OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Detection of immunogenic cell death and its relevance for cancer therapy	459
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers	371
Regulated cell death pathways in doxorubicin-induced cardiotoxicity	273
NLRP3 inflammasome in endothelial dysfunction	239
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?	224
CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway	190
CircRNAs: role in human diseases and potential use as biomarkers	189
N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification	152
The therapeutic potential of mesenchymal stem cells for cardiovascular diseases	148
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI	147
Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate	146
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation	146
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis	145
CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling	144
Advances in the pathogenesis of psoriasis: from keratinocyte perspective	143
Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy	142
RNA-based therapeutics: an overview and prospectus	141
Mitochondria in skin health, aging, and disease	136
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions	134
Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells	132
MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer	130
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer	128
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis	127
MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells	127
Bioactive DNA from extracellular vesicles and particles	124

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?	123
Autophagy as a modulator of cell death machinery	120
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance	117
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury	113
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury	113
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload	112
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction	112
The role of m6A modification in physiology and disease	110
PD-L1 degradation pathway and immunotherapy for cancer	110
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers	109
Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury	107
MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma	106
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity	105
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells	105
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity	104
Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases	101
CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis	101
Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype	100
Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression	99
The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene	98
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway	98
Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer	98
Exosomes and breast cancer drug resistance	98
TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury	97
Interaction between macrophages and ferroptosis	96
TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells	96
Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy	96
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway	95
Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis	94
LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis	91
The emerging role of ferroptosis in intestinal disease	91
Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome	91
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction	91
Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice	90
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines	90
anlotinib alters tumor immune microenvironment by downregulating PD-L1 expression on vascular endothelial cells	89
Which cell death modality wins the contest for photodynamic therapy of cancer?	88
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism	88
Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis	88
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner	88
Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2	87
Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells	87
Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients	86
LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer	86
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease	86
Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis	84
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis	82
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation	82
AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway	82
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR	82

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis	82
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway	82
WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner	81
AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice	80
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection	80