Chemical Science

Article	Citations
Photo-generated radical mediated molecular luminescence enhancement	376
Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform	368
Non-radical pathways control methane sulfonation versus oxygenation C–H functionalization selectivity with Hg( ii	344
Transcriptome-wide identification of single-stranded RNA binding proteins	309
Easy access to amphiphilic nitrogenous block copolymers via switchable catalysis	281
Microstructure of amide-functionalized polyethylenes determined by NMR relaxometry	243
Inside front cover	226
Inside front cover	220
Polymorphism-driven coordination geometry engineering for boosting nitrate electroreduction in Cu-pyrazolate chains	217
The organophosphorus synthesis triangle: introducing methods for the missing quaternization and de-quaternization routes	199
Catalytic asymmetric P (III) -additions to salicylaldehydes enable divergent stereoselective dearomatizations of phenols	196
Hydroalkylation of styrenes enabled by boryl radical mediated halogen atom transfer	193
Correction: Polyterrylenes: synthesis and regioregularity effect on p-type charge transport and deep-red light photodetection in OFETs	189
Ultra-long cycle sodium ion batteries enabled by the glutaric anhydride additive	170
Molybdenum carbonyl assisted reductive tetramerization of CO by activated magnesium( i ) compounds: squarate dianion vs.	169
Multifaceted nucleic acid probing with a rationally upgraded molecular rotor	163
Correction: Magnetic coupling between Fe(NO) spin probe ligands through diamagnetic Ni II , Pd II	157
Photochemical H 2 activation by an Zn–Fe heterometallic: a mechanistic investigation	155
Back cover	145
Efficient helical columnar emitters of chiral homoleptic Pt( ii ) metallomesogens for circularly polarized electroluminescence	143
Inside front cover	142
Contents list	137
Dearomative [2 + 2] photocycloaddition to difluoro bicyclo[2.1.1]hexane bioisosteres	136
Two-sided asymmetric nanofluidic membrane for enhanced ion transport and osmotic energy harvesting	133
Contents list	133

Metal–ligand covalency of C–H activating iridium complexes from L-edge valence-to-core resonant inelastic X-ray scattering	132
Modulatory spin-flip of triplet excitons via diversiform electron-donating units for MR-TADF emitters towards solution-processed narrowband OLEDs	132
High order assembly of multiple protein cages with homogeneous sizes and shapes via limited cage surface engineering	128
Front cover	128
Molecular cyclo -P 3 complexes of the rare-earth elements via	127
Peripherally fused spiro structures enable the development of narrowband TADF emitters for highly efficient blue OLEDs	123
Mori generalized master equations offer an efficient route to predict and interpret polaron transport	121
Detection of single-cell enzyme activity by single-time-point stable isotope probing-mass spectrometry	119
Back cover	118
Beyond chemical structures: lessons and guiding principles for the next generation of molecular databases	117
Isostructural bridging diferrous chalcogenide cores [Fe II (μ-E)Fe II ] (E = O, S, Se, Te) with de	116
Correction: Site- and stereoselective silver-catalyzed intramolecular amination of electron-deficient heterobenzylic C–H bonds	116
Inside front cover	114
Deconvoluting binding sites in amyloid nanofibrils using time-resolved spectroscopy	112
Front cover	112
Intramolecular transamidation enables one-pot synthesis of three chiral, Z-shaped perilenediimides for null-type supramolecular polymer formation	110
Exploring Au( i ) involving halogen bonding with N-heterocyclic carbene Au( i ) aryl complexes in	109
Simulation of ultrafast transient absorption spectra of a perylene-based light harvesting antenna	107
Few-shot molecular property optimization via a domain-specialized large language model	107
Catalysis of a LiF-rich SEI by aromatic structure modified porous polyamine for stable all-solid-state lithium metal batteries	104
The supersaturation perspective on the amyloid hypothesis	104
Back cover	100
109 Ag NMR chemical shift as a descriptor for Brønsted acidity from molecules to materials	100
