Fluids and Barriers of the Cns

Article	Citations
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity	578
Choroid plexus and the blood–cerebrospinal fluid barrier in disease	146
The glymphatic hypothesis: the theory and the evidence	96
Recent advances in human iPSC-derived models of the blood–brain barrier	81
Measuring intracranial pressure by invasive, less invasive or non-invasive means: limitations and avenues for improvement	79
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human	79
Commentary on human pluripotent stem cell-based blood–brain barrier models	71
Extracellular vesicles through the blood–brain barrier: a review	60
Review: pathophysiology of intracranial hypertension and noninvasive intracranial pressure monitoring	59
Intracranial pressure elevation alters CSF clearance pathways	50
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited	50
The regulatory roles of motile cilia in CSF circulation and hydrocephalus	50
Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion	44
SARS-CoV-2: is there neuroinvasion?	43
Functional hyperemia drives fluid exchange in the paravascular space	43
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease	41
Modeling blood–brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms	38
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	38
Identification and in vivo characterization of a brain-penetrating nanobody	36
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model	33
Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells	32
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging	32
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size	32
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip	31
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases	31

Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance	28
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	28
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review	28
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro	26
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1	25
Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure	25
Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas	24
The relationship between cerebral blood flow and venous sinus pressure: can hyperemia induce idiopathic intracranial hypertension?	24
Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia	24
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays	24
Epigenetics in blood–brain barrier disruption	23
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders	23
Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states	22
The CLDN5 gene at the blood-brain barrier in health and disease	21
The choroid plexus and its role in the pathogenesis of neurological infections	20
LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose	19
Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling	19
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model	19
Expression and functions of adenylyl cyclases in the CNS	19
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure	19
Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders	19
Preterm intraventricular hemorrhage in vitro: modeling the cytopathology of the ventricular zone	18
Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells	18
Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema	18
A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood–brain barrier models for drug transport studies	18
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients	18
Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model	18
The potential role of microvascular pathology in the neurological manifestations of coronavirus infection	18
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters	18
CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis	17
Sex difference in cerebrospinal fluid/blood albumin quotients in patients with schizophreniform and affective psychosis	17
Experimental approaches for manipulating choroid plexus epithelial cells	17
Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells	17
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	17
Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse	17
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	17
Brain endothelial LRP1 maintains blood–brain barrier integrity	16
The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)	16
Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders	16
Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice	16
Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism	16
Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury	15
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging	15
Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus	15
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter	15
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics	15
Quantitative analysis of macroscopic solute transport in the murine brain	15
In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces	15
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	14
Variations in the cerebrospinal fluid dynamics of the American alligator (Alligator mississippiensis)	14

Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies	13
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults	13
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping	13
Structural disruption of the blood–brain barrier in repetitive primary blast injury	13
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses	13
Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus	13
Cerebrospinal fluid biomarkers of neuroinflammation in children with hydrocephalus and shunt malfunction	13
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo	13
Upright versus supine MRI: effects of body position on craniocervical CSF flow	13
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology	13
The incidence of obesity, venous sinus stenosis and cerebral hyperaemia in children referred for MRI to rule out idiopathic intracranial hypertension at a tertiary referral hospital: a 10 year review	13
Characterization of a multicenter pediatric-hydrocephalus shunt biobank	12
The impact of genetic manipulation of laminin and integrins at the blood–brain barrier	12
Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice	12
Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers	12
Advancing brain barriers RNA sequencing: guidelines from experimental design to publication	12
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	12
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers	12
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using smal	12
Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils	11
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein	11
The incidence of significant venous sinus stenosis and cerebral hyperemia in childhood hydrocephalus: prognostic value with regards to differentiating active from compensated disease	11
Microdialysis and microperfusion electrodes in neurologic disease monitoring	11
Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels	11
In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and 4D flow MRI	11
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	11
Novel localization of folate transport systems in the murine central nervous system	11
Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury	11
Role of aging in Blood–Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19	11
Comparative investigation of different telemetric methods for measuring intracranial pressure: a prospective pilot study	10
Altered brain fluid management in a rat model of arterial hypertension	10
A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus	10
Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS	10
Angiomodulin (IGFBP7) is a cerebral specific angiocrine factor, but is probably not a blood–brain barrier inducer	10
Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus	10
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors	10
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation	10
VHHs as tools for therapeutic protein delivery to the central nervous system	10
SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity	10
Chronic extradural compression of spinal cord leads to syringomyelia in rat model	10
Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells	10
Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models	10
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning	10
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid	10
Location matters: highly divergent protein levels in samples from different CNS compartments in a clinical trial of rituximab for progressive MS	10
Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline	10
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus	9
Differential proteomic profile of lumbar and ventricular cerebrospinal fluid	9
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood–brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis	9
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	9
A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption	9
Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs	9
Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review	8
Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies	8
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	8
The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure	8
A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments	8
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	8
Quantification of arterial, venous, and cerebrospinal fluid flow dynamics by magnetic resonance imaging under simulated micro-gravity conditions: a prospective cohort study	8
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	8
Intracranial pressure waveform characteristics in idiopathic normal pressure hydrocephalus and late-onset idiopathic aqueductal stenosis	8
Vascular network expansion, integrity of blood–brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat	8
Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells	8
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown	8
Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation	7
Exploring ITM2A as a new potential target for brain delivery	7
Ultrasound-mediated blood–brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer’s disease	7
Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure	7
The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption	7
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	7
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone	7
Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus	7
Blood and cerebrospinal fluid flow oscillations measured with real-time phase-contrast MRI: breathing mode matters	7
Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro	7
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	7
Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier	7
Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit	7
Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model	7
The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis	7
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport	7

Activation of NMDA receptors in brain endothelial cells increases transcellular permeability	7
The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients	6
Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production	6
Microglia activated by microbial neuraminidase contributes to ependymal cell death	6
Effects of fasudil on blood–brain barrier integrity	6
Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial	6
Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy	6
Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery	6
k-Shape clustering for extracting macro-patterns in intracranial pressure signals	6
Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age	6
Mucopolysaccharidoses and the blood–brain barrier	6
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B	6
Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case–control comparison with family members	6
Biochemical profile of human infant cerebrospinal fluid in intraventricular hemorrhage and post-hemorrhagic hydrocephalus of prematurity	6
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	6
Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia	6
Compressed-sensing accelerated 4D flow MRI of cerebrospinal fluid dynamics	6
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	6