Cell Death & Disease

Article	Citations
Detection of immunogenic cell death and its relevance for cancer therapy	459
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers	371
Regulated cell death pathways in doxorubicin-induced cardiotoxicity	273
NLRP3 inflammasome in endothelial dysfunction	239
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?	224
CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway	190
CircRNAs: role in human diseases and potential use as biomarkers	189
N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification	152
The therapeutic potential of mesenchymal stem cells for cardiovascular diseases	148
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI	147
Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate	146
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation	146
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis	145
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling	144
Advances in the pathogenesis of psoriasis: from keratinocyte perspective	143
Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy	142
RNA-based therapeutics: an overview and prospectus	141
Mitochondria in skin health, aging, and disease	136
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions	134
Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells	132
MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer	130
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer	128
MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells	127
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis	127
Bioactive DNA from extracellular vesicles and particles	124

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?	123
Autophagy as a modulator of cell death machinery	120
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance	117
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury	113
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury	113
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload	112
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction	112
PD-L1 degradation pathway and immunotherapy for cancer	110
The role of m6A modification in physiology and disease	110
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers	109
Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury	107
MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma	106
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells	105
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity	105
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity	104
CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis	101
Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases	101
Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype	100
Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression	99
Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer	98
Exosomes and breast cancer drug resistance	98
The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene	98
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway	98
TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury	97
TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells	96
Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy	96
Interaction between macrophages and ferroptosis	96
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway	95
Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis	94
Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome	91
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction	91
LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis	91
The emerging role of ferroptosis in intestinal disease	91
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines	90
Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice	90
anlotinib alters tumor immune microenvironment by downregulating PD-L1 expression on vascular endothelial cells	89
Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis	88
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner	88
Which cell death modality wins the contest for photodynamic therapy of cancer?	88
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism	88
Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2	87
Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells	87
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease	86
Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients	86
LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer	86
Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis	84
The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis	82
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway	82
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis	82
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation	82

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway	82
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR	82
WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner	81
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection	80
AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice	80
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer	79
Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts	79
Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease	78
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis	78
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer	77
Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1	77
Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway	76
Discovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo	76
M2 macrophage-induced lncRNA PCAT6 facilitates tumorigenesis and angiogenesis of triple-negative breast cancer through modulation of VEGFR2	76
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?	75
SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype	75
CSF1R signaling is a regulator of pathogenesis in progressive MS	75
Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C	74
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11	74
Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases	73
Is hydroxychloroquine beneficial for COVID-19 patients?	72
Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death	72
YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA	72
Long noncoding RNA UCA1 from hypoxia-conditioned hMSC-derived exosomes: a novel molecular target for cardioprotection through miR-873-5p/XIAP axis	72
The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?	71
MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions	71
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	71
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1	71
The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway	71
p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation	70
Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice	70
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis	70
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma	69
MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma	69
Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation	69
LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis	68
LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma	68
Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction	68
COVID-19 infection: the China and Italy perspectives	67
The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide	67
Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma	67
Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis	67
Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway	66
In vivo evidence for extracellular DNA trap formation	66
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion	66
A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1	65
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)	65
Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis	65
Ferroptosis: the potential value target in atherosclerosis	65
IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b	65
Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway	65
Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury	64
MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation	64
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes	64
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation	64
N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway	64
Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment	64
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts	63
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders	63
MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy	63
Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury	63
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation	63
The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia	62
Age-related cerebral small vessel disease and inflammaging	62
Lysosomal quality control of cell fate: a novel therapeutic target for human diseases	62
Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice	62
Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition	62
Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation	61
Double-edge sword roles of iron in driving energy production versus instigating ferroptosis	61
Long non-coding RNA CASC9 promotes gefitinib resistance in NSCLC by epigenetic repression of DUSP1	61
Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity	61
Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma	61
The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma	61
Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid h	60
Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer	59
Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling	59
Targeting ferroptosis in acute kidney injury	59
HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis	59
A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer	59
Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis	59

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy	59
Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells	58
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis	58
The emerging roles of neutrophil extracellular traps in wound healing	58
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche	58
Adipose tissue aging: mechanisms and therapeutic implications	58
Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation	58
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA	57
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death	57
M2 macrophage-derived exosomal long non-coding RNA AGAP2-AS1 enhances radiotherapy immunity in lung cancer by reducing microRNA-296 and elevating NOTCH2	57
Strategies and prospects of effective neural circuits reconstruction after spinal cord injury	57
COVID19: an announced pandemic	56
LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype	56
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer	56
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells	55
Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma	55
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma	55
A long way to go: caspase inhibitors in clinical use	55
Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1	55
Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway	55
Quercetin promotes in vitro maturation of oocytes from humans and aged mice	55
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer	55
LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p	55
Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials	55
CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys	55
Altered mitochondrial dynamics and function in APOE4-expressing astrocytes	55
A new risk factor indicator for papillary thyroid cancer based on immune infiltration	54
Calcium and TRPV4 promote metastasis by regulating cytoskeleton through the RhoA/ROCK1 pathway in endometrial cancer	54
Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer	54
RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling	54
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy	54
M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway	54
Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway	54
Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis	54
LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1	53
Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway	53
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies	53
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis	53
Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis	53
Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis	53
METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1	53
BCL-w: apoptotic and non-apoptotic role in health and disease	52
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments	52
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner	52
Zinc transporter ZIP7 is a novel determinant of ferroptosis	52
CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis	52
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling	52
Interactions between m6A modification and miRNAs in malignant tumors	51
Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis	51
Programmed cell death in atherosclerosis and vascular calcification	51
Endoplasmic reticulum stress-mediated cell death in liver injury	51
Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells	51
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway	51
Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion	51
High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression	50
CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1	50
CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129	50
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy	50
Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury	50
Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis	50
Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy	49
High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy	49
NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke	49
Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer	49
Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer	49
ω-6 Polyunsaturated fatty acids (linoleic acid) activate both autophagy and antioxidation in a synergistic feedback loop via TOR-dependent and TOR-independent signaling pathways	49
circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS	48
Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition	48
BCG vaccination policy and preventive chloroquine usage: do they have an impact on COVID-19 pandemic?	48
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation	48
Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression	48
LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes	48
Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts	48
miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR	48
Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis	48
MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling	48
Protein lysine crotonylation: past, present, perspective	48
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species	48
Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-κB/MMP-2 axis	48
N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer	48
Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism	48
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury	47
LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma	47
RETRACTED ARTICLE: ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas	47
Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron	47
Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis	47
Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential	47
Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity	46
Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma	46
The interaction between ferroptosis and inflammatory signaling pathways	46
CISD3 inhibition drives cystine-deprivation induced ferroptosis	46
Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells	46
The crosstalk between HIFs and mitochondrial dysfunctions in cancer development	46
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages	46
Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease	46