eLife

Article	Citations
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	373
Wiring up for controlled flight	317
Shining a light on hematopoietic stem cells	306
Imaging of brain electric field networks with spatially resolved EEG	287
Caspases promote cell proliferation after necrosis	210
Outgrowing self-denial	202
Allosteric regulation of kinase activity in living cells	180
SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling	178
Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism	171
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	166
Space as a scaffold for rotational generalisation of abstract concepts	166
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	166
Integrating analog and digital modes of gene expression at Arabidopsis FLC	166
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function	164
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	163
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	156
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	153
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	146
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	138
Are single-peaked tuning curves tuned for speed rather than accuracy?	136
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	136
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	135
Nucleotide-level linkage of transcriptional elongation and polyadenylation	133
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	132
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	131

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework	127
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	121
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	119
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	116
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	116
Reshaping human neurons	116
A connectomics-based taxonomy of mammals	115
A causal role of the NMDA receptor in recurrent processing during perceptual integration	112
Best practices to promote rigor and reproducibility in the era of sex-inclusive research	110
An emerging view of neural geometry in motor cortex supports high-performance decoding	109
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	107
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	104
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	104
Patterns of interdivision time correlations reveal hidden cell cycle factors	103
Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis	102
Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications	99
Nonlinear feedback modulation contributes to the optimization of flexible decision-making	98
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	97
Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitive FT repressor	96
Correction: Drp1 is required for AgRP neuronal activity and feeding	95
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	95
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	94
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	94
Larger but younger fish when growth outpaces mortality in heated ecosystem	92
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	90
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	90
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	89
Mutant SF3B1 promotes malignancy in PDAC	88
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	88
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	87
Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing	86
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	86
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	86
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	86
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	85
Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l	84
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury	84
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration	83
osl-dynamics, a toolbox for modeling fast dynamic brain activity	83
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	82
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	82
Iridescent structural coloration in a crested Cretaceous enantiornithine bird from the Jehol Biota	81
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	81
Deciding when to move	81
Functionally important residues from graph analysis of coevolved dynamic couplings	81
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B	81
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA	80
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	80
Multi-dimensional social relationships shape social attention in monkeys	80
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	80

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity	79
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	79
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	79
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	79
The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats	79
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	79
Hierarchical encoding of natural sound mixtures in ferret auditory cortex	78
The influence of temporal context on vision over multiple time scales	78
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	78
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	77
Cortico-striatal action control inherent of opponent cognitive-motivational styles	76
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	76
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	75
Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes	75
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	75
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	74
The SAFE Labs Handbook as a tool for improving lab culture	73
Transsaccadic working memory in healthy ageing and neurodegenerative disease	73
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements	73
Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)	73
Conduction pathway for potassium through the Escherichia coli pump KdpFABC	73
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	72
Movies reveal the fine-grained organization of infant visual cortex	72
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	71
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	71
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	71
Biocalcification in porcelaneous foraminifera	70
Language experience shapes predictive coding of rhythmic sound sequences	70
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	70
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	70
Alternative splicing across the tree of life	69
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	69
NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors	69
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	69
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	69
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	69
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	69
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	69
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	68
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	68
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	68
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	68
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	68
Brain areas for reversible symbolic reference, a potential singularity of the human brain	68
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	68
Position representations of moving objects align with real-time position in the early visual response	67
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	67
Cortical adaptation to sound reverberation	67
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	67
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	67
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	66
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	66
Functional and structural segregation of overlapping helices in HIV-1	66
Muscarinic receptors mediate motivation via preparatory neural activity in humans	66
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	66
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	66
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	65
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	65
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	65
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	65
Impact of maximal overexpression of a non-toxic protein on yeast cell physiology	65
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	65
PIMT is a novel and potent suppressor of endothelial activation	64
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	64
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	64
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	64
Decoding the activated stem cell phenotype of the neonatally maturing pituitary	64
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	64
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	64
Goal-directed vocal planning in a songbird	63
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	63
De novo identification of universal cell mechanics gene signatures	63
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	63
Cingulate cortex shapes early postnatal development of social vocalizations	63
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	62
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	62
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	62
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	62
Guanidine production by plant homoarginine-6-hydroxylases	62
Serial attentional resource allocation during parallel feature value tracking	61

Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	61
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	61
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	61
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	61
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	61
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	61
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	61
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	61
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	60
Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation	60
DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments	60
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	60
Mechanism of substrate binding and transport in BASS transporters	60
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	59
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	59
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	59
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	59
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	59
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	59
Mouse germline cysts contain a fusome-like structure that mediates oocyte development	58
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	58
scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues	58
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	58
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	58
Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter	58
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	58
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	58
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	58
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	58
Becoming less beige with age	58
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	57
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	57
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	57
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	57
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	57
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	57
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	56
Conditional and unconditional components of aversively motivated freezing, flight and darting in mice	56
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication	56
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	56
Multisensory integration enhances audiovisual responses in the Mauthner cell	56
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster	56
Endogenous precision of the number sense	56
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	56
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	56
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme	56
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration	55
Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations	55
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	55
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	55
An annotated introductory reading list for neurodiversity	55
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	54
The deep-rooted origin of disulfide-rich spider venom toxins	54
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	54
Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex	54
Dissecting surveying behavior of reactive microglia under chronic neurodegeneration	54
Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange	54
A direct neural signature of serial dependence in working memory	54
Lipid hydroperoxides promote sarcopenia through carbonyl stress	54
Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice	54
T cells discriminate between groups C1 and C2 HLA-C	54
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	54
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging	53
How honey bees make fast and accurate decisions	53
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	53
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	53
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	53
Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells	53
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	53
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	53
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	53
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	53
Intrinsic excitability mechanisms of neuronal ensemble formation	53
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	52
Inference of germinal center evolutionary dynamics via simulation-based deep learning	52
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	52
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	52
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	52
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	52
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	52
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	52
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	52
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	52
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	52
Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates	51
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	51
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	51
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	51
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	51
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	51
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	51
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	51
Information, certainty, and learning	50
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	50
Variation in the basal immune state and implications for disease	50