Biology Open

(The median citation count of Biology Open is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-01-01 to 2024-01-01.)
Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics45
Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine38
Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease36
Assessing the role of historical temperature regime and algal symbionts on the heat tolerance of coral juveniles31
Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)27
BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo27
Osteogenic differentiation potential of porcine bone marrow mesenchymal stem cell subpopulations selected in different basal media24
Efficient and crucial quality control of HAP1 cell ploidy status22
Quantified growth of the human embryonic heart22
An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica20
Uncharted routes: exploring the relevance of auxin movement via plasmodesmata20
Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing20
Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway20
Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice19
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy18
Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids18
The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components17
Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission17
Publishing ethics in the era of paper mills17
Antibiotics in hives and their effects on honey bee physiology and behavioral development17
Fiji plugin for annotating movies with custom arrows17
A versatile, automated and high-throughput drug screening platform for zebrafish embryos16
Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research16
RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition16
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry16
Genome wide association study for the identification of genes associated with tail fat deposition in Chinese sheep breeds15
Local adaptation in thermal tolerance for a tropical butterfly across ecotone and rainforest habitats15
Not just scratching the surface: Distinct radular motion patterns in Mollusca15
iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery15
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells15
Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms15
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane13
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation13
“Whip from the hip”: thigh angular motion, ground contact mechanics, and running speed13
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish13
Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells12
Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42andAppl) inDrosophila melanogaster12
Altered germline cyst formation and oogenesis in Tex14 mutant mice12
Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing12
Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in wistar rats12
Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue12
Dynamic neurotransmitter specific transcription factor expression profiles during Drosophila development12
Auxin confers protection against ER stress in Caenorhabditis elegans12
FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling11
Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination11
Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart11
Mechanical and energetic determinants of impaired gait following stroke: segmental work and pendular energy transduction during treadmill walking11
MicroRNA-96-5p promotes proliferation, invasion and EMT of oral carcinoma cells by directly targeting FOXF211
Bisphenol A promotes stress granule assembly and modulates the integrated stress response11
Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish11
A Caenorhabditis elegans behavioral assay distinguishes early stage prostate cancer patient urine from controls11
Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway11
20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun11
Motion: enhancing signals and concealing cues11
The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization11
Auxin treatment increases lifespan in Caenorhabditis elegans10
First data on microflora of loggerhead sea turtle (Caretta caretta) nests from the coastlines of Sicily (Italy)10
Schistosoma mansoniglyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin10
Shifting away from the business-as-usual approach to research conferences10
Overexpression of long non-coding RNA SBF2-AS1 promotes cell progression in esophageal squamous cell carcinoma (ESCC) by repressing miR-494 to up-regulate PFN2 expression10
Stability of amino acids and related amines in human serum under different preprocessing and pre-storage conditions based on iTRAQ®-LC-MS/MS10
Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis10
Gap junctions: historical discoveries and new findings in the C aenorhabditiselegans nervous system10
Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes10
CD47 differentially regulates white and brown fat function10
Mechanical and molecular parameters that influence the tendon differentiation potential of C3H10T1/2 cells in 2D- and 3D-culture systems9
Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies9
Cardiac hypertrophy in a dish: A human stem cell based model9
Eye morphogenesis in the blind Mexican cavefish9
Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis9
KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance9
Efficient induction and sustenance of pluripotent stem cells from bovine somatic cells9
Microtubule assembly and pole coalescence: early steps in C. elegans oocyte meiosis I spindle assembly9
Endurance exercise protects agingDrosophilafrom high-salt diet(HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity8
Evolutionary insights in Amazonian turtles (Testudines, Podocnemididae): co-location of 5S rDNA and U2 snRNA and wide distribution of Tc1/Mariner8
V-ATPase subunit B plays essential roles in the molting process of Chinese mitten crab, Eriocheir sinensis8
Presynaptic HCN channels constrain GABAergic synaptic transmission in pyramidal cells of the medial prefrontal cortex8
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway8
Establishment of a novel culture method for maintaining intestinal stem cells derived from human induced pluripotent stem cells8
Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis8
Connecting different heart diseases through intercellular communication8
Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster8
Convergent acoustic community structure in South Asian dry and wet grassland birds8
Beyond bold versus shy: Zebrafish exploratory behavior falls into several behavioral clusters and is influenced by strain and sex8
Quantitative analysis of signaling responses during mouse primordial germ cell specification8
Hormones as adaptive control systems in juvenile fish7
