OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	173
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	121
A novel method of fabricating dynamic, heterogenous benchtop lateral and third ventricle phantoms from MRI of hydrocephalus patients: a verification and validation study	101
Modeling neurovascular dysfunction in Alzheimer’s disease using an isogenic brain-chip model	85
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	76
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	71
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	66
Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain	64
Bridging regional neurovascular unit heterogeneity and cognitive function: a review	62
Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus	58
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	56
Translational biomarkers of hypoxic brain injury uncovered in CSF secreting human choroid plexus organoids	55
Effect of intracerebral infusion rate on optic nerve tissue pressure and diurnal intracranial pressure in rats	49
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	47
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	46
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus	46
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	45
Natural killer cells and regulatory T cells in aneurysmal subarachnoid hemorrhage in peripheral blood and cerebrospinal fluid - a pilot study	45
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	42
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	41
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	40
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	39
CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery	38
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	38
Bi-component modeling of cerebrospinal fluid outflow using Time-SLIP MRI	37

BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	36
Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review	36
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	35
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	34
Early-onset ventriculomegaly and neuroimmune alterations in Hoatz-deficient mice	34
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	34
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	33
Endothelial cells temporally orchestrate lymphocyte dynamics and functional outcomes after ischemic stroke	33
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	32
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	32
Neutrophil extracellular traps aggravate blood-brain barrier disruption via ZBP1/FSP1-mediated ferroptosis after traumatic brain injury	31
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	31
Convergent blood–brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models	31
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	30
Ischemic stroke: molecular mechanisms of blood-brain barrier dysfunction and opportunities for drug development	29
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep	29
Evidence for reduced choroid plexus volume in the aged brain	29
Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles	28
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	28
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	27
Post-hemorrhagic hydrocephalus of prematurity is associated with disruption of tight junctions and increased macrophage activity in the choroid plexus	27
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	27
Occludin: a gatekeeper of brain Infection by HIV-1	26
The relationship between CSF/serum immunoglobulin and albumin ratio across laboratories: a retrospective, multi-center study	26
MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice	26
Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging	26
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	26
Evaluation of shunt valve flow dynamics in series	26
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	26
Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer’s disease transgenic and wildtype rats	26
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus	25
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy	25
Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus	24
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	24
Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models	24
Circadian timing of the dystrophin associated complex across the brain and body	23
Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow	22
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain	22
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection	22
Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies	22
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"	22
Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model	22
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	22
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans	22
The choroid plexus and its role in the pathogenesis of neurological infections	22
Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults	22
Novel localization of folate transport systems in the murine central nervous system	21
The impact of chronic and acute sleep deprivation on key Alzheimer’s disease biomarkers: a systematic review and meta-analysis	21
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus	21
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody	20

Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17	20
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus	20
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	20
Relevance of choroid plexus volumes in multiple sclerosis	20
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line	19
Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus	19
Navigating the blood–brain barrier to blood–brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading	19
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain	19
A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension	18
Perivascular spaces balance vascular dimensions without impairing brain clearance mechanisms	18
Transport pathways across the blood-brain barrier for waste clearance and drug delivery	18
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	18
Estimation of human brain fluid clearance using intrathecal imaging contrast agents	18
Glucocorticoids modify intracranial pressure in freely moving rats	18
Cerebrovascular claudin-5 isoform expression correlates with worsened stroke outcomes following thromboembolic stroke	18
Acute amyloid-β exposure disrupts insulin signaling in hCMEC/D3 blood–brain barrier endothelial cells	18
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	18
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	18
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	17
Evaluating the additive properties of differential pressure valves in a novel benchtop shunt model	17
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	17
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	17
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	17
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	17
Eppur si muove: the dynamic brain pericyte	17
Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus	16
Role of cerebroventricular size and surgical placement in modulating catheter flow distribution	16
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	16
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration	16
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	16
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	16
Estimation of metabolic water production in human and rat brain and spinal cord	16
Functions of the basal lamina and ApoE in cerebral amyloid angiopathy	16
Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption	15
Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis	15
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	15
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	15
Blinded gait assessment in idiopathic normal pressure hydrocephalus: reliability and correlation with clinical and patient-reported outcomes	15
Consequences of irradiation on blood-brain tumor barrier model of Diffuse Midline Glioma: characterization of physical and metabolic properties	15
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	15
Mucopolysaccharidoses and the blood–brain barrier	15
VHHs as tools for therapeutic protein delivery to the central nervous system	15
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	15
Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI	15
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	15
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	15
Brain fluid physiology in ischaemic stroke; more than just oedema	15
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	15