Biology of Sex Differences

Article	Citations
Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin	116
Correction to: Consideration of sex and gender differences in addiction medication response	105
Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies	88
Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors	74
Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review	73
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis	69
Psychosocial and clinical characteristics in Takotsubo syndrome	56
Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics	47
Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression	46
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities	46
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice	40
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity	40
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus	38
RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance	36
Sex and gender correlates of sexually polymorphic cognition	36
The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis	35
Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice	34
Estrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice	32
Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males	32
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus	32
The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day”	32
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma	32
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas	30
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations	29
Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic	29

Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality	28
The influence of sex on neuroimmune communication, pain, and physiology	27
Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome	26
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice	25
Sex differences in the human brain related to visual motion perception	24
Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease	23
Sex and gender differences in adverse events following influenza and COVID-19 vaccination	23
Sex dimorphism and tissue specificity of gene expression changes in aging mice	22
Sex differences in song syntax and syllable diversity in testosterone-induced songs of adult male and female canaries	22
Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study	22
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring	22
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta	21
Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain	21
H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads	21
Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains	20
Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients	20
Sex differences in a mouse model of diet-induced obesity: the role of the gut microbiome	20
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort	19
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years	19
The mixed legacy of the rat estrous cycle	19
Sex-related associations between body height and cognitive impairment among low-income elderly adults in rural China: a population-based cross-sectional study	19
Sex differences in mitochondrial gene expression during viral myocarditis	18
Breast cancer: the first comparative evaluation of oncobiome composition between males and females	18
Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)	17
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015–2018 Behavioral Risk Factor Surveillance System Survey	17
Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women’s health cohort	16
Visceral adiposity index and sex differences in relation to peripheral artery disease in normal-weight adults with hypertension	16
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice	16
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring	16
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study	16
The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats	15
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain	15
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	15
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms	15
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers	15
Exclusion of women from COVID-19 studies harms women's health and slows our response to pandemics	15
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome	15
Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model	15
Sympathetic-mediated blunting of forearm vasodilation is similar between young men and women	15
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats	15
Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers	15
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure	14
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice	14
Sex-specific DNA methylation signatures of autism spectrum disorder from whole genome bisulfite sequencing of newborn blood	14
XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner	13
Sex-specific differences in zebrafish brains	13
Nk3R blockade has sex-divergent effects on memory in mice	13
Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition	13
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex	12
Appetite ratings and ghrelin concentrations in young adults after administration of a balanced meal. Does sex matter?	12

CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury	12
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination	12
Remembering the null hypothesis when searching for brain sex differences	12
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank	12
Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study	12
Different mechanisms underlie compulsive alcohol self-administration in male and female rats	11
Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review	11
Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea	11
Comparing the antidepressant-like effects of electroconvulsive seizures in adolescent and adult female rats: an intensity dose–response study	11
Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neu	11
Sex-specific response to A1BG loss results in female dilated cardiomyopathy	11
Association between serum testosterone and measures of cardiovascular health among transgender individuals using gender-affirming testosterone therapy: a cross-sectional study	11
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis	11
The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women	11
Sex-specific role of galectin-3 in aortic stenosis	11
Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study	11
Correction: Variability of temperature measurements recorded by a wearable device by biological sex	11
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease	11
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise	11
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia	10
Treating sex and gender differences as a continuous variable can improve precision cancer treatments	10
Electrocardiographic sex index: a continuous representation of sex	10
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment	10
Correction: Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats	10
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease	10
Prospective paired crossover evaluation of potential impact of investigator gender on perceived pain intensity early after acute or scheduled surgery	10
Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns	10
Sex-related differences in phenotype and nigro-striatal degeneration of c-rel-/- mouse model of Parkinson’s disease	10
Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats	10
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender	10
βeta-2 glycoprotein I is a novel regulator of Apolipoprotein E containing HDL particles in females	10
Chromosomal and gonadal sex have differing effects on social motivation in mice	10
Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats	10
Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study	10
Influences of sex and gender on the associations between risk and protective factors, brain, and behavior	10
Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress	10
Sex differences in type 2 diabetes: an opportunity for personalized medicine	10
Associations of social determinants of health on likelihood of systemic hormone therapy use in midlife women	10
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner	10
Sex differences in fetal intracranial volumes assessed by in utero MR imaging	10
Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut–microbiota composition during activity-based anorexia in mice	10
TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocamp	9
The role of microRNAs in understanding sex-based differences in Alzheimer’s disease	9
TrkB-mediated sustained neuroprotection is sex-specific and $$\text{ER}\alpha$$-dependent in adult mice following neonatal hypoxia ischemia	9
Sex modifies the association between urinary albumin-to-creatinine ratio and diabetes among adults in the United States (NHANES 2011–2018)	9
Sex differences in symptoms following the administration of BNT162b2 mRNA COVID-19 vaccine in children below 5 years of age in Germany (CoVacU5): a retrospective cohort study	9
Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review	9
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance	9
Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury	9
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity	9
Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fi	9
Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women	9
Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis	9
Sex differences in the rapid detection of neutral faces associated with emotional value	9
Sex differences in the social motivation of rats: Insights from social operant conditioning, behavioural economics, and video tracking	9
Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background	9
The role of visual experience in haptic spatial perception: evidence from early blind, late blind, and sighted individuals	9
Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia	9
Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities	9
Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang	9
Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?	8
Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function	8
A meta-analysis of sex differences in neonatal rodent ultrasonic vocalizations and the implication for the preclinical maternal immune activation model	8
Sex differences in bladder cancer: understanding biological and clinical implications	8
Sex differences in contextual pattern separation, neurogenesis, and functional connectivity within the limbic system	8
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank	8
Consideration of sex and gender differences in addiction medication response	8
Sex differences in subjective cognitive impairment and clinical correlates in Chinese patients with subthreshold depression	8
Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model	8
Immune mechanisms associated with sex-based differences in severe COVID-19 clinical outcomes	8
KDM6A facilitates Xist upregulation at the onset of X inactivation	7
Cell line-specific estrogen responses uncover functional sex differences in murine macrophages	7
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia	7
Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes	7
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses	7
Understanding sex and gender disparities in COVID-19 mortality: a narrative review beyond biology	7
Why the estrous cycle matters for neuroscience	7
MetaFun: unveiling sex-based differences in multiple transcriptomic studies through comprehensive functional meta-analysis	7
Gestational saccharin consumption disrupts gut-brain axis glucose homeostasis control in adolescent offspring rats in a sex-dependent manner	7
Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records	7

Women’s health research funding in Canada across 15 years suggests low funding levels with a narrow focus	7
Consideration of sex as a biological variable in diabetes research across twenty years	7
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments	7
Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis	7
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes	6
Three maxims for countering sex essentialism in scientific research	6
Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers	6
SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers	6
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer	6
Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position	6
Own-gender bias in facial feature recognition yields sex differences in holistic face processing	6
A call for inclusive research, policies, and leadership to close the global women’s health gap	6
Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward	6
Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex	6
Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits	6
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells	6
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases	6
Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes	6
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development	6
A cross-species analysis of neuroanatomical covariance sex differences in humans and mice	6
Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals	5
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy	5
Global sex disparities in lifetime risk of alopecia areata: a systematic analysis from the global burden of disease study, 1990 to 2021	5
Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas	5
Sex-dependent effects of a high-fat diet on the hypothalamic response in mice	5
Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions	5
A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala	5
Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex	5
Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism	5
Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health	5
Sex-based associations between neighborhood disadvantage and brain–gut alterations in individuals with irritable bowel syndrome	5
Genotype-by-environment interactive effects and conflict solving during gonadal sex differentiation of pejerrey Odontesthes bonariensis, a fish with dual genotypic/environmental sex determination	5
Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications	5
Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure	5
MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome	5
Sulcal pits as potential markers of early sex-related human brain differences in healthy adults	5