eLife

Article	Citations
Becoming less beige with age	1324
Shining a light on hematopoietic stem cells	503
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	391
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	334
Outgrowing self-denial	310
Larger but younger fish when growth outpaces mortality in heated ecosystem	290
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	277
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	275
Cortico-striatal action control inherent of opponent cognitive-motivational styles	271
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	266
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	263
Serial attentional resource allocation during parallel feature value tracking	240
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	219
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	211
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	208
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	200
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	200
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	198
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	195
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	193
Variation in the basal immune state and implications for disease	177
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	174
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	169
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	165
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	163

T cells discriminate between groups C1 and C2 HLA-C	163
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	160
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	157
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	155
Guanidine production by plant homoarginine-6-hydroxylases	151
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	149
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	143
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	140
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	139
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	132
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	132
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	128
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster	128
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	125
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	125
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	123
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	122
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	119
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	118
Language experience shapes predictive coding of rhythmic sound sequences	118
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	117
Functional and structural segregation of overlapping helices in HIV-1	117
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	117
Resonating neurons stabilize heterogeneous grid-cell networks	116
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	116
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	111
A quadratic model captures the human V1 response to variations in chromatic direction and contrast	111
Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner	110
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	109
Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage	109
Mechanically transduced immunosorbent assay to measure protein-protein interactions	108
Micron-scale geometrical features of microtubules as regulators of microtubule organization	107
Temporo-cerebellar connectivity underlies timing constraints in audition	107
Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link	106
Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport	105
State-dependent representations of mixtures by the olfactory bulb	105
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme	103
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology	102
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	102
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis	102
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	102
Identification of drugs associated with reduced severity of COVID-19 – a case-control study in a large population	102
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	101
Integrating analog and digital modes of gene expression at Arabidopsis FLC	100
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	98
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	98
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	98
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	97
Direct observation of the neural computations underlying a single decision	97
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	96

Mechanism of substrate binding and transport in BASS transporters	92
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	92
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	91
Biocalcification in porcelaneous foraminifera	91
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	90
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	89
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	89
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	89
Goal-directed vocal planning in a songbird	88
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	87
Sex differences and sex bias in human circadian and sleep physiology research	86
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	85
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	85
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	85
Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology	85
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	85
Multisensory integration enhances audiovisual responses in the Mauthner cell	84
Nucleotide-level linkage of transcriptional elongation and polyadenylation	83
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	83
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	83
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	82
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration	81
Correction: Highly contiguous assemblies of 101 drosophilid genomes	80
Correction: Drp1 is required for AgRP neuronal activity and feeding	80
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	80
An emerging view of neural geometry in motor cortex supports high-performance decoding	79
osl-dynamics, a toolbox for modeling fast dynamic brain activity	79
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	79
Position representations of moving objects align with real-time position in the early visual response	79
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	79
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	78
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	78
Brain areas for reversible symbolic reference, a potential singularity of the human brain	78
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	78
Caspases promote cell proliferation after necrosis	77
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	77
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	76
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	75
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	75
Are single-peaked tuning curves tuned for speed rather than accuracy?	75
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	75
Wiring up for controlled flight	75
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	75
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	74
ZAF, the first open source fully automated feeder for aquatic facilities	72
Deciding when to move	72
Movies reveal the fine-grained organization of infant visual cortex	72
Avoiding culture shock with the SARS-CoV-2 spike protein	72
De novo identification of universal cell mechanics gene signatures	72
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	72
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	72
Multi-dimensional social relationships shape social attention in monkeys	72
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation	71
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses	71
The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity	71
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	71
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	70
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	70
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	70
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	70
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	70
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	70
Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy	69
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	69
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	69
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission	69
Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement	68
Muscarinic receptors mediate motivation via preparatory neural activity in humans	68
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	68
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	67
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	67
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation	67
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	67
Allosteric regulation of kinase activity in living cells	67
The deep-rooted origin of disulfide-rich spider venom toxins	67
How honey bees make fast and accurate decisions	67
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	66
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	66
Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans	66
Functionally important residues from graph analysis of coevolved dynamic couplings	66

Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	66
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	66
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity	66
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	65
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	65
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	65
Emerging dynamics from high-resolution spatial numerical epidemics	64
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	64
Cortical adaptation to sound reverberation	64
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	64
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	64
Phagocytic ‘teeth’ and myosin-II ‘jaw’ power target constriction during phagocytosis	64
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	63
Analysis of long and short enhancers in melanoma cell states	63
Conditional and unconditional components of aversively motivated freezing, flight and darting in mice	63
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	63
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	63
NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase	63
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	63
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	62
PIMT is a novel and potent suppressor of endothelial activation	62
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	62
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	61
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	61
Add mass spectrometry to the pandemic toolbox	61
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	61
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	61
Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1	61
Nonlinear transient amplification in recurrent neural networks with short-term plasticity	61
7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis	61
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning	60
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	60
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	60
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	59
Intrinsic excitability mechanisms of neuronal ensemble formation	59
Functional visualization of NK cell-mediated killing of metastatic single tumor cells	59
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	59
Space as a scaffold for rotational generalisation of abstract concepts	59
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	59
Decoding the activated stem cell phenotype of the neonatally maturing pituitary	59
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	59
A connectomics-based taxonomy of mammals	59
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	59
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication	59
A new early branching armored dinosaur from the Lower Jurassic of southwestern China	59
Method development and characterisation of the low-molecular-weight peptidome of human wound fluids	58
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end	58
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	58
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	58
The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo	58
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	58
Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation	58
Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster	58
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	57
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation	57
A meta-analysis of the association between male dimorphism and fitness outcomes in humans	57
Lipid hydroperoxides promote sarcopenia through carbonyl stress	57
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	57
Patterns of interdivision time correlations reveal hidden cell cycle factors	57
Calcium signaling through a transient receptor channel is important for Toxoplasma gondii growth	57
Muscle-specific economy of force generation and efficiency of work production during human running	57
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	57
Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon	57
Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors	57
A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx	57
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	57
Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy	57
Pervasive translation in Mycobacterium tuberculosis	57
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	56
Reversal of the adipostat control of torpor during migration in hummingbirds	56
The structural connectome constrains fast brain dynamics	56
Mutant SF3B1 promotes malignancy in PDAC	56
TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase	56
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	56
Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement	56
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	56
Daily electrical activity in the master circadian clock of a diurnal mammal	56
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	55
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	55
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia	55
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	55
The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging	55
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	55
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	55
STING mediates immune responses in the closest living relatives of animals	55
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	55
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity	55
Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice	55
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	55
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	54
An annotated introductory reading list for neurodiversity	54
A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii	54
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface	54
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	54
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	54