OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	154
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo	144
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	84
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	74
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	71
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	62
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	61
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	61
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage	56
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	56
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	50
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	49
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	48
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	46
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	41
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	41
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	40
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	36
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	36
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	34
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	34
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	34
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	33
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus	33
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	32

Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	31
Active CNS delivery of oxycodone in healthy and endotoxemic pigs	30
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	30
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	30
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	30
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	28
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	28
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	28
Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders	28
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	28
C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury	28
Occludin: a gatekeeper of brain Infection by HIV-1	27
Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging	27
Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"	26
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	26
Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults	26
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	26
Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus	26
Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus	24
Intracranial pressure following surgery of an unruptured intracranial aneurysm—a model for normal intracranial pressure in humans	24
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy	23
ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain	22
The choroid plexus and its role in the pathogenesis of neurological infections	22
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	22
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays	21
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	21
Novel localization of folate transport systems in the murine central nervous system	21
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	21
Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method	21
Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody	20
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus	20
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	20
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17	20
Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline	20
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size	20
A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice	20
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	20
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	19
Hydraulic resistance of three-dimensional pial perivascular spaces in the brain	19
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line	18
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	18
Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus	18
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	18
Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders	18
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	18
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	17
Glucocorticoids modify intracranial pressure in freely moving rats	17
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	17
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	17
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	17

Research priorities for non-invasive therapies to improve hydrocephalus outcomes	16
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	16
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	16
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	16
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	16
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines	16
Mucopolysaccharidoses and the blood–brain barrier	15
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	15
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning	15
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	15
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	15
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	15
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	15
VHHs as tools for therapeutic protein delivery to the central nervous system	14
Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice	14
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	14
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration	14
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	14
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve	14
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	14
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model	14
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	14
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	13
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging	13
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus	13
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	13
The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus	13
Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis	13
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)	13
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	13
Significant individual variation in cardiac-cycle-linked cerebrospinal fluid production following subarachnoid hemorrhage	13
Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage	13
Immunohistochemical visualization of lymphatic vessels in human dura mater: methodological perspectives	13