eLife

Article	Citations
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants	1123
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3	770
SARS-CoV-2 (COVID-19) by the numbers	748
A connectome and analysis of the adult Drosophila central brain	544
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants	536
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission	373
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset	284
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm	281
COVID-19 medical papers have fewer women first authors than expected	269
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm	254
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics	254
How to measure and evaluate binding affinities	247
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities	242
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2	240
Evidence for transmission of COVID-19 prior to symptom onset	239
The connectome of the adult Drosophila mushroom body provides insights into function	214
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome	208
DunedinPACE, a DNA methylation biomarker of the pace of aging	206
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?	200
Antimicrobial resistance and COVID-19: Intersections and implications	188
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway	187
An electrophysiological marker of arousal level in humans	186
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment	183
DNA damage—how and why we age?	180
Sampling alternative conformational states of transporters and receptors with AlphaFold2	176

A 10-year follow-up study of sex inclusion in the biological sciences	167
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane	166
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy	162
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy	161
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study	160
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration	158
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products	157
Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner	153
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin	151
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection	150
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices	150
A whole-brain connectivity map of mouse insular cortex	149
Accurate and versatile 3D segmentation of plant tissues at cellular resolution	149
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation	147
Structure of the bacterial ribosome at 2 Å resolution	146
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition	145
Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis	141
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture	140
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types	140
Sex differences in biological aging with a focus on human studies	139
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study	138
The single-cell eQTLGen consortium	138
Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq	135
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress	135
The natverse, a versatile toolbox for combining and analysing neuroanatomical data	134
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell	133
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses	132
TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields	128
Standardizing workflows in imaging transcriptomics with the abagen toolbox	127
The OpenNeuro resource for sharing of neuroscience data	127
A single-cell survey of Drosophila blood	125
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes	125
Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events	125
Beyond the RNA-dependent function of LncRNA genes	123
Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study	122
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment	122
SpikeInterface, a unified framework for spike sorting	122
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes	120
An open label trial of anakinra to prevent respiratory failure in COVID-19	120
The genomic consequences of hybridization	120
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains	118
Mapping single-cell atlases throughout Metazoa unravels cell type evolution	116
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics	115
Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy	115
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens	114
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations	113
Reporting and misreporting of sex differences in the biological sciences	113
SON and SRRM2 are essential for nuclear speckle formation	113
Racial inequity in grant funding from the US National Institutes of Health	113
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids	111

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation	110
Challenges for assessing replicability in preclinical cancer biology	109
A community-maintained standard library of population genetic models	109
Adjusting for age improves identification of gut microbiome alterations in multiple diseases	109
Prediction signals in the cerebellum: Beyond supervised motor learning	109
Microglial calcium signaling is attuned to neuronal activity in awake mice	109
Investigating the replicability of preclinical cancer biology	108
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population	108
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site	107
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function	107
An open-source, high-performance tool for automated sleep staging	106
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice	105
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation	105
Dynamic metastable long-living droplets formed by sticker-spacer proteins	105
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC	104
Training deep neural density estimators to identify mechanistic models of neural dynamics	103
Temporal cascade of frontal, motor and muscle processes underlying human action-stopping	102
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients	101
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons	100
Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols	100
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation	100
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord	99
Highly contiguous assemblies of 101 drosophilid genomes	99
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals	99
NeuroQuery, comprehensive meta-analysis of human brain mapping	98
p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle	98
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance	98
The social life of Norway rats (Rattus norvegicus)	97
Diverse viral proteases activate the NLRP1 inflammasome	97
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning	96
Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning	96
An interactive meta-analysis of MRI biomarkers of myelin	96
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans	95
Inhibition stabilization is a widespread property of cortical networks	95
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness	95
Patterns of within-host genetic diversity in SARS-CoV-2	95
EDF1 coordinates cellular responses to ribosome collisions	95
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer	94
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets	94
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids	93
A new genetic strategy for targeting microglia in development and disease	93
Generation of vascularized brain organoids to study neurovascular interactions	92
Self-blinding citizen science to explore psychedelic microdosing	92
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women	92
Temporal integration of auxin information for the regulation of patterning	91
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds	91
Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies	91
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth	91
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs	91
Topographic gradients of intrinsic dynamics across neocortex	90
Real-time, low-latency closed-loop feedback using markerless posture tracking	90
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection	89
Information flow, cell types and stereotypy in a full olfactory connectome	89
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice	89
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import	88
Ageing compromises mouse thymus function and remodels epithelial cell differentiation	88
Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?	87
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time	86
Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples	86
Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C	85
Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence	85
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis	85
The LOTUS initiative for open knowledge management in natural products research	84
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth	84
The hazards of smoking and the benefits of cessation: A critical summation of the epidemiological evidence in high-income countries	84
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning	84
Efficient targeted integration directed by short homology in zebrafish and mammalian cells	84
Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples	84
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator	83
Small molecule cognitive enhancer reverses age-related memory decline in mice	82
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent	81
An ER translocon for multi-pass membrane protein biogenesis	81
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity	81
A taxonomy of seizure dynamotypes	81
Structural basis for SARM1 inhibition and activation under energetic stress	81
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs	81
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness	81
Chromosome organization by one-sided and two-sided loop extrusion	80
Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)	80
Standardized and reproducible measurement of decision-making in mice	80

