eLife

Papers
(The TQCC of eLife is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants1164
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 31011
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants616
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset338
DunedinPACE, a DNA methylation biomarker of the pace of aging337
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics279
The connectome of the adult Drosophila mushroom body provides insights into function270
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2258
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities256
Sampling alternative conformational states of transporters and receptors with AlphaFold2245
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway241
DNA damage—how and why we age?221
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products216
Antimicrobial resistance and COVID-19: Intersections and implications213
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy204
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane198
Standardizing workflows in imaging transcriptomics with the abagen toolbox197
Sex differences in biological aging with a focus on human studies194
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection189
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices183
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration177
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture172
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition171
TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields166
The OpenNeuro resource for sharing of neuroscience data165
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes162
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment161
Beyond the RNA-dependent function of LncRNA genes161
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation161
The genomic consequences of hybridization158
Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq158
SpikeInterface, a unified framework for spike sorting156
Mapping single-cell atlases throughout Metazoa unravels cell type evolution153
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses148
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study147
Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events147
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy147
A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0146
SON and SRRM2 are essential for nuclear speckle formation144
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types143
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains142
Reporting and misreporting of sex differences in the biological sciences139
An open-source, high-performance tool for automated sleep staging139
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes137
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics135
Investigating the replicability of preclinical cancer biology135
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals133
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids132
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs130
Racial inequity in grant funding from the US National Institutes of Health129
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning127
Challenges for assessing replicability in preclinical cancer biology127
Generation of vascularized brain organoids to study neurovascular interactions127
An open label trial of anakinra to prevent respiratory failure in COVID-19127
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population124
Highly contiguous assemblies of 101 drosophilid genomes124
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons120
The LOTUS initiative for open knowledge management in natural products research118
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids117
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice117
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice116
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent115
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth114
Information flow, cell types and stereotypy in a full olfactory connectome113
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site113
Diverse viral proteases activate the NLRP1 inflammasome113
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer112
Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols112
Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning111
GENESPACE tracks regions of interest and gene copy number variation across multiple genomes111
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator110
Patterns of within-host genetic diversity in SARS-CoV-2110
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation108
Real-time, low-latency closed-loop feedback using markerless posture tracking108
An interactive meta-analysis of MRI biomarkers of myelin107
The diversity and function of sourdough starter microbiomes106
Topographic gradients of intrinsic dynamics across neocortex105
Single nuclei RNA-seq of mouse placental labyrinth development104
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)104
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness103
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets101
Self-blinding citizen science to explore psychedelic microdosing101
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement100
Viral persistence, reactivation, and mechanisms of long COVID100
Standardized and reproducible measurement of decision-making in mice99
Plasma proteomic biomarker signature of age predicts health and life span98
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels98
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning98
TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs98
Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change98
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation98
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)98
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness98
A cell atlas of the chick retina based on single-cell transcriptomics95
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection95
Small molecule cognitive enhancer reverses age-related memory decline in mice94
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth94
Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)94
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time93
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming92
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background92
Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways91
The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline91
A transcriptomic taxonomy of Drosophila circadian neurons around the clock91
How many neurons are sufficient for perception of cortical activity?90
Virtual conferences raise standards for accessibility and interactions90
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation90
How subtle changes in 3D structure can create large changes in transcription89
Structural basis for SARM1 inhibition and activation under energetic stress89
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo88
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates88
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis87
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila86
Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox86
Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior86
Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli86
Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay86
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing86
Visualizing anatomically registered data with brainrender86
Functional specialization within the inferior parietal lobes across cognitive domains85
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/385
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation85
The brain in motion: How ensemble fluidity drives memory-updating and flexibility84
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study83
Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses83
A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs83
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e83