Platinum-based phosphorescent lifetime probes for the visualisation of G-quadruplex DNA in cells	100
Inside back cover	100
Enhanced ion intercalation in Ni x K 1−2	100
Front cover	99
Substituent effects on paratropicity and diatropicity in π-extended hexapyrrolohexaazacoronene	99
Contents list	98
Facile modification of phosphole-based aggregation-induced emission luminogens with sulfonyl isocyanates	98
RGB tri-luminescence in organic–inorganic zirconium halide perovskites	98
Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers	96
Enantioselective titanium-catalyzed cycloadditions of thiophene- S , S -dioxides with indenes	96
Axially chiral thiophene scaffolds: configurational stability and circularly polarized luminescence	96
Impact of vibrational strong coupling on liquid–liquid phase separation in supramolecular polymers	96
Mechanochemically-induced glass formation from two-dimensional hybrid organic–inorganic perovskites	96
Back cover	95
Leveraging heterocycle-fused 1,4-benzoquinone to design chemical modulators for both metal-free and metal-bound amyloid-β	95
Structure–function relationships in pure archaeal bipolar tetraether lipids	95
Drop-cast gold nanoparticles are not always electrocatalytically active for the borohydride oxidation reaction	95
Arresting dissolution of two-dimensional metal–organic frameworks enables long life in electrochemical devices	94
Photocatalytic remote C(sp 3 )–H alkylation of long-chain alkenes: A tandem multicomponent approach via	94
A tetraazanaphthalene radical-bridged dysprosium single-molecule magnet with a large coercive field	94
Ambipolar conjugated ladder polymers by room-temperature Knoevenagel polymerization	93
Nature of the heavy formal double bonds AsCh, SbCh and BiCh (Ch = S, Se, Te) in NCN-pincer supported arsinidene, stibinidene and bismuthinidene chalcogenides	91
Coupled dehydration and hydrogenation catalysis for one-pot conversion of saccharides into high-value furanic compounds	91
Toward functional and structurally complex Frank–Kasper phases via creating concavities on supramolecular micelles	90
Probing substrate binding inside a paramagnetic cavity: a NMR spectroscopy toolbox for combined experimental and theoretical investigation	90
A high-affinity dopamine aptamer: implications of library diversity and negative selection	88
Acid-catalyzed C–H reductive elimination from Au( iii )	88

NH 4 + -mediated interfacial chemistry for collaborative dual-pathway high-mass-loading energy storage	87
Deciphering the chemical bonding of the trivalent oxygen atom in oxygen doped graphene	86
Electrochemical hydrogenative coupling of nitrobenzene into azobenzene over a mesoporous palladium–sulfur cathode	86
Isothiourea-catalysed enantioselective synthesis of phosphonate-functionalised β-lactones	85
Correction: Ultrahigh photocatalytic hydrogen evolution of linear conjugated terpolymers enabled by an ultra-low ratio of the benzothiadiazole monomer	85
A theoretical framework to understand high electron mobilities in cable bacteria	84
Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry	83
Continually band-tunable bismuth oxyhalides BiOBr 1− x I	83
Back cover	83
How do donor and acceptor substituents change the photophysical and photochemical behavior of dithienylethenes? The search for a water-soluble visible-light photoswitch	82
Light-induced twisting, untwisting, and retwisting of aromatic polyamides: an interplay between the induced chirality and the co-facial π-stacking interactions	81
A silylboronate-mediated strategy for cross-coupling of alkyl fluorides with aryl alkanes: mechanistic insights and scope expansion	80
Stepwise BN bond cleavage by isocyanides: access to the 3-azaborole structural motif	80
Bucking the trend: understanding lipopolysaccharide structure and outer membrane dynamics in cold-adapted Pseudomonas isolated from Enigma Lake, Antarcti	80
Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation	80
Back cover	79
Lattice-coherent interface-reinforced sodium-layered oxide cathodes	79
