OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 86. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	875
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer	662
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation	537
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling	511
BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury	465
Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review	399
Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders	391
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor	373
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication	365
Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation	358
PD-L1 induces autophagy and primary resistance to EGFR–TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway	293
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation	279
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma	277
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma	253
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition	242
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC	233
Knockdown of Porf-2 restores visual function after optic nerve crush injury	213
Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis	206
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway	203
SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24	190
A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling	188
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer	185
PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6	184
Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice	179
Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC	177

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma	174
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer	174
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer	166
Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1	166
Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells	164
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	160
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	158
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction	158
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	156
Retraction Note: Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects	150
Regulatory T cells in skeletal muscle repair and regeneration: recent insights	149
FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers	147
TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway	146
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response	145
CAR-T therapy dilemma and innovative design strategies for next generation	144
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation	136
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity	133
Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1	131
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity	130
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12	129
RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis	129
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	128
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1	127
NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer	123
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	119
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury	119
Leveraging glycosylation for early detection and therapeutic target discovery in pancreatic cancer	117
The N6-methyladenosine-mediated cLMNB1 degrades FGFR4 to overcome osimertinib resistance in non-small cell lung cancer	115
CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis	113
METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling	113
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis	112
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications	111
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation	108
m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization	108
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila	106
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma	106
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	105
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer	104
Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma	103
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression	103
PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma	102
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	101
Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway	101
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	101
TPI1 enhances gemcitabine resistance in bladder cancer by promoting autophagy through activating Beclin-1	99
TRAIL protects the immature lung from hyperoxic injury	98
LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy	96
Stochasticity contributes to explaining minority and majority MOMP during apoptosis	95
Proteasome inhibition as a potential therapeutic target in thymic cancer	95
KLF13 promotes esophageal cancer progression and regulates triacylglyceride and free fatty acid metabolism through GPIHBP1	94

STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma	92
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma	91
Long non-coding RNAs in cancer glycolysis and metabolism: mechanisms and translational opportunities	90
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	90
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy	90
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition	89
Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma	89
Endothelial ETS1 inhibition exacerbate blood–brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition	88
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	87
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	87
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins	86