OOIR: Observatory of International Research

Papers

(The TQCC of Biomaterials Science is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency	176
Introduction to the 31^st Annual Conference of the European Society for Biomaterials (ESB 2021)	175
Inside front cover	139
Site-selective post-modification of short α/γ hybrid foldamers: a powerful approach for molecular diversification towards biomedical applications	133
Influence of lung extracellular matrix from non-IPF and IPF donors on primary human lung fibroblast biology	123
Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions	116
A chiral microenvironment promotes retinal progenitor cell proliferation by activating the Akt and ERK pathways	110
Front cover	100
Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration	98
A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72	91
Exploring therapy transport from implantable medical devices using experimentally informed computational methods	91
Rapid neurostimulation at the micron scale with an optically controlled thermal-capture technique	90
Front cover	90
A universal biocompatible coating for enhanced lubrication and bacterial inhibition	86
A multifunctional theranostics nanosystem featuring self-assembly of alcohol-abuse drug and photosensitizers for synergistic cancer therapy	82
NIR-II imaging-guided photothermal cancer therapy combined with enhanced immunogenic death	81
Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting	81
Mechanical behavior of biomimetic oriented cell sheets from a perspective of living materials	80
Transtympanic delivery of V₂O₅ nanowires with a tympanic-membrane penetrating peptide	79
A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization	79
Artesunate drug-loaded 2D nano-shuttle landing on RBCs infected with malaria parasites	72
Gram-selective antibacterial peptide hydrogels	70
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway	68
Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering	66
Highly selective performance of rationally designed antimicrobial peptides based on ponericin-W1	65

A novel donor–acceptor structured diketopyrrolopyrrole-based conjugated polymer synthesized by direct arylation polycondensation (DArP) for highly efficient antimicrobial photothermal therapy	64
Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation	64
Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens towards enhanced biomineralisation and osteoblastic growth behaviour	63
Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy	63
Lung-targeting lipid nanoparticle-mediated sparstolonin B delivery improves acute lung injury	61
Oxygen vacancy healing boosts the piezoelectricity of bone scaffolds	61
Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs	61
Albumin-coated pH-responsive dimeric prodrug-based nano-assemblies with high biofilm eradication capacity	60
Fluorinated poly(aryl ether)/polypropylene composite patch for prevention of abdominal adhesions after hernia repairs	59
Principles of nucleic acid toehold mediated strand displacement (TMSD) reaction model and its applications in cell environment	57
Does mechanobiology drive respiratory disease? Biomechanical induction of mucus hypersecretion in human bronchial organoids using a photocontrolled biomaterial gel	57
Leveraging microtopography to pattern multi-oriented muscle actuators	57
Soft tissue-mimicking hydrogel stiffness modulates polarisation of human monocyte-derived macrophages	57
Silk fibroin-based piezoelectric nanofibrous scaffolds for rapid wound healing	56
Advances in biomaterials for the treatment of retinoblastoma	56
Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications	56
Microwave-triggered organic sensitizer for synergistic dynamic/thermal therapy of osteosarcoma	56
Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases	55
A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy	55
Hemp sprout-derived exosome-like nanovesicles as hepatoprotective agents attenuate liver fibrosis	54
Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation	54
Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging	54
Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes	53
Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma	53
An intrinsically semi-permeable PDMS nanosheet encapsulating adipose tissue-derived stem cells for enhanced angiogenesis	53
Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights	53
Microporous surface containing flower-like molybdenum disulfide submicro-spheres of sulfonated polyimide with antibacterial effect and promoting bone regeneration and osteointegration	52
Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers	52
Iron oxide-EDTA nanoparticles for chelation-enhanced chemodynamic therapy and ion interference therapy	51
Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects	51
Injectable leonurine nanocrystal-loaded microspheres for long-term hyperlipidemia management	50
Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair	49
Inside front cover	48
LAPONITE® nano-silicates potentiate the angiogenic effects of FG-4592 and osteogenic effects of BMP-2	48
Contents list	48
Back cover	48
Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury	48