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences	80
A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0	80
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement	79
How many neurons are sufficient for perception of cortical activity?	79
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence	79
Functionally heterogeneous human satellite cells identified by single cell RNA sequencing	79
A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs	79
Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage	78
Single nuclei RNA-seq of mouse placental labyrinth development	78
CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance	78
COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest	78
Virtual conferences raise standards for accessibility and interactions	78
How subtle changes in 3D structure can create large changes in transcription	77
The diversity and function of sourdough starter microbiomes	77
Charting the native architecture of Chlamydomonas thylakoid membranes with single-molecule precision	77
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation	76
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy	76
Wikidata as a knowledge graph for the life sciences	76
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background	76
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels	76
Fully automated, sequential focused ion beam milling for cryo-electron tomography	76
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser	76
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage	76
The architecture of EMC reveals a path for membrane protein insertion	76
A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat	76
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models	76
Systematic detection of horizontal gene transfer across genera among multidrug-resistant bacteria in a single hospital	75
Global genome diversity of the Leishmania donovani complex	75
Plasma proteomic biomarker signature of age predicts health and life span	75
A cell atlas of the chick retina based on single-cell transcriptomics	75
Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis	75
Proteome dynamics during homeostatic scaling in cultured neurons	75
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates	74
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization	74
The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline	74
TMEM95 is a sperm membrane protein essential for mammalian fertilization	74
Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways	74
The frequency gradient of human resting-state brain oscillations follows cortical hierarchies	74
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e	74
The sifting of visual information in the superior colliculus	74
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis	73
Genetic mapping of etiologic brain cell types for obesity	73
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis	73
Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon	72
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming	72
Representation of visual landmarks in retrosplenial cortex	72
TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs	71
Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli	71
Visualizing anatomically registered data with brainrender	71
Dynamics of gaze control during prey capture in freely moving mice	71
A Bayesian and efficient observer model explains concurrent attractive and repulsive history biases in visual perception	71
AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions	71
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation	71
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic	71
True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field	71
Bmal1 integrates mitochondrial metabolism and macrophage activation	70
A transcriptomic taxonomy of Drosophila circadian neurons around the clock	70
The unlimited potential of the great pond snail, Lymnaea stagnalis	70
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion	70
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks	70
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo	70
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes	69
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism	69
Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii	69
Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes	69
Structural basis of mitochondrial translation	69
Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox	69
SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters	69
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing	68
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation	68
Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees	68
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat	68
A visual pathway for skylight polarization processing in Drosophila	68
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3	68
Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)	68
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons	68
Performance of a deep learning based neural network in the selection of human blastocysts for implantation	67
Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change	67
Structural basis for pharmacological modulation of the TRPC6 channel	67
Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations	67
Hippocampal remapping as hidden state inference	67
An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes	67
Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray	66
Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3	66
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex	66
Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay	66
Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages	66
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila	66
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2	66
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation	66
Remyelination alters the pattern of myelin in the cerebral cortex	66
HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells	65
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling	65
The brain in motion: How ensemble fluidity drives memory-updating and flexibility	65
Early analysis of the Australian COVID-19 epidemic	65