Visible-light-initiated metal-free C sp 3 –C	79
In silico screening of LRRK2 WDR domain inhibitors using deep docking and free energy simulations	79
Visible light-driven dearomative ring expansion of (aza)arenes to access dihydrofuran-based polycyclic compounds	79
18 F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma	79
Back cover	78
A methyltransferase molecular switch unlocks para -quinone methide generation and oligomerization	78
Free-energy decomposition of salt effects on the solubilities of small molecules and the role of excluded-volume effects	78
Photolysis-driven bond activation by thorium and uranium tetraosmate polyhydride complexes	77
Structural insights into a bacterial terpene cyclase fused with haloacid Dehalogenase-like phosphatase	76
Rational design of circularly polarized luminescence active chiral metal–organic frameworks for logic devices	76
More π, please: What drives the formation of unsaturated molecules in the interstellar medium?	74
Correction: FragGen: towards 3D geometry reliable fragment-based molecular generation	74
Correction: Multi-stimuli programmable FRET based RGB absorbing antennae towards ratiometric temperature, pH and multiple metal ion sensing	73
Identification of metal-centered excited states in Cr( iii ) complexes with time-resolved L-edge X-ray spectroscopy	73
Correction: When SF 5 outplays CF 3 : effects of pentafluorosulfanyl decorated scorpionates on cop	73
Thinking outside the library: cluster synthesis of diverse molecules on a single robotic platform	73
(3 + 2)-Cycloaddition of bicyclobutanes and thioketones: access to 2-thiabicyclo[2.1.1]hexanes without the use of catalysts or light	72
Boraindenes as versatile precursors to benzannulated boron heterocycles	71
Molecular brush-based ultrathin polymer electrolytes with stable interfaces for high-voltage large-areal-capacity lithium metal batteries	71
Inter-layer magnetic tuning by gas adsorption in π-stacked pillared-layer framework magnets	71
Chemiluminescent duplex analysis using phenoxy-1,2-dioxetane luminophores with color modulation	71
Room temperature dinitrogen cleavage and hydrogenation with organometallic complexes of uranium	71
Study of the thermally-activated delayed fluorescence (TADF) mechanism of phenothiazine–dibenzothiophene- S , S	71
Isoacridone dyes with parallel reactivity from both singlet and triplet excited states for biphotonic catalysis and upconversion	70
Inside front cover	70
Fast hydrated-ion transport and desolvation in pyridinyl COF membranes via competitive coordination	70
Identification of allosteric sites and ligand-induced modulation in the dopamine receptor through large-scale alchemical mutation scan	69
Sodium-based donor–acceptor assemblies featuring thermally activated delayed fluorescence enabled by highly efficient through-space charge transfer	69
Phototoxicity of hydroxymethyl-BODIPYs: are photocages that innocent?	69
Chiral cobalt( ii ) complex-promoted asymmetric para -Claisen rearrangement of allyl α-naphthol ethers	69
Front cover	69
De novo synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular S	68
A reflection on ‘A hydrazone-based covalent organic framework for photocatalytic hydrogen production’: teaching sponges new tricks	68
Unveiling upsurge of photogenerated ROS: control of intersystem crossing through tuning aggregation patterns	68
Front cover	68
Outstanding Reviewers for Chemical Science in 2025	67
Formal synthesis of kibdelomycin and derivatisation of amycolose glycosides	66
Back cover	66
Therapeutic efficacy of 211 At-radiolabeled 2,6-diisopropylphenyl azide in mouse models of human lung cancer	66
Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR	65
Photochemical synthesis of carbazole-fused Blatter radicals: effective spin injection to the carbazole system	65
A constitutional isomer selective chemical proteomic strategy for system-wide profiling of protein lysine 5-hydroxylation	64
Enantioselective nickel-catalyzed Mizoroki–Heck cyclizations of amide electrophiles	64
Inside front cover	64
