OOIR: Observatory of International Research

Papers

(The H4-Index of Fluids and Barriers of the Cns is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity	578
Choroid plexus and the blood–cerebrospinal fluid barrier in disease	146
The glymphatic hypothesis: the theory and the evidence	96
Recent advances in human iPSC-derived models of the blood–brain barrier	81
Measuring intracranial pressure by invasive, less invasive or non-invasive means: limitations and avenues for improvement	79
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human	79
Commentary on human pluripotent stem cell-based blood–brain barrier models	71
Extracellular vesicles through the blood–brain barrier: a review	60
Review: pathophysiology of intracranial hypertension and noninvasive intracranial pressure monitoring	59
Intracranial pressure elevation alters CSF clearance pathways	50
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited	50
The regulatory roles of motile cilia in CSF circulation and hydrocephalus	50
Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion	44
SARS-CoV-2: is there neuroinvasion?	43
Functional hyperemia drives fluid exchange in the paravascular space	43
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease	41
Modeling blood–brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms	38
The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments	38
Identification and in vivo characterization of a brain-penetrating nanobody	36
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model	33
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size	32
Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells	32
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging	32
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases	31
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip	31

Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance	28
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review	28
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review	28