BMC Pharmacology & Toxicology

Article	Citations
In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria	52
Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression	45
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats	35
High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines	33
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis	30
Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence	27
Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method	24
Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence	23
Safety of natural anthraquinone emodin: an assessment in mice	23
COVID-19 Vaccines Programs: adverse events following immunization (AEFI) among medical Clerkship Student in Jember, Indonesia	22
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock	21
Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis	21
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients	20
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma	20
Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis	19
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment	18
The cytotoxicity and apoptotic effects of verbascoside on breast cancer 4T1 cell line	18
Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model	18
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test	17
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile	15
Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model	15
Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells	15
The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)	14
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β	14
Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells	14

Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice	14
Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid	14
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity	14
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study	14
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)	13
Cordycepin inhibits colon cancer proliferation by suppressing MYC expression	12
Transcriptome investigation of anti‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid	12
Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs	12
Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats	11
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine	11
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells	11
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer	11
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Ira	10
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells	10
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials	10
Prevalence of potential drug − drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital	10
Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate	10
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells	10
Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway	10
The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats	9
Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis	9
Long-term low-dose exposure of permethrin induces liver and kidney damage in rats	9
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling	9
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt	9
Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study	9
Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma	9
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro	9
Selective serotonin reuptake inhibitors and suicidality in children and young adults: analyses of pharmacovigilance databases	9
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway	9
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway	8
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs	8
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway	8
WHO/INRUD Core drug use indicators and commonly prescribed medicines: a National Survey from Sri Lanka	8
Prediction of mortality and morbidity following paraquat poisoning based on trend of liver and kidney injury	8
Acute bone damage through liver-bone axis induced by thioacetamide in rats	8
The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation	8
miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress	8
Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression	8
Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions	8
Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation	8
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations	8
Extended adverse effects of cyclophosphamide on mouse ovarian function	7
Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations	7
Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database	7
Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System	7
Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells	7
RETRACTED ARTICLE: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout	7
Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19	7
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism	7
Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells	7

Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential	7
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19	7
β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway	7
Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice	6
Novel dihydroartemisinin derivative Mito-DHA5 induces apoptosis associated with mitochondrial pathway in bladder cancer cells	6
Cardioprotective effects of sodium thiosulfate against doxorubicin-induced cardiotoxicity in male rats	6
The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication	6
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells	6
Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis	6
Open-access database of literature derived drug-related Torsade de Pointes cases	6
Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines	6
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway	6
Self-medication practices and their characteristics among Iranian university students	6
Cytotoxic and apoptotic potential of gemini-chrysophanol nanoparticles against human colorectal cancer HCT-116 cell lines	6
Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway	6
GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity	5
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product	5
Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study	5
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm	5
Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model	5
Real-world safety of ulinastatin: a post-marketing surveillance of 11,252 patients in China	5
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol	5
Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults	5
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male partici	5
Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome	5
Glycyrrhetinic acid protects against Multidrug-resistant Acinetobacter baumannii-induced lung epithelial cells injury by regulating inflammation and oxidative stress	5
Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies	5
Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers	5
A randomized, double-blind, phase III, non-inferiority clinical trial comparing the efficacy and safety of TA4415V (a proposed Trastuzumab biosimilar) and Herceptin (Trastuzumab reference product) in	5
Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation	5
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model	5
Presentations of tetramethylammonium hydroxide dermal exposure and the valuable potential of diphoterine solution in decontamination: a retrospective observational study	5
Vanillic acid alleviates methamphetamine-induced mitochondrial toxicity in cardiac mitochondria via antioxidant activity and inhibition of MPT Pore opening: an in-vitro study	5
Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial	5
Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study	5
Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats	5
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats	4
The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial	4
Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims dat	4
Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects	4
High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol	4
Potential antiviral peptides targeting the SARS-CoV-2 spike protein	4
High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin: a retrospective study	4
Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh	4
Pharmacovigilance of cutaneous adverse drug reactions in associations with drugs and medical conditions: a retrospective study of hospitalized patients	4
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial	4
Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran	4
Exploring the potential of taurolidine in inducing mobilization and detachment of colon cancer cells: a preliminary in-vitro study	4
Association between anticholinergic activity and xerostomia and/ or xerophthalmia in the elderly: systematic review	4
The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy	4
Opportunities for successful de-escalation of proton pump inhibitors at a federally qualified health center	4
A disproportionality analysis of adverse events associated to pertuzumab in the FDA Adverse Event Reporting System (FAERS)	4
Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats	4
Controlled release of silica-coated insulin-loaded chitosan nanoparticles as a promising oral administration system	4
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats	4
Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data	4
Bioprospecting the antimicrobial, antibiofilm and antiproliferative activity of Symplocos racemosa Roxb. Bark phytoconstituents along with their biosafety evaluation and detection of antimicrobial com	4
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells	4
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation	4
Study on the thermal stability of nab-paclitaxel during hyperthermic intraperitoneal chemotherapy	4
TGF-β induced reprogramming and drug resistance in triple-negative breast cells	4
Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis	4
Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study	4
Identification and solution of drug-related problems in the neurology unit of a tertiary hospital in China	4
The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials	3
Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway	3
Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model	3
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice	3
RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study	3
Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach	3
Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study	3
Potential drug-drug interactions and associated factors among admitted patients with psychiatric disorders at selected hospitals in Northwest Ethiopia	3
Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rat	3
Correction to: Open-access database of literature derived drug-related Torsade de Pointes cases	3
Wnt-induced secreted proteins-1 play an important role in paraquat-induced pulmonary fibrosis	3
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis	3
The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a systematic review and meta-analysis	3
Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice	3
Hydrogen sulfide attenuates lung injury instigated by Bisphenol-A via suppressing inflammation and oxidative stress	3
Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells	3

Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing	3
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study	3
Medication overdose data analysis: a review of medication error reports in the FDA adverse event reporting system (FAERS)	3
Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin	3
The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats	3
Real life evaluation of the multi-organ effects of Lumacaftor/Ivacaftor on F508del homozygous cystic fibrosis patients	3
Patient safety and public health concerns: poor dissolution rate of pioglitazone tablets obtained from China, Myanmar and internet sites	3
Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes	3
TCDD exposure alters fecal IgA concentrations in male and female mice	3
Berberine-loaded albumin nanoparticles reverse aflatoxin B1-induced liver hyperplasia	3
Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium	3
Evaluation of the importance of mixing during preparation of antibiotic infusions	3
In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica	3
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials	3
Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy	3
Effectiveness and safety of different doses of febuxostat compared with allopurinol in the treatment of hyperuricemia: a meta-analysis of randomized controlled trials	2
In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment	2
Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway	2
Two novel anticancer compounds with minimum cardiotoxic property	2
In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia	2
In vitro comparative quality evaluation of different brands of carbamazepine tablets commercially available in Dessie town, Northeast Ethiopia	2
A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation	2
Detecting medication errors associated with the use of beta-lactams in the Russian Pharmacovigilance database	2
A novel nitidine chloride nanoparticle overcomes the stemness of CD133+EPCAM+ Huh7 hepatocellular carcinoma cells for liver cancer therapy	2
Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance	2
Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats	2
Antitumor effects of erlotinib in combination with berberine in A431 cells	2
Effects of rosuvastatin on serum glucose and insulin in hyperuricemic rats	2
Dexamethasone suppresses the proliferation and migration of VSMCs by FAK in high glucose conditions	2
Determination of the median lethal dose of zinc gluconate in mice and safety evaluation	2
Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese pop	2
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats	2
In-silico evaluation of Malawi essential medicines and reactive metabolites for potential drug-induced toxicities	2
Comparative risk of incidence and clinical outcomes of COVID-19 among proton pump inhibitor and histamine-2 receptor antagonist short-term users: a nationwide retrospective cohort study	2
Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice	2
Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2	2
Aspirin versus placebo on estrogen levels in postmenopausal women: a double-blind randomized controlled clinical trial	2
Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns	2
Preliminary study of the toxicity and radioprotective effects of zymosan in vitro and in vivo	2
Addition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial	2
Safety assessment of subtilisin QK in rats	2
Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs	2
Longitudinal follow-up of zearalenone and deoxynivalenol mycotoxins in breast milk in the first five months of life	2
Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible	2
Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid	2