OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Detection of immunogenic cell death and its relevance for cancer therapy	566
Regulated cell death pathways in doxorubicin-induced cardiotoxicity	348
RNA-based therapeutics: an overview and prospectus	244
Advances in the pathogenesis of psoriasis: from keratinocyte perspective	227
CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway	218
CircRNAs: role in human diseases and potential use as biomarkers	216
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?	200
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation	181
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI	178
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis	168
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer	168
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions	161
Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction	147
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance	145
Interaction between macrophages and ferroptosis	140
PD-L1 degradation pathway and immunotherapy for cancer	140
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells	136
Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease	128
MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma	127
The role of m6A modification in physiology and disease	125
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity	124
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway	122
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction	120
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway	119
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers	117

Exosomes and breast cancer drug resistance	116
Which cell death modality wins the contest for photodynamic therapy of cancer?	115
AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice	112
The emerging role of ferroptosis in intestinal disease	111
The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene	109
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism	108
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines	107
Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts	107
LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer	105
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation	105
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis	105
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway	104
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis	103
The interaction between ferroptosis and inflammatory signaling pathways	103
The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis	102
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11	102
Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation	102
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease	101
Endoplasmic reticulum stress-mediated cell death in liver injury	100
Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells	100
Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis	99
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?	96
MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma	95
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)	95
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer	94
Autophagy: Regulator of cell death	94
Adipose tissue aging: mechanisms and therapeutic implications	93
Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury	93
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders	93
Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury	93
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection	92
Targeting ferroptosis in acute kidney injury	92
Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies	92
Ferroptosis: the potential value target in atherosclerosis	91
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis	90
Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis	90
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	89
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation	88
Discovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo	87
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1	86
Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients	86
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation	85
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA	84
The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide	84
Double-edge sword roles of iron in driving energy production versus instigating ferroptosis	83
YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA	82
Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death	82
p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation	82
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells	82
SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype	81

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments	81
Programmed cell death in atherosclerosis and vascular calcification	79
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion	78
Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer	78
HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis	78