Leveraging reactivity to gain precise control over macromolecular structures with photocatalysis in reversible-deactivation radical polymerizations	64
Peptide stereocomplex cross-links for polymer hydrogels	64
“Dual lock-and-key” triggered and endoplasmic reticulum targeting nanophotosensitizers for activatable Type-I photodynamic and photothermal therapies	63
Excitation generated preferential binding sites for ethane on porous carbon–copper porphyrin sorbents: ethane/ethylene adsorptive separation improved by light	63
Generative intelligence explores the chemical space of ten million catalysts	63
Simultaneously enhancing the planarity and electron-donating capability of donors for through-space charge transfer TADF towards deep-red emission	63
With or without a co-solvent? highly efficient ultrafast phenanthrenequinone-electron rich alkene (PQ-ERA) photoclick reactions	63
On the use of real-world datasets for reaction yield prediction	62
Engineering mechanisms of proton-coupled electron transfer to a titanium-substituted polyoxovanadate–alkoxide	62
Curved graphene nanoribbons derived from tetrahydropyrene-based polyphenylenes via one-pot K-region oxidation and Scholl cyclization	62
Dynamic-structural-distortion of spheroidene activates a hidden 3A g − state mediating carotenoid-to-bacteriochlorophy	62
Polarization-induced nanohelixes of organic cocrystals from asymmetric components with dopant-induced chirality inversion	62
Revisiting the reaction pathways for phospholipid hydrolysis catalyzed by phospholipase A2 with QM/MM methods	61
Time-resolved circular dichroism of excitonic systems: theory and experiment on an exemplary squaraine polymer	61
Influence of the Pt/ionomer/water interface on the oxygen reduction reaction: insights into the micro-three-phase interface	60
Zero-trigger ultrafast charge-transfer J-aggregates via Se/π-directed assembly enable synchronous ROS/heat amplification for NIR-II photoimmunotherapy	60
First synthesis of RuSn solid-solution alloy nanoparticles and their enhanced hydrogen evolution reaction activity	60
[2 + 2] cycloaddition and its photomechanical effects on 1D coordination polymers with reversible amide bonds and coordination site regulation	60
Unraveling the local coordination effect of Cu–N–C single-atom catalysts towards CO adsorption via a gas-phase cluster model approach	59

Double coordination shell modulation of nitrogen-free atomic manganese sites for enhancing oxygen reduction performance	59
Reactivity of 1,3-enyne MIDA boronates: exploration of novel 1,2-alkyne shift via gem -difluorination	59
Polymerization-induced self-assembly enables access to diverse highly ordered structures through kinetic and thermodynamic pathways	59
Bromine radical release from a nickel-complex facilitates the activation of alkyl boronic acids: a boron selective Suzuki–Miyaura cross coupling	59
Superstructure-induced enhancement of solid-state triphenylacrylonitrile photochromism via a macrocycle-mediated blocking strategy	58
Beyond diffusion: ion and electron migration contribute to charge transport in redox-conducting metal–organic frameworks	58
Intramolecular CH⋯π attraction mediated conformational polymorphism of constrained helical peptides	58
Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold	58
Probing the water adsorption and stability under steam flow of Zr-based metal–organic frameworks using 91 Zr solid-state NMR spectroscopy	58
Augmenting genetic algorithms with machine learning for inverse molecular design	58
Light-controlled enzymatic synthesis of γ-CD using a recyclable azobenzene template	58
Negative cooperativity in the formation of H-bond networks involving primary anilines	58
A demethylation-activated fluorescent DNA aptamer strategy for visualising DNA alkylation repair in living cells	58
Visible-light-induced organocatalytic enantioselective N–H insertion of α-diazoesters enabled by indirect free carbene capture	58
Coexisting gases regulate the rates of water adsorption by a flexible one-dimensional coordination polymer	58
Sequence-dependent conformational transitions of disordered proteins during condensation	58
