eLife

Article	Citations
Correction: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci	414
Correction: Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner	346
Nucleotide-level linkage of transcriptional elongation and polyadenylation	224
Correction: Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis	224
Intracranial human recordings reveal association between neural activity and perceived intensity for the pain of others in the insula	185
Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome	185
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs	184
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4	183
Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs	181
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	180
Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances	177
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis	176
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA	176
Variation in the basal immune state and implications for disease	172
The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions	160
The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats	160
Real-time transcriptomic profiling in distinct experimental conditions	155
Inhibitory columnar feedback neurons are involved in motion processing in Drosophila	155
Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies	154
Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei	147
Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis	146
Conduction pathway for potassium through the Escherichia coli pump KdpFABC	144
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma	136
Becoming less beige with age	136
Mouse germline cysts contain a fusome-like structure that mediates oocyte development	129

scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues	125
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing	125
Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model	123
Molecular and mechanical signatures contributing to mouse epidermal differentiation and barrier formation	122
Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control	118
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism	114
Maresin 1 repletion improves muscle regeneration after volumetric muscle loss	110
Goal-directed vocal planning in a songbird	107
Structural mechanism of strand exchange by the RAD51 filament	107
Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium	106
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria	104
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation	103
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex	103
A connectomics-based taxonomy of mammals	102
Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier	98
A computationally informed comparison between the strategies of rodents and humans in visual object recognition	98
Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons	97
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma	96
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia	95
Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020	95
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient	94
Differential functions of the dorsal and intermediate regions of the hippocampus for optimal goal-directed navigation in VR space	94
Mutant SF3B1 promotes malignancy in PDAC	94
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids	93
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells	93
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis	93
Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling	92
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis	92
Are single-peaked tuning curves tuned for speed rather than accuracy?	92
Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110	92
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity	91
Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)	90
Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction	90
Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration	89
De novo identification of universal cell mechanics gene signatures	87
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension	86
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples	86
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses	86
Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication	85
Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing	85
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow	83
Brain areas for reversible symbolic reference, a potential singularity of the human brain	83
Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky	83
A causal role of the NMDA receptor in recurrent processing during perceptual integration	83
Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents	82
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16	82
ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression	82
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis	82
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens	80
Functionally important residues from graph analysis of coevolved dynamic couplings	80

Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process	79
DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments	79
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis	79
Imaging of brain electric field networks with spatially resolved EEG	78
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic	78
Position representations of moving objects align with real-time position in the early visual response	78
Emergence of ion-channel-mediated electrical oscillations in Escherichia coli biofilms	77
Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI	76
Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis	76
A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice	76
Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells	76
Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study	76
Patterns of interdivision time correlations reveal hidden cell cycle factors	75
Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function	75
Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes	75
Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions	74
Mouthparts of the bumblebee (Bombus terrestris) exhibit poor acuity for the detection of pesticides in nectar	74
Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling	74
SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling	74
Dynamics of co-substrate pools can constrain and regulate metabolic fluxes	74
Nutritional state-dependent modulation of insulin-producing cells in Drosophila	73
An annotated introductory reading list for neurodiversity	73
Hierarchical encoding of natural sound mixtures in ferret auditory cortex	73
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses	72
Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity	72
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)	72
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics	72
Transsaccadic working memory in healthy ageing and neurodegenerative disease	71
Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice	71
Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children	70
Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia	70
Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex	70
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration	70
Effort produces after-effects costly for others but valued for self	70
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA	69
A randomized multiplex CRISPRi-Seq approach for the identification of critical combinations of genes	69
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact	69
Guanidine production by plant homoarginine-6-hydroxylases	69
Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice	69
Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states	69
PIMT is a novel and potent suppressor of endothelial activation	68
Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period	67
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia	67
Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics	66
p38γ and p38δ modulate innate immune response by regulating MEF2D activation	66
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs	66
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms	66
Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile	66
Reshaping human neurons	66
BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism	66
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity	66
Multi-dimensional social relationships shape social attention in monkeys	65
Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework	65
An emerging view of neural geometry in motor cortex supports high-performance decoding	65
Insight into the evolutionary assemblage of cranial kinesis from a Cretaceous bird	65
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons	65
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability	65
Serial attentional resource allocation during parallel feature value tracking	65
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor	64
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans	64
Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits	64
The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion	64
Language experience shapes predictive coding of rhythmic sound sequences	64
Iridescent structural coloration in a crested Cretaceous enantiornithine bird from the Jehol Biota	63
Movies reveal the fine-grained organization of infant visual cortex	63
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism	63
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape	63
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity	63
The SAFE Labs Handbook as a tool for improving lab culture	63
The influence of temporal context on vision over multiple time scales	63
Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitive FT repressor	63
Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum	62
The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial	62
Impact of maximal overexpression of a non-toxic protein on yeast cell physiology	62
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state	62
Biocalcification in porcelaneous foraminifera	62
Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia	62
A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following sta	62
Somatic mutation rates scale with time not growth rate in long-lived tropical trees	62
Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B	61

