Systematic Reviews

Article	Citations
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews	4323
PRISMA-S: an extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews	1182
How to properly use the PRISMA Statement	263
Scoping reviews: reinforcing and advancing the methodology and application	256
Considerations for conducting systematic reviews: evaluating the performance of different methods for de-duplicating references	95
Research Screener: a machine learning tool to semi-automate abstract screening for systematic reviews	82
Are ChatGPT and large language models “the answer” to bringing us closer to systematic review automation?	74
Interventions for improving outcomes in patients with multimorbidity in primary care and community setting: a systematic review	72
Mapping reviews, scoping reviews, and evidence and gap maps (EGMs): the same but different— the “Big Picture” review family	67
A comparison of two assessment tools used in overviews of systematic reviews: ROBIS versus AMSTAR-2	65
Where to prospectively register a systematic review	64
The state of population health research performance in the Middle East and North Africa: a meta-research study	62
Guidance for overviews of reviews continues to accumulate, but important challenges remain: a scoping review	58
The incubation period during the pandemic of COVID-19: a systematic review and meta-analysis	55
Challenges in synthesising cost-effectiveness estimates	53
Why do some inter-organisational collaborations in healthcare work when others do not? A realist review	51
Health outcomes of sexual and gender minorities after cancer: a systematic review	49
A systematic and meta-analysis review on the diagnostic accuracy of antibodies in the serological diagnosis of COVID-19	47
A systematic review and meta-analysis of long COVID symptoms	47
Open defecation-free slippage and its associated factors in Ethiopia: a systematic review	43
Retention in opioid agonist treatment: a rapid review and meta-analysis comparing observational studies and randomized controlled trials	43
Perceived stress, stressors, and coping strategies among nursing students in the Middle East and North Africa: an overview of systematic reviews	41
Acceptance and use of complementary and alternative medicine among medical specialists: a 15-year systematic review and data synthesis	39
Statistical stopping criteria for automated screening in systematic reviews	38
Strategies to overcome vaccine hesitancy: a systematic review	38

Under detection of depression in primary care settings in low and middle-income countries: a systematic review and meta-analysis	38
Global prevalence of Rett syndrome: systematic review and meta-analysis	37
The impact of sports participation on mental health and social outcomes in adults: a systematic review and the ‘Mental Health through Sport’ conceptual model	35
Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis	35
Barriers and facilitators to access mental health services among refugee women in high-income countries: a systematic review	34
Progress in the treatment of knee osteoarthritis with high tibial osteotomy: a systematic review	34
Reducing systematic review burden using Deduklick: a novel, automated, reliable, and explainable deduplication algorithm to foster medical research	33
An updated systematic review of interventions to increase awareness of mental health and well-being in athletes, coaches, officials and parents	33
Study protocol for developing, piloting and disseminating the PRISMA-COSMIN guideline: a new reporting guideline for systematic reviews of outcome measurement instruments	32
Guidance to best tools and practices for systematic reviews	32
The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis	32
Prevalence and incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis	32
Dealing with predatory journal articles captured in systematic reviews	31
Barriers and enablers to physical activity in patients during hospital stay: a scoping review	31
Technology-based interventions for health challenges older women face amid COVID-19: a systematic review protocol	30
The psychological subtype of intimate partner violence and its effect on mental health: a systematic review with meta-analyses	30
Paper 2: Performing rapid reviews	30
Proactive psychological programs designed to mitigate posttraumatic stress injuries among at-risk workers: a systematic review and meta-analysis	29
Keloid treatments: an evidence-based systematic review of recent advances	29
Healthcare provider characteristics that influence the implementation of individual-level patient-centered outcome measure (PROM) and patient-reported experience measure (PREM) data across practice se	28
What are the variables associated with Altmetric scores?	28
Systematic review of lifestyle interventions to improve weight, physical activity and diet among people with a mental health condition	28
Text mining to support abstract screening for knowledge syntheses: a semi-automated workflow	28
Preliminary guideline for reporting bibliometric reviews of the biomedical literature (BIBLIO): a minimum requirements	28
Coaching to develop leadership for healthcare managers: a mixed-method systematic review protocol	27
A systematic literature review of attitudes towards secondary use and sharing of health administrative and clinical trial data: a focus on consent	27
Prevalence of hypertension in Ghanaian society: a systematic review, meta-analysis, and GRADE assessment	25
Prevalence of sexual dysfunction in men with multiple sclerosis: a systematic review and meta-analysis	25
Factors associated with antiretroviral treatment failure among people living with HIV on antiretroviral therapy in resource-poor settings: a systematic review and metaanalysis	25
Global concerns of dental and oral health workers during COVID-19 outbreak: a scope study on the concerns and the coping strategies	25
Cost-related medication nonadherence in Canada: a systematic review of prevalence, predictors, and clinical impact	24
The complex relationship between estrogen and migraines: a scoping review	24
Factors that influence adherence to surgical antimicrobial prophylaxis (SAP) guidelines: a systematic review	24
Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review	24
The REPRISE project: protocol for an evaluation of REProducibility and Replicability In Syntheses of Evidence	23
Prevalence and incidence of venous leg ulcers—a protocol for a systematic review	23
Patient engagement strategies for adults with chronic conditions: an evidence map	23
Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysis	23
The views of health guideline developers on the use of automation in health evidence synthesis	23
Inequalities in utilization and provision of dental services: a scoping review	23
The impact of health information technology on prescribing errors in hospitals: a systematic review and behaviour change technique analysis	22
Explaining adults’ mental health help-seeking through the lens of the theory of planned behavior: a scoping review	22
Systematic review of the utility of the frailty index and frailty phenotype to predict all-cause mortality in older people	22
Inflammation scores as prognostic biomarkers in small cell lung cancer: a systematic review and meta-analysis	22
Efficacy, acceptability, and safety of antidepressants for low back pain: a systematic review and meta-analysis	22
AMSTAR 2 appraisal of systematic reviews and meta-analyses in the field of heart failure from high-impact journals	22
The role of pharmacy in the management of cardiometabolic risk, metabolic syndrome and related diseases in severe mental illness: a mixed-methods systematic literature review	21
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)	21
Determinants of adolescent substance use in Africa: a systematic review and meta-analysis protocol	21
Barriers and facilitators to clinical behaviour change by primary care practitioners: a theory-informed systematic review of reviews using the Theoretical Domains Framework and Behaviour Change Wheel	21

Prognostic models of diabetic microvascular complications: a systematic review and meta-analysis	21
The score after 10 years of registration of systematic review protocols	21
Intraoperative and postoperative outcomes of robot-assisted cholecystectomy: a systematic review	21
Detection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer: a systematic review and meta-analysis	20
Initiatives addressing precarious employment and its effects on workers’ health and well-being: a protocol for a systematic review	20
Factors influencing the implementation of mental health recovery into services: a systematic mixed studies review	20
Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review	20
Performance of active learning models for screening prioritization in systematic reviews: a simulation study into the Average Time to Discover relevant records	19
Endectocides as a complementary intervention in the malaria control program: a systematic review	19
Automation of literature screening using machine learning in medical evidence synthesis: a diagnostic test accuracy systematic review protocol	19
Effectiveness of interventions to reduce household air pollution from solid biomass fuels and improve maternal and child health outcomes in low- and middle-income countries: a systematic review protoc	19
Do reporting guidelines have an impact? Empirical assessment of changes in reporting before and after the PRISMA extension statement for network meta-analysis	19
Evidence for implementation of interventions to promote mental health in the workplace: a systematic scoping review protocol	18
The principles of physical restraint use for hospitalized elderly people: an integrated literature review	17
Machine learning reduced workload for the Cochrane COVID-19 Study Register: development and evaluation of the Cochrane COVID-19 Study Classifier	17
Non-invasive and minimally invasive glucose monitoring devices: a systematic review and meta-analysis on diagnostic accuracy of hypoglycaemia detection	17
Effectiveness of training programs based on mindfulness in reducing psychological distress and promoting well-being in medical students: a systematic review and meta-analysis	17
A mega-aggregation framework synthesis of the barriers and facilitators to linkage, adherence to ART and retention in care among people living with HIV	17
Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis	16
Midazolam for sedation before procedures in adults and children: a systematic review update	16
Lessons from past pandemics: a systematic review of evidence-based, cost-effective interventions to suppress COVID-19	16
Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials	16
Safety and efficacy of different antibiotic regimens in patients with ocular toxoplasmosis: systematic review and meta-analysis	16
Factors affecting the delivery of complex rehabilitation interventions in research with neurologically impaired adults: a systematic review	16
Obstructive sleep apnea increases the risk of cardiovascular damage: a systematic review and meta-analysis of imaging studies	16
Rapid reviews for health policy and systems decision-making: more important than ever before	16
Social determinants of health and cancer screening implementation and outcomes in the USA: a systematic review protocol	16
Determining the safety and effectiveness of Tai Chi: a critical overview of 210 systematic reviews of controlled clinical trials	16
Decoding semi-automated title-abstract screening: findings from a convenience sample of reviews	16
srBERT: automatic article classification model for systematic review using BERT	15
A scoping review of the unassisted physical exam conducted over synchronous audio-video telemedicine	15
Prevalence of delirium, depression, anxiety, and post-traumatic stress disorder among COVID-19 patients: protocol for a living systematic review	15
Aligning text mining and machine learning algorithms with best practices for study selection in systematic literature reviews	15
Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients	15
Pornography use and sexting amongst children and young people: a systematic overview of reviews	15
Technology-based health solutions for cancer caregivers to better shoulder the impact of COVID-19: a systematic review protocol	15
The effectiveness of manual therapy applied to craniomandibular structures in the treatment of temporomandibular disorders: protocol for a systematic review	15
Technological interventions for loneliness and social isolation among older adults: a scoping review protocol	15
Diagnosis and treatment of Rosai-Dorfman disease of the spine: a systematic literature review	14
Screening for chlamydia and/or gonorrhea in primary health care: systematic reviews on effectiveness and patient preferences	14
Interprofessional collaboration and patient-reported outcomes in inpatient care: a systematic review	14
Climate change and health in North America: literature review protocol	14
FLT3 inhibitors in acute myeloid leukaemia: assessment of clinical effectiveness, adverse events and future research—a systematic review and meta-analysis	14
Lapatinib and lapatinib plus trastuzumab therapy versus trastuzumab therapy for HER2 positive breast cancer patients: an updated systematic review and meta-analysis	14
The assessment of general movements in term and late-preterm infants diagnosed with neonatal encephalopathy, as a predictive tool of cerebral palsy by 2 years of age—a scoping review	14
Legal concerns in health-related artificial intelligence: a scoping review protocol	14
Establishing a comprehensive search strategy for Indigenous health literature reviews	14
Effect of the PRECEDE-PROCEED model on health programs: a systematic review and meta-analysis	14
The prevalence, risk factors and outcomes of anaemia in South African pregnant women: a systematic review and meta-analysis	14
Efficacy of cognitive remediation on activities of daily living in individuals with mild cognitive impairment or early-stage dementia: a systematic review and meta-analysis	14
Treatment of eating disorders in older people: a systematic review	14
Include or not to include conference abstracts in systematic reviews? Lessons learned from a large Cochrane network meta-analysis including 585 trials	14
Effectiveness of the chronic care model for adults with type 2 diabetes in primary care: a systematic review and meta-analysis	13
Screening for depression in children and adolescents: a protocol for a systematic review update	13
Screening for the primary prevention of fragility fractures among adults aged 40 years and older in primary care: systematic reviews of the effects and acceptability of screening and treatment, and th	13
Wide-awake local anaesthesia no tourniquet (WALANT) vs regional or general anaesthesia for flexor tendon repair in adults: protocol for a systematic review and meta-analysis	13
The effect of lead exposure on IQ test scores in children under 12 years: a systematic review and meta-analysis of case-control studies	13
Predictors of adherence to prescribed exercise programs for older adults with medical or surgical indications for exercise: a systematic review	13
Association between occupational exposures and sarcoma incidence and mortality: systematic review and meta-analysis	13
Elevating the uses of storytelling approaches within Indigenous health research: a critical and participatory scoping review protocol involving Indigenous people and settlers	13
Establishing the effectiveness of technology-enabled dementia education for health and social care practitioners: a systematic review	13
Carotid endarterectomy with patch angioplasty versus primary closure in patients with symptomatic and significant stenosis: a systematic review with meta-analyses and trial sequential analysis of rand	13
Ten circumstances and solutions for finding the sample mean and standard deviation for meta-analysis	13
Efficacy and safety of CD22 chimeric antigen receptor (CAR) T cell therapy in patients with B cell malignancies: a protocol for a systematic review and meta-analysis	12
Partograph utilization as a decision-making tool and associated factors among obstetric care providers in Ethiopia: a systematic review and meta-analysis	12
Effect of interventions based on regular physical activity on weight management in adolescents: a systematic review and a meta-analysis	12
Effect of community-based interventions targeting female sex workers along the HIV care cascade in sub-Saharan Africa: a systematic review and meta-analysis	12
Prevalence of polypharmacy and associated adverse health outcomes in adult patients with chronic kidney disease: protocol for a systematic review and meta-analysis	12
A QuESt for speed: rapid qualitative evidence syntheses as a response to the COVID-19 pandemic	12
Systematic reviews of observational studies of Risk of Thrombosis and Bleeding in General and Gynecologic Surgery (ROTBIGGS): introduction and methodology	12
The effectiveness of virtual reality for rehabilitation of Parkinson disease: an overview of systematic reviews with meta-analyses	12
The effect of medical cannabis on cognitive functions: a systematic review	12
Ethnic differences between South Asians and White Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review	12
Early detection of sepsis using artificial intelligence: a scoping review protocol	12
Theories of change for e-health interventions targeting HIV/STIs and sexual risk, substance use and mental ill health amongst men who have sex with men: systematic review and synthesis	12
The effect of animal versus plant protein on muscle mass, muscle strength, physical performance and sarcopenia in adults: protocol for a systematic review	11
Efficacy of adipose tissue-derived stem cells in locomotion recovery after spinal cord injury: a systematic review and meta-analysis on animal studies	11
Men’s willingness to pay for prostate cancer screening: a systematic review	11
Personal identification with artificial intelligence under COVID-19 crisis: a scoping review	11
Prognostic significance of systemic immune-inflammation index in patients with nasopharyngeal carcinoma: a meta-analysis	11

Team functioning and implementation of innovations in healthcare and human service settings: a systematic review protocol	11
Functional social support and cognitive function in middle- and older-aged adults: a systematic review of cross-sectional and cohort studies	11
Primary care during the transition to adult care for adolescents involved with pediatric specialty services: a scoping review protocol	11
Low birth weight as a predictor of adverse health outcomes during adulthood in twins: a systematic review and meta-analysis	11
The impact of childhood psychological maltreatment on mental health outcomes in adulthood: a protocol for a systematic review and meta-analysis	11
PICO entity extraction for preclinical animal literature	11
The Systematic Review Toolbox: keeping up to date with tools to support evidence synthesis	11
Enrollment, retention, and strategies for including disadvantaged populations in randomized controlled trials: a systematic review protocol	11
The influence of acute exercise on bone biomarkers: protocol for a systematic review with meta-analysis	11
Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations	11
Reviewing the current state of virtual reality integration in medical education – a scoping review protocol	11
A systematic review of risk factors for mortality among tuberculosis patients in South Africa	11
Successful incorporation of single reviewer assessments during systematic review screening: development and validation of sensitivity and work-saved of an algorithm that considers exclusion criteria a	11
Involvement of Indigenous young people in the design and evaluation of digital mental health interventions: a scoping review protocol	11
Paper 3: Selecting rapid review methods for complex questions related to health policy and system issues	10
Hurdles to developing and scaling remote patients’ health management tools and systems: a scoping review	10
Questionnaires in otology: a systematic mapping review	10
Fall prevention interventions for older community-dwelling adults: systematic reviews on benefits, harms, and patient values and preferences	10
Iterative guided machine learning-assisted systematic literature reviews: a diabetes case study	10
Near infrared indocyanine green fluorescent cholangiography versus intraoperative cholangiography to improve safety in laparoscopic cholecystectomy for gallstone disease—a systematic review protocol	10
Influence of pilot and small trials in meta-analyses of behavioral interventions: a meta-epidemiological study	10
Mindfulness-based interventions for children and adolescents across all settings: a scoping review protocol	10
Prognostic factors for persistent symptoms in adults with mild traumatic brain injury: protocol for an overview of systematic reviews	10
Impacts of parental technoference on parent-child relationships and child health and developmental outcomes: a scoping review protocol	10
Evaluating measurement properties of subjective cognitive decline self-reported outcome measures: a systematic review	10
The scope and nature of sexual orientation and gender identity and expression change efforts: a systematic review protocol	10
The ability of comorbidity indices to predict mortality in an orthopedic setting: a systematic review	10
Exercise interventions for older adults with Alzheimer’s disease: a systematic review and meta-analysis protocol	10
Post-abortion family planning use, method preference, and its determinant factors in Eastern Africa: a systematic review and meta-analysis	10
Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study	10
Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews	9
A likelihood ratio test for the homogeneity of between-study variance in network meta-analysis	9
Theoretical approaches to process evaluations of complex interventions in health care: a systematic scoping review protocol	9
Illness perceptions of adults with eczematous skin diseases: a systematic mixed studies review	9
Systematic reviews are rarely used to contextualise new results—a systematic review and meta-analysis of meta-research studies	9
Racism in Australia: a protocol for a systematic review and meta-analysis	9
Theory of planned behaviour-based interventions in chronic diseases among low health-literacy population: protocol for a systematic review	9
Economic evaluation of diagnostic sleep studies for obstructive sleep apnoea: a systematic review protocol	9
Anxiety among children and adolescents during the COVID-19 pandemic in Europe: a systematic review protocol	9
Global evidence on the rapid adoption of telemedicine in primary care during the first 2 years of the COVID-19 pandemic: a scoping review protocol	9
Potato consumption and risk of cardio-metabolic diseases: evidence mapping of observational studies	9
Do descriptive norms messaging interventions backfire? Protocol for a systematic review of the boomerang effect	9
Increasing the transparency of systematic reviews: presenting a generalized registration form	9
The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review	9
Substance use and substance use disorder, in relation to COVID-19: protocol for a scoping review	9
Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews	9
Community-based educational interventions for prevention of type II diabetes: a global systematic review and meta-analysis	9
Objective assessment of mental stress in individuals with different levels of effort reward imbalance or overcommitment using heart rate variability: a systematic review	9
Loneliness in pregnant and postpartum people and parents of children aged 5 years or younger: a scoping review	9
Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and un	9
Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis	8
Repetitive and restricted behaviours and anxiety in autism spectrum disorder: protocol for a systematic review and meta-analysis	8
