OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	1040
Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1	762
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer	526
STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma	475
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	453
PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer	409
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	409
Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish	391
Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells	358
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	327
Retraction Note: MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer	274
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats	270
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function	254
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3	239
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	237
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	213
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor	204
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation	204
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication	204
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation	201
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	181
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	179
Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway	178
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation	176
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice	167

Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	167
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	166
KLF13 promotes esophageal cancer progression and regulates triacylglyceride and free fatty acid metabolism through GPIHBP1	163
Correction: SNRPB promotes gastric cancer progression by regulating aberrant splicing of PUF60	154
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	152
REP-1 deficiency induces aberrant mitochondrial metabolic rewiring from glycolysis to lipid oxidation in CHM disease	151
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	146
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma	146
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis	140
Correction: SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade	138
Stochasticity contributes to explaining minority and majority MOMP during apoptosis	136
Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS)	134
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer	134
LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy	132
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model	124
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival	118
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence	118
Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1	117
Metabolomic profiling delineates the role of adenosine in oocyte quality and embryonic development	117
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition	116
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer	116
NICD3 mediates pro-angiogenic effects through SMAD3/TGFBI axis in colorectal cancer	113
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition	112
Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis	111
USP13 promotes enzalutamide resistance by catalyzing depolyubiquitination of PCMT1 in prostate cancer	111
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications	109
Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma	109
Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization	108
Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way	108
Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis	105
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12	103
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis	102
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity	102
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis	102
JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis	100
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma	98
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation	98
CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma	97
Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1	96
FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers	95
ATRA upregulates OTUD6B to recruit CD8+ T cells to suppress colorectal liver metastasis by stabilizing DDX5/STAT3/CXCL11 axis	95
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma	95
Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC	93
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1	92
Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation	91
CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis	90
TPI1 enhances gemcitabine resistance in bladder cancer by promoting autophagy through activating Beclin-1	90
Identification and validation of NCOA5-ZCCHC3/FGF22 axis as a prognostic marker in lung adenocarcinoma migration and invasion	88
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma	88
Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice	88

METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling	88
PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma	86
SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24	86
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response	86
Astrocytic SCAP deletion ameliorates diabetes-associated cognitive impairment by suppressing microglial neuroinflammation and lipid droplet accumulation via the LCN2–24p3R–mTOR axis	86
Regulatory T cells in skeletal muscle repair and regeneration: recent insights	86
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma	85
USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma	85
Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders	85
Restoration of axon initial segment plasticity via chemogenetic activation rescues autism-related behaviors	85