OOIR: Observatory of International Research

Papers

(The TQCC of Biomarker Research is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Dynamic change of soluble interleukin-2 receptor distinguished molecular heterogeneity and microenvironment alterations in diffuse large B-cell lymphoma	146
Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes	141
Global, regional, and national burden of heart failure and its underlying causes, 1990–2021: results from the global burden of disease study 2021	120
ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2	115
Gene therapy for polygenic or complex diseases	112
Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors	104
New insights into the function of Interleukin-25 in disease pathogenesis	95
PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer	94
Radiogenomic association of deep MR imaging features with genomic profiles and clinical characteristics in breast cancer	92
Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation	90
Current and emerging therapies for primary central nervous system lymphoma	84
Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia	84
Novel strategies for immuno-oncology breakthroughs with cell therapy	82
Advances in the DNA methylation hydroxylase TET1	74
Minimal residual disease in multiple myeloma: current status	71
Tumor reversion: a dream or a reality	70
Circulating extracellular vesicles during pregnancy in women with type 1 diabetes: a secondary analysis of the CONCEPTT trial	65
The Wnt/β-catenin signalling pathway in Haematological Neoplasms	59
The intriguing roles of Siglec family members in the tumor microenvironment	56
SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma	55
Survival benefit and biomarker analysis of pyrotinib or pyrotinib plus capecitabine for patients with HER2-positive metastatic breast cancer: a pooled analysis of two phase I studies	54
Mitochondrial transfer in hematological malignancies	53
Proteomics to predict relapse in patients with myelodysplastic neoplasms undergoing allogeneic hematopoietic cell transplantation	52
The spatial impact of a Western diet in enriching Galectin-1-regulated Rho, ECM, and SASP signaling in a novel MASH-HCC mouse model	52
FGL1 and FGL2: emerging regulators of liver health and disease	47

Functional heterogeneity of cancer-associated fibroblasts with distinct neoadjuvant immunotherapy plus chemotherapy response in esophageal squamous cell carcinoma	46
MicroRNAs predict early complications of autologous hematopoietic stem cell transplantation	46
Skin-permeable gold nanoparticles with modifications azelamide monoethanolamine ameliorate inflammatory skin diseases	44
CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases	43
Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas	43
Survival of patients with transformed follicular lymphoma in the United States: a multiple cohort study	43
Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics	42
Global, regional and national burden of rheumatoid arthritis from 1990 to 2021, with projections of incidence to 2050: a systematic and comprehensive analysis of the Global Burden of Disease study 202	42
Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer	42
The CDK9 inhibitor enitociclib overcomes resistance to BTK inhibition and CAR-T therapy in mantle cell lymphoma	41
Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients	41
The solute carrier transporters (SLCs) family in nutrient metabolism and ferroptosis	40
Molecular mechanisms and clinical applications of exosomes in prostate cancer	40
The emerging role of RNA N6-methyladenosine methylation in breast cancer	40
Decoding burn trauma: biomarkers for early diagnosis of burn-induced pathologies	40
BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia	38
Correction: Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis	36
Risk factors for immune-related adverse events: what have we learned and what lies ahead?	36
NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer	36
A metabolite-based liquid biopsy for detection of ovarian cancer	35
Leveraging oncovirus-derived antigen against the viral malignancies in adoptive cell therapies	35
New cell sources for CAR-based immunotherapy	35
CAR Macrophages: a promising novel immunotherapy for solid tumors and beyond	35
METTL protein family: focusing on the occurrence, progression and treatment of cancer	34
Roles of posttranslational modifications in lipid metabolism and cancer progression	33
A blood-based composite panel that screens Alzheimer’s disease	32
Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021	31
Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy	31
Prevalence and clinical significance of Claudin-3 expression in cancer: a tissue microarray study on 14,966 tumor samples	30
Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors	30
Correction: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma	30
Lentivirus-based production of human chimeric antigen receptor macrophages from peripheral blood	30
Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer	30
Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection	29
Correction: Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer	29
CRISPR/Cas-based CAR-T cells: production and application	29
Lysine methylation modifications in tumor immunomodulation and immunotherapy: regulatory mechanisms and perspectives	28
Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis	28
Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial	28
Imaging biomarkers for evaluating tumor response: RECIST and beyond	28
Metastasis-associated fibroblasts: an emerging target for metastatic cancer	28
Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma	27
EGFR exon 20 insertion mutations in advanced non-small-cell lung cancer: current status and perspectives	27
A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients	27
Single-cell and spatial transcriptomics reveal a high glycolysis B cell and tumor-associated macrophages cluster correlated with poor prognosis and exhausted immune microenvironment in diffuse large B	27
The role of ferroptosis in lung cancer	26
5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma	26
Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers	26
Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed	26
Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis	25

