Open Biology

Article	Citations
Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses	123
Hallmarks of cancer—the new testament	121
Higher-order organization of biomolecular condensates	116
Metarhizium: jack of all trades, master of many	103
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition	83
To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease	80
Black box of phage–bacterium interactions: exploring alternative phage infection strategies	68
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential	68
Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases	65
Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin	59
Senescent cells and macrophages: key players for regeneration?	58
Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy	54
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains	52
Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease	50
ADAMTS proteases in cardiovascular physiology and disease	49
A duplicated amh is the master sex-determining gene for Sebastes rockfish in the Northwest Pacific	49
Adipose tissue in health and disease	48
The intrinsically disorderly story of Ki-67	47
Pathways shaping the mitochondrial inner membrane	46
Substrate recruitment by zDHHC protein acyltransferases	45
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections	44
Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones	44
The role of disorder in RNA binding affinity and specificity	44
The evolutionary origins of the vertebrate olfactory system	41
Brain and testis: more alike than previously thought?	40

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions	38
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders	37
Syndecan receptors: pericellular regulators in development and inflammatory disease	37
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea	36
SUMOylation modification-mediated cell death	34
A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus	34
How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?	34
Notch signalling in healthy and diseased vasculature	33
Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?	32
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories	32
Darwin's bark spider shares a spidroin repertoire with Caerostris extrusa but achieves extraordinary silk toughness through gene expression	31
Ultrastructure expansion microscopy in Trypanosoma brucei	31
Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?	31
Unravelling the mystery of female meiotic drive: where we are	31
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system	30
Reversible bacteriophage resistance by shedding the bacterial cell wall	29
Temperature modulates immune gene expression in mosquitoes during arbovirus infection	29
Protein S -palmitoylation in immunity	29
Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida	28
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate	28
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead	27
Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder	27
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells	27
SIRT7: a sentinel of genome stability	27
RNA polymerase II pausing in development: orchestrating transcription	26
A centriole's subdistal appendages: contributions to cell division, ciliogenesis and differentiation	26
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health	26
Signalling through cerebral cavernous malformation protein networks	26
Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer	25
HIV Rev-isited	25
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers	25
Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer	25
Secondary cell wall patterning—connecting the dots, pits and helices	24
Controlling the topology of mammalian mitochondrial DNA	24
Ferroptosis in myocardial infarction: not a marker but a maker	24
The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways	24
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression	23
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19	23
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27	23
Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature	22
The FBXL family of F-box proteins: variations on a theme	22
What determines eukaryotic translation elongation: recent molecular and quantitative analyses of protein synthesis	22
Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research	22
The plastic cell: mechanical deformation of cells and tissues	22
Capturing crop adaptation to abiotic stress using image-based technologies	22
Aspirin and cancer: biological mechanisms and clinical outcomes	21
Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis	21
Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective	21
Haloferax volcanii —a model archaeon for studying DNA replication and repair	21
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis	21

Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites	20
How neutrophil metabolism affects bacterial killing	20
Patterning principles of morphogen gradients	20
Centrosome-centric view of asymmetric stem cell division	20
Development of the mammalian cortical hem and its derivatives: the choroid plexus, Cajal–Retzius cells and hippocampus	19
Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase	19
The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation	19
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development	19
ANGPTL8 in metabolic homeostasis: more friend than foe?	19
TRIM family proteins: roles in proteostasis and neurodegenerative diseases	18
Lysosomal positioning diseases: beyond substrate storage	18
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics	18
Proteolytic activity of the proteasome is required for female insect reproduction	18
Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth	18
Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies	18
Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface	18
Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration	17
Driving forces in the origins of life	16
