Fluids and Barriers of the Cns

Article	Citations
Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity	149
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model	132
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI	78
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown	74
Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1	70
Retirement of Dr. Hazel Jones as Co-Editor-in-Chief of Fluids and Barriers of the CNS. Dr. Mark Hamilton becomes Co-Editor-in-Chief	60
Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders	59
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies	57
Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis	56
Blood-spinal cord barrier disruption in degenerative cervical myelopathy	53
CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension	50
Exploring ITM2A as a new potential target for brain delivery	49
Expression and functions of adenylyl cyclases in the CNS	48
Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model	47
The influence of upright posture on craniospinal, arteriovenous, and abdominal pressures in a chronic ovine in-vivo trial	44
The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure	44
Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow	40
A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease	39
Physical exercise and goal attainment after shunt surgery in idiopathic normal pressure hydrocephalus: a randomised clinical trial	37
Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B	37
Lumped parameter simulations of cervical lymphatic vessels: dynamics of murine cerebrospinal fluid efflux from the skull	35
Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus	33
Modeling cerebrospinal fluid dynamics across the entire intracranial space through integration of four-dimensional flow and intravoxel incoherent motion magnetic resonance imaging	33
White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery	31
Characterization of passive permeability after low intensity focused ultrasound mediated blood–brain barrier disruption in a preclinical model	30

A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer	30
Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance	30
Choroid plexus aging: structural and vascular insights from the HCP-aging dataset	29
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution	29
Brain barriers virtual: an interim solution or future opportunity?	29
Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis	28
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells	28
Methodological and analytical considerations for intra-operative microdialysis	28
A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia?	28
Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus	27
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains	27
Response to Commentary on “Structural characterization of SLYM – a 4th meningeal membrane” by Julie Siegenthaler and Christer Betsholtz	26
Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia	26
Glucocorticoids modify intracranial pressure in freely moving rats	26
Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid	26
Correction: Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier	25
The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study	25
Resting-state functional-MRI in iNPH: can default mode and motor networks changes improve patient selection and outcome? Preliminary report	25
The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study	24
Correction to: Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	23
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function	23
Abstracts from Hydrocephalus 2024: The 16th Meeting of the Hydrocephalus Society	23
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes	22
Blood-brain barrier disruption: a culprit of cognitive decline?	22
The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF	21
Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?	21
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	20
miRNA-ome plasma analysis unveils changes in blood–brain barrier integrity associated with acute liver failure in rats	20
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses	20
The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus	20
Ventricular volume in relation to lumbar CSF levels of amyloid-β 1–42, tau and phosphorylated tau in iNPH, is there a dilution effect?	20
The neurovascular unit in leukodystrophies: towards solving the puzzle	20
Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models	20
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease	20
Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers	19
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells	19
Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance	19
A year in review: brain barriers and brain fluids research in 2022	19
Role of aquaporin-4 polarization in extracellular solute clearance	18
Hypoxemia exerts detrimental effects on the choroid plexuses and cerebrospinal fluid system in rats	18
Abstracts from the Virtual Symposium “Signal Transduction at the Blood–Brain Barriers”	18
Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit	18
A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs	18
Gait apraxia evaluation in normal pressure hydrocephalus using inertial sensors. Clinical correlates, ventriculoperitoneal shunt outcomes, and tap-test predictive capacity	18
Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier	17
Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer’s disease identifies major pathways of dysfunction and upregulation of cytoprotective responses	17
Intercompartmental communication between the cerebrospinal and adjacent spaces during intrathecal infusions in an acute ovine in-vivo model	17
Research priorities for non-invasive therapies to improve hydrocephalus outcomes	17
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats	16
Mucopolysaccharidoses and the blood–brain barrier	16

Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform	16
The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact	16
High affinity of β-amyloid proteins to cerebral capillaries: implications in chronic lead exposure-induced neurotoxicity in rats	15
Correction to: Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	15
Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature	14
Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery	14
Evaluating the cerebrospinal fluid tap test with the Hellström iNPH scale for patients with idiopathic normal pressure hydrocephalus	14
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain	14
Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis	14
Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy	14
Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia	14
Cerebral arterial flow dynamics during systole and diastole phases in young and older healthy adults	14
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria	14
Effects of fasudil on blood–brain barrier integrity	14
Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries	13
Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath	13
Coupled pulsatile vascular and paravascular fluid dynamics in the human brain	13
Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells	13
Analysis of ischemic stroke-mediated effects on blood–brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging	13
BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI	13
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries	13
Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis	12
Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1	12
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein	12
Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord	12
Serial Tap Test of patients with idiopathic normal pressure hydrocephalus: impact on cognitive function and its meaning	12
Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines	12
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo	12
A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus	12
Response to the letter, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”	12
Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model	12
Blood–brain barrier breakdown in dementia with Lewy bodies	12
Microglia-derived CCL2 has a prime role in neocortex neuroinflammation	12
Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism	11
A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery	11
The glymphatic hypothesis: the theory and the evidence	11
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody	11
Exposure to hyperbaric O2 levels leads to blood-brain barrier breakdown in rodents	11
Brain endothelial cells as phagocytes: mechanisms and implications	11
PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier	11
Transcriptomic analysis of a 3D blood–brain barrier model exposed to disturbed fluid flow	11
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture	11
Differential proteomic profile of lumbar and ventricular cerebrospinal fluid	11
Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema	11
Choroid plexus organoids reveal mechanisms of Streptococcus suis translocation at the blood-cerebrospinal fluid barrier	11
VHHs as tools for therapeutic protein delivery to the central nervous system	11
Commentary on “Structural characterization of SLYM – a 4th meningeal membrane”	11
Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus	10
ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells	10
Elevated peripheral inflammation is associated with choroid plexus enlargement in independent sporadic amyotrophic lateral sclerosis cohorts	10
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model	10
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity	10
Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats	10
Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus	10
Impact of aging on meningeal gene expression	10
Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models	10
The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development	10
Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells	10
Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood–brain barrier	9
Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease	9
Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline	9
Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection	8
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters	8
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats	8
Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis	8
Vascular network expansion, integrity of blood–brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat	8
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al	8
Correction to: The choroid plexus: A door between the blood and the brain for tissue-type plasminogen activator	8
Role of aging in Blood–Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19	8
Influence of head-over-body and body-over-head posture on craniospinal, vascular, and abdominal pressures in an acute ovine in-vivo model	8
Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension	8
Correction: impact of sex differences on thrombin‑induced hydrocephalus and white matter injury: the role of neutrophils	8
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus	8
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension	8
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier	7
Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age	7
Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age	7
k-Shape clustering for extracting macro-patterns in intracranial pressure signals	7
Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-medi	7
Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy	7

Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice	7
Cerebrospinal fluid osmolality cannot predict development or surgical outcome of idiopathic normal pressure hydrocephalus	7
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients	7
Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases	7
Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries	7
Large-scale morphometry of the subarachnoid space of the optic nerve	7
Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics	7
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone	7
Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection	6
Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve	6
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using smal	6
Evaluating the effect of injection protocols on intrathecal solute dispersion in non-human primates: an in vitro study using a cynomolgus cerebrospinal fluid system	6
In response to Mutti et al. 2024 commentary on “Transient intracranial pressure elevations (B waves) associated with sleep apnea: the neglected role of cyclic alternating pattern”	6
Regulation of folate transport at the mouse arachnoid barrier	6
Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus	6
Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro	6
Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit	6
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu	6
Microdialysis and microperfusion electrodes in neurologic disease monitoring	6
Blood-CSF barrier clearance of ABC transporter substrates is suppressed by interleukin-6 in lupus choroid plexus spheroids	5
Sex, hormones and cerebrovascular function: from development to disorder	5
Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics	5
Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis	5
Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation	5
Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging	5
Concentration gradients of monoamines, their precursors and metabolites in serial lumbar cerebrospinal fluid of neurologically healthy patients determined with a novel LC–MS/MS technique	5
Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics	5
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	5
Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier	5
Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice	5
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia	5
Breaking barriers: exploring mechanisms behind opening the blood–brain barrier	5
Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus	5
Structural characterization of SLYM—a 4th meningeal membrane	5
The regulatory roles of motile cilia in CSF circulation and hydrocephalus	5
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome	4
The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus	4
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model	4
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter	4
Breaking boundaries: role of the brain barriers in metastatic process	4
Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis	4
Unique features of the arterial blood–brain barrier	4
Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors	4
Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-we	4
Central nervous system insulin signaling can influence the rate of insulin influx into brain	4
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells	4
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study	4
Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients	4
β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age	4
Cerebrospinal fluid dynamics and subarachnoid space occlusion following traumatic spinal cord injury in the pig: an investigation using magnetic resonance imaging	4
Abstracts from Hydrocephalus 2022: the Fourteenth Meeting of the Hydrocephalus Society	4
Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging	4
A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption	4
Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability	4
Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis	4