Cell and Bioscience

Article	Citations
Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells	243
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor	198
Modulation of foraging-like behaviors by cholesterol-FGF19 axis	190
Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities	169
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation	149
Clinical biomarkers for Lewy body diseases	122
Integrative analysis of bulk and single-cell RNA sequencing reveals the gene expression profile and the critical signaling pathways of type II CPAM	102
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion	99
Correction: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease	87
Correction: The dual role of mTOR signaling in lung development and adult lung diseases	76
Metabolic reprogramming in colorectal cancer: regulatory networks and therapy	73
Sevoflurane induces developmental cardiotoxicity via AMPKα2 dysregulation in zebrafish	73
A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma	72
Comparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis	68
Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers	67
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components	66
PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis	64
Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells	62
RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression	60
Retraction Note: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p	58
Retraction Note: Growth inhibition and apoptosis in colorectal cancer cells induced by vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction pathways	57
Tick-borne encephalitis affects sleep–wake behavior and locomotion in infant rats	56
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma	55
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface	51
Brain nuclear receptors and cardiovascular function	50

HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma	49
Multi-omics in thoracic aortic aneurysm: the complex road to the simplification	49
Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney	48
Slit-Robo expression in the leech nervous system: insights into eyespot evolution	47
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease	46
Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire	45
Correction: RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease	45
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives	44
PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders	44
The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue	44
SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo	44
RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence	43
The dual role of mTOR signaling in lung development and adult lung diseases	43
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer	42
Fibroblast-to-cardiomyocyte lactate shuttle modulates hypertensive cardiac remodelling	42
Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies	42
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson’s disease model	41
IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis	39
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis	39
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis	39
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment	39
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells	38
Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder	36
Precision nephrotoxicity testing using 3D in vitro models	36
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease	36
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1	36
Programmed cell death in the cognitive impairment of obstructive sleep apnea	35
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival	34
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow	34
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice	34
TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation	34
Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2	34
Regulation of telomerase towards tumor therapy	34
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review	33
CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury	33
Editorial Expression of Concern: Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway	32
Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma	32
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models	32
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture	31
Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer’s disease progression	31
The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis	31
NAD+ metabolism-based immunoregulation and therapeutic potential	31
Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner	31
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes	31
Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity	30
HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription	30
Rab11a-dependent recycling of Glut3 inhibits seizure-induced neuronal disulfidptosis by alleviating glucose deficiency	30
Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain	30
Coffee as a dietary strategy to prevent SARS-CoV-2 infection	30
Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1	30

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1	29
Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review	29
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation	29
NOTCH2NLC GGC repeat expansions cause retinal neurodegeneration in neuronal intranuclear inclusion disease mouse model	29
A synthetic pregnenolone analog promotes microtubule dynamics and neural development	29
Chemically defined and xeno-free media enables the derivation of human extended pluripotent stem cell lines from discarded blastocysts with a high efficiency	29
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis	29
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy	29
Structural basis of human PRPS2 filaments	29
Macrophage-derived exosomes mediate glomerular endothelial cell dysfunction in sepsis-associated acute kidney injury	28
Advancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander	28
Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase	28
A cost-effective machine learning-based method for preeclampsia risk assessment and driver genes discovery	28
V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor	28
Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice	28
The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia–hypoxia leads to decreased thymic function via the HPA axis	27
Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury	27
Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells	27
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8	27
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis	27
The role of the striatin family proteins in hippo signaling and cellular regulation	27
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders	27
Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats	26
The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity	26
Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke	26
TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor	26
SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair	26
FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis	26
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma	25
Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design	25
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A	25
Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity	25
Comparison of DNA targeting CRISPR editors in human cells	24
Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation	24
Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex	24
T cell KAT6A deficiency relieves inflammatory bowel disease in mice	24
Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans	24
The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms	24
Macrophages derived from pluripotent stem cells: prospective applications and research gaps	24
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases	24
GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes	24
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy	24
AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway	24
Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway	23
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism	23
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis	23
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice	23
Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis	23
CD24+LCN2+ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury	23
A novel self-inhaled nicotine exposure system in murine models reveals age-dependent metabolic effects of nicotine	22
TSA-PACT: a method for tissue clearing and immunofluorescence staining on zebrafish brain with improved sensitivity, specificity and stability	22
Biological function of RNA-binding proteins in myocardial infarction: a potential emerging therapeutic limelight	22
Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax	22
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes	22
A translational perspective of the malignant hematopoietic proteoglycome	22
SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway	22
Correction: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma	21
Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids	21
The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived s	21
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease	21
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression	21
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance	21
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions	21
Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα	21
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis	21
MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning	21
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction	21
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway	20
Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: emerging role in immune cells and immunosuppressive signaling	20
β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions	20
The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer	20
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity	20
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations	20
Differential impact of BRAFV600E isoforms on tumorigenesis in a zebrafish model of melanoma	20
The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context	20
Novel roles for CREG1 in hematopoiesis revealed by single-cell RNA sequencing	20
Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices	19
Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis	19
Reproductive chemical database: a curated database of chemicals that modulate protein targets regulating important reproductive biological processes	19
Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker	19

Spontaneous whole genome duplication renders mouse embryonic fibroblasts resistant to reprogramming	19
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population	19
Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis	19
Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses	19
Structural properties of immune complexes formed by viral antigens and specific antibodies shape the inflammatory response of macrophages	18
The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands	18
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis	18
A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS	18
Revisiting potential value of antitumor drugs in the treatment of COVID-19	18
Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments	18
Targeting epigenetic regulators to boost T cell immunotherapy against cancer	18
Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury	18
Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis	18
Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection	18
Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome	18
Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy	18
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection	18
Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression	17
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases	17
From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis	17
Retraction Note: The suppressing role of miR-622 in renal cell carcinoma progression by down-regulation of CCL18/MAPK signal pathway	17
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development	17
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease	17
Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits	17
Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer’s disease	17
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium	17
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation	17
The impact and mechanisms of preeclampsia on offspring neurodevelopment	17
Peptides targeting RAB11A–FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals	17
Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy	17
DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases	17
M2 polarization of macrophage induced by IL-33 promotes mouse sciatic nerve regeneration	16
Functions and mechanisms of protein disulfide isomerase family in cancer emergence	16
Golgiphagy: a novel selective autophagy to the fore	16
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate	16
PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies	16
Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways	16
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer	16
NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling	16
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake	16
Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis	16
Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas	15
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway	15
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis	15
ISL1 controls pancreatic alpha cell fate and beta cell maturation	15
Overview of the meningeal lymphatic vessels in aging and central nervous system disorders	15
The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy	15
sRAGE inhibits myocardial ischemia/reperfusion injuries via regulating Treg cells	15
The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases	15
Lack of basic rationale in epithelial-mesenchymal transition and its related concepts	15
CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA	15
The relationship between abnormal glucose metabolism and chronic pain	15
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging	15
A neonatal rat model of pulmonary vein stenosis	15