Open Biology

Papers
(The median citation count of Open Biology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
The role of KLF4 in human primordial germ cell development134
Microsporidian parasite impairs colony fitness in bumblebees91
PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in Drosophila melanogaster87
Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades85
Correlation between circadian and photoperiodic latitudinal clines in Drosophila littoralis71
Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut–lung axis67
Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India67
Ferroptosis in myocardial infarction: not a marker but a maker66
The metabolic control of DNA replication: mechanism and function58
Ghrelin octanoylation by ghrelinO-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling56
Exploring differential exon usage via short- and long-read RNA sequencing strategies54
Capturing crop adaptation to abiotic stress using image-based technologies53
Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective49
Limitations of sequence dissimilarity as a predictor of prokaryotic lineage48
Enzymes enabling the biosynthesis of various C 20 polyunsaturated fatty acids in a sea urchin Hemicentrotus pulcherrimus42
Mapping combinatorial expression of non-clustered protocadherins in the developing brain identifies novel PCDH19-mediated cell adhesion properties41
Into the second decade40
Structural insights into a regulatory mechanism of FIR RRM1–FUSE interaction39
Unravelling the mystery of female meiotic drive: where we are38
Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells36
A simple inland culture system provides insights into ascidian post-embryonic developmental physiology36
Multi-epitope vaccine candidates based on mycobacterial membrane protein large (MmpL) proteins against Mycobacterium ulcerans34
Novel in vivo TDP-43 stress reporter models to accelerate drug development in ALS34
MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex34
The closest lineage of Archaeplastida is revealed by phylogenomics analyses that include Microheliella maris34
Methods to study folding of alpha-helical membrane proteins in lipids34
Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer34
Decoding life's inner workings: advances in quantitative bioimaging33
Optogenetically engineered calcium oscillations promote autophagy-mediated cell death via AMPK activation32
Recent progress in dendritic pruning of Drosophila C4da sensory neurons31
Pseudogenization of NK3 homeobox 2 ( Nkx3.2 ) in monotremes provides insight into unique gastric anatomy and physiology31
Kinetoplastid kinetochore proteins KKT14–KKT15 are divergent Bub1/BubR1–Bub3 proteins31
The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer’s disease31
Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer30
ANGPTL8 in metabolic homeostasis: more friend than foe?30
Visualization of sympathetic neural innervation in human white adipose tissue30
A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis29
High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan29
Lysosomal positioning diseases: beyond substrate storage28
Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours28
Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis28
Comparative analysis of stalked and acorn barnacle adhesive proteomes27
POU-M2 promotes juvenile hormone biosynthesis by directly activating the transcription of juvenile hormone synthetic enzyme genes in Bombyx mori27
IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG26
Comparative transcriptome analysis and CRISPR/Cas9 gene editing reveal that E4BP4 mediates lithium upregulation of Per2 expression26
Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development25
A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans25
RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication24
Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins24
Opening and changing: mammalian SWI/SNF complexes in organ development and carcinogenesis24
The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle24
Reconstitution of an active human CENP-E motor21
On the origin of TSAR: morphology, diversity and phylogeny of Telonemia21
Daughter centrioles assemble preferentially towards the nuclear envelope in Drosophila syncytial embryos21
Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations21
Differential gene expression underpinning the production of distinct sperm morphs in the wax moth Galleria mellonella21
Pruning deficits of the developing Drosophila mushroom body result in mild impairment in associative odour learning and cause hyperactivity20
Spatial positioning of preimplantation mouse embryo cells is regulated by mTORC1 and m 7 G-cap-dependent translation at the 8- to 16-cell transition20
Structure and molecular basis of spermatid elongation in theDrosophilatestis20
Correction to: ‘The functional diversity of the POUV-class proteins across vertebrates’ (2022) by Bakhmet and Tomilin19
Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-619
Mitochondrial biology and dysfunction in secondary mitochondrial disease19
Complex regulatory role of DNA methylation in caste- and age-specific expression of a termite19
