eLife

Article	Citations
A new early branching armored dinosaur from the Lower Jurassic of southwestern China	619
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	394
Add mass spectrometry to the pandemic toolbox	322
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	316
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	306
Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end	291
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	268
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	260
Correction: Drp1 is required for AgRP neuronal activity and feeding	251
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	250
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission	226
Analysis of long and short enhancers in melanoma cell states	224
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	222
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme	199
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	189
Mechanically transduced immunosorbent assay to measure protein-protein interactions	178
Emerging dynamics from high-resolution spatial numerical epidemics	177
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	172
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	167
Are single-peaked tuning curves tuned for speed rather than accuracy?	167
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation	165
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	158
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	151
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	145
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	145

Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	143
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	142
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	139
Direct observation of the neural computations underlying a single decision	137
Movies reveal the fine-grained organization of infant visual cortex	134
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	132
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	127
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	127
Patterns of interdivision time correlations reveal hidden cell cycle factors	126
Reversal of the adipostat control of torpor during migration in hummingbirds	126
Nucleotide-level linkage of transcriptional elongation and polyadenylation	125
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	125
Integrating analog and digital modes of gene expression at Arabidopsis FLC	123
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	123
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	122
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	122
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	121
Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon	120
Pervasive translation in Mycobacterium tuberculosis	119
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	118
STING mediates immune responses in the closest living relatives of animals	116
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	112
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	111
Functional visualization of NK cell-mediated killing of metastatic single tumor cells	110
Daily electrical activity in the master circadian clock of a diurnal mammal	110
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	109
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	108
Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors	106
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses	106
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	104
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	103
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	102
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	101
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	98
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis	97
Sex differences and sex bias in human circadian and sleep physiology research	97
PIMT is a novel and potent suppressor of endothelial activation	97
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	96
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	95
Correction: Highly contiguous assemblies of 101 drosophilid genomes	92
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	92
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	92
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	91
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	90
Becoming less beige with age	90
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	90
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	88
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	87
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	86
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	86

Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation	86
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	85
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	85
De novo identification of universal cell mechanics gene signatures	85
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	85
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	85
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	84
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	83
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	83
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	83
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	83
Serial attentional resource allocation during parallel feature value tracking	82
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	82
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	81
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	81
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	80
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	80
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	79
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	79
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	79
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	78
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	78
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	78
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	77
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	77
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	76
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	76
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	75
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	74
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	74
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	74
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	74
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	74
Mechanism of substrate binding and transport in BASS transporters	73
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	72
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	72
Muscarinic receptors mediate motivation via preparatory neural activity in humans	71
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	71
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	71
Guanidine production by plant homoarginine-6-hydroxylases	71
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	71
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	71
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	71
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	70
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	70
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	69
Wiring up for controlled flight	69
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	68
Functional and structural segregation of overlapping helices in HIV-1	68
The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity	68
Biocalcification in porcelaneous foraminifera	68
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation	68
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	68
A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx	68
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface	67
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	67
Shining a light on hematopoietic stem cells	67
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	67
Deciding when to move	67
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity	66
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	66
Multi-dimensional social relationships shape social attention in monkeys	66
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	66
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	66
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	66
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	66
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	66
A causal role of the NMDA receptor in recurrent processing during perceptual integration	66
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	65
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	65
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	65
Language experience shapes predictive coding of rhythmic sound sequences	64
Imaging of brain electric field networks with spatially resolved EEG	64
Caspases promote cell proliferation after necrosis	64
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	64
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	64
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	63
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	63
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	63
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	63

Goal-directed vocal planning in a songbird	63
An emerging view of neural geometry in motor cortex supports high-performance decoding	63
Allosteric regulation of kinase activity in living cells	63
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	63
Outgrowing self-denial	63
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	63
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	62
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	62
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	62
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	62
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	62
osl-dynamics, a toolbox for modeling fast dynamic brain activity	62
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	62
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	62
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	61
Cortico-striatal action control inherent of opponent cognitive-motivational styles	61
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	61
State-dependent representations of mixtures by the olfactory bulb	61
Functionally important residues from graph analysis of coevolved dynamic couplings	61
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	61
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	61
A direct neural signature of serial dependence in working memory	61
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	60
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	60
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	60
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	60
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	60
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	60
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	60
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	60
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	59
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	59
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	59
Iridescent structural coloration in a crested Cretaceous enantiornithine bird from the Jehol Biota	59
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	59
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	59
Cingulate cortex shapes early postnatal development of social vocalizations	59
A connectomics-based taxonomy of mammals	59
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	59
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	59
Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l	59
Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation	59
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	59
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	58
An annotated introductory reading list for neurodiversity	58
Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism	58
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation	58
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	58
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	58
Variation in the basal immune state and implications for disease	58
Muscle-specific economy of force generation and efficiency of work production during human running	58
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	58
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	58
Temporo-cerebellar connectivity underlies timing constraints in audition	58
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	58
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	57
Decoding the activated stem cell phenotype of the neonatally maturing pituitary	57
Structural mechanism of strand exchange by the RAD51 filament	57
ZAF, the first open source fully automated feeder for aquatic facilities	57
Brain areas for reversible symbolic reference, a potential singularity of the human brain	57
Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange	57
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology	57
Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration	57
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	57
Larger but younger fish when growth outpaces mortality in heated ecosystem	57
Multisensory integration enhances audiovisual responses in the Mauthner cell	57
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	57
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	57
How honey bees make fast and accurate decisions	57
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration	57
Best practices to promote rigor and reproducibility in the era of sex-inclusive research	56
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia	56
Mutant SF3B1 promotes malignancy in PDAC	56
Position representations of moving objects align with real-time position in the early visual response	56
A meta-analysis of the association between male dimorphism and fitness outcomes in humans	56
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	56
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	55
Space as a scaffold for rotational generalisation of abstract concepts	55
Phagocytic ‘teeth’ and myosin-II ‘jaw’ power target constriction during phagocytosis	55
The deep-rooted origin of disulfide-rich spider venom toxins	55
DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments	55
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	55
NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors	55
Conditional and unconditional components of aversively motivated freezing, flight and darting in mice	55
Intrinsic excitability mechanisms of neuronal ensemble formation	55
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	55
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster	55
T cells discriminate between groups C1 and C2 HLA-C	55
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	54
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	54
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	54
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	54
Lipid hydroperoxides promote sarcopenia through carbonyl stress	54
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	54
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	54