OOIR: Observatory of International Research

Papers

(The TQCC of Biology of Sex Differences is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Impact of sex and gender on COVID-19 outcomes in Europe	761
Sex differences in pharmacokinetics predict adverse drug reactions in women	267
Sex differences in severity and mortality from COVID-19: are males more vulnerable?	182
Sex differences in cancer mechanisms	166
The impact of sex and gender on immunotherapy outcomes	108
Gender-related variables for health research	92
Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home orders	70
Fetal sex and maternal pregnancy outcomes: a systematic review and meta-analysis	69
Estrogen-related mechanisms in sex differences of hypertension and target organ damage	60
Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses	50
The role of vitamin D in autoimmune diseases: could sex make the difference?	50
Sex differences in brain atrophy in multiple sclerosis	50
Sex differences in vascular aging in response to testosterone	49
Androgens’ effects on cerebrovascular function in health and disease	47
Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone	47
Sex differences in the immune response to acute COVID-19 respiratory tract infection	44
Thyroid hormone: sex-dependent role in nervous system regulation and disease	44
Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	41
Sex differences in traumatic stress reactivity in rats with and without a history of alcohol drinking	40
Estrogen receptors in pain modulation: cellular signaling	38
Sex differences in the human metabolome	38
Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders	34
Why the estrous cycle matters for neuroscience	32
Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans	31
Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats	30

Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes	30
Reference genome and transcriptome informed by the sex chromosome complement of the sample increase ability to detect sex differences in gene expression from RNA-Seq data	28
Sex and gender considerations in reporting guidelines for health research: a systematic review	28
Sex differences associated with adverse drug reactions resulting in hospital admissions	28
Androgens and the developing hippocampus	27
Sex differences in noise-induced hearing loss: a cross-sectional study in China	26
Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history	25
Sex differences in clinical phenotype and transitions of care among individuals dying of COVID-19 in Italy	23
A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta	23
Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats	22
Sex differences in the intestinal microbiome: interactions with risk factors for atherosclerosis and cardiovascular disease	22
Sex-dependent differences in the secretome of human endothelial cells	21
Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies	21
Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization	20
Sex differences in the medial prefrontal cortical glutamate system	20
Pathophysiological effects of androgens on the female vascular system	20
Investigating transcriptome-wide sex dimorphism by multi-level analysis of single-cell RNA sequencing data in ten mouse cell types	19
Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies	19
Mechanisms of sex hormones in autoimmunity: focus on EAE	19
Sex at the interface: the origin and impact of sex differences in the developing human placenta	18
Sex differences in the aging murine urinary bladder and influence on the tumor immune microenvironment of a carcinogen-induced model of bladder cancer	17
Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants	17
Consideration of sex and gender differences in addiction medication response	17
Association of menopausal status with COVID-19 outcomes: a propensity score matching analysis	17
An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD	17
Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition	16
The roles of sex and gender in women’s eye health disparities in the United States	16
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases	15
Is sex a proxy for mechanical variables during an upper limb repetitive movement task? An investigation of the effects of sex and of anthropometric load on muscle fatigue	15
Gender score development in the Berlin Aging Study II: a retrospective approach	14
Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records	14
Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study	14
Gender differences in the efficacy of pioglitazone treatment in nonalcoholic fatty liver disease patients with abnormal glucose metabolism	14
Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones	14
Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females	13
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	13
The prognostic value of gender in gastric gastrointestinal stromal tumors: a propensity score matching analysis	13
Considering sex and gender in Epidemiology: a challenge beyond terminology. From conceptual analysis to methodological strategies	13
A community-based study of demographics, medical and psychiatric conditions, and gender dysphoria/incongruence treatment in transgender/gender diverse individuals	13
Sex differences in a cohort of COVID-19 Italian patients hospitalized during the first and second pandemic waves	12
Sex differences in circulating proteins in heart failure with preserved ejection fraction	12
Considerations and challenges for sex-aware drug repurposing	12
Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs	12
Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke	12
A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?	12
Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice	12
Gender differences in cardiometabolic health and disease in a cross-sectional observational obesity study	12
Sex differences in the association of sphingolipids with age in Dutch and South-Asian Surinamese living in Amsterdam, the Netherlands	12
Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality	11
Changes in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation	11

Sex-related differences in markers of immune activation in virologically suppressed HIV-infected patients	11
Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females	11
Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia	11
Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation	11
Unfractionated heparin displaces sFlt-1 from the placental extracellular matrix	11
Sex-dependent effects of prenatal food and protein restriction on offspring physiology in rats and mice: systematic review and meta-analyses	11
Association between fetal sex and maternal plasma microRNA responses to prenatal alcohol exposure: evidence from a birth outcome-stratified cohort	11
Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice	11
Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival	11