A modular platform for automated cryo-FIB workflows83
Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates82
HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells82
COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest82
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics81
Charting brain growth and aging at high spatial precision81
Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy81
Bidirectional synaptic plasticity rapidly modifies hippocampal representations80
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes80
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia80
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage80
A visual pathway for skylight polarization processing in Drosophila79
Cell types and neuronal circuitry underlying female aggression in Drosophila79
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney79
Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair78
Common coupling map advances GPCR-G protein selectivity78
Demographic history mediates the effect of stratification on polygenic scores78
Global epistasis emerges from a generic model of a complex trait78
Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair78
Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis77
Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures77
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic77
Freshwater monitoring by nanopore sequencing77
Protein phase separation and its role in tumorigenesis77
Neurovascular coupling and bilateral connectivity during NREM and REM sleep76
Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila76
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation76
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination76
Brain endothelial cell TRPA1 channels initiate neurovascular coupling75
Respiration aligns perception with neural excitability74
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun74
The molecular basis of coupling between poly(A)-tail length and translational efficiency74
Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping74
An increase of inhibition drives the developmental decorrelation of neural activity74
Generation of stress fibers through myosin-driven reorganization of the actin cortex73
Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice72
Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism72
Locating macromolecular assemblies in cells by 2D template matching with cisTEM72
High social status males experience accelerated epigenetic aging in wild baboons71
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients71
Mechanisms of distributed working memory in a large-scale network of macaque neocortex71
Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility71
Niche partitioning facilitates coexistence of closely related honey bee gut bacteria71
Microglial trogocytosis and the complement system regulate axonal pruning in vivo70
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-1970
To lie or not to lie: Super-relaxing with myosins70
On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment70
High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures70
The right time for senescence70
Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters69
Framework for rapid comparison of extracellular vesicle isolation methods69
A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer69
Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons69
Sensory coding and the causal impact of mouse cortex in a visual decision69
Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task69
Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes69
Cohesin residency determines chromatin loop patterns68
Activity-dependent modulation of synapse-regulating genes in astrocytes68
Lapses in perceptual decisions reflect exploration67
A Brownian ratchet model for DNA loop extrusion by the cohesin complex67
The neural basis for a persistent internal state in Drosophila females67
The global burden of yellow fever67
An open-source device for measuring food intake and operant behavior in rodent home-cages67
Cross-reactive antibodies after SARS-CoV-2 infection and vaccination67
Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications67
Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets66
3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images66
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations66
Quantifying the impact of quarantine duration on COVID-19 transmission66
Pupil diameter is not an accurate real-time readout of locus coeruleus activity66
The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions66
Heterogeneity of murine periosteum progenitors involved in fracture healing66
The missing link between genetic association and regulatory function66
A survey of early-career researchers in Australia65
Multiple time-scales of decision-making in the hippocampus and prefrontal cortex65
Massively multiplex single-molecule oligonucleosome footprinting65
Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation65
Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors65
NAIP–NLRC4-deficient mice are susceptible to shigellosis65
Identifying molecular features that are associated with biological function of intrinsically disordered protein regions64
Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci64
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte64
Analysis of ultrasonic vocalizations from mice using computer vision and machine learning64
On the limits of fitting complex models of population history to f-statistics64
Structure and function of axo-axonic inhibition64
Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells63
Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues63
High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing63
Comprehension of computer code relies primarily on domain-general executive brain regions63
Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice63
Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary63
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms63
Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization63
Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires63
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses63
Fixation can change the appearance of phase separation in living cells63
Decoding the physical principles of two-component biomolecular phase separation62
Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis62
Detecting adaptive introgression in human evolution using convolutional neural networks62
The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies62
Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis62
Mesoscale phase separation of chromatin in the nucleus62
Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments62
An integrative study of five biological clocks in somatic and mental health62
Reconsidering the evidence for learning in single cells61
ProteInfer, deep neural networks for protein functional inference61
Understanding implicit sensorimotor adaptation as a process of proprioceptive re-alignment61
MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut61
Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study61
The discriminatory power of the T cell receptor61
Impaired adaptation of learning to contingency volatility in internalizing psychopathology61
Cell non-autonomous regulation of health and longevity61
Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease60
Recovery of consciousness and cognition after general anesthesia in humans60
Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends60
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins60
Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process60
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice60
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation60
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike60
The structural connectome constrains fast brain dynamics60
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death59
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain59
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