Cell Death & Disease

Papers
(The median citation count of Cell Death & Disease is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis355
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model326
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7306
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α300
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons291
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis272
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma214
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma209
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK201
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC200
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3194
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats173
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation169
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12163
IL-17A injury to retinal ganglion cells is mediated by retinal Müller cells in diabetic retinopathy158
α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation156
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis156
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation148
Leveraging glycosylation for early detection and therapeutic target discovery in pancreatic cancer146
Correction: Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis142
Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells142
Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine140
A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells139
Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53139
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma138
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence137
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α135
Knockdown of Porf-2 restores visual function after optic nerve crush injury133
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea132
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication132
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling131
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker130
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation128
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation128
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function125
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment125
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila125
p63, a key regulator of Ago2, links to the microRNA-144 cluster124
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle124
Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way120
Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs119
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist116
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor115
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation115
A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling114
CAR-T therapy dilemma and innovative design strategies for next generation113
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer113
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction110
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation109
Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3109
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD108
Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects107
UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963105
The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression103
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma102
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway102
FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFκB pathway101
Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib101
Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review100
Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1100
MESH1 knockdown triggers proliferation arrest through TAZ repression100
USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma98
NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer97
Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhi96
RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis96
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression95
TRAIL protects the immature lung from hyperoxic injury94
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma91
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease91
Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis90
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis90
METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling89
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis89
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop89
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation87
PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer86
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT386
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury86
Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia85
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis85
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response83
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation83
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival82
CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis82
LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy82
PD-L1 induces autophagy and primary resistance to EGFR–TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway82
Endothelial ETS1 inhibition exacerbate blood–brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition81
Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK280
Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice80
TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway80
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders80
Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma79
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma79
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A179
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition79
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway78
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy78
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma78
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity78
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer77
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer76
PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS675
PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway74
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity74
Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders74
BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury74
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications73
m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization72
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis71
Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish71
SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF2470
JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis70
ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells70
Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model69
CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition69
SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis69
CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling69
Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression69
Regulatory T cells in skeletal muscle repair and regeneration: recent insights69
Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis68
LncRNA FIRRE functions as a tumor promoter by interaction with PTBP1 to stabilize BECN1 mRNA and facilitate autophagy68
MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor68
Metabolic gatekeepers: harnessing tumor-derived metabolites to optimize T cell-based immunotherapy efficacy in the tumor microenvironment67
Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia67
Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy67
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function67
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway66
SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury66
Trim21-mediated CCT2 ubiquitination suppresses malignant progression and promotes CD4+T cell activation in breast cancer66
Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors66
MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer65
Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington’s disease65
Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-120865
Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells64
Androgen-targeted hsa_circ_0085121 encodes a novel protein and improves the development of prostate cancer through facilitating the activity of PI3K/Akt/mTOR pathway and enhancing AR-V7 alternative sp64
TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis64
