OOIR: Observatory of International Research

Papers

(The median citation count of Therapeutic Advances in Chronic Disease is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Chronotherapy of cardiovascular pathologies: a hopeful strategy	171
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study	35
Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient	33
Association between non-alcoholic fatty liver disease and risk of incident heart failure: a meta-analysis of observational studies	28
Development of the ESEx index: a tool for predicting risk of recurrent severe COPD exacerbations	27
Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases	26
Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis	26
An analysis report on the application of immune checkpoint inhibitors after liver transplantation	24
The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly	21
‘When Cryptococcus strikes and lupus is found’: a unique covert unveiling of systemic lupus erythematosus presenting as subacute meningitis	20
Effect of short-term cardiac function changes after cardiac resynchronization therapy on long-term prognosis in heart failure patients with and without diabetes	20
Photodynamic therapy of cervical cancer: a scoping review on the efficacy of various molecules	20
Blood pressure measurement in the elderly with atrial fibrillation: an observational study comparing different noninvasive sphygmomanometers	20
AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning	19
HCV-positive kidney transplant patients treated with direct-acting antivirals maintain stable medium-term graft function despite persistent reduction in tacrolimus trough levels	18
Mineralocorticoid receptor antagonist treatment improved arterial stiffness in patients with primary aldosteronism: a cohort study compared with adrenalectomy	18
Optical coherence tomography biomarkers as predictors of transition to chronic central serous chorioretinopathy after retinal laser photocoagulation	17
Improving diagnosis of primary aldosteronism through education: a modified Delphi study to identify key learning points	17
Elevated activating Fc gamma receptors levels correlated with susceptibility and severity of IgA nephropathy	17
A new dual function dorsal root ganglion stimulation in pain management: a technical note and case report	17
State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus	15
The comparative effectiveness of antidepressants for youths with major depressive disorder: a nationwide population-based study in Taiwan	15
Distinguishing bronchoscopically observed anatomical positions of airway under by convolutional neural network	14
Increased IL-31 expression in serum and tissue protein in prurigo nodularis	14
Granulomatous hepatitis in a Saudi child with IL2RA defect: a case report and literature review	13

Golimumab and certolizumab pegol for the treatment of hidradenitis suppurativa: a literature review and future perspective	13
Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study	13
Evidence of nonsurgical treatment for polycystic liver disease	13
Auricular erythermalgia showing excellent response to itraconazole: a case report	13
A model for predicting high BMI of people living with HIV after receiving antiretroviral therapy	12
Predicting cardiovascular risk in a Chinese primary Sjögren’s syndrome population: development and assessment of a predictive nomogram	12
Biological pathways and mechanisms linking COPD and cardiovascular disease	11
Blood pressure change and cognition in childhood and early adulthood: a systematic review	11
Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism	11
Comparative short-term risks of infection and serious infection in patients receiving biologic and small-molecule therapies for psoriasis and psoriatic arthritis: a systemic review and network meta-an	11
Remission and relapses of myasthenia gravis on long-term tacrolimus: a retrospective cross-sectional study of a Chinese cohort	10
New drugs in cystic fibrosis: what has changed in the last decade?	10
Air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	10
Real-world safety and effectiveness of secukinumab in adult patients with moderate to severe plaque psoriasis: results from postmarketing surveillance in Korea	10
Corrigendum to air pollution and mortality in patients with chronic obstructive pulmonary disease: a cohort study in South Korea	9
Eosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional survey	9
Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials	9
First-line therapeutic strategy for patients with advanced non–small cell lung cancer with Leu858Arg epidermal growth factor receptor mutations: a Bayesian network meta-analysis	9
Establishment of a preliminary FRAX®-based intervention threshold for rheumatoid arthritis–associated fragility fracture: a 3-year longitudinal, observational, cohort study	9
Tenofovir is superior to entecavir in reducing HCC for patients with HBV-related compensated cirrhosis at high HCC risk scores	9
The optimal percutaneous coronary intervention strategy for patients with ST-segment elevation myocardial infarction and multivessel disease: a pairwise and network meta-analysis	9
Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case–control study	8
Clinical scenarios-based guide for tofacitinib in rheumatoid arthritis	8
Resective surgery for patients with frontal lobe diffuse low-grade glioma-related epilepsy: predictors of seizure outcomes	8
Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator	8
Risk factors of significant relapse and appropriate maintenance therapy strategy in SLE-associated immune thrombocytopenia	8
Advancements in prevention and intervention of sensorineural hearing loss	8
Lifetime risk, life expectancy, loss-of-life expectancy, and lifetime healthcare expenditures for psoriasis in Taiwan: a nationwide cohort followed from 2000 to 2017	8
Characteristics of myeloproliferative neoplasm-associated portal hypertension and endoscopic management of variceal bleeding	8
The efficacy of telemedicine for pain management in patients with cancer: a systematic review and meta-analysis	8
Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients	8
Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy	7
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description	7
Shall we start? Ready, set, go! Toward early intervention in infants with unilateral cerebral palsy. A randomized clinical trial protocol	7
Long-term outcomes and associated factors of Crohn’s disease patients achieving transmural healing based on magnetic resonance enterography: a Chinese retrospective cohort study	7
Author response to comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants	7
Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach	7
Effectiveness and safety of low-dose interferon alpha-2a treatment in Behçet’s Syndrome with refractory vascular or neurological involvement: a case series	7
Association of NAFLD with cardiovascular disease and all-cause mortality: a large-scale prospective cohort study based on UK Biobank	7
Trends in mortality from infection among patients with hematologic malignancies: differences according to hematologic malignancy subtype	7
Comparison of the efficacy and safety of leflunomide versus placebo combined with basic prednisone therapy in patients with active disease phase of Takayasu arteritis: study protocol for a randomized,	7
Metformin and the risk of dementia based on an analysis of 396,332 participants	7
Efficacy and safety of intravenous immunoglobulin for treating refractory livedoid vasculopathy: a systematic review	7
Emerging roles of macrophages in heart failure and associated treatment approaches	6
Untimely surgery for stent-fracture-related death after transjugular intrahepatic portosystemic shunt: a case report	6
How do phytocannabinoids affect cardiovascular health? An update on the most common cardiovascular diseases	6
Prevalence of major non-communicable diseases and their associated risk factors in Afghanistan: a systematic review and meta-analysis	6
Inheritance and innovation of the diagnosis of peripheral pulmonary lesions	6
Predictors of seizure outcomes in stereo-electroencephalography-guided radio-frequency thermocoagulation for MRI-negative epilepsy	6
Periprocedural, short-term, and long-term outcomes following transcatheter tricuspid valve repair: a systemic review and meta-analysis	6

Short- and long-term effects of whole-body photobiomodulation on pain, functionality, tissue quality, central sensitisation and psychological factors in a population suffering from fibromyalgia: proto	6
Preoperative malnutrition as an independent risk factor for the postoperative mortality in elderly Chinese individuals undergoing hip surgery: a single-center observational study	6
Predialysis trajectories of estimated GFR and concurrent trends of Chronic Kidney Disease-relevant biomarkers	6
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?	6
Associations between age-related hearing loss, cognitive decline, and depression in Chinese centenarians and oldest-old adults	6
Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: a case report	5
Take vedolizumab home: transition from intravenous to subcutaneous treatment	5
Aortic arch calcification increases major adverse cardiac event risk, modifiable by echocardiographic left ventricular hypertrophy, in end-stage kidney disease patients	5
Relationship between vascular access and angulation of vena cava filter at placement and retrieval: a multicenter retrospective cohort study	5
The emerging role of digital health in the management of asthma	5
Exploring the risk factors and prognosis of transverse myelitis in systemic lupus erythematosus	5
Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis	5
Willingness to start insulin therapy among insulin-naïve persons with type 2 diabetes mellitus at Gulu Regional Referral Hospital, Gulu City, Uganda	5
Effects of non-invasive brain stimulation in multiple sclerosis: systematic review and meta-analysis	5
Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study	5
Hip BMD is associated with visceral fat change: a registry study of osteoporosis and sarcopenia	5
Cyclosporin A as an adjunct may enhance the therapeutic effect of interferon alpha-2a in patients with refractory Behcet’s uveitis: a retrospective cohort study	5
Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants	5
Strongyloidiasis: what every gastroenterologist needs to know	5
Sailing the ship of life: scurvy and autoimmunity . . .	5
Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?	5
Bimekizumab for the treatment of moderate-to-severe plaque psoriasis: a meta-analysis of randomized clinical trials	5
Tafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis	4
Medication adherence in Medicare-enrolled older adults with asthma and chronic obstructive pulmonary disease before and during COVID-19 pandemic	4
