OOIR: Observatory of International Research

Papers

(The TQCC of Biology of Sex Differences is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	107
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	94
Correction to: Consideration of sex and gender differences in addiction medication response	75
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	72
Psychosocial and clinical characteristics in Takotsubo syndrome	69
In search of sex-related mediators of affective illness	66
Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females	48
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	46
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	46
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	45
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	37
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	36
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	36
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	35
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	34
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	34
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	34
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	33
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	30
Sex and gender correlates of sexually polymorphic cognition	30
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	29
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	28
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	28
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	27
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	26

The influence of sex on neuroimmune communication, pain, and physiology	25
Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	24
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	23
Sex differences in the human brain related to visual motion perception	22
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	22
Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease	22
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	21
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	20
Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome	20
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	20
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	20
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	20
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads	20
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	20
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	19
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	19
Sex dimorphism and tissue specificity of gene expression changes in aging mice	19
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	19
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	18
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	17
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	17
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey	17
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	16
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	16
The mixed legacy of the rat estrous cycle	16
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	16
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	16
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	15
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)	15
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	15
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	14
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	14
Sex differences in mitochondrial gene expression during viral myocarditis	14
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	14
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	14
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	14
Sex-related associations between body height and cognitive impairment among low-income elderly adults in rural China: a population-based cross-sectional study	14
Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model	14
Sex-specific association of hair cortisol concentration with stress-related psychological factors in healthy young adults	13
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	13
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	13
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	13
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	13
Nk3R blockade has sex-divergent effects on memory in mice	12
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers	12
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study	12
Sex-specific differences in zebrafish brains	12
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	12
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome	12
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	12

Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	11
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	11
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	11
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	11
Remembering the null hypothesis when searching for brain sex differences	11
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	10
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	10
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	10
Treating sex and gender differences as a continuous variable can improve precision cancer treatments	10
Electrocardiographic sex index: a continuous representation of sex	10
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	10
Sex-specific role of galectin-3 in aortic stenosis	10
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia	10
Sex-specific response to A1BG loss results in female dilated cardiomyopathy	10
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	10
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	10
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	10
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	10
Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice	10
Different mechanisms underlie compulsive alcohol self-administration in male and female rats	10
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	10
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	10
Sex differences in recovery of motor function in a rhesus monkey model of cortical injury	10
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only	10
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	10
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	10
Influences of sex and gender on the associations between risk and protective factors, brain, and behavior	10
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender	10
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns	10