Cell quiescence in planarian stem cells, interplay between p53 and nutritional stimuli19
Identification of novel microtubule inhibitors effective in fission yeast and human cells and their effects on breast cancer cell lines18
Polo-like kinase and Aurora B kinase phosphorylate and cooperate with the CIF1-CIF2 complex to promote cytokinesis initiation in Trypanosoma brucei18
A large panel of chicken cells are invaded in vivo by Salmonella Typhimurium even when depleted of all known invasion factors18
Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod18
The role of cilia during organogenesis in zebrafish18
The small compound Icerguastat reduces muscle defects in oculopharyngeal muscular dystrophy through the PERK pathway of the unfolded protein response18
Differential modulation of innate immune response by lipopolysaccharide of Leptospira18
Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress17
Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates17
Retraction: ‘HOXD-AS1 confers cisplatin resistance in gastric cancer through epigenetically silencing PDCD4 via recruiting EZH2’ (2019), by Ye et al.17
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis17
Cosegregation of asymmetric features during cell division17
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 116
Centromere function in asymmetric cell division in Drosophila female and male germline stem cells16
Structural and functional insights into the C-terminal signal domain of the Bacteroidetes type-IX secretion system16
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains16
Development and repair of blood vessels in the zebrafish spinal cord16
Killing the competition: a theoretical framework for liver-stage malaria15
Head transcriptome profiling of glossiphoniid leech ( Helobdella austinensis ) reveals clues about proboscis development15
Genomic mining and diversity of assembly line polyketide synthases15
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders15
The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis14
MYH7 R453C induced cardiac remodelling via activating TGF-β/Smad2/3, ERK1/2 and Nox4/ROS/NF-κB signalling pathways14
Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms14
Comparative mitogenomic analysis and phylogeny of Veneridae with doubly uniparental inheritance14
Higher-order organization of biomolecular condensates14
Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin13
TSPO: an emerging role in appetite for a therapeutically promising biomarker13
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo13
7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate13
Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo13
Haem-responsive gene transporter enables mobilization of host haem in ticks13
Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin13
Fic and non-Fic AMPylases: protein AMPylation in metazoans13
Reviewers in 202113
The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation13
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system12
Rapid Raman spectroscopy-based test for antimicrobial resistance12
Nucleolar origins: challenging perspectives on evolution and function12
MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development12
The signalling lipid PI3,5P 2 is essential for timely mitotic exit12
Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins12
Immune competence and spleen size scale with colony status in the naked mole-rat12
A high-throughput protein tagging toolkit that retains endogenous untranslated regions for studying gene regulation in kinetoplastids12
ATP-dependent polymerization dynamics of bacterial actin proteins involved in Spiroplasma swimming11
Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus11
Notch signalling in healthy and diseased vasculature11
SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation11
Complement receptor 3-dependent engagement by Candida glabrata β-glucan modulates dendritic cells to induce regulatory T-cell expansion11
The Aurora B-controlled PP1/RepoMan complex determines the spatial and temporal distribution of mitotic H2B S6 phosphorylation11
Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi11
A model of metformin mitochondrial metabolism in metachromatic leukodystrophy: first description of human Schwann cells transfected with CRISPR-Cas911
A mitochondrion-free eukaryote contains proteins capable of import into an exogenous mitochondrion-related organelle11
Risk factors for severe COVID-19 disease increase SARS-CoV-2 infectivity of endothelial cells and pericytes11
Essential roles of the nucleolus during early embryonic development: a regulatory hub for chromatin organization11
Evolution and assembly of Anopheles aquasalis 's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands10
Phosphorylation of ‘SDT-like’ motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression10
NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors10
Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish10
Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration10
Migration and differentiation of muscle stem cells are coupled by RhoA signalling during regeneration10
