Acta Neuropathologica Communications

Article	Citations
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation	204
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease	132
Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage	100
Macrophages and microglia: the cerberus of glioblastoma	99
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus	93
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease	87
Neuroinflammation and protein pathology in Parkinson’s disease dementia	87
An update on the neurological short tandem repeat expansion disorders and the emergence of long-read sequencing diagnostics	84
Molecular and clinicopathologic features of gliomas harboring NTRK fusions	84
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease	81
Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients	80
Biological links between traumatic brain injury and Parkinson’s disease	80
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies	79
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease	77
CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations	75
Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease	73
Perspective of mesenchymal transformation in glioblastoma	63
Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)	61
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches	59
Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes	57
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic	57
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function	55
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study	54
Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis	53
Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke	52

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies	52
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome	51
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies	48
Mild hypoxia triggers transient blood–brain barrier disruption: a fundamental protective role for microglia	47
Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis	47
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations	46
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma	45
Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesis	45
Roles of neuropathology-associated reactive astrocytes: a systematic review	44
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease	44
Towards an improved early diagnosis of neurodegenerative diseases: the emerging role of in vitro conversion assays for protein amyloids	44
Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy	43
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain	41
Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model	41
Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration	41
Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF	39
Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development	39
Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition	38
Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity	38
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy	37
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy	37
Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease	37
Alzheimer’s disease brain contains tau fractions with differential prion-like activities	36
Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease	36
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor	35
Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis	35
Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels	35
Characterising cellular and molecular features of human peripheral nerve degeneration	34
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology	33
Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling	33
Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy	33
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study	32
RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM	32
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease	32
Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes	32
Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG	31
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease	31
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease	31
Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing	31
Synaptic tau: A pathological or physiological phenomenon?	30
Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice	30
Transmission of ALS pathogenesis by the cerebrospinal fluid	30
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis	30
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro	30
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease	30
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain	29
Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease	29
Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes	29
Altered ribosomal function and protein synthesis caused by tau	29
Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2	29

EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression	29
Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia	29
The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects	29
Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease	28
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s	28
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients	28
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury	28
Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients	28
Clinical and mutational profiles of adult medulloblastoma groups	28
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy	28
Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury	28
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease	27
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease	27
Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma	27
RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury	27
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model	27
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter	27
Glioma cells require one-carbon metabolism to survive glutamine starvation	26
Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome	26
Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases	26
Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease	26
Sex-specific DNA methylation differences in Alzheimer’s disease pathology	26
TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations	26
Oculopharyngodistal myopathy with coexisting histology of systemic neuronal intranuclear inclusion disease: Clinicopathologic features of an autopsied patient harboring CGG repeat expansions in LRP12	26
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration	26
Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury	26
Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study	26
Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma	26
Quantitative patterns of motor cortex proteinopathy across ALS genotypes	26
DNA methylation as a diagnostic tool	25
Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery	25
Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons	25
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions	25
Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis	24
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature	24
Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease	24
The degree of astrocyte activation is predictive of the incubation time to prion disease	24
Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity	24
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation	24
Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS	24
KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment	24
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation	24
The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy	24
A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma	23
Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila	23
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures	23
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease	23
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia	23
The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts	23
Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study	23
The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role	23
Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation	23
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions	23
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology	22
Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice	22
Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease	22
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants	22
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease	22
Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs	22
Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease	22
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders	22
BDNF-dependent modulation of axonal transport is selectively impaired in ALS	22
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice	22
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice	22
Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease	22
Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review	22
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies	22
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research	21
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation	21
The unfolded protein response is activated in the olfactory system in Alzheimer’s disease	21
Generation of human chronic wasting disease in transgenic mice	21
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression	21
Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits	21
Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation	21
Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons	21
The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons	20
Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice	20
Diffuse leptomeningeal glioneuronal tumor: a double misnomer? A report of two cases	20
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs	20
Early onset senescence and cognitive impairment in a murine model of repeated mTBI	20

In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery	20
Validation of machine learning models to detect amyloid pathologies across institutions	20
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling	20
Defining novel functions for cerebrospinal fluid in ALS pathophysiology	19
Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models	19
Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis	19
Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 15	19
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein	19
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease	19
Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas	19
Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms	19
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions	19
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice	19
The polyG diseases: a new disease entity	19
STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks	18
Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas	18
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia	18
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation	18
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate	18
Prenatal alcohol exposure is a leading cause of interneuronopathy in humans	18
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response	18
Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures	18
Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis	18
Clinical, radiological and molecular characterization of intramedullary astrocytomas	18
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice	18
Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma	18
Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment	18
Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology	18
Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain	17
Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage	17
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers	17
A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology	17
Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits	17
Three-dimensional vascular microenvironment landscape in human glioblastoma	17
Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation	17
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2	17
The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”	17
Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns	17
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity	17
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease	17
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition	16
Fyn depletion ameliorates tauP301L-induced neuropathology	16
RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3	16
Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons	16
Assessment of radial glia in the frontal lobe of fetuses with Down syndrome	16
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis	16
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease	16
Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia	16
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model	16
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein	16
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss	16
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates	16
In vivo evidence of exosome-mediated Aβ neurotoxicity	16
Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population	16
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration	16
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease	16
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex	16