OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Bridging regional neurovascular unit heterogeneity and cognitive function: a review	245
Modeling neurovascular dysfunction in Alzheimer’s disease using an isogenic brain-chip model	141
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	111
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	93
Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain	73
A novel method of fabricating dynamic, heterogenous benchtop lateral and third ventricle phantoms from MRI of hydrocephalus patients: a verification and validation study	65
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	65
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	62
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	62
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	59
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus	57
Effect of intracerebral infusion rate on optic nerve tissue pressure and diurnal intracranial pressure in rats	54
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	53
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	49
CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery	45
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	44
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	44
Bi-component modeling of cerebrospinal fluid outflow using Time-SLIP MRI	44
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	43
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	43
Translational biomarkers of hypoxic brain injury uncovered in CSF secreting human choroid plexus organoids	40
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	39
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	38
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study	37
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	37

A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	37
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	36
Evidence for reduced choroid plexus volume in the aged brain	35
Early-onset ventriculomegaly and neuroimmune alterations in Hoatz-deficient mice	35
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	35
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	35
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	34
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	34
Endothelial cells temporally orchestrate lymphocyte dynamics and functional outcomes after ischemic stroke	33
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	32
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	32
Neutrophil extracellular traps aggravate blood-brain barrier disruption via ZBP1/FSP1-mediated ferroptosis after traumatic brain injury	30
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	29
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	28
Post-hemorrhagic hydrocephalus of prematurity is associated with disruption of tight junctions and increased macrophage activity in the choroid plexus	28
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	28
Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles	28
The relationship between CSF/serum immunoglobulin and albumin ratio across laboratories: a retrospective, multi-center study	27
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	27
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep	27
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	27
Occludin: a gatekeeper of brain Infection by HIV-1	27
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	27
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	27
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	26
Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging	26
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders	26
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"	25
Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults	25
MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice	25
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy	24
Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method	24
Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow	24
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans	24
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	24
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain	24
Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus	24
The impact of chronic and acute sleep deprivation on key Alzheimer’s disease biomarkers: a systematic review and meta-analysis	24
Evaluation of shunt valve flow dynamics in series	23
Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies	23
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection	22
The choroid plexus and its role in the pathogenesis of neurological infections	22
Circadian timing of the dystrophin associated complex across the brain and body	22
Novel localization of folate transport systems in the murine central nervous system	22
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	22
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus	22
Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models	22
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain	21
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	21
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	21

Navigating the blood–brain barrier to blood–brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading	21
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody	20
Relevance of choroid plexus volumes in multiple sclerosis	20
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus	20
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus	20
A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice	20
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line	20
Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus	19
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	19
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	19
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	19
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17	19
Glucocorticoids modify intracranial pressure in freely moving rats	19
Perivascular spaces balance vascular dimensions without impairing brain clearance mechanisms	18
A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension	18
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	18
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	18
Cerebrovascular claudin-5 isoform expression correlates with worsened stroke outcomes following thromboembolic stroke	17
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	17
Evaluating the additive properties of differential pressure valves in a novel benchtop shunt model	17
VHHs as tools for therapeutic protein delivery to the central nervous system	17
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	17
Eppur si muove: the dynamic brain pericyte	17
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	17
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	17
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	17
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	17
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration	17
Role of cerebroventricular size and surgical placement in modulating catheter flow distribution	17
Brain fluid physiology in ischaemic stroke; more than just oedema	16
Estimation of metabolic water production in human and rat brain and spinal cord	16
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	16
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	16
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	16
Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus	15
Functions of the basal lamina and ApoE in cerebral amyloid angiopathy	15
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	15
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	15
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model	15
Blinded gait assessment in idiopathic normal pressure hydrocephalus: reliability and correlation with clinical and patient-reported outcomes	15
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	15
Mucopolysaccharidoses and the blood–brain barrier	15
Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis	15
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	15
Consequences of irradiation on blood-brain tumor barrier model of Diffuse Midline Glioma: characterization of physical and metabolic properties	14
Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI	14
Correction: Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid	14
Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice	14
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	14
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve	14
Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption	14
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	14
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	14
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)	14