eLife

Article	Citations
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants	1062
The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications	968
SARS-CoV-2 (COVID-19) by the numbers	690
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3	507
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants	438
A connectome and analysis of the adult Drosophila central brain	425
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission	357
Brian 2, an intuitive and efficient neural simulator	310
DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning	274
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm	266
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification	260
COVID-19 medical papers have fewer women first authors than expected	257
Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19	255
Common activation mechanism of class A GPCRs	251
Ten simple rules for the computational modeling of behavioral data	250
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset	235
Evidence for transmission of COVID-19 prior to symptom onset	219
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities	218
Consistent and correctable bias in metagenomic sequencing experiments	213
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2	204
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm	204
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform	203
Variable prediction accuracy of polygenic scores within an ancestry group	203
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics	202
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome	200

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice	195
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?	191
How to measure and evaluate binding affinities	189
Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation	181
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy	181
The connectome of the adult Drosophila mushroom body provides insights into function	173
Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction	167
Derivation of trophoblast stem cells from naïve human pluripotent stem cells	159
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment	155
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study	151
Single cell transcriptional signatures of the human placenta in term and preterm parturition	151
Tight nuclear tethering of cGAS is essential for preventing autoreactivity	149
Stimulation of Piezo1 by mechanical signals promotes bone anabolism	146
Antimicrobial resistance and COVID-19: Intersections and implications	143
An electrophysiological marker of arousal level in humans	143
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up	142
Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei	142
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner	141
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration	138
A 10-year follow-up study of sex inclusion in the biological sciences	134
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway	133
DNA damage—how and why we age?	131
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy	131
Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID	130
Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes	130
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies	129
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types	127
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart	127
Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls	126
An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species	126
A genetic, genomic, and computational resource for exploring neural circuit function	125
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study	125
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy	125
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane	124
The human coronavirus HCoV-229E S-protein structure and receptor binding	124
Spatiotemporal constraints on optogenetic inactivation in cortical circuits	123
Ten common statistical mistakes to watch out for when writing or reviewing a manuscript	122
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model	119
The single-cell eQTLGen consortium	118
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices	118
A whole-brain connectivity map of mouse insular cortex	117
Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis	117
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture	116
Discovery of several thousand highly diverse circular DNA viruses	115
Structure of the bacterial ribosome at 2 Å resolution	115
Accurate and versatile 3D segmentation of plant tissues at cellular resolution	113
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation	113
Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events	113
Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury	112
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin	110

The natverse, a versatile toolbox for combining and analysing neuroanatomical data	109
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress	108
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products	108
Noninvasive quantification of axon radii using diffusion MRI	107
Molecular and anatomical organization of the dorsal raphe nucleus	107
Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis	106
Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation	106
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition	106
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection	106
An open label trial of anakinra to prevent respiratory failure in COVID-19	105
DunedinPACE, a DNA methylation biomarker of the pace of aging	105
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo	105
Sampling alternative conformational states of transporters and receptors with AlphaFold2	104
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes	104
Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq	104
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses	104
Development of a confinable gene drive system in the human disease vector Aedes aegypti	103
Sex differences in biological aging with a focus on human studies	102
Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria	101
Beyond the RNA-dependent function of LncRNA genes	100
Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study	100
DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila	100
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block	99
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL	99
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex	99
Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle	98
Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes	98
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes	98
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC	97
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function	96
Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides	96
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients	95
A single-cell survey of Drosophila blood	95
TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields	94
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations	93
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila	93
GC content shapes mRNA storage and decay in human cells	92
Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements	91
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids	91
Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes	91
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell	91
The OpenNeuro resource for sharing of neuroscience data	90
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens	90
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate	90
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site	89
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment	89
Adjusting for age improves identification of gut microbiome alterations in multiple diseases	89
Dynamic metastable long-living droplets formed by sticker-spacer proteins	89
Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols	89
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice	89
SpikeInterface, a unified framework for spike sorting	88
Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments	88
Protein engineering expands the effector recognition profile of a rice NLR immune receptor	88
