OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Extracellular Vesicles is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches	448
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles	222
A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles	216
Formation of a protein corona on the surface of extracellular vesicles in blood plasma	206
Biodistribution of extracellular vesicles following administration into animals: A systematic review	199
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles	188
Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	174
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?	155
Identification of storage conditions stabilizing extracellular vesicles preparations	154
Microbiota‐derived extracellular vesicles in interkingdom communication in the gut	133
Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium	123
The impact of storage on extracellular vesicles: A systematic study	120
Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery	119
Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing	117
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions	112
Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes	111
Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25	110
Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus	110
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms	108
Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples	106
Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy	105
Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future	105
A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation	102
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy	92
Extracellular vesicles from adipose tissue‐derived stem cells alleviate osteoporosis through osteoprotegerin and miR‐21‐5p	89

Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment	89
Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases	89
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p	89
Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles	88
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk	87
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model o	85
Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution	84
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases	82
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo	82
A call for Rigor and standardization in plant extracellular vesicle research	79
A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants	77
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo	76
Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications	75
Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease	74
Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury	71
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation	71
Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry	71
Foetal bovine serum influence on in vitro extracellular vesicle analyses	69
Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles	66
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?	65
Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion	65
Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography	65
Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy	65
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo	65
Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity	64
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain	64
Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour	62
Functional assays to assess the therapeutic potential of extracellular vesicles	62
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform	62
Extracellular vesicles carry SARS‐CoV‐2 spike protein and serve as decoys for neutralizing antibodies	62
Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells	61
Single‐vesicle imaging and co‐localization analysis for tetraspanin profiling of individual extracellular vesicles	61
Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides	61
A compendium of single extracellular vesicle flow cytometry	60
Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes	59
Establishment of a simplified dichotomic size‐exclusion chromatography for isolating extracellular vesicles toward clinical applications	58
Engineered Cas9 extracellular vesicles as a novel gene editing tool	58
Localized fluorescent imaging of multiple proteins on individual extracellular vesicles using rolling circle amplification for cancer diagnosis	57
Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	56
Extracellular vesicles in the development of organ‐specific metastasis	56
Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment	55
First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles	54
Cryptococcus extracellular vesicles properties and their use as vaccine platforms	53
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae	52
Identification of anti‐inflammatory vesicle‐like nanoparticles in honey	52
Exogenous loading of miRNAs into small extracellular vesicles	52
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours	51
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors	51
Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling	50
Understanding the extracellular vesicle surface for clinical molecular biology	49

Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding	49
Highly efficient magnetic labelling allows MRI tracking of the homing of stem cell‐derived extracellular vesicles following systemic delivery	48
Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions	47
Rigor and standardization of extracellular vesicle research: Paving the road towards robustness	47
Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bow	46
Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol‐dependent manner	46
Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR‐29 family	44
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy	44
CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment	43
Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions	42
Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis	42
WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1	42
β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis	41
Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation	41
Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells	41
Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles	41
First‐in‐human clinical trial of allogeneic, platelet‐derived extracellular vesicles as a potential therapeutic for delayed wound healing	41
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases	41
Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression	40
Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease	40
COVID‐19 therapy with mesenchymal stromal cells (MSC) and convalescent plasma must consider exosome involvement: Do the exosomes in convalescent plasma antagonize the weak immune antibodies?	40
Inflammasome‐induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses	39
Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays	36
Imaging of surface microdomains on individual extracellular vesicles in 3‐D	36
Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method	36
Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells	36
Morphine‐mediated release of miR‐138 in astrocyte‐derived extracellular vesicles promotes microglial activation	35
A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles	35
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity	34
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo	34
Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator	34
Bioorthogonally surface‐edited extracellular vesicles based on metabolic glycoengineering for CD44‐mediated targeting of inflammatory diseases	33
The proteomic landscape of small urinary extracellular vesicles during kidney transplantation	33
Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll‐like receptor 2	33
Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx	33
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models	32
Single‐step equipment‐free extracellular vesicle concentration using super absorbent polymer beads	32
The dark side of foetal bovine serum in extracellular vesicle studies	32
Nephron mass determines the excretion rate of urinary extracellular vesicles	32
Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP	31
Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo: An exploratory study	31
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles	31
Microglial derived extracellular vesicles activate autophagy and mediate multi‐target signaling to maintain cellular homeostasis	31
Early prediction of COVID‐19 severity using extracellular vesicle COPB2	30
WNT3A‐loaded exosomes enable cartilage repair	30
Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes	30
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection	29
Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery	29
Small extracellular vesicles deliver osteolytic effectors and mediate cancer‐induced osteolysis in bone metastatic niche	29
Proteome‐minimized outer membrane vesicles from Escherichia coli as a generalized vaccine platform	29
TPI1‐reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis	29
Urinary extracellular vesicles: Assessment of pre‐analytical variables and development of a quality control with focus on transcriptomic biomarker research	29
Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV‐CATCHER): A customizable purification assay designed for small‐RNA biomarker identification and evaluation of circulating	28
Encapsulating Cas9 into extracellular vesicles by protein myristoylation	28
Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics	28
Anti‐SARS‐CoV‐2 effect of extracellular vesicles released from mesenchymal stem cells	28
Cross‐flow microfiltration for isolation, selective capture and release of liposarcoma extracellular vesicles	28
CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells	28
Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles	28
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl‐2/caspase‐3 pathway	27
Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation	27
Identification of faecal extracellular vesicles as novel biomarkers for the non‐invasive diagnosis and prognosis of colorectal cancer	27
LncRNA‐encoded microproteins: A new form of cargo in cell culture‐derived and circulating extracellular vesicles	27