A feather star is born: embryonic development and nervous system organization in the crinoid Antedon mediterranea10
Proposed three-phenylalanine motif involved in magnetoreception signalling of an Actinopterygii protein expressed in mammalian cells10
Serum amyloid P component accumulates and persists in neurones following traumatic brain injury10
Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes?9
Iron-sulfur flavoenzymes: the added value of making the most ancient redox cofactors and the versatile flavins work together9
Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology9
The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model9
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-29
Automated optimization of the solubility of a hyper-stable α-amylase9
Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants9
Min oscillations in bacteria as real-time reporter of environmental challenges at the single-cell level9
Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA9
SID-2 is a conserved extracellular vesicle protein that is not associated with environmental RNAi in parasitic nematodes9
Transiently restricting individual amino acids protects Drosophila melanogaster against multiple stressors9
2024: The quest continues9
Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty9
Spatial activation of ezrin by epidermal growth factor receptor and focal adhesion kinase co-ordinates epithelial cell migration9
A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks9
Single-cell expression predicts neuron-specific protein homeostasis networks9
Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species9
Significance of quantitative analyses of the impact of heterogeneity in mitochondrial content and shape on cell differentiation9
Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer8
Identification and characterization of host miRNAs that target the mouse mammary tumour virus (MMTV) genome8
PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties8
Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells8
Discovery and functional analysis of a novel ALPK1 variant in ROSAH syndrome8
The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA8
Myelin sheath and cyanobacterial thylakoids as concentric multilamellar structures with similar bioenergetic properties8
MYC regulates metabolism through vesicular transfer of glycolytic kinases8
Hoxa9 / meis1 -transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance8
Distribution and regulatory roles of oxidized 5-methylcytosines in DNA and RNA of the basidiomycete fungi Laccaria bicolor and Coprinopsis cinerea8
Pericentric major satellite transcription is essential for meiotic chromosome stability and spindle pole organization8
Time-optimized feeding is beneficial without enforced fasting8
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs8
Every good biologist deserves favour8
Plum modulates Myoglianin and regulates synaptic function in D. melanogaster8
Expression and function of PDGF-C in development and stem cells8
Aspirin and cancer: biological mechanisms and clinical outcomes8
Expression of concern: ‘Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9-5p/PPARA expression’ (2019), by Cai K et al.7
Footprints in the Sno: investigating the cellular and molecular mechanisms of SNORD1167
Retraction: ‘TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin’ (2016), by Wang et al.7
Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A7
Pathways shaping the mitochondrial inner membrane7
Sperm-borne mRNAs: potential roles in zygote genome activation and epigenetic inheritance7
F.A.C.E.: Friendly And Considerate Editors7
Retraction: ‘Long non-coding RNA LINC00346 contributes to cisplatin resistance in nasopharyngeal carcinoma by repressing miR-342-5p’ (2020), by Cui et al.7
Bacterial degrons in synthetic circuits7
Secondary cell wall patterning—connecting the dots, pits and helices7
Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy7
Retraction: ‘Involvement of miR-4262 in paclitaxel resistance through the regulation of PTEN in non-small cell lung cancer’ (2019), by Sun et al.7
Distinct molecular profile of the chick organizer as a stem zone during axial elongation7
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p277
Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease7
Expression of concern: Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial–mesenchymal transition by regulating HIF-1α via miR-1387
Cellular and molecular signatures of motherhood in the adult and ageing rat brain7
CNTN4 modulates neural elongation through interplay with APP7
The fundamental role of mitochondria–endoplasmic reticulum contacts in ageing and declining healthspan7
TRIM family proteins: roles in proteostasis and neurodegenerative diseases7
Pigment-dispersing factor is present in circadian clock neurons of pea aphids and may mediate photoperiodic signalling to insulin-producing cells7
AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration7
RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts7
Retraction: ‘Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138’7
RNA splicing: a split consensus reveals two major 5′ splice site classes6
