eLife

Article	Citations
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	390
Wiring up for controlled flight	326
Shining a light on hematopoietic stem cells	215
Caspases promote cell proliferation after necrosis	212
Outgrowing self-denial	178
Allosteric regulation of kinase activity in living cells	174
SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling	174
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	172
Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism	172
Integrating analog and digital modes of gene expression at Arabidopsis FLC	171
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function	170
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	167
Are single-peaked tuning curves tuned for speed rather than accuracy?	157
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	156
Nucleotide-level linkage of transcriptional elongation and polyadenylation	149
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	145
Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework	142
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	142
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation	140
Reshaping human neurons	137
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	137
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	132
A causal role of the NMDA receptor in recurrent processing during perceptual integration	127
An emerging view of neural geometry in motor cortex supports high-performance decoding	127
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	123

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	120
Patterns of interdivision time correlations reveal hidden cell cycle factors	119
Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis	116
Nonlinear feedback modulation contributes to the optimization of flexible decision-making	115
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	112
Correction: Drp1 is required for AgRP neuronal activity and feeding	109
Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitive FT repressor	109
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	105
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	104
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	100
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	100
Larger but younger fish when growth outpaces mortality in heated ecosystem	100
Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear	100
Mutant SF3B1 promotes malignancy in PDAC	98
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	98
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	94
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	93
Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing	93
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	92
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury	91
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	90
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	90
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	90
Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis	89
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	89
Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates	89
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	89
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	89
Structural mechanism of strand exchange by the RAD51 filament	88
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	87
Information, certainty, and learning	86
Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex	86
Lipid hydroperoxides promote sarcopenia through carbonyl stress	85
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes	84
The deep-rooted origin of disulfide-rich spider venom toxins	84
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	83
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	83
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation	83
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	83
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging	83
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	82
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	82
Multisensory integration enhances audiovisual responses in the Mauthner cell	82
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	82
An annotated introductory reading list for neurodiversity	81
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	81
Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations	81
Evidence accumulation, not ‘self-control’, explains dorsolateral prefrontal activation during normative choice	81
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	80
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	80

A direct neural signature of serial dependence in working memory	80
scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues	80
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	78
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	77
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	77
Mouse germline cysts contain a fusome-like structure that mediates oocyte development	77
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	77
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity	76
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	76
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow	75
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	75
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	75
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	74
Variation in the basal immune state and implications for disease	74
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	73
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	73
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	72
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	72
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	71
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	71
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B	71
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	71
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	70
Deciding when to move	70
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA	70
Iridescent structural coloration in a crested Cretaceous enantiornithine bird from the Jehol Biota	70
Multi-dimensional social relationships shape social attention in monkeys	70
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	69
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	69
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	69
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	69
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	68
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	68
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	68
Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity	68
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	68
Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes	68
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	68
The influence of temporal context on vision over multiple time scales	68
Cortico-striatal action control inherent of opponent cognitive-motivational styles	68
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	68
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	67
Conduction pathway for potassium through the Escherichia coli pump KdpFABC	67
Movies reveal the fine-grained organization of infant visual cortex	67
Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)	67
The SAFE Labs Handbook as a tool for improving lab culture	67
Biocalcification in porcelaneous foraminifera	66
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	66
Language experience shapes predictive coding of rhythmic sound sequences	66
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	66
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	66
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	66
Alternative splicing across the tree of life	65
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	65
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	65
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	64
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	64
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	64
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	64
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	64
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	63
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	63
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	63
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	63
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	63
Impact of maximal overexpression of a non-toxic protein on yeast cell physiology	63
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	63
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	63
Muscarinic receptors mediate motivation via preparatory neural activity in humans	63
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	63
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	62
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	62
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	62
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	62
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	62
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	62
De novo identification of universal cell mechanics gene signatures	61
PIMT is a novel and potent suppressor of endothelial activation	61
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	61
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	61

Spatial transformation of multi-omics data unlocks novel insights into cancer biology	61
Goal-directed vocal planning in a songbird	61
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	61
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	61
Guanidine production by plant homoarginine-6-hydroxylases	60
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	60
Serial attentional resource allocation during parallel feature value tracking	60
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	60
Cingulate cortex shapes early postnatal development of social vocalizations	60
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	60
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	60
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	59
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	59
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	59
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	59
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	59
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	59
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	59
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	58
DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments	58
Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes	58
Mechanism of substrate binding and transport in BASS transporters	58
Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation	58
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	57
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	57
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	57
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	57
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	57
Becoming less beige with age	56
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	56
Space as a scaffold for rotational generalisation of abstract concepts	56
osl-dynamics, a toolbox for modeling fast dynamic brain activity	56
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	56
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	56
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	56
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration	56
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	56
Effort produces after-effects costly for others but valued for self	56
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	56
Transsaccadic working memory in healthy ageing and neurodegenerative disease	55
Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells	55
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	55
The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats	55
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements	55
Imaging of brain electric field networks with spatially resolved EEG	55
Inference of germinal center evolutionary dynamics via simulation-based deep learning	55
Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter	55
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	55
Real-time transcriptomic profiling in distinct experimental conditions	54
Hierarchical encoding of natural sound mixtures in ferret auditory cortex	54
Endogenous precision of the number sense	54
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics	54
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	53
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	53
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	53
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	53
Functionally important residues from graph analysis of coevolved dynamic couplings	53
Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications	53
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	53
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	53
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	53
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	52
Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia	52
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	52
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	52
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	52
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	52
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	52
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	52
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	52
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	52
A connectomics-based taxonomy of mammals	52
Inhibitory columnar feedback neurons are involved in motion processing in Drosophila	52
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	52
High-grade serous ovarian carcinoma organoids as models of chromosomal instability	52
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	51
Dissecting surveying behavior of reactive microglia under chronic neurodegeneration	51
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	51
Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei	51
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	51
Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control	51
How honey bees make fast and accurate decisions	51
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	51
Brain areas for reversible symbolic reference, a potential singularity of the human brain	51
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	51
Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange	50
Position representations of moving objects align with real-time position in the early visual response	50
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	50
Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys	50
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	50
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	50
Direct observation of the neural computations underlying a single decision	50
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy	50
Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l	50
Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish	50