OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Death & Disease is 84. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons	923
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer	700
Phosphorylation of USP33 by CDK1 stabilizes the mTORC2 component SIN1	557
Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer	536
STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma	480
Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation	425
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α	422
Proteasome inhibition as a potential therapeutic target in thymic cancer	383
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition	370
Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation	311
PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer	307
Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish	286
Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis	258
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins	239
Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma	228
Stochasticity contributes to explaining minority and majority MOMP during apoptosis	221
Correction: Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells	215
Long non-coding RNAs in cancer glycolysis and metabolism: mechanisms and translational opportunities	194
Correction: Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea	194
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival	188
Retraction Note: MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer	188
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats	181
ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function	180
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3	176
Hypoxia-responsive circRNAs: A novel but important participant in non-coding RNAs ushered toward tumor hypoxia	166

ATRA upregulates OTUD6B to recruit CD8+ T cells to suppress colorectal liver metastasis by stabilizing DDX5/STAT3/CXCL11 axis	165
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway	163
JUND/linc00976 promotes cholangiocarcinoma progression and metastasis, inhibits ferroptosis by regulating the miR-3202/GPX4 axis	160
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α	159
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation	156
FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers	156
RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response	155
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation	154
m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization	154
Retraction Note: Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects	151
Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis	137
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3	137
NADH:ubiquinone oxidoreductase core subunit S8 expression and functional significance in non-small cell lung cancer	137
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity	135
Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor	133
USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma	131
Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC	131
Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice	130
Knockdown of Porf-2 restores visual function after optic nerve crush injury	129
miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication	126
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation	121
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation	119
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment	118
USP13 promotes enzalutamide resistance by catalyzing depolyubiquitination of PCMT1 in prostate cancer	117
Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization	116
RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis	111
IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer	111
Single-cell RNA-seq and pathological phenotype reveal the functional atlas and precise roles of Sox30 in testicular cell development and differentiation	109
PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma	109
Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway	109
Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way	108
TPI1 enhances gemcitabine resistance in bladder cancer by promoting autophagy through activating Beclin-1	108
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis	107
CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma	106
α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation	106
ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation	105
FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression	104
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7	100
FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFκB pathway	99
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model	98
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy	96
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice	96
CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis	96
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma	96
Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma	95
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling	94
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker	93
KLF13 promotes esophageal cancer progression and regulates triacylglyceride and free fatty acid metabolism through GPIHBP1	92
Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1	89
Correction: SNRPB promotes gastric cancer progression by regulating aberrant splicing of PUF60	89

TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway	88
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle	88
METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling	85
KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma	85
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC	85
REP-1 deficiency induces aberrant mitochondrial metabolic rewiring from glycolysis to lipid oxidation in CHM disease	85
Zipper-interacting protein kinase mediates neuronal cell death and cognitive dysfunction in traumatic brain injury via regulating DEDD	85
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer	85
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis	84
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1	84
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence	84