OOIR: Observatory of International Research

Papers

(The median citation count of Cancer & Metabolism is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma	83
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles	52
Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells	49
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma	40
Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc–ODC1 nexus	37
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study	30
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells	29
GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation	27
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states	24
Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells	23
The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells	22
Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish	21
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition	21
Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls	21
The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer	20
BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria	19
Obesity and breast cancer prognosis: pre-diagnostic anthropometric measures in relation to patient, tumor, and treatment characteristics	16
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines	16
Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models	16
Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression	15
Real-time assessment of relative mitochondrial ATP synthesis response against inhibiting and stimulating substrates (MitoRAISE)	14
Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies	13
Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma	13
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	13
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma	13

Scaffold-mediated switching of lymphoma metabolism in culture	12
Metabolic changes preceding bladder cancer occurrence among Korean men: a nested case-control study from the KCPS-II cohort	12
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia	12
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells	11
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer	11
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1	11
The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients	11
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment	11
High-fat diet promotes prostate cancer metastasis via RPS27	11
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer	11
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer	10
Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX	10
Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species	10
Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma	10
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness	9
Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines	9
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis	9
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	8
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma	7
Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia	7
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer	7
The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study	7
13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo	7
Brief report: The uricase mutation in humans increases our risk for cancer growth	6
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells	6
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus	6
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases	5
Circulating metabolome landscape in Lynch syndrome	5
Inflammatory metabolic profile of South African patients with prostate cancer	5
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth	5
Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin	5
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes	5
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study	5
Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15	4
Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability	4
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity	4
PAF1/HIF1α axis rewires the glycolytic metabolism to fuel aggressiveness of pancreatic cancer	4
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages	4
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling	4
Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism	3
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors	3
Correction to: Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	3
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis	3
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	3
RNF2 promotes chondrosarcoma progression by regulating ubiquitination and degradation of CBX7	3