Deep learning-based classification of infectious keratitis on slit-lamp images	4
Relationship between bullous pemphigoid and metabolic syndrome: a 12-year case–control study conducted in China	4
Effect of postoperative radiotherapy on survival in patients with completely resected and pathologically confirmed stage N2 non-small-cell lung cancer: a systematic review and meta-analysis	4
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome	4
Comparative risk of herpes zoster in patients with psoriatic disease on systemic treatments: a systematic review and network meta-analysis	4
The early diagnostic value of serum renalase level in diabetic kidney disease and diabetic macroangiopathy: a retrospective case–control study	4
Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis	4
Thanks to Reviewers	4
One-year outcomes and predictive factors for primary patency after stent placement for treatment of central venous occlusive disease in hemodialysis patients	4
Synchronized application of closed-loop NMES and precision tACS in post-stroke hand rehabilitation: a protocol of neurorehabilitation trial	4
Changes of circulating biomarkers of inflammation and glycolipid metabolism by CPAP in OSA patients: a meta-analysis of time-dependent profiles	4
Physical activity and the ‘pediatric inactivity triad’ in children living with chronic kidney disease: a narrative review	4
Application and observation of artificial intelligence in clinical practice of fundus screening for diabetic retinopathy with non-mydriatic fundus photography: a retrospective observational study of T	4
Synergistic effect of albuminuria on atherosclerosis in patients with primary aldosteronism	4
Patient preferences for active ulcerative colitis treatments and fecal microbiota transplantation	4
Comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants	4
Comparison of the profiles of first-line PD-1/PD-L1 inhibitors for advanced NSCLC lacking driver gene mutations: a systematic review and Bayesian network meta-analysis	4
The early diagnostic value of optical coherence tomography (OCT) and OCT angiography in thyroid-associated ophthalmopathy	4
Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis	4
The dynamics of the general practitioner-nephrologist collaboration for the management of patients with chronic kidney disease before and after dialysis initiation: a mixed-methods study	4
Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial	4
Comparative efficacy of different noninvasive brain stimulation therapies for recovery of global cognitive function, attention, memory, and executive function after stroke: a network meta-analysis of	4
Two-year real-world outcome data from a single tertiary centre shows reduced ustekinumab persistence in a non-bio-naïve Crohn’s disease cohort with penetrating disease, -ostomies and sarcopenia	3
Autoimmune colitis and neutropenia in adjuvant anti-PD-1 therapy for malignant melanoma: efficacy of Vedolizumab, a case report	3
Afterload-related cardiac performance is a powerful hemodynamic predictor of mortality in patients with chronic heart failure	3
Long-chain omega-3 polyunsaturated fatty acids and the risk of heart failure	3
Association between serum pyridoxal 5′-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study	3
Is Helicobacter pylori infection associated with pancreatic cancer? A systematic review and meta-analysis of observational studies	3
Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells: a retrospective cohort study in a high vascular risk population	3
Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury	3
Transcranial alternating current stimulation and its effects on cognition and the treatment of psychiatric disorders: a systematic review and meta-analysis	3
Deep and unbiased proteomics, pathway enrichment analysis, and protein–protein interaction of biomarker signatures in migraine	3
Computerized migraine diagnostic tools: a systematic review	3
Characterization of serum polyunsaturated fatty acid profile in patients with inflammatory bowel disease	3
Dynamic shifts in lung cytokine patterns in post-COVID-19 interstitial lung disease patients: a pilot study	3
A primer on common supplements and dietary measures used by patients with inflammatory bowel disease	3
Associations between bone mineral density and coronary artery calcification: a systematic review and meta-analysis	3
Potential roles of gut microbiota and microbial metabolites in chronic inflammatory pain and the mechanisms of therapy drugs	3
The need for a strategic therapeutic approach: multiple sclerosis in check	3
Morphological alterations of the hypothalamus in idiopathic intracranial hypertension	3
Fractional nitric oxide measurement in exhaled air (FeNO): perspectives in the management of respiratory diseases	3
Efficacy of tacrolimus as long-term immunotherapy for neuronal surface antibody-mediated autoimmune encephalitis	3
Validity of serum and urinary hepcidin as biomarkers for late-onset sepsis in premature infants	3
Relaxation-weighted ²³Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis	3
Non-inferiority of 1 month versus longer dual antiplatelet therapy in patients undergoing PCI with drug-eluting stents: a systematic review and meta-analysis of randomized clinical trials	3
Association between galectin-3 and hepatosteatosis in a community-based cross-sectional study	3