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts	87
Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex	87
Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1	87
Racial inequity in grant funding from the US National Institutes of Health	86
Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis	86
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics	86
Decreasing human body temperature in the United States since the Industrial Revolution	86
A community-maintained standard library of population genetic models	85
The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition	85
Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila	85
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance	84
A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery	84
Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation	84
Prediction signals in the cerebellum: Beyond supervised motor learning	84
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation	84
Microglial calcium signaling is attuned to neuronal activity in awake mice	84
Molecular mechanism of TRPV2 channel modulation by cannabidiol	84
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation	84
Navigating the garden of forking paths for data exclusions in fear conditioning research	83
Temporal cascade of frontal, motor and muscle processes underlying human action-stopping	83
The social life of Norway rats (Rattus norvegicus)	83
Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins	83
Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice	83
Alpha/beta power decreases track the fidelity of stimulus-specific information	82
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population	82
Reporting and misreporting of sex differences in the biological sciences	81
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells	80

An interactive meta-analysis of MRI biomarkers of myelin	80
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins	80
Investigating the replicability of preclinical cancer biology	80
NeuroQuery, comprehensive meta-analysis of human brain mapping	80
Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects	80
Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions	79
Challenges for assessing replicability in preclinical cancer biology	79
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation	79
Mapping single-cell atlases throughout Metazoa unravels cell type evolution	79
SON and SRRM2 are essential for nuclear speckle formation	78
An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms	78
Training deep neural density estimators to identify mechanistic models of neural dynamics	78
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import	78
Functional clustering of dendritic activity during decision-making	78
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains	77
Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health	77
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling	77
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets	77
Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence	77
Patterns of within-host genetic diversity in SARS-CoV-2	77
Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies	77
Shifts in myeloarchitecture characterise adolescent development of cortical gradients	77
Single-cell transcriptomic evidence for dense intracortical neuropeptide networks	77
Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane	77
NINscope, a versatile miniscope for multi-region circuit investigations	76
Releasing a preprint is associated with more attention and citations for the peer-reviewed article	76
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle	76
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds	76
Diverse viral proteases activate the NLRP1 inflammasome	75
Single cell transcriptome atlas of the Drosophila larval brain	75
Information flow, cell types and stereotypy in a full olfactory connectome	75
Structural basis for SARM1 inhibition and activation under energetic stress	75
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord	75
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons	74
SIRT6 is a DNA double-strand break sensor	74
Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum	74
The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus	74
Real-time, low-latency closed-loop feedback using markerless posture tracking	74
Standardizing workflows in imaging transcriptomics with the abagen toolbox	74
Single-cell proteomics reveals changes in expression during hair-cell development	73
The genomic consequences of hybridization	73
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness	73
Highly contiguous assemblies of 101 drosophilid genomes	73
Efficient targeted integration directed by short homology in zebrafish and mammalian cells	73
Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells	72
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization	72
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection	72
Temporal integration of auxin information for the regulation of patterning	72
A new genetic strategy for targeting microglia in development and disease	72
A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS	72
Chromosome organization by one-sided and two-sided loop extrusion	72
Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade	72
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS	72
Inhibition stabilization is a widespread property of cortical networks	72
Molecular structures of the human Slo1 K+ channel in complex with β4	71
Ageing compromises mouse thymus function and remodels epithelial cell differentiation	71
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer	71
Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence	71
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity	71
A new class of disordered elements controls DNA replication through initiator self-assembly	71
Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis	71
ParB spreading on DNA requires cytidine triphosphate in vitro	70
Virtual conferences raise standards for accessibility and interactions	70
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women	70
Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations	70
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time	70
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy	70
Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?	69
EDF1 coordinates cellular responses to ribosome collisions	69
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth	69
Topographic gradients of intrinsic dynamics across neocortex	69
Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles	69
Self-blinding citizen science to explore psychedelic microdosing	69
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning	69
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals	69
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis	68
Structure-based inhibitors of amyloid beta core suggest a common interface with tau	68
MRGPRX4 is a bile acid receptor for human cholestatic itch	68
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons	68
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids	68
Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA	68
Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning	68
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage	67
Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response	67
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth	67
Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples	67
Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis	67
COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest	67
Nucleolar dynamics and interactions with nucleoplasm in living cells	67
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease	67
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis	67
A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs	67
How many neurons are sufficient for perception of cortical activity?	67
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)	67
Proteome dynamics during homeostatic scaling in cultured neurons	67
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome	67
A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture	67
Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples	67
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans	67
A taxonomy of seizure dynamotypes	66
Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics	66
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage	66
Profilin and formin constitute a pacemaker system for robust actin filament growth	66
Charting the native architecture of Chlamydomonas thylakoid membranes with single-molecule precision	66
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance	66
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e	66
Stereotyped transcriptomic transformation of somatosensory neurons in response to injury	66
Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants	66
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs	66
Global genome diversity of the Leishmania donovani complex	66
Opioids depress breathing through two small brainstem sites	65
Fully automated, sequential focused ion beam milling for cryo-electron tomography	65
FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences	65
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration	65
Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C	65
KymoButler, a deep learning software for automated kymograph analysis	65
The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability	64
An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway	64
The hazards of smoking and the benefits of cessation: A critical summation of the epidemiological evidence in high-income countries	64
The architecture of EMC reveals a path for membrane protein insertion	64
H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis	64
A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat	64
Functionally heterogeneous human satellite cells identified by single cell RNA sequencing	64
Dynamics of gaze control during prey capture in freely moving mice	63
Elevating acetyl-CoA levels reduces aspects of brain aging	63
TMEM95 is a sperm membrane protein essential for mammalian fertilization	63
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis	63
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence	63
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation	63
Preclinical murine tumor models: A structural and functional perspective	63
An ER translocon for multi-pass membrane protein biogenesis	63
A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity	62
A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila	62
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion	62
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness	62
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator	62
Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice	62
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice	62
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier	62
Systematic detection of horizontal gene transfer across genera among multidrug-resistant bacteria in a single hospital	62
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser	62
Robust olfactory responses in the absence of odorant binding proteins	62
Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin	62
Structure of a mitochondrial ATP synthase with bound native cardiolipin	62
Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy	61

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α	61
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning	61
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks	61
True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field	61
The sifting of visual information in the superior colliculus	61
Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex	61
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy	61
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models	60
An open-source, high-performance tool for automated sleep staging	60
Visualizing anatomically registered data with brainrender	60
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates	60
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic	60
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement	60
Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages	60
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis	60
Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes	60
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans	60
High fat diet induces microbiota-dependent silencing of enteroendocrine cells	59
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs	59
Structural basis of mitochondrial translation	59
Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon	59
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background	59
Cortical tau deposition follows patterns of entorhinal functional connectivity in aging	59
Small molecule cognitive enhancer reverses age-related memory decline in mice	59
Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy	59
Wikidata as a knowledge graph for the life sciences	59
Hippocampal remapping as hidden state inference	58
Local cortical desynchronization and pupil-linked arousal differentially shape brain states for optimal sensory performance	58
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy	58
Structural basis for pharmacological modulation of the TRPC6 channel	58
Performance of a deep learning based neural network in the selection of human blastocysts for implantation	58
Hemimetabolous insects elucidate the origin of sexual development via alternative splicing	58
Representation of visual landmarks in retrosplenial cortex	58
Bmal1 integrates mitochondrial metabolism and macrophage activation	58
Endangered wild salmon infected by newly discovered viruses	58
AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions	57
Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3	57
The unlimited potential of the great pond snail, Lymnaea stagnalis	57
How subtle changes in 3D structure can create large changes in transcription	57
ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis	57
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel	57
Quantitative analysis of 1300-nm three-photon calcium imaging in the mouse brain	57
The diversity and function of sourdough starter microbiomes	57
Single nuclei RNA-seq of mouse placental labyrinth development	57
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism	57
Early analysis of the Australian COVID-19 epidemic	57
Endothelin signalling mediates experience-dependent myelination in the CNS	57
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation	57
Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3	57
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions	57
Standardized and reproducible measurement of decision-making in mice	57
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes	56
Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense	56
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress	56
Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions	56
The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline	56
SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters	56
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement	56
A Bayesian and efficient observer model explains concurrent attractive and repulsive history biases in visual perception	56
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis	56
C-mannosylation supports folding and enhances stability of thrombospondin repeats	56
Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset	56
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia	56
Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations	56
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2	56
The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats	55
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation	55
Generation of vascularized brain organoids to study neurovascular interactions	55
Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis	55
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia	55
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo	55
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection	55
Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing	55
Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees	55
Single molecule mechanics resolves the earliest events in force generation by cardiac myosin	55
Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways	55
FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory	55
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates	55
Anosognosia for hemiplegia as a tripartite disconnection syndrome	54
A visual pathway for skylight polarization processing in Drosophila	54
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3	54
Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe	54
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat	54
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation	54
Myosin II isoforms play distinct roles in adherens junction biogenesis	54
Rare variants contribute disproportionately to quantitative trait variation in yeast	54
Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin	54
Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data	54
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients	54
Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila	54
Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons	53
A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors	53
Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli	53
The structure of the endogenous ESX-3 secretion system	53
Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system	53
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo	53
A scalable platform for the development of cell-type-specific viral drivers	53
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir	53
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans	53
Surface-to-volume scaling and aspect ratio preservation in rod-shaped bacteria	53
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels	53
Stable task information from an unstable neural population	53
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling	53
The genetic basis of aneuploidy tolerance in wild yeast	53
The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity	53
Improving on legacy conferences by moving online	53
Dynamic turnover of centromeres drives karyotype evolution in Drosophila	53
Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray	53
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells	53
Quantifying the impact of quarantine duration on COVID-19 transmission	52
On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment	52
Contextual and cross-modality modulation of auditory cortical processing through pulvinar mediated suppression	52
Neurovascular coupling and bilateral connectivity during NREM and REM sleep	52
Combining magnetoencephalography with magnetic resonance imaging enhances learning of surrogate-biomarkers	52
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance	52
The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm	52
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis	52
Cerebellar climbing fibers encode expected reward size	52
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication	51
Primate homologs of mouse cortico-striatal circuits	51
Tgfβ signaling is critical for maintenance of the tendon cell fate	51
The yellow gene influences Drosophila male mating success through sex comb melanization	51
Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii	51
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice	51
Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1	51
Structure and activation mechanism of the BBSome membrane protein trafficking complex	51
Protein phase separation and its role in tumorigenesis	51
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model	51
Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration	51
The frequency gradient of human resting-state brain oscillations follows cortical hierarchies	51
A cell atlas of the chick retina based on single-cell transcriptomics	51
Molecular mechanism for direct actin force-sensing by α-catenin	51
Biochemical reconstitution of branching microtubule nucleation	51
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons	51
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice	50
Freshwater monitoring by nanopore sequencing	50
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex	50
The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors	50
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation	50
A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21	50
A synthetic dataset primer for the biobehavioural sciences to promote reproducibility and hypothesis generation	50
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling	50
Structure of the human BBSome core complex	50
A transcriptomic taxonomy of Drosophila circadian neurons around the clock	50
Coordination of tissue cell polarity by auxin transport and signaling	50
Remyelination alters the pattern of myelin in the cerebral cortex	50
Spinal signalling of C-fiber mediated pleasant touch in humans	50
Genetic mapping of etiologic brain cell types for obesity	49
Predicting geographic location from genetic variation with deep neural networks	49
The brain in motion: How ensemble fluidity drives memory-updating and flexibility	49
Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making	49
Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications	49
The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes	49
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin	49
The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship	49
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response	49
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry	49
Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle	49
Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila	49
Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior	49
Cortical encoding of melodic expectations in human temporal cortex	49
Paranoia as a deficit in non-social belief updating	49
Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015	49
Differentiating between integration and non-integration strategies in perceptual decision making	49
The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons	49
Human perivascular stem cell-derived extracellular vesicles mediate bone repair	49
Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells	49
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation	49
Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training	49
Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys	49
Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons	49
Plasma proteomic biomarker signature of age predicts health and life span	48
Deep generative models for T cell receptor protein sequences	48
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma	48
Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation	48
Mitochondrial fusion is required for spermatogonial differentiation and meiosis	48
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation	48
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72	48
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent	48
Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa	48
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations	48
The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions	48
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination	48
Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state	48
Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance	48
High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing	48
Mapping sequence structure in the human lateral entorhinal cortex	48
Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex	48
A model for focal seizure onset, propagation, evolution, and progression	48
Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change	47
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model	47
Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays	47
Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ	47
CTCF confers local nucleosome resiliency after DNA replication and during mitosis	47
Novel genetic loci affecting facial shape variation in humans	47
Confidence predicts speed-accuracy tradeoff for subsequent decisions	47
Demographic history mediates the effect of stratification on polygenic scores	47
Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells	47
Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts	47
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics	47