The closest lineage of Archaeplastida is revealed by phylogenomics analyses that include Microheliella maris	16
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease	16
Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer	16
Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology	16
The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis	16
Role of amylopectin synthesis in Toxoplasma gondii and its implication in vaccine development against toxoplasmosis	15
The supernumerary B chromosome of maize: drive and genomic conflict	15
Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons	15
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors	15
An open-source pipeline for analysing changes in microglial morphology	15
Iron-sulfur flavoenzymes: the added value of making the most ancient redox cofactors and the versatile flavins work together	15
Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy	15
Blood–brain barrier disruption in atrial fibrillation: a potential contributor to the increased risk of dementia and worsening of stroke outcomes?	14
Modern and prebiotic amino acids support distinct structural profiles in proteins	14
Ghrelin octanoylation by ghrelinO-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling	14
Mechanism and regulation of P element transposition	14
Neuronal signalling of zinc: from detection and modulation to function	14
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)	14
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review	14
Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria	14
Reconstitution of the recombinant human γ-tubulin ring complex	14
A glitch in the snitch: the role of linker histone H1 in shaping the epigenome in normal and diseased cells	13
Comparative analysis of stalked and acorn barnacle adhesive proteomes	13
Age separation dramatically reduces COVID-19 mortality rate in a computational model of a large population	13
Opinion: PARP inhibitors in cancer—what do we still need to know?	13
Metamorphic proteins: the Janus proteins of structural biology	13
Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation	13
MicroRNAs: master regulators in host–parasitic protist interactions	12
miR-155-3p: processing by-product or rising star in immunity and cancer?	12
Live imaging YAP signalling in mouse embryo development	12
Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A	12
Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India	12
Emerging roles of centrosome cohesion	12
Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism	12
Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi	12
Mitochondrial biology and dysfunction in secondary mitochondrial disease	12
Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties	12
Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development	12
Modelling population dynamics in a unicellular social organism community using a minimal model and evolutionary game theory	12
ATP-dependent polymerization dynamics of bacterial actin proteins involved in Spiroplasma swimming	12
MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex	12
Appendage regeneration is context dependent at the cellular level	11
A genetic model for in vivo proximity labelling of the mammalian secretome	11
Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins	11
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis	11
Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster	11
Functional characterization of the human Cdk10/Cyclin Q complex	11
Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain	11
The three-component helicase/primase complex of herpes simplex virus-1	11
The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities	11
Structural basis for the coiled-coil architecture of human CtIP	11
Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo	11
BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ	10
Recent insights into mechanisms preventing ectopic centromere formation	10
Regulatory effects of protein S-acylation on insulin secretion and insulin action	10
Viruses, cancer and non-self recognition	10
Evolution of thymopoietic microenvironments	10
In the footsteps of sea stars: deciphering the catalogue of proteins involved in underwater temporary adhesion	10
Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering	10
A homology independent sequence replacement strategy in human cells using a CRISPR nuclease	10
Cell wall deficiency as an escape mechanism from phage infection	10
Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod	10

Structural and biophysical characterization of the tandem substrate-binding domains of the ABC importer GlnPQ	10
Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system	10
The utility of nuclear magnetic resonance spectroscopy in assisted reproduction	10
Phytophthora capsici sterol reductase PcDHCR7 has a role in mycelium development and pathogenicity	10
From infection to cancer: how DNA tumour viruses alter host cell central carbon and lipid metabolism	10
Developing and maintaining a nose-to-brain map of odorant identity	9
High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan	9
A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors	9
Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching between biomolecular condensates and polymers	9
Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer	9
Methods to study folding of alpha-helical membrane proteins in lipids	9
Characterization of microglia behaviour in healthy and pathological conditions with image analysis tools	9
Light-induced reversible reorganizations in closed Type II reaction centre complexes: physiological roles and physical mechanisms	9
AMPK phosphorylates NAMPT to regulate NAD + homeostasis under ionizing radiation	9
Biochemical evidence for diverse strategies in the inner kinetochore	9
Osmolarity-regulated swelling initiates egg activation in Drosophila	9
Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation	9
The multifaceted role of lemur tyrosine kinase 3 in health and disease	8
TSPO: an emerging role in appetite for a therapeutically promising biomarker	8
Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define the growth physiology	8
On the origin of TSAR: morphology, diversity and phylogeny of Telonemia	8
GNL3 is an evolutionarily conserved stem cell gene influencing cell proliferation, animal growth and regeneration in the hydrozoan Hydractinia	8
The role of α-sheet structure in amyloidogenesis: characterization and implications	8
Bronchoconstriction: a potential missing link in airway remodelling	8
DDX21 is a p38-MAPK-sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification	8
Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration	8
Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression	8
The application of rapid evaporative ionization mass spectrometry in the analysis of Drosophila species—a potential new tool in entomology	8
A fast-growing dengue virus mutant reveals a dual role of STING in response to infection	8
The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis	8
A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans	8
Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons	8
Myeloid-derived suppressor cells and the pathogenesis of human immunodeficiency virus infection	8
Primary cilia and lipid raft dynamics	8
Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly inDrosophila	7
A quick protocol for the preparation of mouse retinal cryosections for immunohistochemistry	7
Planar cell polarity in the larval epidermis of Drosophila and the role of microtubules	7
Bacterial degrons in synthetic circuits	7
Immune competence and spleen size scale with colony status in the naked mole-rat	7
POU-M2 promotes juvenile hormone biosynthesis by directly activating the transcription of juvenile hormone synthetic enzyme genes in Bombyx mori	7
Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence	7
Parakeet: a digital twin software pipeline to assess the impact of experimental parameters on tomographic reconstructions for cryo-electron tomography	7
Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA	7
Cellular and molecular signatures of motherhood in the adult and ageing rat brain	7
Haem-responsive gene transporter enables mobilization of host haem in ticks	7
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1	7
Exploring differential exon usage via short- and long-read RNA sequencing strategies	7
Crystals of TELSAM–target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts	7
Protein phase separation hotspots at the presynapse	7
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells	7
MYC regulates metabolism through vesicular transfer of glycolytic kinases	7
Time-optimized feeding is beneficial without enforced fasting	7
Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite	7
Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB inStreptomyces	7
Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis	7
The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes	6
Gene duplication is the primary driver of intraspecific genomic divergence in coral algal symbionts	6
Functional insight into LOAD-associated microglial response genes	6
Mapping molecular complexes with super-resolution microscopy and single-particle analysis	6
tRNA copy number and codon usage in the sea cucumber genome provide insights into adaptive translation for saponin biosynthesis	6
Expression and function of PDGF-C in development and stem cells	6
Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis	6
A unifying mechanism for protein transport through the core bacterial Sec machinery	6
Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation	6
Integrative omics identification, evolutionary and structural analysis of low affinity nitrate transporters in diatoms, diNPFs	6
The potential roles of retinoids in combating drug resistance in cancer: implications of ATP-binding cassette (ABC) transporters	6
Identification of FoxP circuits involved in locomotion and object fixation in Drosophila	6
Prebiotic chemistry: a review of nucleoside phosphorylation and polymerization	6
NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors	6
Centromere function in asymmetric cell division in Drosophila female and male germline stem cells	6
Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila	6
In vivoassessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy	6
A novel methodological approach to simultaneously extract high-quality total RNA and proteins from cortical and trabecular bone	6
Analysis of the phosphoproteome of CK2 α (–/–) /Δ α′ C2C12 myoblasts compared to the wild-type cells	6
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation	6
Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation	6
Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea	6
Cellular sociology regulates the hierarchical spatial patterning and organization of cells in organisms	5
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs	5
Reconstitution of an active human CENP-E motor	5
SWIP—a stabilized window for intravital imaging of the murine pancreas	5
Key thermally dimorphic fungal pathogens: shaping host immunity	5
Boundary bypass activity in theabdominal-Bregion of theDrosophilabithorax complex is position dependent and regulated	5
Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I	5
Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling	5
Fic and non-Fic AMPylases: protein AMPylation in metazoans	5
Towards understanding centriole elimination	5
Cytoplasmic mRNA recapping has limited impact on proteome complexity	5
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH	5
Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair	5
Serum amyloid P component accumulates and persists in neurones following traumatic brain injury	5
The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA	5
ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth	5
Live-cell microscopy or fluorescence anisotropy with budded baculoviruses—which way to go with measuring ligand binding to M 4 muscarinic receptors?	5
In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases	5