OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Extracellular Vesicles is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Metabolic labelling of a subpopulation of small extracellular vesicles using a fluorescent palmitic acid analogue	1768
Neuropathogenic role of astrocyte‐derived extracellular vesicles in HIV‐associated neurocognitive disorders	375
The immunomodulatory ballet of tumour‐derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD‐L1 pathway in cancer	304
Beyond basic characterization and omics: Immunomodulatory roles of platelet‐derived extracellular vesicles unveiled by functional testing	263
Helminth extracellular vesicles co‐opt host monocytes to drive T cell anergy	250
Arabidopsis Produces Distinct Subpopulations of Extracellular Vesicles That Respond Differentially to Biotic Stress, Altering Growth and Infectivity of a Fungal Pathogen	221
Tumour‐derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8‐mediated creatine import in NPM1‐mutated acute myeloid leukaemia	214
	181
GMP‐Compliant Process for the Manufacturing of an Extracellular Vesicles‐Enriched Secretome Product Derived From Cardiovascular Progenitor Cells Suitable for a Phase I Clinical Trial	175
Correction to "DetectEV: a Functional Enzymatic Assay to Assess Integrity and Bioactivity of Extracellular Vesicles"	159
Nanoscopic Profiling of Small Extracellular Vesicles via High‐Speed Atomic Force Microscopy (HS‐AFM) Videography	154
Circulating extracellular vesicles in healthy and pathological pregnancies: A scoping review of methodology, rigour and results	142
Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma	139
Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation	139
Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis	132
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases	129
A new subtype of artificial cell‐derived vesicles from dental pulp stem cells with the bioequivalence and higher acquisition efficiency compared to extracellular vesicles	126
Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis	124
Gut Microbiota‐Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats	123
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Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery	113
Breast Cancer‐Derived Extracellular Vesicles Modulate the Cytoplasmic and Cytoskeletal Dynamics of Blood‐Brain Barrier Endothelial Cells	109
Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography	104
A multiantigenic antibacterial nanovaccine utilizing hybrid membrane vesicles for combating Pseudomonas aeruginosa infections	103
Engineered Cas9 extracellular vesicles as a novel gene editing tool	103

A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy	99
Imaging of surface microdomains on individual extracellular vesicles in 3‐D	99
	98
ISEV2023 Abstract Book	97
Extracellular vesicles and high‐density lipoproteins: Exercise and oestrogen‐responsive small RNA carriers	95
Correction to “Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation”	95
TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression	92
Extracellular vesicle surface display of αPD‐L1 and αCD3 antibodies via engineered late domain‐based scaffold to activate T‐cell anti‐tumor immunity	92
Extracellular Vesicle (EV) Targeted Cells Release Secondary Effector EVs: Indication of How To Account for Histocompatibility and Disease Specificity of EV Treatments	90
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	81
Bacterial outer membrane vesicles induce a transcriptional shift in arabidopsis towards immune system activation leading to suppression of pathogen growth in planta	79
	75
Dynamic Change of PD‐L2 on Circulating Plasma Extracellular Vesicles as a Predictor of Treatment Response in Melanoma Patients Receiving Anti‐PD‐1 Therapy	72
Correction to "Microbead Encapsulation Strategy for Efficient Production of Extracellular Vesicles Derived From Human Mesenchymal Stem Cells"	71
USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation	70
Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles	68
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models	67
Phloem sap from melon plants contains extracellular vesicles that carry active proteasomes which increase in response to aphid infestation	66
A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants	66
MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research	63
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles	62
Hyaluronic acid: An overlooked extracellular vesicle contaminant	61
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The Procoagulant and Fibrinolytic Balance of Extracellular Vesicles Predicts Mortality in Septic Shock Patients	59
Extracellular Vesicles From Xylella fastidiosa Carry sRNAs and Genomic Islands, Suggesting Roles in Recipient Cells	59
Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes	58
Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease	57
Corrigendum	57
Homosalate boosts the release of tumour‐derived extracellular vesicles with protection against anchorage‐loss property	56
Cell‐engineered virus‐mimetic nanovesicles for vaccination against enveloped viruses	56
Quantitative imaging of vesicle–protein interactions reveals close cooperation among proteins	56
Correction to “Cell‐engineered virus‐mimetic nanovesicles for vaccination against enveloped viruses”	53
Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility	52
IFN‐γ‐Induced CD317 Tethers Extracellular Vesicles to Mesenchymal Stromal Cells Interfering With Immune Modulation	51
Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia	51
HTLV‐1 infected T cells cause bone loss via small extracellular vesicles	50
A 96‐Well Ultrafiltration Approach for the High‐Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium	50
Small Extracellular Vesicles Engineered Using Click Chemistry to Express Chimeric Antigen Receptors Show Enhanced Efficacy in Acute Liver Failure	49
Metastatic prostate cancer‐derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein	49
Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers	48
RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release	47
Reflecting on 2100 Days at the Helm of Journal of Extracellular Vesicles: A Thank You Editorial	44
Late Breaking Orals	44
Extracellular Vesicles From Prostate Cancer‐Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site	44
The trajectory of vesicular proteomic signatures from HBV‐HCC by chitosan‐magnetic bead‐based separation and DIA‐proteomic analysis	44
