OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	46
Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway	39
Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats	32
Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure	30
PEGylation of liposome-encapsulated midazolam does not improve the bioavailability of midazolam when administered orally	29
Sodium thiosulfate (hydrogen sulfide donor) ameliorates the pancreatic and liver damage induced by cyclophosphamide and/or ionizing gamma radiation in male albino rats	28
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	27
Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats	26
L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis	25
A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab	21
Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial	20
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	19
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity	19
The therapeutic role of naringenin nanoparticles on hepatocellular carcinoma	18
Appropriate use of triazolam in elderly patients considering a quantitative benefit-risk assessment based on the pharmacokinetic-pharmacodynamic modeling and simulation approach supported by real-worl	17
In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation	17
Conditioned medium from human adipose-derived mesenchymal stem cells attenuates cardiac injury induced by Movento in male rats: role of oxidative stress and inflammation	17
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson’s disease model	17
Real-world safety analysis of deutetrabenazine post-marketing: a disproportionality study leveraging the FDA Adverse Event Reporting System (FAERS) database	17
Oxidative stress and anti-oxidant status in children with sepsis	16
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells	16
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice	16
A phase I study comparing the biosimilarity of the pharmacokinetics and safety of recombinant humanized anti-vascular endothelial growth factor monoclonal antibody injection with Avastin® in healthy C	15
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	15
Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity	15

Safety analysis of romiplostim, eltrombopag, and avatrombopag post-market approval: a pharmacovigilance study based on the FDA Adverse Event Reporting System	15
Sustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice	15
Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022	15
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	15
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination	14
Acute, sub-acute and developmental toxicity studies of molybdenum disulfide nanoflowers in rats, as per OECD guidelines	14
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients	13
Quality analysis of albendazole formulations available in veterinary pharmacies of Nepal	13
Safety assessment of asenapine in the FAERS database: real adverse event analysis and discussion on neurological and psychiatric side effects	13
Development and validation of simple colorimetric methods for assessing norfloxacin in pure form, in pharmaceutical products and in biological material	13
The risk of hyponatremia induced by SSRIs and SNRIs antidepressants: a systematic review and meta-analysis	13
Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways	13
Can quercetin reduce arsenic induced toxicity in mouse BALB/c 3T3 fibroblast cells? A study involving in vitro, molecular docking, and ADME predictions	12
Development of nanospray loaded with ciclopirox for dermal fungus treatment: determination of pro-inflammatory interleukin IL-2 mRNA expression	12
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm	12
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation	12
Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system	11
Epoetin alfa has a potent anxiolytic effect on naive female rats	11
The subchronic toxicity of higher olefins in Han Wistar rats	11
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats	11
Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients	11
Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder	11
A disproportionality analysis of real-world events from the FDA Adverse Event Reporting System (FAERS) for Atezolizumab	11
Risk factors for gastrointestinal complications during glucocorticoid therapy in internal medicine inpatients: a real-world retrospective analysis	11
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	11
Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover	11
Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure	11
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells	10
Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese	10
Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis	10
Neuroprotective effects of berberine in preclinical models of ischemic stroke: a systematic review	10
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials	10
Comparative analysis of safety and efficacy between brand and generic lamotrigine products in the Saudi market	10
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin	9
Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor	9
Investigation of the protective effects of dichloroacetic acid in a rat model of diabetic neuropathy	9
Stratified analysis of the association between anti-obesity medications and digestive adverse events: a real-world study based on the FDA adverse event reporting system database	9
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	9
Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan	9
Retraction Note: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats	9
Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice	9
Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects	9
Pulrodemstat, a selective inhibitor of KDM1A, suppresses head and neck squamous cell carcinoma growth by triggering apoptosis	9
Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment	9
Extracellular vesicle therapy for acute pancreatitis: experimental validation of mesenchymal stem cell-derived nanovesicles	8
Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish mode	8
A disproportionality analysis of adverse events associated with loop diuretics in the FDA Adverse Event Reporting System (FAERS)	8
NSAIDs, analgesics, antiplatelet drugs, and decline in renal function: a retrospective case-control study with SIDIAP database	8
Adverse events associated with IL-23 and IL-12/23 inhibitors in the clinical management of psoriasis: a comprehensive pharmacovigilance analysis	8
Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification	8

Potential antiviral peptides targeting the SARS-CoV-2 spike protein	8
Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study	8
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells	8
Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital	7
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	7
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	7
The efficacy and safety of belzutifan inhibitor in patients with advanced or metastatic clear cell renal cell carcinoma: a meta-analysis	7
Immunomodulatory effects of detoxification agents on dendritic cell populations in methamphetamine addiction	7
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	7
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers	7
Informal sale of antibiotics in Guatemalan convenience stores before and after implementation of federal antibiotic dispensing legislation	7
Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2	7
Ameliorative effects of agomelatine against doxorubicin-induced hepatotoxicity	7
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	7
Retraction Note: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	7
Intratympanic N-acetylcysteine in the prevention of cisplatin-induced ototoxicity: a systematic review and meta-analysis of randomized controlled trials	7
Safety, pharmacokinetics, preliminary efficacy, pharmacodynamics, and immunogenicity of QX002N, an anti-IL-17A monoclonal antibody, after short-term treatment of active ankylosing spondylitis	6
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	6
Genetic prediction of antihyperglycemic drug targets and risk of epilepsy: a mendelian randomisation study	6
Efficacy of daily versus alternate day oral iron supplementation for management of anaemia among general population: a systematic review and meta-analysis	6
Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation	6
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells	6
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	6
A novel nitidine chloride nanoparticle overcomes the stemness of CD133+EPCAM+ Huh7 hepatocellular carcinoma cells for liver cancer therapy	6
Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats	6
Toxicology study of a tissue anchoring paclitaxel prodrug	6
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study	6
Protective effects of Alamandine against doxorubicin-induced liver injury in rats	6
Trimetazidine effect on kidney function in patients undergoing coronary procedures	6
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells	6
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model	6
The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial	6
Correction: Modified diatom-based ocular suspension for sustained diclofenac sodium delivery: a novel drug carrier approach	6
Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible	6
Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance	6
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	6
Comparison of the prophylactic effect of cefazolin injection versus oral levofloxacin as prophylactic antibiotic in TURP surgery: a randomized clinical trial	6
The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial	6
Efficacy and safety of a B-cell-driven rituximab regimen for the treatment of refractory idiopathic membranous nephropathy	6
Nephroprotective role of resveratrol in renal ischemia-reperfusion injury: a preclinical study in Sprague-Dawley rats	5
Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice	5
Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function	5
Can vildagliptin protect against radiation-induced premature ovarian failure? Insights into the AMPK and AKT signaling pathways	5
Open-access database of literature derived drug-related Torsade de Pointes cases	5
Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rat	5
Coenzyme Q10 microemulsion ion-activated gel: a promising ophthalmic delivery system for enhanced corneal protection and sustained release	5
Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study	5
Naringin mitigated doxorubicin-induced kidney injury by the reduction of oxidative stress and inflammation with a synergistic anticancer effect	5
Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats	5
Post-marketing safety profile of ganirelix in women: a 20-year pharmacovigilance analysis of global adverse drug event databases (2004–2024)	5
Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats	5
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer	5
Aspirin versus placebo on estrogen levels in postmenopausal women: a double-blind randomized controlled clinical trial	5
Saikosaponin D inhibits the inflammatory response of secretory otitis media through FTO-mediated N6-methyladenosine modification of TLR4 mRNA	5
New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice	5
Correction: Aspirin plus clopidogrel versus cilostazol -based triple antiplatelet therapy in patients with ischemic heart disease undergoing PCI: a systematic review and meta-analysis of randomized co	5
Medication overdose data analysis: a review of medication error reports in the FDA adverse event reporting system (FAERS)	5
Acute bone damage through liver-bone axis induced by thioacetamide in rats	5
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male partici	5
The effect of oral supplementation of Paricalcitol on C-reactive protein levels in chronic kidney disease patients: GRADE-assessed systematic review and dose-response meta-analysis of data from random	5
Musculoskeletal adverse events associated with CDK4/6 inhibitors: a real-world study using FDA Adverse Event Reporting System (FAERS) database	5
Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital	5
Identification of novel dihydroorotate dehydrogenase (DHODH) inhibitors for cancer: computational drug repurposing strategy	5
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro	5
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial	5
Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome	5
Drug risks associated with sarcopenia: a real-world and GWAS study	5
In vitro comparative quality evaluation of different brands of carbamazepine tablets commercially available in Dessie town, Northeast Ethiopia	5
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study	5
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions	5
Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions	5
Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis	5