A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes7
Validating accelerometry-derived proxies of energy expenditure using the doubly labelled water method in the smallest penguin species7
Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish7
Downregulated brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 inhibits osteogenesis of BMSCs through p53 in type 2 diabetes mellitus7
LncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p7
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing7
Denovo designing, retrosynthetic analysis, and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzy7
The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly7
Perinatal exposure to synergistic multiple stressors leads to cellular and behavioral deficits mimicking Schizophrenia-like pathology7
Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome7
A glucose-supplemented diet enhances gut barrier integrity in Drosophila7
Conditional targeting of phosphatidylserine decarboxylase to lipid droplets7
Heart rate and cardiac response to exercise during voluntary dives in captive sea turtles (Cheloniidae)7
Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development7
Src family kinases inhibit differentiation of intestinal epithelial cells through the Hippo effector YAP17
Squids use multiple escape jet patterns throughout ontogeny7
Heart rate and startle responses in diving, captive harbour porpoises (Phocoena phocoena) exposed to transient noise and sonar7
Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world7
Compartment and cell-type specific hypoxia responses in the developing Drosophila brain7
Quantitative analysis of subcellular distributions with an open-source, object-based tool7
Inhibition of ER stress improves progressive motor deficits in a REEP1-null mouse model of hereditary spastic paraplegia7
Muscle forces and the demands of human walking6
The importance of considering regulatory domains in genome-wide analyses – the nearest gene is often wrong!6
MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β6
The role of macrophage migration inhibitory factor in promoting benign prostatic hyperplasia epithelial cell growth by modulating COX-2 and P53 signaling6
Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors6
Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 26
Pigment pattern morphospace ofDaniofishes: evolutionary diversification and mutational effects6
RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes6
Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism6
Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus6
A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity6
The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate6
Regulation of NANOG and SOX2 expression by activin A and a canonical WNT agonist in bovine embryonic stem cells and blastocysts6
Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure6
Interaction between Discs large and Pins/LGN/GPSM2: a comparison across species6
Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs6
Bumblebees land remarkably well in red-blue greenhouse LED light conditions6
Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states6
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila6
Wound-induced polyploidization is dependent on integrin-yki signaling6
MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB16
A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference6
Apoptosis is a generator of Wnt-dependent regeneration and homeostatic cell renewal in the ascidian Ciona6
Design of a 3D printed, motorized, uniaxial cell stretcher for microscopic and biochemical analysis of mechanotransduction6
Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density6
A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila6
Transduction of rat and human adipose-tissue derived mesenchymal stromal cells by adeno-associated viral vector serotype DJ6
MonitoringSchizosaccharomyces pombegenome stress by visualizing end-binding protein Ku6
Associative learning in larval and adultDrosophilais impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine6
Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia6
Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in the IUGR mice5
Energetics of whiskered bats in comparison to other bats of the family Vespertilionidae5
Phospholipids containing ether-bound hydrocarbon-chains are essential for efficient phagocytosis and neutral lipids of the ester-type perturb development in Dictyostelium5
Developmental expression patterns of toolkit genes in male accessory gland ofDrosophilaparallels those of mammalian prostate5
Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging vs hypoxia5
Zebrafish models of alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye5
A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection5
A Year at the Forefront of Engineering Photosynthesis5
Smoking flies: testing the effect of tobacco cigarettes on heart function ofDrosophila melanogaster5
CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production5
Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages5
Oviductal fluid counterbalances the negative effect of high temperature on sperm in an ectotherm model5
BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT45
TRBP–Dicer interaction may enhance HIV-1 TAR RNA translation via TAR RNA processing, repressing host-cell apoptosis5
Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model5
Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury5
Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence5
A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression5
A guide to preprinting for early-career researchers5
Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems5
Lizard colour plasticity tracks background seasonal changes5
Responses to transient receptor potential (TRP) channel agonists inChlamydomonas reinhardtii5
Mummichog gill and operculum exhibit functionally consistent claudin-10 paralog profiles and Claudin-10c hypersaline response5
Orally administered branaplam does not impact neurogenesis in juvenile mice, rats, and dogs5
Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia5
Antimicrobial peptide expression in the cockroach gut during enterobacterial infection is specific and influenced by type III secretion5
Influence of maternal diet on offspring survivorship, growth, and reproduction in a sheetweb spider5
Parametric generation of three-dimensional gait for robot-assisted rehabilitation5
Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy5
Single-cell sequencing reveals the potential oncogenic expression atlas of human iPSC-derived cardiomyocytes4
The genomic basis of host and vector specificity in non-pathogenic trypanosomatids4
Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+rats4