Biological roles of RNA m5C modification and its implications in Cancer immunotherapy	25
Revolutionizing oncology: the role of Artificial Intelligence (AI) as an antibody design, and optimization tools	25
Detection of circulating tumor cells: opportunities and challenges	24
Advances of mRNA vaccine in tumor: a maze of opportunities and challenges	24
Sintilimab for the treatment of non-small cell lung cancer	24
Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma	23
Correction: Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions	22
Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology	22
Global research hotspots, development trends and prospect discoveries of phase separation in cancer: a decade-long informatics investigation	22
Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy	22
Nanobody-enhanced chimeric antigen receptor T-cell therapy: overcoming barriers in solid tumors with VHH and VNAR-based constructs	22
Extrachromosomal circular DNA (eccDNA): an emerging star in cancer	22
Impact of NSCLC metabolic remodeling on immunotherapy effectiveness	21
Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma	21
Folate receptor 1 is a stemness trait-associated diagnostic and prognostic marker for hepatocellular carcinoma	20
MiR-124-3p impedes the metastasis of non-small cell lung cancer via extracellular exosome transport and intracellular PI3K/AKT signaling	20
Deciphering LAG-3: unveiling molecular mechanisms and clinical advancements	20
Integrated analysis of spatial transcriptomics and CT phenotypes for unveiling the novel molecular characteristics of recurrent and non-recurrent high-grade serous ovarian cancer	20
The role of macrophage plasticity in neurodegenerative diseases	20
A patient with multiple primary malignant neoplasms with high variant allele frequencies of RB1, TP53, and TERT	20
Correction: Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives	19
Physio-pathological effects of N6-methyladenosine and its therapeutic implications in leukemia	19
Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target	19
Empiric use of anticoagulation in hospitalized patients with COVID-19: a propensity score-matched study of risks and benefits	19
Correction: Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia	19
CAR-T cell potency: from structural elements to vector backbone components	19
Redefining prostate cancer risk stratification: a pioneering strategy to estimate outcome based on Ki67 immunoscoring	18
Correction: Redefining prostate cancer risk stratification: a pioneering strategy to estimate outcome based on Ki67 immunoscoring	18
BCL7A is silenced by hypermethylation to promote acute myeloid leukemia	18
Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis	17
Model integrating CT-based radiomics and genomics for survival prediction in esophageal cancer patients receiving definitive chemoradiotherapy	17
Dynamic changes of bone microarchitecture and volumetric mineral density assessed by HR-pQCT in patients with cervical cancer after concurrent chemoradiotherapy: a prospective study	17
Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation	17
Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)	16
A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma	16
Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression	16
The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma	15
MicroRNA-based signatures impacting clinical course and biology of ovarian cancer: a miRNOmics study	15
Global surveillance of circulating microRNA for diagnostic and prognostic assessment of acute myocardial infarction based on the plasma small RNA sequencing	15
Liquid biopsy to identify biomarkers for immunotherapy in hepatocellular carcinoma	15
The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both	15
Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy	15
Brush swab as a noninvasive surrogate for tissue biopsies in epigenomic profiling of oral cancer	15
Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC	15
E-Cadherin expression in human tumors: a tissue microarray study on 10,851 tumors	15
State of the art CRISPR-based strategies for cancer diagnostics and treatment	15
Key regulators of sensitivity to immunomodulatory drugs in cancer treatment	14
Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool	14
DeepMPTB: a vaginal microbiome-based deep neural network as artificial intelligence strategy for efficient preterm birth prediction	14
CAR-T cell therapy followed by allogenic hematopoietic stem cell transplantation yielded comparable outcome between Ph like ALL and other high-risk ALL	14
A functional role of Ephrin type-B receptor 6 (EPHB6) in T-cell acute lymphoblastic leukemia	14
Association between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study	14
Integrative multi-omics analysis depicts the methylome and hydroxymethylome in recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression	14
Prognostic value of secretory autophagosomes in patients with acute respiratory distress syndrome	14
S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1	14