OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Extracellular Vesicles is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles	181
Biodistribution of extracellular vesicles following administration into animals: A systematic review	155
A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles	151
Formation of a protein corona on the surface of extracellular vesicles in blood plasma	150
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles	148
miR‐23a‐3p‐abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration	142
Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin	135
RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?	130
A combined “eat me/don't eat me” strategy based on extracellular vesicles for anticancer nanomedicine	122
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging	115
Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus	102
Microbiota‐derived extracellular vesicles in interkingdom communication in the gut	100
Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery	99
Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing	99
Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium	98
Adipose‐derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR‐25	95
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions	94
Extracellular vesicles from human iPSC‐derived neural stem cells: miRNA and protein signatures, and anti‐inflammatory and neurogenic properties	94
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms	93
Identification of storage conditions stabilizing extracellular vesicles preparations	90
Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes	89
The impact of storage on extracellular vesicles: A systematic study	85
A novel three step protocol to isolate extracellular vesicles from plasma or cell culture medium with both high yield and purity	83
Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy	79
Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future	78

Extracellular vesicles from adipose tissue‐derived stem cells alleviate osteoporosis through osteoprotegerin and miR‐21‐5p	77
Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia	76
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy	74
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p	74
Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples	74
Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles	73
The future of Extracellular Vesicles as Theranostics – an ISEV meeting report	73
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment	73
Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases	73
Monitoring HSP70 exosomes in cancer patients’ follow up: a clinical prospective pilot study	72
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk	72
A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation	71
Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration	71
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model o	71
Influence of species and processing parameters on recovery and content of brain tissue‐derived extracellular vesicles	69
Lactobacillus plantarum‐derived extracellular vesicles induce anti‐inflammatory M2 macrophage polarization in vitro	68
A circulating extracellular vesicles‐based novel screening tool for colorectal cancer revealed by shotgun and data‐independent acquisition mass spectrometry	67
A call for Rigor and standardization in plant extracellular vesicle research	66
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo	66
Systematic review of extracellular vesicle‐based treatments for lung injury: are EVs a potential therapy for COVID‐19?	64
Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo	63
Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury	62
Triple knockdown of CDC37, HSP90‐alpha and HSP90‐beta diminishes extracellular vesicles‐driven malignancy events and macrophage M2 polarization in oral cancer	61
Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease	61
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases	60
Exosome therapeutics for lung regenerative medicine	59
Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles	59
Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution	59
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo	59
Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles	58
Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity	58
Foetal bovine serum influence on in vitro extracellular vesicle analyses	56
Mesenchymal stromal cell‐derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia‐induced lung injury	56
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?	56
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation	55
Design of experiment (DoE)‐driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper‐free click chemistry‐based labelling	55
Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer	55
Stem cell‐derived extracellular vesicles mitigate ageing‐associated arterial stiffness and hypertension	54
Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour	54
Synthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy	54
Functional assays to assess the therapeutic potential of extracellular vesicles	54
A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants	54
Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry	53
The RNA‐binding protein hnRNPU regulates the sorting of microRNA‐30c‐5p into large extracellular vesicles	52
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain	52
In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo	50
Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes	50
Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses	50
Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography	50
Localized fluorescent imaging of multiple proteins on individual extracellular vesicles using rolling circle amplification for cancer diagnosis	49

Single‐vesicle imaging and co‐localization analysis for tetraspanin profiling of individual extracellular vesicles	48
Extracellular vesicles in the development of organ‐specific metastasis	48
Engineered Cas9 extracellular vesicles as a novel gene editing tool	47
Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells	47
Establishment of a simplified dichotomic size‐exclusion chromatography for isolating extracellular vesicles toward clinical applications	47
Characterization of brain‐derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake	46
Endothelial cell‐derived extracellular vesicles alter vascular smooth muscle cell phenotype through high‐mobility group box proteins	46
Membrane‐binding peptides for extracellular vesicles on‐chip analysis	45
Cryptococcus extracellular vesicles properties and their use as vaccine platforms	45
Protein markers for Candida albicans EVs include claudin‐like Sur7 family proteins	44
Exogenous loading of miRNAs into small extracellular vesicles	44
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae	44
Extracellular vesicles carry SARS‐CoV‐2 spike protein and serve as decoys for neutralizing antibodies	44
Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion	44
Bisecting GlcNAc modification diminishes the pro‐metastatic functions of small extracellular vesicles from breast cancer cells	43
First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles	43
Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides	43
Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment	43
Identification of anti‐inflammatory vesicle‐like nanoparticles in honey	42
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors	42
Human ESC‐sEVs alleviate age‐related bone loss by rejuvenating senescent bone marrow‐derived mesenchymal stem cells	41
DC‐SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte‐derived dendritic cells	41
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours	40
The αvβ6 integrin in cancer cell‐derived small extracellular vesicles enhances angiogenesis	40
Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding	40
Highly efficient magnetic labelling allows MRI tracking of the homing of stem cell‐derived extracellular vesicles following systemic delivery	40
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform	39
Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol‐dependent manner	39
Metabolic characteristics of large and small extracellular vesicles from pleural effusion reveal biomarker candidates for the diagnosis of tuberculosis and malignancy	38
Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR‐29 family	38
COVID‐19 therapy with mesenchymal stromal cells (MSC) and convalescent plasma must consider exosome involvement: Do the exosomes in convalescent plasma antagonize the weak immune antibodies?	37
Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease	37
Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions	37
Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications	37
Rigor and standardization of extracellular vesicle research: Paving the road towards robustness	37
Comprehensive palmitoyl‐proteomic analysis identifies distinct protein signatures for large and small cancer‐derived extracellular vesicles	37
Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression	37
Dendritic cells release exosomes together with phagocytosed pathogen; potential implications for the role of exosomes in antigen presentation	36
Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells	36
WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1	36
Inflammasome‐induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses	36
Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles	35
Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation	35
Morphine‐mediated release of miR‐138 in astrocyte‐derived extracellular vesicles promotes microglial activation	34
Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling	34
miRNA‐ and cytokine‐associated extracellular vesicles mediate squamous cell carcinomas	34
Y‐RNA subtype ratios in plasma extracellular vesicles are cell type‐ specific and are candidate biomarkers for inflammatory diseases	34
Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays	32
Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells	32
Fusion protein engineered exosomes for targeted degradation of specific RNAs in lysosomes: a proof‐of‐concept study	32
Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bow	32