OOIR: Observatory of International Research

Papers

(The H4-Index of Translational Neurodegeneration is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Life and disease status of patients with Parkinson’s disease during and after zero-COVID in China: an online survey	244
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease	166
Exploring the skin as an open window onto neurodegenerative diseases	159
Retraction Note: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease	148
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model	147
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice	146
Attenuating α-synuclein pathology in mice with in situ engineered astrocytes	124
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy	117
Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise	117
The C. elegans gba-3 gene encodes a glucocerebrosidase that exacerbates α-synuclein-mediated impairments in deletion mutants	111
Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases	108
Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application	106
Retraction Note: Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism	105
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease	88
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors	88
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology	82
Role of dopamine in the pathophysiology of Parkinson’s disease	81
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients	77
Correction: A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau	74
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies	73
Aquaporin-4 as a cerebrospinal fluid biomarker of Alzheimer’s disease	72
A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer's disease	72
Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer’s disease: a comprehensive review of the characteristics and therapeutic strategies	71
ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein	68
Defective mitophagy and the etiopathogenesis of Alzheimer’s disease	68

Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease	66
Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China	66
Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging	65
Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease	61
Inflammasomes in neurodegenerative diseases	56
Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside	56
Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications	55
Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity	55
Nose-to-brain drug delivery: from bench to bedside	53
Hybrid nanostructures for neurodegenerative disease theranostics: the art in the combination of biomembrane and non-biomembrane nanostructures	52
The emerging role of furin in neurodegenerative and neuropsychiatric diseases	49
Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study	49
Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease	48
Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease	47
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Cav3.2 calcium signaling in astrocytes	47
Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson’s disease	44
Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology	44
Molecular mechanisms of exercise-induced improvements in Alzheimer’s disease: a focus on lipid homeostasis	44
Peripheral proteinopathy in neurodegenerative diseases	44