Cell and Bioscience

Article	Citations
SARS-CoV-2: from its discovery to genome structure, transcription, and replication	171
Extracellular matrix: an important regulator of cell functions and skeletal muscle development	128
Structure, kinetic properties and biological function of mechanosensitive Piezo channels	122
Three-dimensional in vitro culture models in oncology research	109
BIRC3 and BIRC5: multi‐faceted inhibitors in cancer	107
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor	100
The role of lysosomes in cancer development and progression	97
Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls	93
Targeting tumor-associated macrophages for cancer treatment	89
ACE2: the molecular doorway to SARS-CoV-2	89
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases	87
Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice	85
Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect	82
The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases	78
Thymidine kinase 1 through the ages: a comprehensive review	71
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor	67
CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?	66
The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application	65
Potential roles and prognostic significance of exosomes in cancer drug resistance	59
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases	57
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner	57
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood–brain barrier destruction in Alzheimer’s disease	57
New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction	55
DNA in extracellular vesicles: from evolution to its current application in health and disease	54
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease	54

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases	52
Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity	51
Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases	49
Post-translational modifications of EZH2 in cancer	49
Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel	47
Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing	44
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy	44
Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury	44
Unfolded protein response in colorectal cancer	43
CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2	41
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities	41
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway	41
Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases	40
Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma	39
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer	38
Research models and mesenchymal/epithelial plasticity of osteosarcoma	37
Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis	37
Mechanism of mesenchymal stem cells in spinal cord injury repair through macrophage polarization	36
Multiple functions of autophagy in vascular calcification	36
Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions	34
Biological functions of m6A methyltransferases	34
Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health	34
RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma	33
Tissue-specific role and associated downstream signaling pathways of adiponectin	33
SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1	33
Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients	32
Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications	31
UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral ischemic/reperfusion insult	31
Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence	31
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination	30
The role of CPEB family proteins in the nervous system function in the norm and pathology	30
Low-dose Diosbulbin-B (DB) activates tumor-intrinsic PD-L1/NLRP3 signaling pathway mediated pyroptotic cell death to increase cisplatin-sensitivity in gastric cancer (GC)	29
SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages	29
In vivo interactome profiling by enzyme‐catalyzed proximity labeling	29
Why do poxviruses still matter?	29
Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis	29
The crucial roles of N6-methyladenosine (m6A) modification in the carcinogenesis and progression of colorectal cancer	29
The cGAS–STING pathway: more than fighting against viruses and cancer	29
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer	28
Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease	28
Turning the tide on Alzheimer’s disease: modulation of γ-secretase	28
Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment	28
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression	28
The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages	27
Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome	27
Botulinum toxin type A alleviates neuropathic pain and suppresses inflammatory cytokines release from microglia by targeting TLR2/MyD88 and SNAP23	27
ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron	27
YAP1 protects against septic liver injury via ferroptosis resistance	27
Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review	27
Long non‐coding RNA NEAT1 transported by extracellular vesicles contributes to breast cancer development by sponging microRNA-141-3p and regulating KLF12	27

Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor	26
Single‐cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between genders	26
Dapagliflozin attenuates hypoxia/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK	26
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level	26
MIR210HG promotes breast cancer progression by IGF2BP1 mediated m6A modification	26
Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors	26
Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1	25
Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression	25
Golgi-associated Rab GTPases implicated in autophagy	25
The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation	25
Autophagy deficiency in neurodevelopmental disorders	24
Neddylation regulation of mitochondrial structure and functions	24
Multiple responses contribute to the enhanced drought tolerance of the autotetraploid Ziziphus jujuba Mill. var. spinosa	24
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation	24
The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway	24
Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway	23
Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway	23
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake	23
Aging and respiratory viral infection: from acute morbidity to chronic sequelae	23
The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles	23
Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication	23
SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study	23
KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway	22
Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses	22
Bile acid-mediated signaling in cholestatic liver diseases	22
Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches	22
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation	22
The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior	22
Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication	21
Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury	21
Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors	21
The dual role of p62 in ferroptosis of glioblastoma according to p53 status	21
Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: “alliance” or “war” in intercellular signals	21
The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis	21
Emerging roles of N6-methyladenosine (m6A) modification in breast cancer	21
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy	21
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture	21
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges	21
The function of LncRNA-H19 in cardiac hypertrophy	21
Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation	20
Emerging roles of non-histone protein crotonylation in biomedicine	20
rpoS-mutation variants are selected in Pseudomonas aeruginosa biofilms under imipenem pressure	20
TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes	20
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation	20
MicroRNAs: emerging driver of cancer perineural invasion	20
Sexual dimorphism in chronic respiratory diseases	20
Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri‐mir‐375 to miR-375	20
Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma	20
FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2	20
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis	19
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment	19
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function	19
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma	19
The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons	19
STAT3 plays an important role in DNA replication by turning on WDHD1	19
Neural stemness contributes to cell tumorigenicity	19
Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices	19
The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis	19
Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis	19
Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling	19
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation	19
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression	18
Generation of macrophage containing alveolar organoids derived from human pluripotent stem cells for pulmonary fibrosis modeling and drug efficacy testing	18
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration	18
Unconventional protein post-translational modifications: the helmsmen in breast cancer	18
EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway	18
Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy	18
Liver organoids: an in vitro 3D model for liver cancer study	18
Ubiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation	18
Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells	18
The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure	18
ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12	17
Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology	17
Stress granules: functions and mechanisms in cancer	17
Genetically modified large animal models for investigating neurodegenerative diseases	17
Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells	17
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases	17
RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer	17
Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2	17
Comparative evaluation of methods for isolating small extracellular vesicles derived from pancreatic cancer cells	17

PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner	17
Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes	17
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3	17
Metabolic reprogramming in colorectal cancer: regulatory networks and therapy	17
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone	17
Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors	17
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma	16
Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy	16
Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer	16
From nasal to basal: single-cell sequencing of the bursa of Fabricius highlights the IBDV infection mechanism in chickens	16
α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox	16
A cost-effective machine learning-based method for preeclampsia risk assessment and driver genes discovery	16
The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives	16
Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms	16
Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell–cell contact to activate the Jagged1/Notch1 pathway	16
Roles of bile acids signaling in neuromodulation under physiological and pathological conditions	16
GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis	16
Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease	15
Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective	15
Neural function of Bmal1: an overview	15
Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank	15
Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail	15
Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans	15
Macrophages derived from pluripotent stem cells: prospective applications and research gaps	15
RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway	15
SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury	15
Cardiac effects and clinical applications of MG53	15
Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy	15
The crucial regulatory role of type I interferon in inflammatory diseases	14
Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease	14
EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression	14
NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix	14
Functions and mechanisms of protein disulfide isomerase family in cancer emergence	14
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis	14
A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development	14
FFAR2 antagonizes TLR2- and TLR3-induced lung cancer progression via the inhibition of AMPK-TAK1 signaling axis for the activation of NF-κB	14
Overview of the meningeal lymphatic vessels in aging and central nervous system disorders	14
Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury	14
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A	14
Comparative transcriptome analysis revealed differential gene expression in multiple signaling pathways at flowering in polyploid Brassica rapa	13
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains	13
YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development	13
BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma	13
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis	13
When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping	13
Artificial intelligence and guidance of medicine in the bubble	13
Human AZFb deletions cause distinct testicular pathologies depending on their extensions in Yq11 and the Y haplogroup: new cases and review of literature	13
The lymphatic vascular system: much more than just a sewer	13
AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology	13
Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model	12
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice	12
SEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival	12
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy	12
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes	12
Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2	12
Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis	12
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy	12
Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer	12
The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation	12
Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture	12
Alterations of RNA splicing patterns in esophagus squamous cell carcinoma	12
Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1–JNK–DRP1 pathway	12
Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study	12
Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion	12
ADAMTS-1: a novel target gene of an estrogen-induced transcription factor, EGR1, critical for embryo implantation in the mouse uterus	12
Decrease of peripheral blood mucosal‐associated invariant T cells and impaired serum Granzyme-B production in patients with gastric cancer	12
TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation	12
A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses	12
Myelin basic protein enhances axonal regeneration from neural progenitor cells	12