OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	53
Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway	43
Sodium thiosulfate (hydrogen sulfide donor) ameliorates the pancreatic and liver damage induced by cyclophosphamide and/or ionizing gamma radiation in male albino rats	31
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	31
Selinexor, a selective inhibitor of nuclear export, shows anti-proliferative and anti-migratory effects on male germ cells in vitro	28
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson’s disease model	28
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	24
Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats	24
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity	22
Appropriate use of triazolam in elderly patients considering a quantitative benefit-risk assessment based on the pharmacokinetic-pharmacodynamic modeling and simulation approach supported by real-worl	22
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats	22
PEGylation of liposome-encapsulated midazolam does not improve the bioavailability of midazolam when administered orally	21
The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma	20
A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab	19
Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial	19
Identifying key molecular interactions and pathways linking DEHP and its metabolite MEHP to allergic rhinitis: a network toxicology and molecular dynamics study	19
Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure	19
Conditioned medium from human adipose-derived mesenchymal stem cells attenuates cardiac injury induced by Movento in male rats: role of oxidative stress and inflammation	19
Real-world safety analysis of deutetrabenazine post-marketing: a disproportionality study leveraging the FDA Adverse Event Reporting System (FAERS) database	18
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis	18
Mechanistic decoding of triclosan-induced endometriosis via network toxicology, Mendelian randomization, and molecular docking	17
Oxidative stress and anti-oxidant status in children with sepsis	17
Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues	17
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice	17
Therapeutic potential of zinc oxide/berberine nanoparticles in mitigating acute respiratory distress syndrome: in vivo and in silico approaches	16

Biochemical and histopathological investigation to study the impact of pyriproxyfen exposure on ovarian morphology and reproductive function in female rats	16
Canadine protects against doxorubicin-induced cardiac and brain injury by inhibiting Oxidative stress	16
In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation	16
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells	16
Experimental evaluation of N-acetylcysteine against doxorubicin cardiotoxicity in rats	15
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice	15
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	15
Safety analysis of romiplostim, eltrombopag, and avatrombopag post-market approval: a pharmacovigilance study based on the FDA Adverse Event Reporting System	14
Development and validation of a UPLC-MS/MS method for the quantification of asciminib and its pharmacokinetic interaction and metabolic stability with shikonin	14
A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin® in healthy C	14
Safety assessment of asenapine in the FAERS database: real adverse event analysis and discussion on neurological and psychiatric side effects	14
Exploring the mechanisms of Benzo[a]pyrene-induced lung adenocarcinoma based on network toxicology and machine learning	14
Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity	14
Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways	14
Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022	14
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination	14
7-hydroxy flavones, isolated bioflavonoids, ameliorate LPS-induced AD via inhibition of the NFKB pathway	14
Acute, sub-acute and developmental toxicity studies of molybdenum disulfide nanoflowers in rats, as per OECD guidelines	14
Coenzyme Q10 protects against atorvastatin-induced hepatotoxicity via attenuation of oxidative stress and functional modulation of CYP3A1	13
Quality analysis of albendazole formulations available in veterinary pharmacies of Nepal	13
Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer	13
Development and validation of simple colorimetric methods for assessing norfloxacin in pure form, in pharmaceutical products and in biological material	13
The risk of hyponatremia induced by SSRIs and SNRIs antidepressants: a systematic review and meta-analysis	12
Development of nanospray loaded with ciclopirox for dermal fungus treatment: determination of pro-inflammatory interleukin IL-2 mRNA expression	12
Compound 7 h exerts its anti-oncogenic effects on colorectal cancer cells by inducing death-receptor-mediated apoptosis, promoting DNA damage, and obstructing autophagic flux	12
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients	12
Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system	11
Condensation of fluconazole and zinc undecylanate particles using low-pressure RF plasma: a novel drug combination approach	11
To investigate the effect of a high-fat diet on pharmacokinetics/renal function/RAAS-related parameters after a single dose of empagliflozin in healthy Chinese adults	11
Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients	11
Decrypting potential mechanisms linking ochratoxin A to hepatocellular carcinoma: an integrated approach combining toxicology, machine learning, molecular docking, and molecular dynamics simulation	11
Risk factors for gastrointestinal complications during glucocorticoid therapy in internal medicine inpatients: a real-world retrospective analysis	11
Can quercetin reduce arsenic induced toxicity in mouse BALB/c 3T3 fibroblast cells? A study involving in vitro, molecular docking, and ADME predictions	11
Assessment of the efficiency of new regenerative gel and spray in experimental model systems	11
Mechanistic study of deoxycholic acid in colorectal cancer based on network toxicology and machine learning approaches	11
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm	11
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	10
Comparative analysis of safety and efficacy between brand and generic lamotrigine products in the Saudi market	10
The subchronic toxicity of higher olefins in Han Wistar rats	10
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials	10
Targeting a novel tamoxifen-using pathway to preserve ovarian reserve in rats with experimental chemotherapy-induced ovarian failure	10
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation	10
Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover	10
A disproportionality analysis of real-world events from the FDA Adverse Event Reporting System (FAERS) for Atezolizumab	10
Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment	10
Exploring the toxic mechanism of excessive intake of naringin on drug-induced liver injury using network toxicology and experiment validation strategy	10
Metallic nanoparticles in the treatment of staphylococcus infections: a scoping review	10
