Therapeutic Advances in Chronic Disease

Article	Citations
Neurological manifestations of long-COVID syndrome: a narrative review	117
Nomenclature and clinical phenotypes of atopic dermatitis	42
A narrative review of current evidence supporting the implementation of electronic patient-reported outcome measures in the management of chronic diseases	28
Dual inhibition of IL-17A and IL-17F in psoriatic disease	27
The neurological symptoms of COVID-19: a systematic overview of systematic reviews, comparison with other neurological conditions and implications for healthcare services	26
New perspectives on the treatment of hidradenitis suppurativa	24
MicroRNA-21 from bone marrow mesenchymal stem cell-derived extracellular vesicles targets TET1 to suppress KLF4 and alleviate rheumatoid arthritis	23
Serum-derived exosomes containing NEAT1 promote the occurrence of rheumatoid arthritis through regulation of miR-144-3p/ROCK2 axis	23
Impact of previous biologic use and body weight on the effectiveness of guselkumab in moderate-to-severe plaque psoriasis: a real-world practice	22
Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease	21
Characteristics and outcomes of patients with chronic thromboembolic pulmonary hypertension in the era of modern therapeutic approaches: data from the Polish multicenter registry (BNP-PL)	21
Effects of non-invasive brain stimulation in multiple sclerosis: systematic review and meta-analysis	19
Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/PTEN/Wnt/β-catenin axis	19
Steatosis grading consistency between controlled attenuation parameter and MRI-PDFF in monitoring metabolic associated fatty liver disease	18
The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly	18
Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials	18
Mesenchymal stem cell-based treatment in autoimmune liver diseases: underlying roles, advantages and challenges	17
Long-chain omega-3 polyunsaturated fatty acids and the risk of heart failure	17
Exploring polypharmacy phenomenon in newly diagnosed relapsing–remitting multiple sclerosis: a cohort ambispective single-centre study	16
The association between NAFLD and risk of chronic kidney disease: a cross-sectional study	16
Feature selection from magnetic resonance imaging data in ALS: a systematic review	16
The need for a strategic therapeutic approach: multiple sclerosis in check	15
Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment	15
Impact of exclusive e-cigarettes and heated tobacco products use on muco-ciliary clearance	14
Flare management in atopic dermatitis: from definition to treatment	14

Chinese traditional medicine (GuiZhi-ShaoYao-ZhiMu decoction) as an add-on medication to methotrexate for rheumatoid arthritis: a meta-analysis of randomized clinical trials	13
Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis	13
Deep learning-based classification of infectious keratitis on slit-lamp images	13
Relationship between sarcopenia/myosteatosis and frailty in hospitalized patients with cirrhosis: a sex-stratified analysis	13
Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient	12
Segmental involvement of the corpus callosum inC9orf72-associated ALS: a tract of interest-based DTI study	12
The influence of delayed treatment due to COVID-19 on patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy	12
Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases	12
Sodium-glucose cotransporter 2 inhibitors and neurological disorders: a scoping review	12
Rheumatic immune-related adverse events associated with immune checkpoint inhibitors compared with placebo in oncologic patients: a systemic review and meta-analysis	11
Computerized migraine diagnostic tools: a systematic review	10
Endoscopic treatment for gastric antral vascular ectasia	10
EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGFβ/SMAD pathway	10
Proteomic analysis reveals rotator cuff injury caused by oxidative stress	10
Advances in the diagnosis and the management of primary hyperparathyroidism	10
Effect of semaglutide and liraglutide in individuals with obesity or overweight without diabetes: a systematic review	10
The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial	9
Short- and long-term effects of whole-body photobiomodulation on pain, functionality, tissue quality, central sensitisation and psychological factors in a population suffering from fibromyalgia: proto	9
Association of NAFLD with cardiovascular disease and all-cause mortality: a large-scale prospective cohort study based on UK Biobank	9
Association between non-alcoholic fatty liver disease and risk of incident heart failure: a meta-analysis of observational studies	9
Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial	9
Comparisons of psychological distress and self-stigma among three types of substance use disorders receiving treatment-as-usual approaches: real-world data from a 9-month longitudinal study	9
Relationship between long head of the biceps tendon histopathology and long-term functional results in smokers. A time to reevaluate the Bonar score?	8
Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis	8
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?	8
Skin barrier status during dupilumab treatment in patients with severe atopic dermatitis	8
Metformin and the risk of dementia based on an analysis of 396,332 participants	8
KDM4C contributes to cytarabine resistance in acute myeloid leukemia via regulating the miR-328-3p/CCND2 axis through MALAT1	8
Twelve-month effects of everolimus on renal and lung function in lung transplantation: differences in chronic lung allograft dysfunction phenotypes	7
A randomized, controlled trial on fenofibrate in primary biliary cholangitis patients with incomplete response to ursodeoxycholic acid	7
Preoperative malnutrition as an independent risk factor for the postoperative mortality in elderly Chinese individuals undergoing hip surgery: a single-center observational study	7
Effectiveness of using calligraphic activity to treat people with schizophrenia: a randomized controlled trial in Southern Taiwan	7