A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma64
Nitroglycerin: a comprehensive review in cancer therapy63
DDX5 deficiency drives non-canonical NF-κB activation and NRF2 expression, influencing sorafenib response and hepatocellular carcinoma progression63
Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD13263
High dose androgen suppresses natural killer cytotoxicity of castration-resistant prostate cancer cells via altering AR/circFKBP5/miRNA-513a-5p/PD-L1 signals62
An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models62
Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis62
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease62
Stanniocalcin 1 promotes lung metastasis of breast cancer by enhancing EGFR–ERK–S100A4 signaling62
Downregulated liver-elevated long intergenic noncoding RNA (LINC02428) is a tumor suppressor that blocks KDM5B/IGF2BP1 positive feedback loop in hepatocellular carcinoma62
Correction: MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TET–SOCS1–MMP9 signaling axis62
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer61
TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner61
Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies61
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ61
Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells61
Correction: FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation61
Retraction Note: Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer60
Retraction Note: Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer60
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss60
Correction to: Tumor-associated macrophage-derived exosomes transmitting miR-193a-5p promote the progression of renal cell carcinoma via TIMP2-dependent vasculogenic mimicry60
Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis60
Retraction Note: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer60
MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance60
Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation60
LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/259
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation59
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC459
p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-159
Role of cardiolipins, mitochondria, and autophagy in the differentiation process activated by all-trans retinoic acid in acute promyelocytic leukemia59
S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis59
Balancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapy58
Selective degradation of AR-V7 to overcome castration resistance of prostate cancer57
Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells57
A novel Hoxd13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSmad5/p65/c-Fos/Rank axis56
The feedback loop between MTA1 and MTA3/TRIM21 modulates stemness of breast cancer in response to estrogen56
Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction55
BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment55
Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries55
STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection55
Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma55
The role of vitamin K and its antagonist in the process of ferroptosis-damaged RPE-mediated CNV55
ZFP36L2 regulates myocardial ischemia/reperfusion injury and attenuates mitochondrial fusion and fission by LncRNA PVT155
Ascitic fluid shear stress in concert with hepatocyte growth factor drive stemness and chemoresistance of ovarian cancer cells via the c-Met-PI3K/Akt-miR-199a-3p signaling pathway55
YAP1 facilitates the pathogenesis of psoriasis via modulating keratinocyte proliferation and inflammation55
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice54
Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma54
Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells54
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis54
Transglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death54
MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer53
GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy53
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation53
Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development53
Card9 protects sepsis by regulating Ripk2-mediated activation of NLRP3 inflammasome in macrophages53
A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia53
Circulating miR-184 is a potential predictive biomarker of cardiac damage in Anderson–Fabry disease53
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy53
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy53
Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion53
SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin52
Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect52
Tumor-associated macrophage-derived exosomes transmitting miR-193a-5p promote the progression of renal cell carcinoma via TIMP2-dependent vasculogenic mimicry52
Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans52
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair52
β‐arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-κB activation and autophagy induced by TLR3 and TLR452
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL1052
Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy51
Systemic mechanisms of necrotic cell debris clearance51
Downregulation of TPX2 impairs the antitumor activity of CD8+ T cells in hepatocellular carcinoma51
Retraction Note to: Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression51
O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis51
Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications51
Exosomal circTGFBR2 promotes hepatocellular carcinoma progression via enhancing ATG5 mediated protective autophagy51
TRIM26 deficiency enhancing liver regeneration through macrophage polarization and β-catenin pathway activation51
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism50
Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma50
Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK150
The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer50
Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress50
AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer49
The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m6A methylation: a novel mechanism early during radiation-induced liver injury49
Transcriptome reprogramming of Epstein-Barr virus infected epithelial and B cells reveals distinct host-virus interaction profiles49
ETS-1-activated LINC01016 over-expression promotes tumor progression via suppression of RFFL-mediated DHX9 ubiquitination degradation in breast cancers49
CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3β/β-catenin signaling pathway49
Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion49
Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p49
c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability48
FRMD3 inhibits the growth and metastasis of breast cancer through the ubiquitination-mediated degradation of vimentin and subsequent impairment of focal adhesion48
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L48
Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction48
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF248
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN248
Potential role of senescent macrophages in radiation-induced pulmonary fibrosis48
nNOS in Erbb4-positive neurons regulates GABAergic transmission in mouse hippocampus48
Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases48
EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling48
HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells48
Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma progression via miR-25-3p/PTEN47
Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury47
Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis47
PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation47
LMO2 promotes the development of AML through interaction with transcription co-regulator LDB147
Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer47
The duality of CXCR3 in glioblastoma: unveiling autocrine and paracrine mechanisms for novel therapeutic approaches47
CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway46
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation46
PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling46
Suppression of lncRNA NLRP3 inhibits NLRP3-triggered inflammatory responses in early acute lung injury46
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer’s disease46
Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor46
TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis46
PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ46
The regulations of telomerase reverse transcriptase (TERT) in cancer46
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