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats	10
Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese	10
Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder	10

Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin	10
Stratified analysis of the association between anti-obesity medications and digestive adverse events: a real-world study based on the FDA adverse event reporting system database	10
In- vitro assessment of the anti- malarial potential of Alpha Onocerin; cytotoxicity and hemolytic effect, multi-stage activity and molecular docking	9
Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor	9
Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study	9
NSAIDs, analgesics, antiplatelet drugs, and decline in renal function: a retrospective case-control study with SIDIAP database	9
Neuroprotective effects of berberine in preclinical models of ischemic stroke: a systematic review	9
Potential antiviral peptides targeting the SARS-CoV-2 spike protein	9
Epidemiology of drug-related liver injury among the elderly: a systematic review and meta-analysis of incidence, and risk factors	9
Epoetin alfa has a potent anxiolytic effect on naive female rats	9
Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure	9
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan	9
Association between air pollution and dry eye: insights from network toxicology and molecular docking analysis	9
Retraction Note: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats	9
Comparative study of cardio-protective effect of metformin versus dapagliflozin in experimentally induced myocardial infarction in diabetic rats	9
Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice	8
A disproportionality analysis of adverse events associated with loop diuretics in the FDA Adverse Event Reporting System (FAERS)	8
Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis	8
Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital	8
Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish mode	8
Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy	8
Clinical pharmacist-led prevention of intravenous drug incompatibilities in an adult ICU: a prospective observational study	8
Extracellular vesicle therapy for acute pancreatitis: experimental validation of mesenchymal stem cell-derived nanovesicles	8
Surfactant-driven modulation of protein corona on solid lipid nanoparticles: Insights including molecular docking studies	8
Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis	8
Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects	8
In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia	8
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	8
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation	8
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study	7
Retraction Note: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	7
Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance	7
Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible	7
Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification	7
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells	7
Insulin use in diabetes association with cognitive impairment and dementia incidence	7
Intratympanic N-acetylcysteine in the prevention of cisplatin-induced ototoxicity: a systematic review and meta-analysis of randomized controlled trials	7
The efficacy and safety of belzutifan inhibitor in patients with advanced or metastatic clear cell renal cell carcinoma: a meta-analysis	7
Cisplatin-induced toxicity in the hippocampus: a dose-dependent mechanism of damage	7
Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats	7
Correction: Modified diatom-based ocular suspension for sustained diclofenac sodium delivery: a novel drug carrier approach	7
Protective effects of Alamandine against doxorubicin-induced liver injury in rats	7
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers	7
Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2	7
Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current	7
Ameliorative effects of agomelatine against doxorubicin-induced hepatotoxicity	7
Toxicology study of a tissue anchoring paclitaxel prodrug	7
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	7
Apocynin ameliorates liver fibrosis events in vivo through modulation of oxidative stress, inflammatory, and apoptotic mediators	7
Safety, pharmacokinetics, preliminary efficacy, pharmacodynamics, and immunogenicity of QX002N, an anti-IL-17A monoclonal antibody, after short-term treatment of active ankylosing spondylitis	7
Immunomodulatory effects of detoxification agents on dendritic cell populations in methamphetamine addiction	7
Appropriateness of proton pump inhibitor prescription for prevention of gastrointestinal bleeding in patients receiving warfarin: a real world, database study	7
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	7
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	7
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model	6
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study	6
Comparison of the prophylactic effect of cefazolin injection versus oral levofloxacin as prophylactic antibiotic in TURP surgery: a randomized clinical trial	6
Drug risks associated with sarcopenia: a real-world and GWAS study	6
The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial	6
Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis	6
The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial	6
Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation	6
Efficacy of daily versus alternate day oral iron supplementation for management of anaemia among general population: a systematic review and meta-analysis	6
New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice	6
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial	6
Trimetazidine effect on kidney function in patients undergoing coronary procedures	6
A tissue-penetrably engineered deoxyribonuclease 1 to prevent nasal polyp formation in chronic rhinosinusitis	6
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	6
Effects of MDMA treatment and cessation on sexual behaviour and testicular functons in male sprague-dawley rats	6
Efficacy and safety of a B-cell-driven rituximab regimen for the treatment of refractory idiopathic membranous nephropathy	6
A novel nitidine chloride nanoparticle overcomes the stemness of CD133+EPCAM+ Huh7 hepatocellular carcinoma cells for liver cancer therapy	6
Saikosaponin D inhibits the inflammatory response of secretory otitis media through FTO-mediated N6-methyladenosine modification of TLR4 mRNA	6
Can vildagliptin protect against radiation-induced premature ovarian failure? Insights into the AMPK and AKT signaling pathways	6
Exploring the toxicological impact of DEHP exposure on colorectal cancer through network toxicology, machine learning and bioinformatics analysis	6
iRGD-functionalized PLGA nanocomplex co-loaded with paclitaxel and Trametes robiniophila Murr for targeted inhibition of chemoresistant and metastatic signaling gene PDCD4 in colon cancer	6
Impact of SLCO1B1 (rs2306283) polymorphism on personalized atorvastatin dosing in a genetically distinct South Asian cohort	6