HCl-mediated silylation of C–H bonds in (hetero)arenes with trialkylsilanes	58
Proton transfer induced excited-state aromaticity gain for chromophores with maximal Stokes shifts	57
Characterization of a LanC-free pathway for the formation of an ll -MeLan residue and an allo AviMeCys	57
Spin polarized electron dynamics enhance water splitting efficiency by yttrium iron garnet photoanodes: a new platform for spin selective photocatalysis	57
Nanoarchitectonics of molecular machines, biomolecular machines, and microrobots in their collective behaviour	57
An AND-gate bioluminescent probe for precise tumor imaging	57
A pair of conjoined trinuclear sub-frameworks in a pentanuclear double-cavity discrete coordination cage	56
LnDOTA puppeteering: removing the water molecule and imposing tetragonal symmetry	56
A solid composite electrolyte based on three-dimensional structured zeolite networks for high-performance solid-state lithium metal batteries	56
Orbital electron delocalization of axial-coordinated modified FeN 4 and structurally ordered PtFe intermetallic synergistically for efficient oxygen	56
Molecular engineering of 1D conjugated copper anilate coordination polymers for boosting electrocatalytic nitrate reduction to ammonia	56
Metal-free visible-light carbonylation of alkyl iodides to amides via consecutive photoinduced electron transfer	56
Mechanism and dynamics of photoswitchable flavoprotein charge-transfer complexes	56
Aminocatalytic enantioselective [2 + 2] cycloaddition of Bicyclo[1.1.0]butanes and α,β-unsaturated aldehydes	56
Solvation-driven interphase engineering and mechanical failure pathways in large-scale anode-free lithium metal batteries	55
A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase	55
Inside front cover	55
Synthesis of functionalised isochromans: epoxides as aldehyde surrogates in hexafluoroisopropanol	55
RAFT step-growth polymerization via the Z-group approach and deconstruction by RAFT interchange	55
Inch-sized achiral perovskite ferroelectric single crystals for multiaxial passive circularly polarized light response	55
Unified ionic and radical C-4 alkylation and arylation of pyridines	55
Guiding catalytic CO 2 reduction to ethanol with copper grain boundaries	54
Self-sensitized Cu( ii )-complex catalyzed solar driven CO 2 reduction	54
MR-TADF liquid crystals: towards self assembling host–guest mixtures showing narrowband emission from the mesophase	54
Effect of cyclic topology versus linear terpolymers on antibacterial activity and biocompatibility: antimicrobial peptide avatars	54
Acridine photocatalysis enables tricomponent direct decarboxylative amine construction	54
Synergistic effect of MOF fillers and succinonitrile in PEO-based electrolytes for long-cycle all-solid-state Li–CO 2 batteries	54
Correction: Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance	54
Intramolecular-locking modification enables efficient asymmetric donor–acceptor–donor′ type ultraviolet emitters for high-performance OLEDs with reduced efficiency roll-off and high color purity	54
Gaining control on optical force by the stimulated-emission resonance effect	54
Roles of adhesives in forming mechanically robust superhydrophobic coatings	54
Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers	54
pH jump kinetics in colliding microdroplets: accelerated synthesis of azamonardine from dopamine and resorcinol	54
Engineering Pd-based charge-asymmetrical metal pair sites to promote *CHO–CHO coupling for selective C 2 photoreduction to C	54
Increasing connectivity through self-complementarity enables permanent porosity in a halogen-bonded organic framework	54
Affinity-based protein profiling of MDM2 inhibitor Navtemadlin	54
Hexaazatrinaphthylene self-fused multi-N-heterocycles for high-capacity and long-life aqueous magnesium-ion batteries	53
“Mn-locking” effect by anionic coordination manipulation stabilizing Mn-rich phosphate cathodes	53
Dynamic handedness inversion of self-organized helical superstructures enabled by novel thermally stable light-driven chiral hydrazone switches	53
