OOIR: Observatory of International Research

Papers

(The TQCC of Fluids and Barriers of the Cns is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity	797
The glymphatic hypothesis: the theory and the evidence	119
Extracellular vesicles through the blood–brain barrier: a review	89
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited	63
The regulatory roles of motile cilia in CSF circulation and hydrocephalus	58
Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion	56
SARS-CoV-2: is there neuroinvasion?	49
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	47
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease	46
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size	38
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip	38
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases	37
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging	37
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review	37
The choroid plexus and its role in the pathogenesis of neurological infections	36
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	36
The CLDN5 gene at the blood-brain barrier in health and disease	32
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays	31
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1	31
Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia	30
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	30
Expression and functions of adenylyl cyclases in the CNS	29
Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas	28
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro	27
Epigenetics in blood–brain barrier disruption	26

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model	26
The relationship between cerebral blood flow and venous sinus pressure: can hyperemia induce idiopathic intracranial hypertension?	26
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure	25
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	25
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	24
Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema	23
CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis	23
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters	23
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies	22
Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice	22
Brain endothelial LRP1 maintains blood–brain barrier integrity	22
Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model	21
Experimental approaches for manipulating choroid plexus epithelial cells	21
Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism	20
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	20
Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers	19
Ultrasound-mediated blood–brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer’s disease	19
Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders	19
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology	19
Sex difference in cerebrospinal fluid/blood albumin quotients in patients with schizophreniform and affective psychosis	19
The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis	18
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging	18
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping	18
In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces	18
The impact of genetic manipulation of laminin and integrins at the blood–brain barrier	17
Role of aging in Blood–Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19	17
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	17
Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models	17
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using smal	17
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	17
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	16
Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice	16
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels	16
Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury	16
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo	16
Quantitative analysis of macroscopic solute transport in the murine brain	16
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter	16
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics	16
Upright versus supine MRI: effects of body position on craniocervical CSF flow	15
Activation of NMDA receptors in brain endothelial cells increases transcellular permeability	15
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation	15
Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus	15
Structural disruption of the blood–brain barrier in repetitive primary blast injury	15
VHHs as tools for therapeutic protein delivery to the central nervous system	15
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	15
Novel localization of folate transport systems in the murine central nervous system	15
Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation	15
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses	15
Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury	14
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	14

Cerebrospinal fluid biomarkers of neuroinflammation in children with hydrocephalus and shunt malfunction	14
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid	14
Variations in the cerebrospinal fluid dynamics of the American alligator (Alligator mississippiensis)	14
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	14
Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils	13
Microdialysis and microperfusion electrodes in neurologic disease monitoring	13
In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and 4D flow MRI	12
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	12
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	12
Breaking barriers: exploring mechanisms behind opening the blood–brain barrier	12
Effects of fasudil on blood–brain barrier integrity	12
Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS	12
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein	12
A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments	12
Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age	12
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning	12
SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity	12
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	12