A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides	47
Contents list	47
Biomimetic organomineral layers with antibacterial properties based on di/tetrahydroquinolinediol and nanocrystalline hydroxyapatite deposited on enamel surface	46
Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers	46
Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin	46
Engineering goat milk-derived extracellular vesicles for multiple bioimaging-guided and photothermal-enhanced therapy of colon cancer	46
Fe₃O₄/MnCO₃ microbubbles for efficient elimination of bacterial biofilms by mechanical/sonodynamic effects under ultrasound irradiation and magnetic field targeting	46
Front cover	46
Engineered human H-chain ferritin with reversed charge of the internal cavity exhibits RNA-mediated spongelike effect for loading RNA/DNA-binding molecules	45
Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery	45
Molecular weight tuning optimizes poly(2-methoxyethyl acrylate) dispersion to enhance the aging resistance and anti-fouling behavior of denture base resin	44
A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin	44
Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer	44

Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy	44
In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy	43
Biofabricated tissue model for determining biocompatibility of metallic coatings	43
Immunogenic dead cells engineered by the sequential treatment of ultraviolet irradiation/cryo-shocking for lung-targeting delivery and tumor vaccination	43
Microstructured silk fiber scaffolds with enhanced stretchability	43
Substrate-independent adsorption of nanoparticles as anti-biofilm coatings	43
Construction strategies of whole tumor cell vaccines	43
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels	42
All-in-one CoFe₂O₄@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy	42
Ir(iv) and Ir(iii) in situ transition promotes ROS generation for eradicating multidrug-resistant bacterial infection	42
Trends in protein derived materials for wound care applications	42
Recent advances in responsive antibacterial materials: design and application scenarios	42
Carboxylated gelatin-based instant dissolvable microneedles with robust mechanical properties and biomolecule stabilization for biomedical applications	41
MnO₂ coated nanotheranostic LDH for synergistic cascade chemo/chemodynamic cancer therapy under the guidance of MRI-targeted diagnosis	41
pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss	41
The olfactory epithelium as a gateway for bloodborne nanoparticles to the central nervous system	41
Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases	41
Antibacterial sponge for rapid noncompressible hemostatic treatment: spatiotemporal studies using a noninvasive model	40
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance	40
Redox chemistry-enabled stepwise surface dual nanoparticle engineering of 2D MXenes for tumor-sensitive T₁ and T₂ MRI-guided photonic breast-cancer hyperthermia in	40
A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alka	40
Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	40
Indocyanine green-based nanomedicine for theranostic applications	39
Modulation of the inflammatory microenvironment after SCI to achieve enhanced nerve regeneration using pteryxin-releasing methylacrylated hyaluronic acid	39
A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment	39
A polydopamine-based photodynamic coating on the intraocular lens surface for safer posterior capsule opacification conquering	39
Polyphenol derived bioactive carbon quantum dot-incorporated multifunctional hydrogels as an oxidative stress attenuator for antiaging and in vivo wound-healing applications	39
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes	38
Thiadiazoloquinoxaline derivative-based NIR-II organic molecules for NIR-II fluorescence imaging and photothermal therapy	38
Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review	38
Reactive oxygen species-scavenging biomaterials for neural regenerative medicine	38
Fucoidan based hydrogel biomaterials for tissue engineering	38
Blood–brain barrier-crossing dendrimers for glioma theranostics	38
Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis	38
The marriage of nanozymes and phages promotes pathogenic bacteria detection and elimination: a review	37
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly(glutamic acid)s	37
Optimization of magnetic nanoparticles for engineering erythrocytes as theranostic agents	37
Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease	37
Electrical hydrogel: electrophysiological-based strategy for wound healing	37
Efficient CRISPR-Cas9-based knockdown of RUNX2 to induce chondrogenic differentiation of stem cells	37
Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance	37
Glutathione peroxidase-like nanozymes: mechanism, classification, and bioapplication	37
Extended siponimod release via low-porosity PLGA fibres: a comprehensive three-month in vitro evaluation for neovascular ocular diseases	36
Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies	36
Back cover	36
Contents list	36
Impact of material characteristics on nanoparticle penetration and retention in thrombi: implications for thrombolysis	36
Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors	36
Front cover	36
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting	36
Correction: Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment	36
Contents list	36
Mesopore-encaged active MnOx in nano-silica selectively suppresses lung cancer cells by inducing autophagy	35
A tissue-engineered endothelial cell – smooth muscle cell arteriole-like model	35
Front cover	35
Base-modified factor VIII mRNA delivery with galactosylated lipid nanoparticles as a protein replacement therapy for haemophilia A	35
Quercetin alleviates nanoparticle-induced osteolysis via deactivating pyroptosis	35
Back cover	35
The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid	35
Drug carrier-assisted combined chemo- and radionuclide therapy for tumors of diverse origins: effects of therapeutic schemes on tumor responses	35
Front cover	35
Front cover	35
Front cover	34
Cationic PPC liposomes with dual targeting modules for enhanced liver fibrosis therapy via the extracellular matrix barrier	34
Contents list	34
Ultra-low attachment surface enabling 3D co-culture of human B cells with CD40L-expressing stromal cells for in vitro mimicry of secondary lymphoid organs	34
Ligand free FeSn₂ alloy nanoparticles for safe T₂-weighted MR imaging of in vivo lung tumors	34
Contents list	34
Construction of strontium-loaded injectable lubricating hydrogel and its role in promoting repair of cartilage defects	34
A novel exopolysaccharide (p-CY01) from the Antarctic bacterium Pseudoalteromonas sp. strain CY01 cryopreserves human red blood cells	34
Outstanding Reviewers for Biomaterials Science in 2024	34
Emerging innovations in 3D and 4D bioprinting	34
Polyaspartic acid coatings for blood-contacting surfaces: Promising antithrombotic and antibacterial properties under static and dynamic conditions	34
Cell-free and cytokine-free self-assembling peptide hydrogel-polycaprolactone composite scaffolds for segmental bone defects	34
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence	33
Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements	33
3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes	33
Restoring endothelial function: shedding light on cardiovascular stent development	33
Spherical α-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI)	33
An antibacterial and healing-promoting collagen fibril constructed by the simultaneous strategy of fibril reconstitution and ε-polylysine anchoring for infected wound repair	33

Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment	33
3D printing microporous scaffolds from modular bioinks containing sacrificial, cell-encapsulating microgels	33
Chitosan-based multifunctional oxygenating antibiotic hydrogel dressings for managing chronic infection in diabetic wounds	33
Ultra-small NIR J-aggregates of BODIPY for potent phototheranostics	33
Synthetic and biological nanoparticles for cancer immunotherapy	32
Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer	32
Safe magnetic resonance imaging on biocompatible nanoformulations	32
Tissue engineered scaffolds for corneal endothelial regeneration: a material's perspective	32
Delivery of rapamycin by biomimetic peptide nanoparticles targeting oxidized low-density lipoprotein in atherosclerotic plaques	32
Glutathione-triggered release of SO₂gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy	32
Biocompatibility and wound-healing prospect of KAPs-depleted residual hair biomaterial	32
Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing	32
Multi-functional intelligent drug-loaded microalgae for the repair of diabetic wounds: oxygen supply, cell proliferation promotion, and hypoglycemic effect	31
Multifunctional FeS₂@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy	31
Engineering of an in-cell protein crystal for fastening a metastable conformation of a target miniprotein	31
Enabling global access to potent subunit vaccines with a simple and scalable injectable hydrogel platform	31
4D-printed multifunctional hydrogels as flexible strain sensors and nerve conduits	31
Improved survival rate and minimal side effects of doxorubicin for lung metastasis using engineered discoidal polymeric particles	31
Microencapsulation system for scalable differentiation of peripheral motor neurons from human induced pluripotent stem cells	30
Back cover	30
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis	30
Inhibition and eradication of bacterial biofilm using polymeric materials	30
Liposomal MRI probes containing encapsulated or amphiphilic Fe( iii ) coordination complexes	30
Back cover	30
Multifunctional antibacterial hydrogels for chronic wound management	30
Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis models	30
Recent advances in functional polyurethane elastomers: from structural design to biomedical applications	30
Melatonin and the nervous system: nanomedicine perspectives	30
PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance	29
Effects of the aspect ratio of plasmonic gold nanorods on the inhibition of lysozyme amyloid formation	29
Correction: Bioactivity of cerium dioxide nanoparticles as a function of size and surface features	29
