OOIR: Observatory of International Research

Papers

(The TQCC of BMC Pharmacology & Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria	52
Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression	45
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats	35
High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines	33
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis	30
Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence	27
Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method	24
Safety of natural anthraquinone emodin: an assessment in mice	23
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence	23
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia	22
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	21
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock	21
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients	20
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma	20
Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis	19
The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line	18
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	18
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment	18
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test	17
Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells	15
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile	15
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model	15
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity	14
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study	14
The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)	14

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	14
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells	14
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice	14
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid	14
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)	13
Transcriptome investigation of anti‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid	12
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs	12
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	12
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine	11
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells	11
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer	11
Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats	11
Prevalence of potential drug − drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital	10
Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate	10
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells	10
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway	10
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Ira	10
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells	10
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials	10
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt	9
Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study	9
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma	9
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro	9
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases	9
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	9
The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats	9
Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis	9
Long-term low-dose exposure of permethrin induces liver and kidney damage in rats	9
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling	9
The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation	8
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	8
Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression	8
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions	8
Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation	8
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	8
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	8
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	8
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway	8
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka	8
Prediction of mortality and morbidity following paraquat poisoning based on trend of liver and kidney injury	8
Acute bone damage through liver-bone axis induced by thioacetamide in rats	8
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells	7
RETRACTED ARTICLE: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	7
Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19	7
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism	7
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells	7
Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential	7
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19	7
β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway	7
Extended adverse effects of cyclophosphamide on mouse ovarian function	7

Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations	7
Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database	7
Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System	7
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	6
Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats	6
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway	6
Cytotoxic and apoptotic potential of gemini-chrysophanol nanoparticles against human colorectal cancer HCT-116 cell lines	6
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	6
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice	6
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells	6
The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication	6
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells	6
Self-medication practices and their characteristics among Iranian university students	6
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	6
Open-access database of literature derived drug-related Torsade de Pointes cases	6