Thermal measurements support a role of the ABA/LANCL1−2 hormone/receptors system in thermogenesis6
Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways6
Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes6
In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases6
Kre28–Spc105 interaction is essential for Spc105 loading at the kinetochore6
Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation6
Trace elements increase replicability of microbial growth6
Phytochemical S -methyl- L -cysteine sulfoxide from Brassicaceae: a key to health or a poison for bees?6
The role of α-sheet structure in amyloidogenesis: characterization and implications6
Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons6
Correction to ‘Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define the growth physiology’6
Bdellovibrio bacteriovorus phosphoglucose isomerase structures reveal novel rigidity in the active site of a selected subset of enzymes upon substrate binding6
Brain and testis: more alike than previously thought?6
Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism6
Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation6
A myzozoan-specific protein is an essential membrane-anchoring component of the succinate dehydrogenase complex in Toxoplasma parasites6
Unravelling nicotinic receptor and ligand features underlying neonicotinoid knockdown actions on the malaria vector mosquito Anopheles gambiae6
Phytophthora capsici sterol reductase PcDHCR7 has a role in mycelium development and pathogenicity6
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)5
Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling5
Correction to ‘Exaggerated trans-membrane charge of ammonium transporters in nutrient-poor marine environments’ (2022) by Kellom et al .5
Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg215
Greatwall-Endos-PP2A/B55 Twins network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo 5
The C-terminus of CFAP410 forms a tetrameric helical bundle that is essential for its localization to the basal body5
Phylogenomic diversity of archigregarine apicomplexans5
Regulation of the heterochromatin spreading reaction by trans- acting factors5
Lyme disease transmission by severely impaired ticks5
Mutant SPART causes defects in mitochondrial protein import and bioenergetics reversed by Coenzyme Q5
Microanatomical and secretory characterization of the salivary gland of the Rhodnius prolixus (Hemiptera, Reduviidae, Triatominae), a main vector of Chagas disease5
Prebiotic chemistry: a review of nucleoside phosphorylation and polymerization5
Exploring the therapeutic potential of forkhead box O for outfoxing COVID-195
Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation5
Modern and prebiotic amino acids support distinct structural profiles in proteins5
Au naturale: use of biologically derived cyclic di-nucleotides for cancer immunotherapy5
Genome editing in East African cichlids and tilapias: state-of-the-art and future directions5
Ageing genetic signature of hypersomatotropism5
Cell cycle visualization tools to study cardiomyocyte proliferation in real-time5
Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response5
Mapping molecular complexes with super-resolution microscopy and single-particle analysis5
Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula5
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH5
A pro-BMP function exerted by Rhodnius prolixus short gastrulation reveals great diversity in the role of BMP modulators during embryonic patterning5
Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer5
High-throughput functional analysis provides novel insight into type VII secretion in Staphylococcus aureus5
Revisiting the origin of interleukin 1 in anamniotes and sub-functionalization of interleukin 1 in amniotes5
Ultrastructural features of psychological stress resilience in the brain: a microglial perspective5
A comparative analysis of parechovirus protein structures with other picornaviruses5
Primary cilia and lipid raft dynamics5
AMPK phosphorylates NAMPT to regulate NAD + homeostasis under ionizing radiation5
tRNA copy number and codon usage in the sea cucumber genome provide insights into adaptive translation for saponin biosynthesis5
The post-translational modification O-GlcNAc is a sensor and regulator of metabolism5
Implication of synaptotagmins 4 and 7 in activity-dependent somatodendritic dopamine release in the ventral midbrain5
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells4
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics4
The intrinsically disorderly story of Ki-674
Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons4
Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation4
Parallel evolution of trehalose production machinery in anhydrobiotic animals via recurrent gene loss and horizontal transfer4
Cell wall deficiency as an escape mechanism from phage infection4
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections4
Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching between biomolecular condensates and polymers4
Developing and maintaining a nose-to-brain map of odorant identity4
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