Correction: Carbazate-modified cross-linked dextran microparticles suppress the progression of osteoarthritis by ROS scavenging	29
Front cover	29
Front cover	29
Front cover	28
Correction: Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants	28
Ultrasound-enhanced cascade chemodynamic tumor nanotherapy with lactic acid-enabled hydrogen peroxide self-production	28
Contents list	28
Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors	28
Front cover	28
A ratiometric theranostic system for visualization of ONOO⁻ species and reduction of drug-induced hepatotoxicity	28
Front cover	28
Magnetic nanoparticle-facilitated rapid mass production of high affinity polymeric materials (nanoMIPs) for protein recognition and biosensing	28
Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens	28
Nanomedicine-mediated co-expression of a PD-1 blockade agent and CXCL9 synergizes T cell infiltration and activation in solid tumors	28
Magnetic alignment of injectable hydrogel scaffolds for spinal cord injury repair	27
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection	27
Micro/nano-modified titanium surfaces accelerate osseointegration via Rab7-dependent mitophagy	27
Flexible use of commercial rhenium disulfide for various theranostic applications	27
Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites	27
Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid	27
Cationic porphyrin-based nanoparticles for photodynamic inactivation and identification of bacteria strains	27
Micro/nanomotors for active inflammatory disease therapy	27
Single atom nanozymes for bacterial infection therapy	27
Aptamers in dentistry: diagnosis, therapeutics, and future perspectives	27
Wound-healing biodegradable microparticles: an in vitro investigation	27
Casein microparticles filled with cellulase to enzymatically degrade nanocellulose for cell growth	27
Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control	27
Cascade nanozymes based on the “butterfly effect” for enhanced starvation therapy through the regulation of autophagy	27
Correction: Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	27
A sugar modified amphiphilic cationic nano-adjuvant ceased tumor immune suppression and rejuvenated peptide vaccine induced antitumor immunity in cervical cancer	27
Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels	27
Expanding opportunities to engineer mucosal vaccination with biomaterials	27
The molecular design of performance-enhanced intraocular lens composites	27
One-pot synthesis of dynamically cross-linked polymers for serum-resistant nucleic acid delivery	27
Harnessing the potential of oxygen-generating materials and their utilization in organ-specific delivery of oxygen	27
Overcoming the novel glycan–lectin checkpoints in tumor microenvironments for the success of the cross-presentation-based immunotherapy	27
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers	26
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties	26
Correction: Hybrid protein microspheres and their responsive release behaviors and inhibitory effects on melanin synthesis	26
Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting	26
A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor	26
BSA-templated ultrasmall Ag/Gd₂O₃ as a self-enabled nanotheranostic for MR/CT/PA tri-modality imaging and photothermal therapy	26
P407 hydrogel loaded with nitric oxide microbubbles promotes angiogenesis and functional improvement in testicular transplantation	26
A nanoparticle reinforced microporous methacrylated silk fibroin hydrogel to promote bone regeneration	26
Injectable hybrid hydrogel-mediated calcium-sensing receptor (CaSR) activation for enhanced osteogenesis and bone remodeling	26
PET image-guided kidney injury theranostics enabled by a bipyramidal DNA framework	26
The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation	26
Retraction: NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway	25
Contents list	25
Mesoporous silica nanoparticle-supported nanocarriers with enhanced drug loading, encapsulation stability, and targeting efficiency	25
Improved osseointegration of strontium-modified titanium implants by regulating angiogenesis and macrophage polarization	25
Optimized synthesis of biphasic calcium phosphate: enhancing bone regeneration with a tailored β-tricalcium phosphate/hydroxyapatite ratio	25
Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance	25
Back cover	25
Contents list	25
Integrating microfluidics, hydrogels, and 3D bioprinting for personalized vessel-on-a-chip platforms	25
mRNA-carrying lipid nanoparticles that induce lysosomal rupture activate NLRP3 inflammasome and reduce mRNA transfection efficiency	25
The engineering and application of extracellular matrix hydrogels: a review	25
Contents list	25
Back cover	25
Development of non-viral vectors for neuronal-targeted delivery of CRISPR-Cas9 RNA-proteins as a therapeutic strategy for neurological disorders	25
Development of organic photosensitizers for antimicrobial photodynamic therapy	25
Stimulus-responsive hydrogels for diabetic wound management via microenvironment modulation	25
Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration	25