Cortico-striatal action control inherent of opponent cognitive-motivational styles	61
Combining mutation and recombination statistics to infer clonal families in antibody repertoires	61
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells	61
osl-dynamics, a toolbox for modeling fast dynamic brain activity	60
Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization	60
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging	60
Antigenic strain diversity predicts different biogeographic patterns of maintenance and decline of antimalarial drug resistance	60
Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes	60
Cell size modulates ferroptosis susceptibility	60
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation	60
Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism	60
Endogenous precision of the number sense	60
Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter	60
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor	59
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia	59
Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows	59
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response	59
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome	58
Cingulate cortex shapes early postnatal development of social vocalizations	58
Spatial transformation of multi-omics data unlocks novel insights into cancer biology	58
Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli	58
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers	58
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel	57
Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes	57
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors	57
SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA	57
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition	57
A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster	57
Integrating analog and digital modes of gene expression at Arabidopsis FLC	57
Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates	57
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements	57
COVID-19 cluster size and transmission rates in schools from crowdsourced case reports	57
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production	57
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids	56
Mechanism of substrate binding and transport in BASS transporters	56
Ligand bias underlies differential signaling of multiple FGFs via FGFR1	56
Direct observation of the neural computations underlying a single decision	56
Netrin signaling mediates survival of dormant epithelial ovarian cancer cells	56
Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons	56
Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons	56
PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification	56
A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma	56
Muscarinic receptors mediate motivation via preparatory neural activity in humans	56
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis	55
Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma	55
Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis	55
Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis	55
Space as a scaffold for rotational generalisation of abstract concepts	55
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures	55
Wiring up for controlled flight	54
Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota	54
Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population	54
Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species	54
FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall	54
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration	54
Airway basal cells show regionally distinct potential to undergo metaplastic differentiation	53
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity	53
Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9	53
Nonlinear feedback modulation contributes to the optimization of flexible decision-making	53
Major nuclear locales define nuclear genome organization and function beyond A and B compartments	53
Shining a light on hematopoietic stem cells	53
Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish	53
Caspases promote cell proliferation after necrosis	53
The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila	53
New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking	53
Best practices to promote rigor and reproducibility in the era of sex-inclusive research	53
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury	52
Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange	52
The view tolerance of human identity recognition depends on horizontal face information	52
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism	51
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo	51
High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy	51
Inference of germinal center evolutionary dynamics via simulation-based deep learning	51
Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations	51
Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli	51
Outgrowing self-denial	51
Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control	51
The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins	51
Deciding when to move	51
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration	51
Apoptotic signaling clears engineered Salmonella in an organ-specific manner	51
Information, certainty, and learning	51
A direct neural signature of serial dependence in working memory	50
Comparing the outputs of intramural and extramural grants funded by National Institutes of Health	50
Anterior cingulate cortex monitors action state and action content in complex associative learning	50
How honey bees make fast and accurate decisions	50
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis	49
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress	49
Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics	49
Recalibrating vision-for-action requires years after sight restoration from congenital cataracts	49
Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications	49
Dissecting surveying behavior of reactive microglia under chronic neurodegeneration	49
The deep-rooted origin of disulfide-rich spider venom toxins	49
Larger but younger fish when growth outpaces mortality in heated ecosystem	49
The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP	48