Variations in oxidative stress and antioxidant defense level during different phases of hibernation in common Asian toad,Duttaphrynus melanostictus4
Research culture: science from bench to society4
Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation4
Serotonin: an overlooked regulator of endocytosis and endosomal sorting?4
Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS4
A node-based informed modularity strategy to identify organizational modules in anatomical networks4
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro4
A fully automated deep learning pipeline for high-throughput colony segmentation and classification4
Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs4
Minimal functional domains of the core polarity regulator Dlg4
The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain4
Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment4
Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish4
Tight junction stabilization prevents HepaRG cell death in drug-induced intrahepatic cholestasis4
DNMT1 is a negative regulator of osteogenesis4
Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype4
Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model4
Factors influencing prey capture success and profitability in Australasian gannets (Morus serrator)4
A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe syndrome4
Effect of heterogeneous substrate adhesivity of follower cells on speed and tension profile of leader cells in primary keratocyte collective cell migration4
Development of a highly pulmonary metastatic orthotopic renal cell carcinoma murine model4
Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites4
Metabolic scaling of fire ants (Solenopsis invicta) engaged in collective behaviors4
Model selection versus traditional hypothesis testing in circular statistics: a simulation study4
A Year at the Forefront of Bacterial Defense Systems Against Neutrophilic Oxidants4
Overexpression of Wnt7a enhances radiosensitivity of non-small-cell lung cancer via the Wnt/JNK pathway4
A gum arabic assisted sustainable drug delivery system for adult Drosophila4
Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C14
Assessing methods to quantitatively validate TGFβ-dependent autophagy4
Modulation of mitochondrial nucleoid structure during aging and by mtDNA content in Drosophila4
Patterns of variations in dorsal colouration of the Italian wall lizard Podarcis siculus4
Dirichlet process mixture models for single-cell RNA-seq clustering4
Integrated analysis of cell shape and movement in moving frame4
Actin cytoskeleton in angiogenesis4
Initial parasitic behaviour of the temporary social parasitic ant Polyrhachis lamellidens can be induced by host-like cuticles in laboratory environment4
Quantifying Drosophila adults with the use of a smartphone4
Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the innate immune pathway in a reactive oxygen species-dependent manner4
Investigating the effect of cholinergic and adrenergic blocking agents on maternal-fetal heart rates and their interactions in mice fetuses4
Odours of cancerous mouse congeners: detection and attractiveness3
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways3
Brain-encysting trematodes (Euhaplorchis californiensis) decrease raphe serotonergic activity in California killifish (Fundulus parvipinnis)3
Tissue-specific transcriptome profiles identify functional differences key to understanding whole plant response to life in variable salinity3
Coilin as a regulator of NF-kB mediated inflammation in preeclampsia3
A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture3
Nondeterministic nature of sensorineural outcomes following noise trauma3
Advanced oxidation protein products change biological behaviors of rats endometrial epithelial cells by activating ERK/P38 signaling pathways3
MICAL-L1 is required for cargo protein delivery to the cell surface3
Communication between Cyclin dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe3
DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer3
EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice3
The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)3
Ocean acidification affects the expression of neuroplasticity and neuromodulation markers in seabream3
Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants3
Visualization of X chromosome reactivation in mouse primordial germ cells in vivo3
NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis3
Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect3
Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage3
Multiple neural bHLHs ensure the precision of a neuronal specification event in Caenorhabditis elegans3
A new method to localise and quantify oxidative stress in live juvenile mussels3
Clutch may predict growth of hatchling Burmese pythons better than food availability or sex3
Chromatin dynamics through mouse preimplantation development revealed by single molecule localisation microscopy3
HSP70 drives myoblast fusion during C2C12 myogenic differentiation3
Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?3
exTREEmaTIME: a method for incorporating uncertainty into divergence time estimates3
Crosstalk between basal extracellular matrix adhesion and building of apical architecture during morphogenesis3
Vitamin A cycle byproducts explain retinal damage and molecular changes thought to initiate retinal degeneration3
Effects of short-term fasting on spontaneous activity and excess post-exercise oxygen consumption in four juvenile fish species with different foraging strategies3
Spatial odor discrimination in the hawkmoth, Manduca sexta (L.)3
Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells3
New approach and new permutation tests with R programs for analyses of false negatives-contaminated data in medicine and biology3
Maternal glucocorticoid levels during incubation predict breeding success, but not reproductive investment, in a free-ranging bird3
Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium3
Pressure-induced changes on the morphology and gene expression in mammalian cells3
A machine vision system for tracking population behavior of zooplankton in small-scale experiments: a case study on salmon lice (Lepeophtheirus salmonis Krøyer, 1838) copepodite population resp3
Unique histological features of the tail skin of cotton rat (Sigmodon hispidus) related to caudal autotomy3
Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S43
Correction: Characterization and analysis of CCR and CAD gene families at the whole-genome level for lignin synthesis of stone cells in pear (Pyrus bretschneideri) fruit3
Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility3
Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis3
Functionally distinct roles for T and Tbx6 during mouse development3
The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome3