Open Biology

Article	Citations
Wound healing: cellular mechanisms and pathological outcomes	557
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines	225
Anti-cancer peptides: classification, mechanism of action, reconstruction and modification	127
Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses	104
Hallmarks of cancer—the new testament	100
Higher-order organization of biomolecular condensates	99
The rise and rise of mitochondrial DNA mutations	89
Metarhizium: jack of all trades, master of many	86
Bacterial chromosome segregation by the ParABS system	77
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease	68
Satellite cells in ageing: use it or lose it	68
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition	68
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester	67
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle	63
To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease	61
Molecular mechanisms of olfactory detection in insects: beyond receptors	59
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential	59
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine	59
SARS-CoV-2 envelope protein topology in eukaryotic membranes	54
Senescent cells and macrophages: key players for regeneration?	51
An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease	51
Black box of phage–bacterium interactions: exploring alternative phage infection strategies	50
Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin	50
Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases	45
Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy	45

ADAMTS proteases in cardiovascular physiology and disease	45
Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease	40
A duplicated amh is the master sex-determining gene for Sebastes rockfish in the Northwest Pacific	40
Adipose tissue in health and disease	39
Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues	39
Substrate recruitment by zDHHC protein acyltransferases	39
Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones	38
Role of antioxidants and a nutrient rich diet in Alzheimer's disease	38
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains	37
Pathways shaping the mitochondrial inner membrane	35
The evolutionary origins of the vertebrate olfactory system	35
The intrinsically disorderly story of Ki-67	33
Syndecan receptors: pericellular regulators in development and inflammatory disease	31
Brain and testis: more alike than previously thought?	30
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs	30
Modulators of calcium signalling at fertilization	29
Molecular mechanisms behind mRNA localization in axons	29
Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?	29
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders	28
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea	28
The role of disorder in RNA binding affinity and specificity	28
Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida	27
Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture	27
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories	27
Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate	26
How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?	26
Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?	26
A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus	26
Darwin's bark spider shares a spidroin repertoire with Caerostris extrusa but achieves extraordinary silk toughness through gene expression	26
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead	25
Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle	25
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate	25
A centriole's subdistal appendages: contributions to cell division, ciliogenesis and differentiation	25
Protein S -palmitoylation in immunity	24
Signalling through cerebral cavernous malformation protein networks	24
Insight into m 6 A methylation from occurrence to functions	24
The structure and function of deubiquitinases: lessons from budding yeast	24
Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions	24
Reversible bacteriophage resistance by shedding the bacterial cell wall	24
Notch signalling in healthy and diseased vasculature	24
Molecular insights into the powerful mucus-based adhesion of limpets ( Patella vulgata L.)	23
SIRT7: a sentinel of genome stability	23
Unravelling the mystery of female meiotic drive: where we are	23
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health	23
Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders	23
Temperature modulates immune gene expression in mosquitoes during arbovirus infection	22
Ultrastructure expansion microscopy in Trypanosoma brucei	22
Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder	22
Prader-Willi syndrome: reflections on seminal studies and future therapies	22
Vascular underpinning of COVID-19	21

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system	21
TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases	21
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells	21
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers	21
Non-apoptotic roles of apoptotic proteases: new tricks for an old dog	21
The FBXL family of F-box proteins: variations on a theme	20
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19	20
RNA polymerase II pausing in development: orchestrating transcription	20
HIV Rev-isited	20
The impact of autophagy during the development and survival of glioblastoma	20
Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer	20
The contribution of non-coding regulatory elements to cardiovascular disease	19
Controlling the topology of mammalian mitochondrial DNA	19
What determines eukaryotic translation elongation: recent molecular and quantitative analyses of protein synthesis	19
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections	19
Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase	19
Ferroptosis in myocardial infarction: not a marker but a maker	18
Long non-coding RNA-polycomb intimate rendezvous	18
Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research	18
The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways	18
Capturing crop adaptation to abiotic stress using image-based technologies	18
RETRACTED: Long non-coding RNA LINC00346 contributes to cisplatin resistance in nasopharyngeal carcinoma by repressing miR-342-5p	18
The plastic cell: mechanical deformation of cells and tissues	18
Centrosome-centric view of asymmetric stem cell division	18
Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies	18
Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis	18
Metabolomics of human fasting: new insights about old questions	18
The role of Wnt signalling in development of coronary artery disease and its risk factors	18
Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer	17
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis	17
The aerobic mitochondrial ATP synthesis from a comprehensive point of view	17
Cellular and molecular mechanisms that regulate mammalian digit tip regeneration	17
SUMOylation modification-mediated cell death	17
The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation	17
Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration	16
Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature	16
Proteolytic activity of the proteasome is required for female insect reproduction	16
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development	15
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27	15
Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer	15
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression	15
Haloferax volcanii —a model archaeon for studying DNA replication and repair	15
Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms	15
Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth	15
Development of the mammalian cortical hem and its derivatives: the choroid plexus, Cajal–Retzius cells and hippocampus	15
ANGPTL8 in metabolic homeostasis: more friend than foe?	15
Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology	14
Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective	14
Human intestinal models to study interactions between intestine and microbes	14
The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer	14
Lysosomal positioning diseases: beyond substrate storage	14
RETRACTED: DDP-resistant ovarian cancer cells-derived exosomal microRNA-30a-5p reduces the resistance of ovarian cancer cells to DDP	14
SUMOylation in the control of cholesterol homeostasis	14
Diversity from similarity: cellular strategies for assigning particular identities to actin filaments and networks	14
Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3	14
PGE 2 upregulates gene expression of dual oxidase in a lepidopteran insect midgut via cAMP signalling pathway	14
Aspirin and cancer: biological mechanisms and clinical outcomes	14
Patterning principles of morphogen gradients	13
Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites	13
Neutrophil interactions with the sexually transmitted parasite Trichomonas vaginalis: implications for immunity and pathogenesis	13
Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer	13
Mechanism and regulation of P element transposition	13
Establishment and function of chromatin modification at enhancers	13
Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation	13
Driving forces in the origins of life	13
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics	13
Iron-sulfur flavoenzymes: the added value of making the most ancient redox cofactors and the versatile flavins work together	13
Convalescent plasma therapy: a promising coronavirus disease 2019 treatment strategy	12
Airinemes: thin cellular protrusions mediate long-distance signalling guided by macrophages	12
Secondary cell wall patterning—connecting the dots, pits and helices	12
Comparative analysis of stalked and acorn barnacle adhesive proteomes	12
Genomic instability and cancer: lessons from Drosophila	12
Role of amylopectin synthesis in Toxoplasma gondii and its implication in vaccine development against toxoplasmosis	12
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease	12
TRIM family proteins: roles in proteostasis and neurodegenerative diseases	12
Ghrelin octanoylation by ghrelin O -acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling	12
Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population	12
An open-source pipeline for analysing changes in microglial morphology	12
Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface	12
The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis	12

The closest lineage of Archaeplastida is revealed by phylogenomics analyses that include Microheliella maris	12
Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India	11
miR-155-3p: processing by-product or rising star in immunity and cancer?	11
Modelling population dynamics in a unicellular social organism community using a minimal model and evolutionary game theory	11
Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi	11
Metamorphic proteins: the Janus proteins of structural biology	11
Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons	11
Reconstitution of the recombinant human γ-tubulin ring complex	11
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review	11
Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes	11
How neutrophil metabolism affects bacterial killing	11
A homology independent sequence replacement strategy in human cells using a CRISPR nuclease	10
Opinion: PARP inhibitors in cancer—what do we still need to know?	10
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis	10
Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster	10
Structural basis for the coiled-coil architecture of human CtIP	10
Effects of malleable kinetochore morphology on measurements of intrakinetochore tension	10
The utility of nuclear magnetic resonance spectroscopy in assisted reproduction	10
Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria	10
Modern and prebiotic amino acids support distinct structural profiles in proteins	10
Image integrity and standards	10
MicroRNAs: master regulators in host–parasitic protist interactions	10
Functional characterization of the human Cdk10/Cyclin Q complex	10
Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development	10
Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins	10
Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism	10
The supernumerary B chromosome of maize: drive and genomic conflict	10
Emerging roles of centrosome cohesion	10
Appendage regeneration is context dependent at the cellular level	9
Thylakoid membrane reorganizations revealed by small-angle neutron scattering of Monstera deliciosa leaves associated with non-photochemical quenching	9
The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities	9
A glitch in the snitch: the role of linker histone H1 in shaping the epigenome in normal and diseased cells	9
Viruses, cancer and non-self recognition	9
ATP-dependent polymerization dynamics of bacterial actin proteins involved in Spiroplasma swimming	9
Reprogramming of human cells to pluripotency induces CENP-A chromatin depletion	9
Phenotypes from cell-free DNA	9
Characterization of microglia behaviour in healthy and pathological conditions with image analysis tools	9
Recent insights into mechanisms preventing ectopic centromere formation	9
Understanding the mammalian TRAP complex function(s)	9
Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer	9
From infection to cancer: how DNA tumour viruses alter host cell central carbon and lipid metabolism	9
MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex	9
BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ	9
Regulatory effects of protein S-acylation on insulin secretion and insulin action	9
Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish	9
Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy	9
Neuronal signalling of zinc: from detection and modulation to function	9
Core regulatory circuitries in defining cancer cell identity across the malignant spectrum	9
Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo	9
Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod	9
High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan	8
A genetic model for in vivo proximity labelling of the mammalian secretome	8
Blood–brain barrier disruption in atrial fibrillation: a potential contributor to the increased risk of dementia and worsening of stroke outcomes?	8
AMPK phosphorylates NAMPT to regulate NAD + homeostasis under ionizing radiation	8
Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain	8
Evolution of thymopoietic microenvironments	8
Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties	8
Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system	8
Osmolarity-regulated swelling initiates egg activation in Drosophila	8
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)	8
Biochemical evidence for diverse strategies in the inner kinetochore	8
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis	8
Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering	8
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12	8
Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching between biomolecular condensates and polymers	8
In the footsteps of sea stars: deciphering the catalogue of proteins involved in underwater temporary adhesion	7
The application of rapid evaporative ionization mass spectrometry in the analysis of Drosophila species—a potential new tool in entomology	7
C-terminal eYFP fusion impairs Escherichia coli MinE function	7
Bronchoconstriction: a potential missing link in airway remodelling	7
Cell wall deficiency as an escape mechanism from phage infection	7
Polo-like kinase in trypanosomes: an odd member out of the Polo family	7
Methods to study folding of alpha-helical membrane proteins in lipids	7
The three-component helicase/primase complex of herpes simplex virus-1	7
Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts	7
Fractal analysis of concurrently prepared latex rubber casts of the bronchial and vascular systems of the human lung	7
A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors	7
The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies	7
Primary cilia and lipid raft dynamics	7
Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A	7
On the origin of TSAR: morphology, diversity and phylogeny of Telonemia	7
DDX21 is a p38-MAPK-sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification	7
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors	7
Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns	7
Myeloid-derived suppressor cells and the pathogenesis of human immunodeficiency virus infection	7
Live imaging YAP signalling in mouse embryo development	7
A self-assembled cylindrical platform for Plk4-induced centriole biogenesis	7
Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration	7
Exploring differential exon usage via short- and long-read RNA sequencing strategies	7
Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define the growth physiology	7
Haem-responsive gene transporter enables mobilization of host haem in ticks	6
POU-M2 promotes juvenile hormone biosynthesis by directly activating the transcription of juvenile hormone synthetic enzyme genes in Bombyx mori	6
Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response	6
Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces	6
Mitochondrial biology and dysfunction in secondary mitochondrial disease	6
Centromere function in asymmetric cell division in Drosophila female and male germline stem cells	6