Comparison of the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) associated with periodon	7
Early fibroproliferative signs on high-resolution CT are associated with mortality in COVID-19 pneumonia patients with ARDS: a retrospective study	7
Accessing behavioral health care during COVID: rapid transition from in-person to teleconferencing medical group visits	7
Long-term outcomes of antibiotic combination therapy for ulcerative colitis	7
ANCA-associated vasculitis following the CoronaVac vaccination	7
Current situation and progress of drugs for reducing intraocular pressure	7
Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: a case report	7
Community-based screening to determine the prevalence, health and nutritional status of patients with CKD in rural and peri-urban Bangladesh	7
Optimal cut-off points for adherence measure among patients with type 2 diabetes in primary care clinics: a retrospective analysis	7
Physical activity and the ‘pediatric inactivity triad’ in children living with chronic kidney disease: a narrative review	7
Dupilumab and tezepelumab in severe refractory asthma: new opportunities	6
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy	6
Advances and caveats in modern achalasia management	6
Anemia, sarcopenia, physical activity, and the risk of tuberculosis in the older population: a nationwide cohort study	6
Review of current and future therapeutics in ABPA	6
Psychosomatic interactions in kidney transplantation: role of personality dimensions in mental health-related quality of life	6
Time-domain full-field optical coherence tomography (TD-FF-OCT) in ophthalmic imaging	6
Impact of the chronic disease self-management program (CDSMP) on self-perceived frailty condition: the EU-EFFICHRONIC project	6

Multiple endocrine neoplasia 1: a broad overview	6
Digital work engagement among Italian neurologists	6
COVID-19-induced psoriatic arthritis: a case report	6
Cost-effectiveness of telemedicine care for patients with uncontrolled type 2 diabetes mellitus during the COVID-19 pandemic in Saudi Arabia	6
The five-repetition sit-to-stand test is a predictive factor of severe exacerbations in COPD	6
Efficacy and tolerability of infliximab retreatment in patients with inflammatory bowel disease: a systematic review and meta-analysis	6
Plasma ST6GAL1 regulates IgG sialylation to control IgA nephropathy progression	6
Prognostic implication of noninvasive right ventricle-to-pulmonary artery coupling in chronic thromboembolic pulmonary hypertension	5
Prevalence, prescriptions, outcomes and costs of type 2 diabetes patients with or without prior coronary artery disease or stroke: a longitudinal 5-year claims-data analysis of over 7 million inhabita	5
Optimal treatment strategies for coronary artery disease in patients with advanced kidney disease: a meta-analysis	5
Are muscle weakness and stiffness risk factors of the development of rotator cuff tendinopathy in overhead athletes: a systematic review	5
What is the role of Von Willebrand factor in chronic hepatitis B virus infection to hepatocellular carcinoma: a review article	5
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome	5
Development of a medication review tool for residents in Korean long-term care facilities	5
A cross-sectional study: an assessment of low muscle mass and osteoporosis in type 2 diabetes mellitus patients with a high glycated hemoglobin level	5
Cardiac manifestations of eosinophilic granulomatosis with polyangiitis from a single-center cohort in China: clinical features and associated factors	5
Risk assessment in systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study	5
The spectrum of clinical sequelae associated with alpha-1 antitrypsin deficiency	5
Is Helicobacter pylori infection associated with pancreatic cancer? A systematic review and meta-analysis of observational studies	5
Associated factors of potential drug-drug interactions and drug–food interactions in patients with multiple sclerosis	5
Chronic obstructive pulmonary disease: moving from symptom relief to mortality reduction	5
A retrospective comparative study on arthroscopic suture anchors repair and tendon debridementversusarthroscopic tendon debridement for treatment of recalcitrant lateral epicondylitis	5
Changes of circulating biomarkers of inflammation and glycolipid metabolism by CPAP in OSA patients: a meta-analysis of time-dependent profiles	5
Variants ofSERPINA1and the increasing complexity of testing for alpha-1 antitrypsin deficiency	5
Metformin use is associated with low risk of case fatality and disability rates in first-ever stroke patients with type 2 diabetes	5
Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism	5
Decreased numbers and sex-based differences of circulating regulatory T cells in patients with seropositive undifferentiated arthritis	5
Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results	5
Lung and liver transplantation in patients with alpha-1 antitrypsin deficiency	5
The role of pre-emptive Transjugular Intrahepatic Portosystemic Shunt in acute variceal bleeding: a literature review	5
Identification of mortality-risk-related missense variant for renal clear cell carcinoma using deep learning	5
RETRACTED: A meta-analysis of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody treatment for COVID-19 patients	4
Incidence, causes, and predictors of unsuccessful decannulation following prolonged weaning	4
Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future	4
Effects of nonsurgical, minimally or noninvasive therapies for urinary incontinence due to neurogenic bladder: a systematic review and meta-analysis	4
Improved clinical outcomes of tocilizumab versus cyclophosphamide for IgG4-related disease: insights from a prospective IgG4-related disease registry	4
One-year outcomes and predictive factors for primary patency after stent placement for treatment of central venous occlusive disease in hemodialysis patients	4
