OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Conditioned medium from human adipose-derived mesenchymal stem cells attenuates cardiac injury induced by Movento in male rats: role of oxidative stress and inflammation	58
Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy	35
Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis	33
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study	27
Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure	27
Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe	23
Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor	22
A systematic review of the drug-drug interaction between Statins and Quinolones	21
Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study	21
Ethacrynic acid is an inhibitor of human factor XIIIa	20
Potential antiviral peptides targeting the SARS-CoV-2 spike protein	19
Analysis of the effect of CYP2C19 gene properties on the anti-platelet aggregation of clopidogrel after carotid artery stenting under network pharmacology	18
Safety assessment of subtilisin QK in rats	18
Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions	18
Acute bone damage through liver-bone axis induced by thioacetamide in rats	16
Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats	16
Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese pop	15
Remifentanil but not sufentanil induces cardioprotection in human ischemic heart muscle in vitro	15
Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis	15
Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	14
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	14
Preparation and evaluation of transdermal permeation of Huperzine A ethosomes gel in vitro	14
The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from random	14
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan	13
Retraction Note: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats	12

Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway	12
Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells	12
Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach	11
Efficacy and safety of proxalutamide (GT0918) in severe or critically ill patients with COVID-19: study protocol for a prospective, open-label, single-arm, single-center exploratory trial	11
Opportunities for successful de-escalation of proton pump inhibitors at a federally qualified health center	11
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male partici	10
In vitro comparative quality evaluation of different brands of carbamazepine tablets commercially available in Dessie town, Northeast Ethiopia	10
Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study	10
Appropriate use of triazolam in elderly patients considering a quantitative benefit-risk assessment based on the pharmacokinetic-pharmacodynamic modeling and simulation approach supported by real-worl	10
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes	10
Drugs and gut microbiome interactions—an emerging field of tailored medicine	10
Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice	9
New onset diabetes mellitus and cardiovascular events in Korean patients with acute myocardial infarction receiving high-intensity statins	9
In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software	9
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson’s disease model	9
Preliminary study of the toxicity and radioprotective effects of zymosan in vitro and in vivo	9
Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium	9
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme	9
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	9
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	9
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions	9
Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions	8
Levocetrizine attenuates cyclophosphamide-induced lung injury through inhibition of TNF-α, IL-1β, TGF-β and MMP-9	8
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	8
Echis ocellatus venom-induced sperm functional deficits, pro-apoptotic and inflammatory activities in male reproductive organs in rats: antagonistic role of kaempferol	8
Bisdemethoxycurcumin alleviates LPS-induced acute lung injury via activating AMPKα pathway	8
NSAIDs, analgesics, antiplatelet drugs, and decline in renal function: a retrospective case-control study with SIDIAP database	8
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	8
A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab	8
Prediction of mortality and morbidity following paraquat poisoning based on trend of liver and kidney injury	8
Differential impact of pegfilgrastim, a recombinant human granulocyte colony stimulating factor, on the neutrophil count of male and female deer mice (Peromyscus maniculatus bairdii)	8
The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma	7
Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models	7
Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis	7
Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials	7
Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells	7
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	7
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid	7
Correction: Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice	7
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis	7
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity	7
A systematic review and Bayesian analysis of the adverse effects of dienogest	7
Evaluation of the importance of mixing during preparation of antibiotic infusions	7
Prescribing pattern of anti-hypertensive medications among hypertensive outpatients at selected hospitals of South Gondar Zone, Amhara, Ethiopia: a hospital based cross sectional study	6
Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212–2 administration in mice	6
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	6
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment	6
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	6
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats	6
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats	6

The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy	6
Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity	6
Musculoskeletal adverse events associated with CDK4/6 inhibitors: a real-world study using FDA Adverse Event Reporting System (FAERS) database	6
Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2	6
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	6
High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol	6
Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats	5
Cardioprotective effect of crude polysaccharide fermented by Trametes Sanguinea Lyoyd on doxorubicin-induced myocardial injury mice	5
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	5
Hydrogen sulfide attenuates lung injury instigated by Bisphenol-A via suppressing inflammation and oxidative stress	5
(S)-3-(3,4-Dihydroxybenzyl) piperazine-2,5-dione (cyclo-Gly-L-DOPA or CG-Nio-CGLD) peptide loaded in Chitosan Glutamate-Coated Niosomes as anti-Colorectal cancer activity	5
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	5
Clinical effectiveness and safety comparison between direct oral anticoagulants and warfarin for nonvalvular atrial fibrillation patients following percutaneous left atrial appendage closure operation	5
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells	5
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation	5
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice	5
Potential antihyperlipidemic effects of myrcenol and curzerene in high-fat fed rats	5
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway	5
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers	5
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation	5
Comparison of three different prophylactic treatments for postoperative nausea and vomiting after total joint arthroplasty under general anesthesia: a randomized clinical trial	5
Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics use	5
Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda	5