Cell and Bioscience

Article	Citations
Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells	247
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor	193
Modulation of foraging-like behaviors by cholesterol-FGF19 axis	174
Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities	151
RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression	90
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion	79
Integrative analysis of bulk and single-cell RNA sequencing reveals the gene expression profile and the critical signaling pathways of type II CPAM	76
Correction: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease	75
Tick-borne encephalitis affects sleep–wake behavior and locomotion in infant rats	75
Correction: The dual role of mTOR signaling in lung development and adult lung diseases	70
Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney	69
Multi-omics in thoracic aortic aneurysm: the complex road to the simplification	68
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma	66
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma	64
Brain nuclear receptors and cardiovascular function	62
Correction: RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease	61
Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells	59
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease	59
Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers	57
Comparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis	54
Sevoflurane induces developmental cardiotoxicity via AMPKα2 dysregulation in zebrafish	54
Clinical biomarkers for Lewy body diseases	51
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation	50
Retraction Note: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p	49
Brain-wide spatiotemporal mapping of glutamate/GABA dual-transmitter neurons during postnatal development in mice	49

Retraction Note: Growth inhibition and apoptosis in colorectal cancer cells induced by vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways	48
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface	47
Slit-Robo expression in the leech nervous system: insights into eyespot evolution	46
Metabolic reprogramming in colorectal cancer: regulatory networks and therapy	45
PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis	45
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma	45
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components	44
IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis	43
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders	43
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson’s disease model	42
SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo	42
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis	41
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment	41
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer	40
Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies	40
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells	40
Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder	38
Precision nephrotoxicity testing using 3D in vitro models	38
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease	37
The dual role of mTOR signaling in lung development and adult lung diseases	36
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis	35
The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue	35
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives	35
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1	35
Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer’s disease progression	34
Fibroblast-to-cardiomyocyte lactate shuttle modulates hypertensive cardiac remodelling	34
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes	34
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models	34
CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury	33
Programmed cell death in the cognitive impairment of obstructive sleep apnea	33
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow	32
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice	32
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review	32
Editorial Expression of Concern: Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway	31
Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2	31
Regulation of telomerase towards tumor therapy	31
TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation	31
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival	31
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture	30
Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain	30
Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity	30
The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis	30
Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma	30
Coffee as a dietary strategy to prevent SARS-CoV-2 infection	30
NAD+ metabolism-based immunoregulation and therapeutic potential	30
Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner	30
Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1	30
A synthetic pregnenolone analog promotes microtubule dynamics and neural development	29
Chemically defined and xeno-free media enables the derivation of human extended pluripotent stem cell lines from discarded blastocysts with a high efficiency	29
NOTCH2NLC GGC repeat expansions cause retinal neurodegeneration in neuronal intranuclear inclusion disease mouse model	29

Structural basis of human PRPS2 filaments	29
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy	29
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation	29
Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury	28
ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1	28
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis	28
Advancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander	27
Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review	27
A cost-effective machine learning-based method for preeclampsia risk assessment and driver genes discovery	27
The role of the striatin family proteins in hippo signaling and cellular regulation	27
HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription	27
Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase	27
SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair	27
Rab11a-dependent recycling of Glut3 inhibits seizure-induced neuronal disulfidptosis by alleviating glucose deficiency	27
Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice	27
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8	27
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders	26
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis	26
The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity	26
Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury	26
The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia–hypoxia leads to decreased thymic function via the HPA axis	26
Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells	26
Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats	26
Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke	25
FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis	25
V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor	25
TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor	25
ESRG maintains human pluripotent stem cell self-renewal by binding NPM1 to regulate BMP4 protein and TGF-β signaling pathway	25
AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway	24
Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex	24
Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design	24
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma	24
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy	24
T cell KAT6A deficiency relieves inflammatory bowel disease in mice	24
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A	24
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases	24
Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation	23
Macrophages derived from pluripotent stem cells: prospective applications and research gaps	23
Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis	23
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice	23
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis	23
CD24+LCN2+ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury	23
Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway	22
Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERα signaling in ER-positive breast cancer cells	22
Comparison of DNA targeting CRISPR editors in human cells	22
Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity	22
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes	22
The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms	22
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism	22
SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway	22
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance	21
TSA-PACT: a method for tissue clearing and immunofluorescence staining on zebrafish brain with improved sensitivity, specificity and stability	21
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis	21
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning	21
Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax	21
Correction: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma	21
A novel self-inhaled nicotine exposure system in murine models reveals age-dependent metabolic effects of nicotine	21
A translational perspective of the malignant hematopoietic proteoglycome	21
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression	21
Biological function of RNA-binding proteins in myocardial infarction: a potential emerging therapeutic limelight	20
The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived s	20
Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids	20
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease	20
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction	20
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions	20
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes	20
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity	20
The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer	19
Differential impact of BRAFV600E isoforms on tumorigenesis in a zebrafish model of melanoma	19
Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα	19
Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: emerging role in immune cells and immunosuppressive signaling	19
Novel roles for CREG1 in hematopoiesis revealed by single-cell RNA sequencing	19
β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions	19
Spontaneous whole genome duplication renders mouse embryonic fibroblasts resistant to reprogramming	19
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations	19
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis	19
Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis	19
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway	19
Revisiting potential value of antitumor drugs in the treatment of COVID-19	18
A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS	18

Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker	18
Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection	18
Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury	18
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population	18
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses	18
The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands	18
Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression	17
Peptides targeting RAB11A–FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals	17
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development	17
Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis	17
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy	17
Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome	17
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease	17
Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy	17
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis	17
Reproductive chemical database: a curated database of chemicals that modulate protein targets regulating important reproductive biological processes	17
Targeting epigenetic regulators to boost T cell immunotherapy against cancer	17
Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments	17
Structural properties of immune complexes formed by viral antigens and specific antibodies shape the inflammatory response of macrophages	17
Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits	17
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection	17
The impact and mechanisms of preeclampsia on offspring neurodevelopment	17
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway	16
Targeting the 5-HT1A receptor in the ventral hippocampus alleviates anxiety-like behavior in mice with angiotensin II-induced hypertension	16
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer	16
The relationship between abnormal glucose metabolism and chronic pain	16
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis	16
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy	16
From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis	16
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate	16
DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases	15
NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling	15
Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways	15
Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer’s disease	15
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas	15
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium	15
Functions and mechanisms of protein disulfide isomerase family in cancer emergence	15
Retraction Note: The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway	15
sRAGE inhibits myocardial ischemia/reperfusion injuries via regulating Treg cells	15
M2 polarization of macrophage induced by IL-33 promotes mouse sciatic nerve regeneration	15
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation	15
PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies	15
CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA	15