OOIR: Observatory of International Research

Papers

(The median citation count of Cancer & Metabolism is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A role of arginase-1-expressing myeloid cells in cachexia	117
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma	55
The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study	55
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition	42
Gut microbiota-derived indole-3-propionic acid promotes lymph node metastasis in gastric cancer via the aryl-hydrocarbon receptor signaling pathway	40
GCN2-SLC7A11 axis coordinates autophagy, cell cycle and apoptosis and regulates cell growth in retinoblastoma upon arginine deprivation	31
Measurement of mitochondria amount and clearance using flow cytometry: effect of mitophagy inhibitors in leukemia cells	29
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival	28
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response	28
Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells	27
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma	27
Identification and impact of microbiota-derived metabolites in ascites of ovarian and gastrointestinal cancer	25
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	25
Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer	24
Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes	24
Circulating metabolome landscape in Lynch syndrome	23
In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T	23
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells	21
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages	21
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis	19
Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling	18
POU2F1 drives cholesterol biosynthesis and lipid remodeling through the DHCR24/ELOVL2 axis in endometrial cancer	17
CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function	16
CYP8B1 suppressed by Ras/ERK leads to cholesterol accumulation and bile acids reduction and facilitates hepatic tumorigenesis	16
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors	14

Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental lynch syndrome	13
Pharmacological inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) imparts selective leukemia cell death	13
Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo	13
VAV2 drives glycolytic reprogramming in esophageal squamous cell carcinoma via EIF3F-mediated MTA1 deubiquitination	13
Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells	13
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging	13
PFKFB4 promotes M2 polarization of tumor-associated macrophages through aerobic glycolysis-mediated modification of histone H3K18 lactylation in hepatocellular carcinoma	12
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells	12
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma	12
Correction: STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	12
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles	12
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states	12
The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer	11
STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma	11
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1	11
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells	11
Lactate metabolism in clonal plasma cells and its therapeutic implications in multiple myeloma patients with elevated serum LDH levels	11
Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRafV600E/Pten−/− mice	10
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment	10
Fatty acid synthase-derived lipid stores support breast cancer metastasis	10
METTL16 regulates the mRNA stability of FBXO5 via m6A modification to facilitate the malignant behavior of breast cancer	10
Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation	10
Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus	10
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition	10
Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance to anti-PD1 in oncogenic Kras-driven lung adenocarcinoma	10
Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer	10
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation	10
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo	10
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer	9
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells	9
RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition	9
A HIF-1α inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells	8
Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effect	8
Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression	8
Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma	8
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia	8
Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis	7
Normoxic HIFα-mediated metabolic rewiring in cancer as a novel therapeutic target of tumor heterogeneity	7
Metabolic targeting of cyst(e)ine enhances carboplatin responsiveness in ovarian cancer	7
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGFβ1-promoted stem-like properties in head and neck cancer	7
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases	7
Correction: A role of arginase-1-expressing myeloid cells in cachexia	7
SENP1 drives de novo cholesterogenesis via disrupting SUMOylation-mediated SREBP2-FBXW7 interaction	7
CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells	7
Caloric restriction enhances radiosensitivity of colorectal tumors through the cGAS-STING pathway activation	6
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway	6
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study	6
Metabolic alterations and cellular responses to β-Hydroxybutyrate treatment in breast cancer cells	6
Scaffold-mediated switching of lymphoma metabolism in culture	5
S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer	5

Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway	5
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH	5
The FGL1-LAG-3 axis attenuates melanoma-induced cachexia in mice	5
Cdk5 regulates glutamine metabolism in colorectal cancer via the EZH2-GLS1 axis	5
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells	5
The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells	5
Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer	5
Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors	5
Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells	5