Extracellular vesicles for ischemia/reperfusion injury-induced acute kidney injury: a systematic review and meta-analysis of data from animal models	8
Solitary pulmonary nodule malignancy predictive models applicable to routine clinical practice: a systematic review	8
The effects of meditation on length of telomeres in healthy individuals: a systematic review	8
Alcohol use and the gender-specific risk of suicidal behavior: a systematic review and meta-analysis protocol	8
Promoting physical activity to patients: a scoping review of the perceptions of doctors in the United Kingdom	8
Psychometric properties of patient-reported outcome measures for dysphagia in head and neck cancer: a systematic review protocol using COSMIN methodology	8
The development and education of a workforce in childhood cancer services in low- and middle-income countries: a scoping review protocol	8
A mapping of facilitators and barriers to evidence-based management in health systems: a scoping review study	8
Safety of exercise training in multiple sclerosis: a protocol for an updated systematic review and meta-analysis	8
Male involvement in family planning use and its determinants in Ethiopia: a systematic review and meta-analysis protocol	8
Assessing the causal relationship between income inequality and mortality and self-rated health: protocol for systematic review and meta-analysis	8
Non-adherence and non-persistence to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy: a systematic review and meta-analysis	8
The clinical effects of cerebral near-infrared spectroscopy monitoring (NIRS) versus no monitoring: a protocol for a systematic review with meta-analysis and trial sequential analysis	8
Medications for preventing hypertensive disorders in high-risk pregnant women: a systematic review and network meta-analysis	8
The global economic burden of COVID-19 disease: a comprehensive systematic review and meta-analysis	8
Ocular adverse events from pharmacological treatment in patients with multiple sclerosis—A systematic review of the literature	8
Sexual and reproductive health services during outbreaks, epidemics, and pandemics in sub-Saharan Africa: a literature scoping review	8
Expanding enhanced recovery protocols for cardiac surgery to include the patient voice: a scoping review protocol	8
Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review	8
Definition, harms, and prevention of redundant systematic reviews	8
Antimicrobial prescription patterns in East Africa: a systematic review	8
Research on simulation in radiography education: a scoping review protocol	8
Public views on ethical issues in healthcare artificial intelligence: protocol for a scoping review	8
Color difference for shade determination with visual and instrumental methods: a systematic review and meta-analysis	8
Prediction models for breast cancer-related lymphedema: a systematic review and critical appraisal	8
Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Anal	8
Empirical comparisons of heterogeneity magnitudes of the risk difference, relative risk, and odds ratio	8
Experiences of loneliness: a study protocol for a systematic review and thematic synthesis of qualitative literature	8
Efficacy of vitamin C supplementation as an adjunct in the non-surgical management of periodontitis: a systematic review	8
Meta-research evaluating redundancy and use of systematic reviews when planning new studies in health research: a scoping review	8
Interventions to improve the detection of depression in primary healthcare: systematic review	8
A systematic review of economic evaluations of cervical cancer screening methods	8
Intimate partner violence against women during pregnancy: a systematic review and meta-analysis protocol for producing global and regional estimates	7
Overcoming challenges in conducting systematic reviews in implementation science: a methods commentary	7
The incidence of TB and MDR-TB in pediatrics and therapeutic options: a systematic review	7
Usefulness of machine learning softwares to screen titles of systematic reviews: a methodological study	7
Conceptualising, operationalising, and measuring trust in participatory health research networks: a scoping review	7
Effectiveness of task-shifting for the detection of diabetic retinopathy in low- and middle-income countries: a rapid review protocol	7
Unsupervised title and abstract screening for systematic review: a retrospective case-study using topic modelling methodology	7
Communication strategies in the prevention of type 2 diabetes and gestational diabetes in vulnerable groups: a scoping review	7
Peer support for smoking cessation: a protocol of systematic review and meta-analysis	7
HPV self-sampling versus healthcare provider collection on the effect of cervical cancer screening uptake and costs in LMIC: a systematic review and meta-analysis	7
Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions	7