Biology of Sex Differences

Papers
(The TQCC of Biology of Sex Differences is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice86
Sex-dependent effects of a high-fat diet on the hypothalamic response in mice72
Sex and hand differences in haptic processing: implications for mental rotation ability61
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats57
Considerations and challenges for sex-aware drug repurposing56
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats56
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies42
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome40
Correction to: Consideration of sex and gender differences in addiction medication response38
The maternal reduced uteroplacental perfusion model of preeclampsia induces sexually dimorphic metabolic responses in rat offspring37
Integrated analysis of robust sex-biased gene signatures in human brain34
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases33
Higher testosterone is associated with open-angle glaucoma in women: a genetic predisposition?30
Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences30
Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)30
Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females29
Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking28
A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?28
High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study27
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats25
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking24
Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions24
Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas24
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities23
Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus23
Sex-specific association of hair cortisol concentration with stress-related psychological factors in healthy young adults22
The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies22
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition21
Sex-biased and parental allele-specific gene regulation by KDM6A21
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance20
Sex-specific differences in intestinal microbiota associated with cardiovascular diseases19
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity19
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy19
Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism19
TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia18
Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging18
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice18
Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants18
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers17
Sex-specific differences in zebrafish brains16
Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health16
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics16
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms16
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner15
The role of microRNAs in understanding sex-based differences in Alzheimer’s disease15
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review15
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin14
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats14
A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta14
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors14
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis14
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury13
Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure13
In search of sex-related mediators of affective illness13
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome12
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice12
Reconsidering tools for measuring gender dimensions in biomedical research12
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocamp12
Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia12
Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis12
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank12
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner12
Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice12
Sex differences in sucrose reinforcement in Long-Evans rats12
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance11
Correction: MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis11
Sex differences in the relationship between olfactory and cognitive impairment among subjects with subjective cognitive decline and mild cognitive impairment11
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?11
Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice11
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis11
Examining the role of social determinants of health in maternal mental health screening and treatment engagement during the perinatal period11
Sex modifies the association between urinary albumin-to-creatinine ratio and diabetes among adults in the United States (NHANES 2011–2018)10
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice10
Coronary artery calcification and aortic valve calcification in patients with kidney failure: a sex-disaggregated study10
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination10
Integrative multi-omics characterization reveals sex differences in glioblastoma10
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity10
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males10
Breast may not always be best: moderation of effects of postnatal depression by breastfeeding and infant sex10
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex10
Nk3R blockade has sex-divergent effects on memory in mice9
Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease9
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways9
Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs9
Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background9
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus9
Sex and gender correlates of sexually polymorphic cognition9
Correction: Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis9
Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans9
Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer9
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