Outcomes of coronavirus 2019 infection in patients with chronic kidney disease: a systematic review and meta-analysis	4
Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know	4
HbA1c trajectory and cardiovascular outcomes: an analysis of data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study	4
Transcranial alternating current stimulation and its effects on cognition and the treatment of psychiatric disorders: a systematic review and meta-analysis	4
Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis	4
Remission and relapses of myasthenia gravis on long-term tacrolimus: a retrospective cross-sectional study of a Chinese cohort	4
Associations between bone mineral density and coronary artery calcification: a systematic review and meta-analysis	4
Characteristics of tinnitus and factors influencing its severity	4
The ipsilateral silent period: an early diagnostic marker of callosal disconnection in ALS	4
Tocilizumab for faster and safer remission of Takayasu’s arteritis	4
Efficacy of the use of unaffected hand containment in unimanual intensive therapy to increase visuomotor coordination in children with hemiplegia: a randomized controlled pilot study	4
Physiotherapy interventions may relieve pain in individuals with central neuropathic pain: a systematic review and meta-analysis of randomised controlled trials	4
Increased IL-31 expression in serum and tissue protein in prurigo nodularis	4
Serum fatty acids profile and association with early-onset coronary artery disease	4
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description	4
Alpha-1 antitrypsin deficiency research and emerging treatment strategies: what’s down the road?	4
Revascularization or medical therapy for stable coronary artery disease patients with different degrees of ischemia: a systematic review and meta-analysis of the role of myocardial perfusion	4
Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetes	4
Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience	4
Microscopic colitis in older adults: impact, diagnosis, and management	4
Proteomic analysis of pulmonary arterial hypertension	4
Cardiovascular diseases or type 2 diabetes mellitus and chronic airway diseases: mutual pharmacological interferences	4
Can acid exposure time replace the DeMeester score in the diagnosis of gastroesophageal reflux-induced cough?	4
The dawn phenomenon in type 2 diabetes: its association with glucose excursions and changes after oral glucose-lowering drugs	4
Impaired muscle capacity of the hip and knee in individuals with isolated patellofemoral osteoarthritis: a cross-sectional study	4
AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning	4
Relaxation-weighted 23Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis	4
Machine learning approaches for the mortality risk assessment of patients undergoing hemodialysis	4
Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs	4
Exceptional response to lurbinectedin and irinotecan in BRCA-mutated platinum-resistant ovarian cancer patient: a case report	3
Ocular microvascular alteration in Sjögren’s syndrome treated with hydroxychloroquine: an OCTA clinical study	3
Validity of serum and urinary hepcidin as biomarkers for late-onset sepsis in premature infants	3
Characteristics and outcomes of patients with psoriasis treated with apremilast in the real-world in Austria – results the APPRECIATE study	3
Prior percutaneous coronary intervention and outcomes in patients after coronary artery bypass grafting: a meta-analysis of 308,284 patients	3
Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants	3
Understanding racial differences of COPD patients with an ecological model: two large cohort studies in the US and Korea	3
Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary	3
Morphological alterations of the hypothalamus in idiopathic intracranial hypertension	3
Comparative risk of herpes zoster in patients with psoriatic disease on systemic treatments: a systematic review and network meta-analysis	3
Effect of TO901317 on GF to promote the differentiation of human bone marrow mesenchymal stem cells into dopamine neurons on Parkinson’s disease	3
State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus	3
Fractional nitric oxide measurement in exhaled air (FeNO): perspectives in the management of respiratory diseases	3
An analysis report on the application of immune checkpoint inhibitors after liver transplantation	3

Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator	3
Eosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional survey	3
Autoimmune colitis and neutropenia in adjuvant anti-PD-1 therapy for malignant melanoma: efficacy of Vedolizumab, a case report	3
Liver disease with unknown etiology – have you ruled out alpha-1 antitrypsin deficiency?	3
Establishment of a preliminary FRAX®-based intervention threshold for rheumatoid arthritis–associated fragility fracture: a 3-year longitudinal, observational, cohort study	3
Application and observation of artificial intelligence in clinical practice of fundus screening for diabetic retinopathy with non-mydriatic fundus photography: a retrospective observational study of T	3
Novel homozygous mutation of PNLIP gene in congenital pancreatic lipase deficiency: an extended family study	3
Anti-cyclic-citrullinated-protein-antibodies in psoriatic arthritis patients: how autoimmune dysregulation could affect clinical characteristics, retention rate of methotrexate monotherapy and first l	3
Personalized medicine with drugs targeting the underlying protein defect in cystic fibrosis: is monitoring of treatment response necessary?	3
Association of protein consumption and energy intake on sarcopenia in tuberculosis survivors	3
Chemotherapy for patients with advanced lung cancer with interstitial lung disease: a prospective observational study	3
Sailing the ship of life: scurvy and autoimmunity . . .	3
Imaging in alpha-1 antitrypsin deficiency: a window into the disease	3
Associations between age-related hearing loss, cognitive decline, and depression in Chinese centenarians and oldest-old adults	3