BMC Pharmacology & Toxicology

Article	Citations
Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression	42
The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats	42
In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria	37
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats	32
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis	30
In vitro and in vivo effects of flubendiamide and copper on cyto-genotoxicity, oxidative stress and spleen histology of rats and its modulation by resveratrol, catechin, curcumin and α-tocopherol	28
Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis	27
High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines	27
Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence	26
A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia	22
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia	19
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	19
Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days	19
18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice	19
Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole	18
Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells	18
Adverse event profiles of dipeptidyl peptidase-4 inhibitors: data mining of the public version of the FDA adverse event reporting system	18
Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method	18
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock	18
Safety of natural anthraquinone emodin: an assessment in mice	18
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma	18
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients	17
Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis	17
Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis	16
A protein interaction map identifies existing drugs targeting SARS-CoV-2	15

Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	15
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence	15
Furosemide and spironolactone doses and hyponatremia in patients with heart failure	14
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment	14
Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells	14
The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line	13
Oritavancin for the treatment of complicated gram-positive infection in persons who inject drugs	13
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice	13
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test	13
Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib	12
The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)	12
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	12
Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies	11
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile	11
Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway	11
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells	11
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid	11
The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice	10
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells	10
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study	10
Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease	10
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer	10
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity	10
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model	10
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model	10
Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats	10
Transcriptome investigation of anti‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid	10
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Ira	9
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma	9
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	9
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs	9
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro	9
Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial	9
Effects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE−/− mice	9
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells	9
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials	9
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects	8
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases	8
Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis	8
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	8
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	8
Dual anti-platelet therapy following percutaneous coronary intervention in a population of patients with thrombocytopenia at baseline: a meta-analysis	8
Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874	8
The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study	8
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway	8
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine	8
Favorable response to pembrolizumab after durvalumab failure in a stage III sarcomatoid carcinoma of the lung: a case report	7
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism	7
Effect of aerosolized nicotine on human bronchial epithelial cells is amplified after co-administration with cannabidiol (CBD): a pilot in vitro study	7
The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats	7

Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure	7
Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate	7
5-Hydroxytryptamine-3 receptor antagonist and dexamethasone as prophylaxis for chemotherapy-induced nausea and vomiting during moderately emetic chemotherapy for solid tumors: a multicenter, prospecti	7
Electrolytes supplementation can decrease the risk of nephrotoxicity in patients with solid tumors undergoing chemotherapy with cisplatin	6
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling	6
Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study	6
Long-term low-dose exposure of permethrin induces liver and kidney damage in rats	6
Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin	6
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19	6
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	6
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	6
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells	6
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	6
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway	6
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)	6
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells	6
Glycyrrhetinic acid protects against Multidrug-resistant Acinetobacter baumannii-induced lung epithelial cells injury by regulating inflammation and oxidative stress	5
Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation	5
Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers	5
The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication	5
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	5
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product	5
Extended adverse effects of cyclophosphamide on mouse ovarian function	5
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells	5
Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19	5
Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial	5
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka	5
Comparative effect of dipeptidyl-peptidase 4 inhibitors on laboratory parameters in patients with diabetes mellitus	5
Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults	5
Successful clozapine rechallenge following recurrent clozapine-associated pancreatitis: a case report	5
Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database	5
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt	5
Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells	5
Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System	5
Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database	5
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions	5
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells	4
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study	4
The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy	4
Opportunities for successful de-escalation of proton pump inhibitors at a federally qualified health center	4
RETRACTED ARTICLE: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	4
Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers	4
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm	4
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model	4
Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data	4
High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol	4
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	4
The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation	4
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice	4
Prevalence of potential drug − drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital	4
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	4
The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial	4
Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression	4
Acute bone damage through liver-bone axis induced by thioacetamide in rats	4
Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis	4
Pharmacovigilance of cutaneous adverse drug reactions in associations with drugs and medical conditions: a retrospective study of hospitalized patients	4
Open-access database of literature derived drug-related Torsade de Pointes cases	4
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010–2017	4
A randomized, double-blind, phase III, non-inferiority clinical trial comparing the efficacy and safety of TA4415V (a proposed Trastuzumab biosimilar) and Herceptin (Trastuzumab reference product) in	3
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice	3
Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects	3
Potential antiviral peptides targeting the SARS-CoV-2 spike protein	3
Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats	3
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male partici	3
Presentations of tetramethylammonium hydroxide dermal exposure and the valuable potential of diphoterine solution in decontamination: a retrospective observational study	3
Evaluation of the importance of mixing during preparation of antibiotic infusions	3
Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome	3
Prediction of mortality and morbidity following paraquat poisoning based on trend of liver and kidney injury	3
Identification and solution of drug-related problems in the neurology unit of a tertiary hospital in China	3
Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran	3
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway	3
A randomized single-dose, two-period crossover bioequivalence study of two fixed-dose Paracetamol/Orphenadrine combination preparations in healthy volunteers under fasted condition	3
Real-world safety of ulinastatin: a post-marketing surveillance of 11,252 patients in China	3
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation	3
RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study	3
Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential	3
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	3
Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study	3
Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report	3
Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study	3

Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	3
Dramatic neurological and biological effects by botulinum neurotoxin type A on SH-SY5Y neuroblastoma cells, beyond the blockade of neurotransmitter release	3
Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats	3
Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies	3
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells	3
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model	3
Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study	3
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	3
Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats	3
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells	3
Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh	3
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	3
Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rat	3
Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium	3
High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin: a retrospective study	3
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	3
TGF-β induced reprogramming and drug resistance in triple-negative breast cells	3
Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations	3
1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function	3
Bioprospecting the antimicrobial, antibiofilm and antiproliferative activity of Symplocos racemosa Roxb. Bark phytoconstituents along with their biosafety evaluation and detection of antimicrobial com	3