A beginner's guide to study extracellular vesicles in human blood plasma and serum	43
Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data	42
Formation of a protein corona on the surface of extracellular vesicles in blood plasma	42

Scalable production of siRNA‐encapsulated extracellular vesicles for the inhibition of KRAS‐mutant cancer using acoustic shock waves	41
	41
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection	41
Unraveling multilayered extracellular vesicles: Speculation on cause	41
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Transfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours	40
Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions	40
Development of Broadly Applicable Reference EVs Expressing Horseradish Peroxidase	40
Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles	39
Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes	38
The activity of the quorum sensing regulator HapR is modulated by the bacterial extracellular vesicle (BEV)‐associated protein ObfA of Vibrio cholerae	38
Cocaine perturbs mitovesicle biology in the brain	38
Correction to Heat inactivation of foetal bovine serum performed after EV‐depletion influences the proteome of cell‐derived extracellular vesicles	38
Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury	38
Tumour tissue‐derived small extracellular vesicles reflect molecular subtypes of bladder cancer	38
Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification	37
An immunogold single extracellular vesicular RNA and protein (^AuSERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients	37
Non‐Invasive imaging of extracellular vesicles: Quo vaditis in vivo?	37
First‐In‐Human Application of Human Umbilical Cord‐Derived Extracellular Vesicles in Tethered Spinal Cord Release Surgery	37
Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk	36
Light‐induced high‐efficient cellular production of immune functional extracellular vesicles	36
Direct delivery of immune modulators to tumour‐infiltrating lymphocytes using engineered extracellular vesicles	36
Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion	35
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model	35
Defining the Parameters for Sorting of RNA Cargo Into Extracellular Vesicles	35
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Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non‐CSF biomarkers of Alzheimer's disease	34
EV‐COMM: A database of interspecies and intercellular interactions mediated by extracellular vesicles	34
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Differential temporal release and lipoprotein loading in B. thetaiotaomicron bacterial extracellular vesicles	34
Anti‐SARS‐CoV‐2 effect of extracellular vesicles released from mesenchymal stem cells	33
Extracellular Vesicles From Limosilactobacillus johnsonii Enhance Milk Fat Synthesis by Inducing CD36 Dynamic Palmitoylation and Activating PPARγ Signalling	33
Untouched isolation enables targeted functional analysis of tumour‐cell‐derived extracellular vesicles from tumour tissues	33
Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion	33
Extracellular vesicles derived from nasopharyngeal carcinoma induce the emergence of mature regulatory dendritic cells using a galectin‐9 dependent mechanism	33
Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis	33
Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles	32
Umbilical Cord‐Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non‐Alcoholic Fatty Liver Disease	32
Fusobacterium nucleatum‐Derived Outer Membrane Vesicles Promote Immunotherapy Resistance via Changes in Tryptophan Metabolism in Tumour‐Associated Macrophages	32
Endothelial extracellular vesicles promote tumour growth by tumour‐associated macrophage reprogramming	32
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform	32
Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise	31
Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells	30
Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model	30
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer	30
An aptamer‐guided fluorescence polarisation platform for extracellular vesicle liquid biopsy	30
An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood	30
Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo	30
Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing	29
Establishment of a simplified dichotomic size‐exclusion chromatography for isolating extracellular vesicles toward clinical applications	29
EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open‐source ImageJ/Fiji plugin	29
Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression	29
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases	29
A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles	28
Extracellular vesicles as human therapeutics: A scoping review of the literature	28
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis	28
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The importance of controlled clinical trials with extracellular vesicles	26
Defining Biological Variability, Analytical Precision and Quantitative Biophysiochemical Characterization of Human Urinary Extracellular Vesicles	26
Small and Large Extracellular Vesicles From Human Preovulatory Follicular Fluid Display Distinct ncRNA Cargo Profiles and Differential Effects on KGN Granulosa Cells	26
Potential Role of Menstrual Fluid‐Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesis	26
Proviral role of human respiratory epithelial cell‐derived small extracellular vesicles in SARS‐CoV‐2 infection	26
Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple‐Negative Breast Cancer	26
From sweat to hope: The role of exercise‐induced extracellular vesicles in cancer prevention and treatment	26
Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles in SARS‐CoV‐2 and H1N1 influenza‐induced acute lung injury	25
Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery	25
Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment	25
The dark side of foetal bovine serum in extracellular vesicle studies	25
Reporter gene assay for membrane fusion of extracellular vesicles	24
Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles	24
Lipid A in outer membrane vesicles shields bacteria from polymyxins	24
Extracellular Vesicle‐Mediated Delivery of 20S Proteasomes Enhances Tau Degradation in Recipient Cells	24
Correction to “Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF‐1α”	24
Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion	24