pathology of dysferlinopathy is distinct from calpainopathy, Becker muscular dystrophy, and inflammatory myopathies	17
Transcription factor-based classification of pituitary adenomas / PitNETs: a comparative analysis and clinical implications across WHO 2004, 2017 and 2022 in 921 cases	17
Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis	16
The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration	16
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease	16
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice	16
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease	16
Development and characterization of novel anti-acetylated tau monoclonal antibodies to probe pathogenic tau species in Alzheimer’s disease	16
Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition	16
The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease	16
TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice	16
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain	16
Trem2-deficiency aggravates and accelerates age-related myelin degeneration	15
Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development an	15
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis	15
Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation	15
Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic	15
Correction to: High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease	15
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells	15
Quantitative multiplex immunohistochemistry with colorimetric staining (QUIVER) may still benefit from MILAN	15
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease	15
On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells	15
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease	14
Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse	14
Acquired neuropathology and its associations with key patterns of placental pathology	14
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study	14
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion	14
Comparison of plasma ALZpath p-Tau217 with Lilly p-Tau217 and p-Tau181 in a neuropathological cohort	14
Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A	14
Homozygous CDKN2A/B deletions in low- and high-grade glioma: a meta-analysis of individual patient data and predictive values of p16 immunohistochemistry testing	14
PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth	14
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias	13
Interface astrogliosis in contact sport head impacts and military blast exposure	13
Correction: Clinical implications of DNA methylation-based integrated classification of histologically defined grade 2 meningiomas	13
Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion	13
CNS embryonal tumour with concomitant novel BRD4::CTRC1 fusion and BCOR internal tandem duplication – evidence for synergism and non-mutually exclusive alterations in CNS embryonal tumours	13
AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD	13
Plasma proteome profiling identifies changes associated to AD but not to FTD	13
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway	13
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy	13
Amygdala granular fuzzy astrocytes are independently associated with both LATE neuropathologic change and argyrophilic grains: a study of Japanese series with a low to moderate Braak stage	13
Correction to: Dynamic profiling of medulloblastoma surfaceome	13
Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence	13
Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review	13
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects	13
Beyond the brain: early autonomic dysfunction in Alzheimer’s disease	13
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection	13