eLife

Article	Citations
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	686
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	421
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	351
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	327
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	320
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	285
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	271
Correction: Highly contiguous assemblies of 101 drosophilid genomes	253
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	239
Becoming less beige with age	237
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	213
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	198
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	185
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	180
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	179
De novo identification of universal cell mechanics gene signatures	179
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	169
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	161
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	155
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	152
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	151
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	150
Serial attentional resource allocation during parallel feature value tracking	150
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	144
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	143

Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	139
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	139
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	138
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	137
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	135
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	134
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	130
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	130
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	130
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	128
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	125
Iridescent structural coloration in a crested Cretaceous enantiornithine bird from the Jehol Biota	122
Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation	122
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	121
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	120
Cortico-striatal action control inherent of opponent cognitive-motivational styles	120
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	120
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	114
Mechanism of substrate binding and transport in BASS transporters	113
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	112
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	111
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	106
Guanidine production by plant homoarginine-6-hydroxylases	106
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	105
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	105
Muscarinic receptors mediate motivation via preparatory neural activity in humans	104
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	104
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	103
Biocalcification in porcelaneous foraminifera	102
Wiring up for controlled flight	102
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	99
Functional and structural segregation of overlapping helices in HIV-1	99
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	98
Deciding when to move	96
Shining a light on hematopoietic stem cells	96
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	95
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	95
Multi-dimensional social relationships shape social attention in monkeys	94
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	94
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	94
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	92
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	91
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	91
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	90
Caspases promote cell proliferation after necrosis	89
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	89
Imaging of brain electric field networks with spatially resolved EEG	89
Goal-directed vocal planning in a songbird	89
Language experience shapes predictive coding of rhythmic sound sequences	89
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	89

Outgrowing self-denial	87
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	87
An emerging view of neural geometry in motor cortex supports high-performance decoding	87
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	87
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	86
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	84
Allosteric regulation of kinase activity in living cells	84
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	83
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	82
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	82
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	81
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	80
Functionally important residues from graph analysis of coevolved dynamic couplings	80
Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l	79
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	79
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	79
Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism	78
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end	78
Sex differences and sex bias in human circadian and sleep physiology research	78
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	77
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	77
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	77
Nonlinear feedback modulation contributes to the optimization of flexible decision-making	76
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	75
Multisensory integration enhances audiovisual responses in the Mauthner cell	75
Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes	75
ZAF, the first open source fully automated feeder for aquatic facilities	75
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	74
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	74
The influence of temporal context on vision over multiple time scales	74
T cells discriminate between groups C1 and C2 HLA-C	73
Analysis of long and short enhancers in melanoma cell states	73
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	73
Larger but younger fish when growth outpaces mortality in heated ecosystem	73
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	72
scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues	72
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	72
Impact of maximal overexpression of a non-toxic protein on yeast cell physiology	72
Cingulate cortex shapes early postnatal development of social vocalizations	72
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	72
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication	72
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	72
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	71
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	70
A causal role of the NMDA receptor in recurrent processing during perceptual integration	70
NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors	69
Alternative splicing across the tree of life	69
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	69
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	69
Integrating analog and digital modes of gene expression at Arabidopsis FLC	69
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	69
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	69
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	68
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	68
Daily electrical activity in the master circadian clock of a diurnal mammal	68
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	68
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	68
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	67
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	67
Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors	67
Structural mechanism of strand exchange by the RAD51 filament	67
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	66
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	66
Variation in the basal immune state and implications for disease	65
Space as a scaffold for rotational generalisation of abstract concepts	65
Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitive FT repressor	65
STING mediates immune responses in the closest living relatives of animals	65
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	65
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	65
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	65
Conditional and unconditional components of aversively motivated freezing, flight and darting in mice	65
PIMT is a novel and potent suppressor of endothelial activation	65
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	65
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	64
State-dependent representations of mixtures by the olfactory bulb	64
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	64
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	64
Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement	64
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	64
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	64

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx	64
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	64
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	63
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	63
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	63
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	63
Functional visualization of NK cell-mediated killing of metastatic single tumor cells	63
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	63
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	62
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	62
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	62
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme	62
Correction: Drp1 is required for AgRP neuronal activity and feeding	62
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission	62
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	62
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	61
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	61
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	61
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	61
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	61
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology	60
Reversal of the adipostat control of torpor during migration in hummingbirds	60
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	60
SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling	60
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	60
Movies reveal the fine-grained organization of infant visual cortex	60
Patterns of interdivision time correlations reveal hidden cell cycle factors	60
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	60
Hierarchical encoding of natural sound mixtures in ferret auditory cortex	60
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	60
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	60
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	60
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	60
An annotated introductory reading list for neurodiversity	60
Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells	60
DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments	59
Cortical adaptation to sound reverberation	59
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	59
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	59
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration	59
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	59
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	59
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	59
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	58
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	58
Brain areas for reversible symbolic reference, a potential singularity of the human brain	58
A new early branching armored dinosaur from the Lower Jurassic of southwestern China	58
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	58
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	58
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface	58
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	58
Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation	58
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	57
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	57
A direct neural signature of serial dependence in working memory	57
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia	57
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	57
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	57
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	57
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	57
Mutant SF3B1 promotes malignancy in PDAC	56
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation	56
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis	56
A connectomics-based taxonomy of mammals	56
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	56
Nucleotide-level linkage of transcriptional elongation and polyadenylation	56
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses	56
Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans	56
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	56
Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity	56
Nonlinear transient amplification in recurrent neural networks with short-term plasticity	56
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration	55
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	55
Direct observation of the neural computations underlying a single decision	55
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	55
osl-dynamics, a toolbox for modeling fast dynamic brain activity	55
Pervasive translation in Mycobacterium tuberculosis	55
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	55
Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates	55
Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads	55
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	54
Position representations of moving objects align with real-time position in the early visual response	54
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	54
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	54
Are single-peaked tuning curves tuned for speed rather than accuracy?	54
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	54
The deep-rooted origin of disulfide-rich spider venom toxins	54
Add mass spectrometry to the pandemic toolbox	54
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	54
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	54
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	54
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation	54
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	54
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	53
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	53