Role of the Fe–FeCl 2 contact interface in promoting redox reversibility and electrochemical kinetics in Fe/FeCl 2	53
Competing dynamics of intramolecular deactivation and bimolecular charge transfer processes in luminescent Fe( iii ) N-heterocyclic carbene complexes	53
Minimum effort, maximum effect: modulating twisted intramolecular charge transfer for ultralong room temperature phosphorescence	53
Planar pentacoordinate s-block metals	53
Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and – lactams	53
Molten-salt flash synthesis of P-doped iron oxide with engineered oxygen vacancies for lattice-oxygen water oxidation	53
Distinct adsorption behavior and structures of cell-penetrating peptides at a model lipid membrane interface: a heterodyne-detected vibrational sum frequency generation spectroscopy study	53
Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade	53
Mechanisms of controlled stabilizer-free synthesis of gold nanoparticles in liquid aerosol containing plasma	53
Deciphering the mechanism of hydrogen peroxide formation in ultrasound-mediated water-in-oil microdroplets	53
Front cover	52
Development of 8–17 XNAzymes that are functional in cells	52
Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains	52
Unveiling the switching mechanism of robust tetrazine-based memristive nociceptors via a spectroelectrochemical approach	52
Revealing the nature of covalently tethered distonic radical anions in the generation of heteroatom-centered radicals: evidence for the polarity-matching PCET pathway	52
Luminescent carbene–copper( i )–amide polymers for efficient host-free solution-processed OLEDs	52
A metal-free strategy to construct fluoroalkyl–olefin linkages using fluoroalkanes	52
A general catalytic synthetic strategy for highly strained methylenecyclobutanes and spiromethylenecyclobutanes	52
Engineering the solid electrolyte interphase for enhancing high-rate cycling and temperature adaptability of lithium-ion batteries	52
Selective chiral dimerization and folding driven by arene–perfluoroarene force	52
Quantitative and spatially defined functionalization of nanostructures by overcoming the strong steric hindrance through bioinspired nucleobase interactions	52
Single solvent molecule effect over S N 2 and E2 competition in the hydroperoxide anion reaction with ethyl-iodide	52
Front cover	51
New insights into the mechanism of synergetic photoredox/copper( i )-catalyzed carbocyanation of 1,3-dienes: a DFT study	51
Gradient mesoporosity in hierarchical ZIF-8 by temperature-modulated soft-templating	51
Correction: THRUST: translesion synthesis-driven hierarchical regulation using a template-activator construct for Cas12a activity	51
Synthesis of N-CD 3 aryl amines via iron-catalysed site-selective aromatic C–H amination	51
Deducing the conformational space for an octa-proline helix	51
Improving the interfacial stability of ultrahigh-nickel cathodes with PEO-based electrolytes by targeted chemical reactions	51
Transient-absorption spectroscopy of dendrimers via nonadiabatic excited-state dynamics simulations	51
Inside front cover	51
Simplifying the problem: metal salts can be active and controlled catalysts in polyester synthesis	51
The clinical potential of l -oligonucleotides: challenges and opportunities	51
Confining ultrasmall Au nanoclusters in an ionic Ir( iii )-based cage for selective photoreduction	51
Wide-range color-tunable polycyclo-heteraborin multi-resonance emitters containing B–N covalent bonds	50
Correction: Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment	50
Structural and biochemical characterisation of Co 2+ -binding sites on serum albumins and their interplay with fatty acids	50
Confined semiconducting polymers with boosted NIR light-triggered H 2 O 2 production for hypoxia-t	50
Promoting cationic redox and stabilizing lattice oxygen in an Fe-based DRX cathode by the synergy of initial Li deficiency and 3D hierarchical porous architecture	50
Methyl scanning approach for enhancing the biological activity of the linear peptidic natural product, efrapeptin C	49