eLife

Papers
(The TQCC of eLife is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants1114
SARS-CoV-2 (COVID-19) by the numbers741
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3715
A connectome and analysis of the adult Drosophila central brain534
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants521
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission370
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm279
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset272
COVID-19 medical papers have fewer women first authors than expected268
Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19265
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics249
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm246
How to measure and evaluate binding affinities239
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2235
Evidence for transmission of COVID-19 prior to symptom onset234
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice234
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities233
The connectome of the adult Drosophila mushroom body provides insights into function211
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome207
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?200
DunedinPACE, a DNA methylation biomarker of the pace of aging189
Derivation of trophoblast stem cells from naïve human pluripotent stem cells188
Antimicrobial resistance and COVID-19: Intersections and implications185
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment181
An electrophysiological marker of arousal level in humans178
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway178
DNA damage—how and why we age?169
A 10-year follow-up study of sex inclusion in the biological sciences166
Sampling alternative conformational states of transporters and receptors with AlphaFold2163
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane160
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study160
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up158
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy156
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy155
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration154
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products152
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner151
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies148
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices146
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation145
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection144
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin143
A whole-brain connectivity map of mouse insular cortex143
Accurate and versatile 3D segmentation of plant tissues at cellular resolution141
Structure of the bacterial ribosome at 2 Å resolution141
Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis139
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types139
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition137
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture136
Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury134
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study134
The single-cell eQTLGen consortium133
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress132
Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq130
Sex differences in biological aging with a focus on human studies129
The natverse, a versatile toolbox for combining and analysing neuroanatomical data129
Discovery of several thousand highly diverse circular DNA viruses127
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses125
Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation124
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell123
Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events122
Noninvasive quantification of axon radii using diffusion MRI122
TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields122
Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study122
The OpenNeuro resource for sharing of neuroscience data121
A single-cell survey of Drosophila blood120
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes119
Beyond the RNA-dependent function of LncRNA genes119
An open label trial of anakinra to prevent respiratory failure in COVID-19119
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes116
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment116
Standardizing workflows in imaging transcriptomics with the abagen toolbox115
SpikeInterface, a unified framework for spike sorting115
The genomic consequences of hybridization113
Mapping single-cell atlases throughout Metazoa unravels cell type evolution113
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations112
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens111
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids111
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics110
Reporting and misreporting of sex differences in the biological sciences109
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains109
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy109
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation109
Racial inequity in grant funding from the US National Institutes of Health108
Microglial calcium signaling is attuned to neuronal activity in awake mice108
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population107
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site107
Adjusting for age improves identification of gut microbiome alterations in multiple diseases107
SON and SRRM2 are essential for nuclear speckle formation106
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila106
Investigating the replicability of preclinical cancer biology106
Prediction signals in the cerebellum: Beyond supervised motor learning105
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function105
Challenges for assessing replicability in preclinical cancer biology104
A community-maintained standard library of population genetic models104
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL104
Dynamic metastable long-living droplets formed by sticker-spacer proteins104
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice103
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC102
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation102
Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes102
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients101
Temporal cascade of frontal, motor and muscle processes underlying human action-stopping100
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate99
Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions99
Training deep neural density estimators to identify mechanistic models of neural dynamics99
An open-source, high-performance tool for automated sleep staging98
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation98
Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols97
NeuroQuery, comprehensive meta-analysis of human brain mapping97
The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition97
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals96
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons96
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance95
Highly contiguous assemblies of 101 drosophilid genomes95
The social life of Norway rats (Rattus norvegicus)95
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord94
Diverse viral proteases activate the NLRP1 inflammasome93
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle93
An interactive meta-analysis of MRI biomarkers of myelin93
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness93
Inhibition stabilization is a widespread property of cortical networks93
EDF1 coordinates cellular responses to ribosome collisions92
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets92
Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning91
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning91
Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies91
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer90
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women90
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids89
Self-blinding citizen science to explore psychedelic microdosing89
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans89
A new genetic strategy for targeting microglia in development and disease89
Temporal integration of auxin information for the regulation of patterning88
Topographic gradients of intrinsic dynamics across neocortex88
Real-time, low-latency closed-loop feedback using markerless posture tracking88
Patterns of within-host genetic diversity in SARS-CoV-287
Information flow, cell types and stereotypy in a full olfactory connectome87
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth87
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection87
Ageing compromises mouse thymus function and remodels epithelial cell differentiation87
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import86
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time86
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds86
Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence85
Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?85
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice85
Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C84
Efficient targeted integration directed by short homology in zebrafish and mammalian cells84
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning82
Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence82
Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples82
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator81
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth81
Structural basis for SARM1 inhibition and activation under energetic stress81
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs80
Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples80
Chromosome organization by one-sided and two-sided loop extrusion80
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis80
Generation of vascularized brain organoids to study neurovascular interactions80
A taxonomy of seizure dynamotypes80
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness80
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity80
The LOTUS initiative for open knowledge management in natural products research79
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs79
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)79
The hazards of smoking and the benefits of cessation: A critical summation of the epidemiological evidence in high-income countries79
How many neurons are sufficient for perception of cortical activity?78
FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences78
Standardized and reproducible measurement of decision-making in mice78
COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest78
Opioids depress breathing through two small brainstem sites78
A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs78
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage78
An ER translocon for multi-pass membrane protein biogenesis78
ParB spreading on DNA requires cytidine triphosphate in vitro78
Small molecule cognitive enhancer reverses age-related memory decline in mice77
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence77
A Bayesian approach to single-particle electron cryo-tomography in RELION-4.076
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance76
The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability76
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage76
Fully automated, sequential focused ion beam milling for cryo-electron tomography76
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis75
The architecture of EMC reveals a path for membrane protein insertion75
Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis75
The diversity and function of sourdough starter microbiomes75
Functionally heterogeneous human satellite cells identified by single cell RNA sequencing75
Virtual conferences raise standards for accessibility and interactions75
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent74
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models74
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e74
Wikidata as a knowledge graph for the life sciences74
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates74
A cell atlas of the chick retina based on single-cell transcriptomics74
Proteome dynamics during homeostatic scaling in cultured neurons74
A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat74
Systematic detection of horizontal gene transfer across genera among multidrug-resistant bacteria in a single hospital74
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser74
Single nuclei RNA-seq of mouse placental labyrinth development74
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization74
The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline74
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy73
Global genome diversity of the Leishmania donovani complex73
How subtle changes in 3D structure can create large changes in transcription73
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis72
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation72
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement72
Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways72
Charting the native architecture of Chlamydomonas thylakoid membranes with single-molecule precision72
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background72
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis71
Visualizing anatomically registered data with brainrender71
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels71
The sifting of visual information in the superior colliculus71
TMEM95 is a sperm membrane protein essential for mammalian fertilization71
Genetic mapping of etiologic brain cell types for obesity71
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic70
Representation of visual landmarks in retrosplenial cortex70
True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field70
Dynamics of gaze control during prey capture in freely moving mice70
The unlimited potential of the great pond snail, Lymnaea stagnalis69
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism69
Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon69
Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes69
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α69
The frequency gradient of human resting-state brain oscillations follows cortical hierarchies69
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion69
AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions69
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo68
Structural basis of mitochondrial translation68
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation68
SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters68
Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli68
Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii68
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks67
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat67
Hippocampal remapping as hidden state inference67
Plasma proteomic biomarker signature of age predicts health and life span67
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming67
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/366
Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox66
A visual pathway for skylight polarization processing in Drosophila66
A Bayesian and efficient observer model explains concurrent attractive and repulsive history biases in visual perception66
Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray66
Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages66
An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes66
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation66
Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing65
A transcriptomic taxonomy of Drosophila circadian neurons around the clock65
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