OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis	355
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model	326
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	306
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	300
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	291
USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis	272
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma	214
Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma	209
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK	201
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC	200
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3	194
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats	173
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation	169
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12	163
IL-17A injury to retinal ganglion cells is mediated by retinal Müller cells in diabetic retinopathy	158
α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation	156
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	156
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	148
Leveraging glycosylation for early detection and therapeutic target discovery in pancreatic cancer	146
Correction: Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis	142
Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells	142
Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine	140
Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53	139
A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells	139
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma	138

Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence	137
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α	135
Knockdown of Porf-2 restores visual function after optic nerve crush injury	133
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication	132
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	132
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling	131
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	130
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation	128
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	128
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function	125
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	125
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila	125
p63, a key regulator of Ago2, links to the microRNA-144 cluster	124
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	124
Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way	120
Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs	119
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist	116
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor	115
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation	115
A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling	114
CAR-T therapy dilemma and innovative design strategies for next generation	113
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer	113
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction	110
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation	109
Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3	109
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	108
Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects	107
UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963	105
The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression	103
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway	102
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma	102
FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFκB pathway	101
Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib	101
Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1	100
MESH1 knockdown triggers proliferation arrest through TAZ repression	100
Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review	100
USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma	98
NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer	97
RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis	96
Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhi	96
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression	95
TRAIL protects the immature lung from hyperoxic injury	94
NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma	91
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease	91
Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis	90
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis	90
METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling	89
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis	89
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop	89
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation	87

PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer	86
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	86
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury	86
Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia	85
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis	85
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response	83
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation	83
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival	82
CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis	82
LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy	82
PD-L1 induces autophagy and primary resistance to EGFR–TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway	82